1AD1,1EYE,2VP8


Conserved Protein Domain Family
DHPS

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TIGR01496: DHPS 
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dihydropteroate synthase
This model represents dihydropteroate synthase, the enzyme that catalyzes the second to last step in folic acid biosynthesis. The gene is usually designated folP (folic acid biosynthsis) or sul (sulfanilamide resistance). This model represents one branch of the family of pterin-binding enzymes (pfam00809) and of a cluster of dihydropteroate synthase and related enzymes (COG0294). Other members of pfam00809 and COG0294 are represented by model TIGR00284. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]
Statistics
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PSSM-Id: 273657
Aligned: 21 rows
Threshold Bit Score: 263.349
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1AD1_A         4 KIMGILNVTPDSFSDGGKFNNVESAVTRVKAMMDEGADIIDVGGVSTRPGHEMITVEEELNRVLPVVEAIVGf--dVKIS 81  Staphylococcus ...
P28822        26 LVMGILNVTPDSFSDGGKYDSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKel-gVPIS 104 Bacillus subtil...
O33724        13 AIMGILNVTPDSFSDGGSYTTVQKALDHVEQMIADGAKIIDVGGESTRPGCQFVSATDEIDRVVPVIKAIKEny-dILIS 91  Streptococcus p...
O06274         7 QVMGVLNVTDDSFSDGGCYLDLDDAVKHGLAMAAAGAGIVDVGGESSRPGATRVDPAVETSRVIPVVKELAAq--gITVS 84  Mycobacterium t...
O05308        43 LIMAIVNRTPDSFYDKGATFSDAAARDAVHRAVADGADVIDVGGVKAGPGE-RVDVDTEITRLVPFIEWLRGaypdQLIS 121 Mycobacterium t...
EET97638      11 QIMGIVNTTPDSFSDGGSYTTVDVAYQHALHLLEAGADILDIGGQSTRPGYEEVSPQVEADRVLPLIKKIREts-lAPIS 89  Enterococcus fa...
WP_010921057   8 RVMGIVNVTPDSFSDGGKFLAAQDGVEHARRLIAQGADILDIGGESTRPGAAPVSEFDEILRVVPLIEAVRRas-dVPVS 86  Caulobacter vib...
WP_010909659  21 VVVGILNVTPDSFSDGGLFDAPEAALAQARRMIGEGAGIIDVGGESTRPGAAAISASEEQARVLPVIEALARsg-dVLIS 99  Mesorhizobium loti
1EYE_A         7 QVMGVLNVTDDSFSDGGCYLDLDDAVKHGLAMAAAGAGIVDVGGESSRPGATRVDPAVETSRVIPVVKELAAq--gITVS 84  Mycobacterium t...
2VP8_A        43 LIMAIVNRTPDSFYDKGATFSDAAARDAVHRAVADGADVIDVGGVKAGPG-ERVDVDTEITRLVPFIEWLRGaypdQLIS 121 Mycobacterium t...
1AD1_A        82 VDTFRSEVAEACLKLGVDIINDQWAGLyDHRMFQVVAKY-DAEIVLMHNG---NGN-----RD----EPVVEEMLTSLLA 148 Staphylococcus ...
P28822       105 VDTYKASVADEAVKAGASIINDIWGAKhDPKMASVAAEH-NVPIVLMHNR---PER-----NY----NDLLPDMLSDLME 171 Bacillus subtil...
O33724        92 IDTYKTETARAALEAGADILNDVWAGLyDGQMFALAAEY-DAPIILMHNQ---DEE-----VY----QEVTQDVCDFLGN 158 Streptococcus p...
O06274        85 IDTMRADVARAALQNGAQMVNDVSGGRaDPAMGPLLAEA-DVPWVLMHWRavsADTphvpvRY----GNVVAEVRADLLA 159 Mycobacterium t...
O05308       122 VDTWRAQVAKAACAAGADLINDTWGGV-DPAMPEVAAEF-GAGLVCAHTGgalPRTrpfrvSYgtttRGVVDAVISQVTA 199 Mycobacterium t...
EET97638      90 VDTYYPEVAEAAIQAGATMINDIKGLD-TPGMAEVLAQYpEVQVVIMHSRkrq-------------slSLKEELHQFYTE 155 Enterococcus fa...
WP_010921057  87 IDTMKPAVARAAVKAGATMWNDVTALRfSPDAPEVAAEL-GCEVVLMHMLg-ePGTmqdapRY----DDVVSEVEAFLLA 160 Caulobacter vib...
WP_010909659 100 VDTYRADTARLAVAAGAHIVNDVWGLQrEPDIARVAAET-GAGLIIMHTGrd-------rkKL----PDVIADQFAFLER 167 Mesorhizobium loti
1EYE_A        85 IDTMRADVARAALQNGAQMVNDVSGGRaDPAMGPLLAEA-DVPWVLMHWRavsADTphvpvRY----GNVVAEVRADLLA 159 Mycobacterium t...
2VP8_A       122 VDTWRAQVAKAACAAGADLINDTWGGV-DPAMPEVAAEF-GAGLVCAHTGgalPRTrpfrvSYgtttRGVVDAVISQVTA 199 Mycobacterium t...
1AD1_A       149 QAHQAKIAGIPSNKIWLDPGIGFAK-TRNEEAEVMARLDELVATEYPVLLATSRKRFTKEMM--Gy----dTT-PVERDE 220 Staphylococcus ...
P28822       172 SVKIAVEAGVDEKNIILDPGIGFAK-TYHDNLAVMNKLEIFSGLGYPVLLATSRKRFIGRVL--D------LP-PEERAE 241 Bacillus subtil...
O33724       159 RAQAALDAGVPKNNIWVDPGFGFAK-SVQQNTELLKGLDRVCQLGYPVLFGISRKRVVDALL--Gg----nTK-AKERDG 230 Streptococcus p...
O06274       160 SVADAVAAGVDPARLVLDPGLGFAK-TAQHNWAILHALPELVATGIPVLVGASRKRFLGALL--AgpdgvmRP-TDGRDT 235 Mycobacterium t...
O05308       200 AAERAVAAGVAREKVLIDPAHDFGK-NTFHGLLLLRHVADLVMTGWPVLMALSNKDVVGETL--G------VD-LTERLE 269 Mycobacterium t...
EET97638     156 KIEQCQKYGLSLEKICFDPGIGFHK-TVAENLQLLKDPNAFRYQDYPLLYGVSRKRTIGALT--N------EPePANRDF 226 Enterococcus fa...
WP_010921057 161 RAFTAMAAGVAKDKIWLDPGIGFGK-TLAHNLALIAALPRFVALGYPILLGASRKRFIAGIDssA------HE-ASDRLG 232 Caulobacter vib...
WP_010909659 168 SLEIARRNGIADDRIVLDPGFGFAKeTAEENLDLMARFSELHALGFPLMAGTSRKRFIGTVT--G------RD-AADRAP 238 Mesorhizobium loti
1EYE_A       160 SVADAVAAGVDPARLVLDPGLGFAK-TAQHNWAILHALPELVATGIPVLVGASRKRFLGALL--AgpdgvmRP-TDGRDT 235 Mycobacterium t...
2VP8_A       200 AAERAVAAGVAREKVLIDPAHDFGK-NTFHGLLLLRHVADLVMTGWPVLMALSNKDVVGETL--G------VD-LTERLE 269 Mycobacterium t...
1AD1_A       221 VTAATTAYGIMKGVRAVRVHNVELNAKLAKGIDFL 255 Staphylococcus aureus
P28822       242 GTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM 276 Bacillus subtilis subsp. subtilis str. 168
O33724       231 ATAALSAYALGKGCQIVRVHDVKANQDIVAVLSQL 265 Streptococcus pyogenes
O06274       236 ATAVISALAALHGAWGVRVHDVRASVDAIKVVEAW 270 Mycobacterium tuberculosis
O05308       270 GTLAATALAAAAGARMFRVHEVAATRRVLEMVASI 304 Mycobacterium tuberculosis
EET97638     227 GSAAASLYAAQQGVEILRVHNVQGLKQTFDVWRAL 261 Enterococcus faecalis T2
WP_010921057 233 GSIAAHLAGAEAGVAAVRVHDVRETVQALDVLRAI 267 Caulobacter vibrioides
WP_010909659 239 GTAATSVILRLKGAHLFRVHDVAINVdalamadam 273 Mesorhizobium loti
1EYE_A       236 ATAVISALAALHGAWGVRVHDVRASVDAIKVVEAW 270 Mycobacterium tuberculosis H37Rv
2VP8_A       270 GTLAATALAAAAGARMFRVHEVAATRRVLEMVASI 304 Mycobacterium tuberculosis H37Rv
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