Conserved Protein Domain Family
Claudin_2

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pfam13903: Claudin_2 
PMP-22/EMP/MP20/Claudin tight junction
Members of this family are claudins, that form tight junctions between cells.
Statistics
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PSSM-Id: 372799
Aligned: 14 rows
Threshold Bit Score: 114.057
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q16RP0        16 IIAVALLAIAFSTDNW--LS---YEVKRNNIqtfiakhpd---gasltesfNNRlvyYTRTRGL-FRYCYPKEKPPASSV 86  yellow fever mo...
Q6E5P4        18 CLAWIFVMITTGLNEWrlWY---LDVGNTSV--------------------ITS---GVAWVGI-WRACFYSHVLAKVEN 70  torafugu
Q9VX17        16 IIATALLAIAFSTDNW--LH---YDVWRNQIqsfaakhsdaesllhnmnvkYYY---YTRTRGL-FRICYPKERPPVSAV 86  fruit fly
1_pfamImport   1 LVGVVLALVAVVTDHW--AV---LSPELDhh-------------------nATC---EAAHFGL-WRICTKRIVMTDSKD 52 
XP_002007879  40 IFAFAFIAIAFATPSW--LV---SDYRITG-----------------------A---KLDKLGL-WVHCFRSLPDVNDDS 87 
Q17AR2        35 VIALVTVLVAFATPSW--LV---SDYRIT-----------------------GA---KLDRLGL-WTHCFRSLPDVNDDY 82  yellow fever mo...
XP_002416528  25 YCSTVLLLISFASPYW--LEs--YQEANAEFvrlglwdvc---frnyrhpsYQY---DETFNGChWVHSYAYQNIRDW-- 92 
XP_002090123  16 VFSLICFIIAFSTPYW--LV---TDGSLQ-----------------------NP---RFTNLGL-WEVCFNNFQDIHRFF 63 
XP_001861470  16 AVAFLFILIAFVSPYW--LQ---TDGRLE-----------------------NP---KFHNLGL-WELCLNDFQDIHRFY 63 
Q0V9E0        15 ALGILIYLVAFGSDYW--LLakeIEKCSENQetgd-------------natHSV---LLHHEGF-FWRCWFNHAEEENSN 75  tropical clawed...
Q16RP0        87 QIYlspvethcsnidy---fpqteedksspgFNEDIMARLHLARSVIaafilsfVAI-FCAFWTGL-SGCWKRSA----- 156 yellow fever mo...
Q6E5P4        71 CQS----------------------------ISIAAPFAPAEIPVAQ-------VLM-MLAVVAGL-VANICGAVamrlv 113 torafugu
Q9VX17        87 PTYlspiethcsni------dyfpqaedekiANEDATSRLHLARSCIalfiisfVTI-FCAFWTGL-SGCWKRSS----- 153 fruit fly
1_pfamImport  53 KTCgpitlpgekncs-----yfrhfnpgetsEIFHVTTQKEYSISAAaiaifslGFI-IMGTTCAL-LSFPKKRD----- 120
XP_002007879  88 QRRffvgcrwvyd---------pftkgydeiRGFLLPAFMITTQFFYtltfigmLVS-AIGVLVFFlCAGPDQKYf---- 153
Q17AR2        83 QRRffvgcrwvyd---------pfttgydeiRGFLIPPFMIATQFFYtlctigvILSmIMVLFFFL-CAGPDQKFf---- 148 yellow fever mo...
XP_002416528  93 -------------------------------------LLPGWFMFVQsmmtlalMFA-FTALVLVS-ILLMRFLLrf--- 130
XP_002090123  64 DNPfngclw----------------vfeeeyYIIHDFLLPGFYISVQlfa-tlcFVM-CLVVIPLT-AAFLRTSRddd-- 122
XP_001861470  64 DTRfsgcmw----------------ifeeeyYILHDYILPGFFIAVQffftlcfTLL-LLGILMTL-LFLVCSKDndr-- 123
Q0V9E0        76 TMEnfwftnqaptkncthaylspfpqnrdnsNSTSYHSALVYRGFWNifmllgvVTA-VIGGFLII-CAAPFTNH----- 148 tropical clawed...
Q16RP0       157 -----------GAITATAILMLtacllAAGAMGLWHTVEFFEKEK--VVGDDYYQSWTTVL-RDNTRISYDWSYIVAWAG 222 yellow fever mo...
Q6E5P4       114 yfsvadrrnmrLVFVLAGMLYL-----LTSGLCLVPLLWNINSVA--KNNTIDFPQEFQLP-SAPVRQQIGSAIGVGIFA 185 torafugu
Q9VX17       154 -----------GAITATSILLLvtcllAAGAMGLWHTVEFFEKEK--VVGEDYFQQWNTVL-RDNTKIAYDWSYIVAWAG 219 fruit fly
1_pfamImport 121 -----------YLXPAR----------PAGLCIFVSVEVTRQSVK--RM-------IDSEH-TVWIEYNYSWSFACACAA 169
XP_002007879 154 ----------iTLIRSVGYVLL-----GAGVCAAIAVIVFAVFG--------NRNGWMPEH-ANN---WFGWSFVMACVG 206
Q17AR2       149 ----------lKLIRTMGFLTL-----ASGISGGIGVIVFAIFGN--K------DKWMPEH-ANN---WFGWSFILACIG 201 yellow fever mo...
XP_002416528 131 ---------eiIVLMVAFILEA-----ITSIPLFLSVAVFGGMC-----FERS---W---L-QNPIYNHLSWAYALAVVA 184
XP_002090123 123 --------rymVLLLAIGSCQV-----VGSVFGFIAVVTFGAKGD--------SRDWMPGW-QNN---DMGWSFALGVVG 177
XP_001861470 124 ---------yiMLLLTNGTTMV-----VGAICGLIAVLTFGCYGD--SRD------WMPNW-EHN---GMGWAFALGVVG 177
Q0V9E0       149 -----------RIYKAGGGLFI-----TSGILFALVVVMHVFWVQsvSDIKGYTDTRQQDCsQFTVYVSFGWSFMLAPFG 212 tropical clawed...
Q16RP0       223 VASSLLASILLSG 235 yellow fever mosquito
Q6E5P4       186 SVLSLISGLLFLS 198 torafugu
Q9VX17       220 IGTCLLASILLSG 232 fruit fly
1_pfamImport 170 FVLLFLGGLALLL 182
XP_002007879 207 TVLTLVAATLFLT 219
Q17AR2       202 AVACGIAASLFLT 214 yellow fever mosquito
XP_002416528 185 FFFHTVAAMMLLG 197
XP_002090123 178 AVLLLPAGVLYLV 190
XP_001861470 178 VFALFPAGILFIV 190
Q0V9E0       213 IFFCLFAGMLFLL 225 tropical clawed frog
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