Conserved Protein Domain Family
NYAP_N

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pfam15439: NYAP_N 
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
NYAP_N is an N-terminal family of eukaryotic proteins that are substrates of tyrosine kinase in the brain. When first identified, the family members were referred to as unconventional myosin XVI, or Myr 8. However, proteins have now been identified as being integrally involved in neuronal function and morphogenesis. The family is involved in both the activation of phosphoinositide 3-kinase (PI3K) and the recruitment of the downstream effector WAVE complex to the close vicinity of PI3K; it also appears to regulate the brain size and neurite outgrowth in mice.
Statistics
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PSSM-Id: 464717
Aligned: 29 rows
Threshold Bit Score: 137.215
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007245255   44 LYRksrldwRHRDQEGKKSSsckdassat----------vgkvrdlasFRRHFRMGFMTMPASQDLSp------HSCAAA 107 
XP_023207578   50 TYLqekhqkKRRQEEAIKRIgedvat----------------asdgaySGKHFRMGFMTMPAPQDRVp------TPT-PG 106 
XP_003975643   42 LFLqekndkKRKKEEAIKRTged----------------------iatEGKHLRIGSITMPEPQERMpiplpqaLACGQA 99  
XP_003197868   42 INFqekndkKRKQEEAIKRgee-----------------------vvtEGKHLRMGSMSMPAPAEHMsph-qhqHPCNPG 97  
XP_001340925   48 TYLqeknqkKRRQEEAIKRIgedvarv---------------tegggyAGKHFRMGFMTMPAPQDRVp------PPCGPG 106 
XP_007233584   48 AYLqeqsqkKRRQDEAIKRMgedvgsm---------------adggayAGKHFRMGFMTMPAPLDRLp------PPSGPG 106 
XP_003768872    4 LYRktklewRQHKEEEAKRStskevgpagpsg----pgpgvrardvssLRRSLRMGFMTMPASQEHVp------HPCRSA 73  
XP_006249151    4 LYRktklewRQHKEEEAKRSsskeaaptgpvgsgavpgpgvrvrdiasLRRSLRMGFMTMPASQEHTp------HPCRSA 77  
TMS14338       44 LYRksrldwRQRDQEGSKKSssqndpsat----------vgkvrdlasFRRHFRMGFMTMPASQDLSp------HSCASA 107  large yellow ...
XP_014353933   49 LYRktkiewKHHREEEAKRStakdvgvg-------------kvrdiasFRKHFRMGFMTMPASQDHVp------HPCASS 109  coelacanth
XP_007245255  108 MAPRSQSCHAV-------GTGEGEslenGDYP-----------DSDTQstpntsrcPPAKPKRHPSTRLSSTPQQEH--P 167 
XP_023207578  107 FTVRSQSLHSV-------GGGEED------SN-----------HSRKQ--------PPPKPKRDPTTKLSSSSEAVDgvS 154 
XP_003975643  100 FSVRSQSLHSVggggnsgGGGDEE----VGSP-----------TSRKQ--------PPPKPRRDPATKLSMSSEAVD--H 154 
XP_003197868   98 FSVRSQSLHSV-------GGLEEE-----GSP-----------TSRKQ--------PPPKPRRDPSTKLSISSEAVDisP 146 
XP_001340925  107 FTVRSQSLHSV-------GGGEEE-----GSP-----------TSRKQ--------PPPKPRRDPNTKLSTSSETVN--A 153 
XP_007233584  107 FTVRSQSLHSV-------GGGEEEg---GGSP-----------TLRKQ--------PPPKPKRDPNTKLSTSSETVN--A 155 
XP_003768872   74 MAPRSLSCHSV-------GSMESS----GSTTggggssgvggdVGARR--------PPVKPRRHPSTKLSMAAS------ 128 
XP_006249151   78 MAPRSLSCHSV-------GSMDs----vGGGPggggg-glledSSTRR--------PPAKPRRHPSTKLSMAGP------ 131 
TMS14338      108 MAPRSQSCHAV-------GAGDTSle-nGDYS-----------DTQSQhgg---rcPPAKPKRHPSTRLSSSsaD----- 160  large yellow ...
XP_014353933  110 MAPRSLSCHSV-------GSVEn----gGDEP-----------CSRK---------PPAKPKRHPSTKLSMSGD------ 152  coelacanth
XP_007245255  168 ARgShGPP-DAPpppppq-nskhseKKNAMKKSDSGEMQGRKVPPQKPKRSPSTQL--SFDPPPPRv-----pPPA---- 234 
XP_023207578  155 GF-IkREYqEAKd-----------gAELSEARYHHHSEESRKMPPPKPKRDPNTQLssSFDEsy--------vRNHcsk- 213 
XP_003975643  155 SP-MsTCRgDRC-------------------DAQGCSEDCRRVPPPKPKRNPNTQLsvSFDEsy--------iKSHgsga 206 
XP_003197868  147 TY-CkGDEsERCd-----------gTQ-------GCSEDCRKVPPPKPKRNPNTQLstSFDEsy--------iRSNgsk- 198 
XP_001340925  154 GL-StGKSaKDSe-----------kFD-ASKSRPCSEEY-RRMPPPKPKRNPNTQLstSFDEsy--------iQHHsskg 211 
XP_007233584  156 TL-StGKGgKETd-----------kSD-ASKSRPCSEEY-RRMPPPKPKRNPNTQLstSFDEsy--------iRNHgtkf 213 
XP_003768872  129 -----GAE-LPPs-----------kKAGSQKPGPEGRESSRKIPPQKPKRSPNTQLsvSFDESCSM-------APTsrv- 183 
XP_006249151  132 -----Ga--ETPps----------rKAGSQKPTPECRESSRKVPPQKPRRSPNTQLsvSFDESCAPapsprggNLP---- 190 
TMS14338      161 ---GrG-LpETPppasthsqskhsdKKNAMKKSDSGEIGAKKVPPLKPKRSPSTQL--SFDPLPPRvphs---------- 224  large yellow ...
XP_014353933  153 ---ArGa--VTPeqstl----vpgkKTGSQKARPESTEFGRKIPPLKPKRNPNTQLsaSFDEAYANrpsvmmaSVA---- 219  coelacanth
XP_007245255  235 ----------TPLPFQSADPSPH----GEGGDDEPVYIEMVG-QVFTREtsgaqt----------phpltpSA---TtpD 286 
XP_023207578  214 --------kssFQGDKSSSQSHSpa-sRDTDDEEPVYIEMVG-NILREL----------------------KGq----eA 257 
XP_003975643  207 icpskhlhrvVSPSELNASPQSDes-pTDDCEDEPVYIEMGGiDVGSRE----------------------PLk-----S 258 
XP_003197868  199 -------gstTM---LFSRDGQTps-pQPQDLDEPVYIEMSG-NVGQEA----------------------TPr-----T 239 
XP_001340925  212 k----saslpRVSKKKSASQNQSpa-pDTDDEVEPVYIEMVG-NILRDF----------------------SRiagAngD 263 
XP_007233584  214 k----saslpRRQKKKSASQNQSpa-lDTDEEAEPVYIEMVG-NILRDF----------------------NQitgGhaD 265 
XP_003768872  184 --------gaLPLQRHSRGGRGVgehdLSSQDEEPVYIEMVG-DVFQGGggssgrssggpagasvggggtgPP---TgpD 251 
XP_006249151  191 ------------LQRLSRASRIAgdldAGAQEEEPVYIEMVG-DVFRGGgrsggglt-------gpplgsgGPtppAaaD 250 
TMS14338      225 ---------atsLPFQATDSQIQ----TEDGEDEPVYIEMVG-QVFTRDsqta--------------tphpVTpvaTtpD 276  large yellow ...
XP_014353933  220 ------------LPRYNTTDSHRtmqgSDGEDEEPVYIEMVG-DVLKGQ---------------------------NtpD 259  coelacanth
XP_007245255  287 SDSDQGEAIYEEMKYP------------------------------------------------IAEDaaRDAQRRLPPK 318 
XP_023207578  258 VDDEQSESVYEEMKYP------------------------------------------------MLED------------ 277 
XP_003975643  259 EDEEPGESVYEEMKYP------------------------------------------------ALDD---------MEY 281 
XP_003197868  240 EEDEPGEAVYEEMKYP------------------------------------------------ALDE------------ 259 
XP_001340925  264 EEDDQGESVYEEMKYP------------------------------------------------AYDD-----------L 284 
XP_007233584  266 EEDNQDESVYEEMKYP------------------------------------------------MYDE-----------V 286 
XP_003768872  252 SDSEESEAIYEEMKYP------------------------------------------------LPEDvaEGRANGAPPT 283 
XP_006249151  251 SDSEDSEAIYEEMKYP------------------------------------------------LPEEtgDGRANGPPPL 282 
TMS14338      277 SDSDQSEAIYEEMKYPlqedresqrhlptkheklrnskhfhvtpsssssssslprpsssspsysKPKAtvSISHSSPLPS 356  large yellow ...
XP_014353933  260 EDSDESEAIYEEMKYP------------------------------------------------LLEDpgEPKGNGP--- 288  coelacanth
XP_007245255  319 -HRSA------KAYHHSSSISSSSSs-sLPRPAssspSCPSssskpkatvsishssplpsstssasstpvplqplstsph 390 
XP_023207578  278 -----------FLQDVQ-STIIDSEaw---------sSRGS--------------------------------------- 297 
XP_003975643  282 -RTDP------VGCRSACP-TPAPYd-pEPLSRcstpRNIP--------------------------------------- 313 
XP_003197868  260 -----------YD--------SRWDl-vNCRSLcvtpCPSEseiytplsr------------------------------ 289 
XP_001340925  285 -PSSL------DHGQSRWEQCPTPGv-pEVELTrpttPRGS--------------------------------------- 317 
XP_007233584  287 -APPA------DQAQSRWEPCPTSAv-pDVELTrpstPRGS--------------------------------------- 319 
XP_003768872  284 -AAVS------PLHHTHSHHSHRRPasaLQSRQngasTKIS--------------------------------------- 317 
XP_006249151  283 mAPSPpqqphvLQPHPHPH---RRPasaLPSRRdgtpTKTT--------------------------------------- 320 
TMS14338      357 sASSTpvp-qvLSASPHTPRAPTPYllqGNKSEaesnT------------------------------------------ 393  large yellow ...
XP_014353933  289 --TSPl--------HRHVHAKARREatrTPTps---lSKNS--------------------------------------- 316  coelacanth
XP_007245255  391 ppraptpfllpgtkseseigsSSKIPAPFPNLLQHKPPLLAFPQP---------AAASSGISAQH--------------- 446 
XP_023207578  298 ---------------------FCDIPPPFPNLLTHRPPLLVFPSApvqcspnsdESPLTPLDVTR--------------- 341 
XP_003975643  314 ---------------------LCDIPAPFPNLLTHRPPLLVFPPApaqcspnsdESPLTPLDVTK--------------- 357 
XP_003197868  290 -------------cttprgvpLCDIPAPFPNLLSHRPPLLVFPPApaqcspnsdESPLTPLDVAK--------------- 341 
XP_001340925  318 ---------------------LCDIPAPFPNLLSHRPPLLVFPPApaqcspnsdESPLTPLDVTK--------------- 361 
XP_007233584  320 ---------------------LCDIPAPFPNLLTHRPPLLVFPPApaqcspnsdESPLTPLDVTK--------------- 363 
XP_003768872  318 ---------------------PCEIPPPFPNLLQHRPPLLAFPQAk-------pTTRTPGDGVSR--------------- 354 
XP_006249151  321 ---------------------PCEIPPPFPNLLQHRPPLLAFPQAk-------sASRAPGDGVSR--------------- 357 
TMS14338      394 -----------------------KIPAPFPNLLQHRPPLLAFPQP---------AAASSGVGVQNkasasakmgtqtssa 441  large yellow ...
XP_014353933  317 ---------------------LCEIPPPFPNLLQHRPPLLAFPQAlsqksgyklATGSTQLG-SK--------------- 359  coelacanth
XP_007245255  447 ------------KSSSAkSGNSSGQA--PSSLPPnags-------sssKESSGGEKDREKDRKD-GHLGPA--PGLRARS 502 
XP_023207578  342 ------------LPMLE-NVSLSKSG---GAEHP--------------QGSGHHRKDRDRDRDRdASHTHT--ITSSGRS 389 
XP_003975643  358 ------------LPMLE-NQSYSKSP--TSSAEP--------------PPSAHLR-------RE-LTATPT--LTVSGRS 398 
XP_003197868  342 ------------LPMFE-NGSFGKSPt-SSSLEPsg-----------sASTSHMR-----RAEReLTATPT--ITASGRS 389 
XP_001340925  362 ------------LPMFD-NVGIVKPGasPTGTEPqpeaq----qqvsgKHHHHHHHHHHKKSAE-TKEQQT--ITASGRS 421 
XP_007233584  364 ------------LPMIE-NVGYVKPGssPTAGDPgqpvpeqpkpsghhHHHHHHHHKKSSDSKE-GSSTHT--ITVSGRS 427 
XP_003768872  355 ------------LPVL----CHTKESa-VPVPAL--------------QVPGRDQETTPTPPPA-ANLLLLg-PSGRARS 401 
XP_006249151  358 ------------LPVL----CHSKESa-GSTPAP--------------QVPARERETPPLPPPPpAANLLLlgPSGRARS 406 
TMS14338      442 ttqastssssssNVPASlS-SKESS----EGGAT--------------KQDKHSRESQLGPA-----------PGLRARS 491  large yellow ...
XP_014353933  360 ------------LPVLQgGPPHPKDPp-STPVTP--------------QVPGQQKGEKDLST---SQNMLY--PSGRARS 407  coelacanth
XP_007245255  503 HSTPLPpssk----------sssPY 517 
XP_023207578  390 -SAPPLassfykssssahsvhgyPR 413 
XP_003975643  399 -SAPPLpctlyk-----sssssyQR 417 
XP_003197868  390 -SAPPLpcalyks---ssssysyQR 410 
XP_001340925  422 -SAPPLtsalyksg-gssaahgyPR 444 
XP_007233584  428 -SAPPLpsalyksg-gssaahgyPR 450 
XP_003768872  402 HSTPLPpqgsgqpr--gekereiPN 424 
XP_006249151  407 HSTPLPpqgsgqt----rgerelPN 427 
TMS14338      492 HSTPLPpssk----------stsPF 506  large yellow croaker
XP_014353933  408 HSTPLPpqasgqq----kserelPT 428  coelacanth
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