Conserved Protein Domain Family
SLC5sbd_SMIT
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cd11491: SLC5sbd_SMIT 
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain
Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Links
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Statistics
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PSSM-Id: 271382
Aligned: 5 rows
Threshold Bit Score: 947.765
Created: 18-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1: putative glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on site mutagenesis and examination of partial transcripts of rabbit SGLT1
  • Citation:PMID 1903656
  • Comment:predicted for human SMIT
  • Citation:PMID 9612208
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
P53794      9 DIAIVALYFILVMCIGFFAMWKsNRSTVSGYFLAGRSMTWVTIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALL 88  human
EDO43582   14 DVVFIMLYFIVVMAICIYAMTKtNRATVSGYFLAGRLMTWLPVGASVFASNIGSEHLIGLAGSGAAAGFGVGSFEINAMI 93  starlet sea anemone
CCD77070    7 DIIVLVIYFAALLGTGIYALFAsRRGTVTGYFLAGRFMTWLPVGASLFASNIGSEHFIGLAGSGAAAGIAVGAFELNASI 86  Schistosoma mansoni
P31637      9 DIAIVALYFILVMCIGFFAMWKsNRSTVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALL 88  dog
Q9JKZ2      9 DIAVVALYFILVMCIGFFAMWKsNRSTVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALL 88  house mouse

Feature 1                                                                                     
P53794     89 LLQLLGWVFIPIYIRSGVY-TMPEYLSKRFGGhRIQVYFAALSLILYIFTKLSVDLYSGALFIQESLGWNLYVSVILLIG 167 human
EDO43582   94 MIDAWLAVRSSVHRSRGRVcTLPEYIHRRFGGqRIRVWLSVLSLLLYIFTKISVNLYSGALFINLALGWNLYAAIILLLG 173 starlet sea anemone
CCD77070   87 LLQLLGWVFLPVYIASGVF-TLPEYMKKRYGGeRIHMYLALLSLILYIFTKISVNLYSGSLFLTEALKWNTWVSIVLLLF 165 Schistosoma mansoni
P31637     89 LLQLLGWVFIPIYIRSGVY-TMPEYLSKRFGGhRIQVYFAALSLILYIFTKLSVDLYSGALFIQESLGWNLYVSVILLIG 167 dog
Q9JKZ2     89 LLQLLGWVFIPIYIRSGVY-TMPEYLSKRFGGhRIQVYFAALSLLLYIFTKLSVDLYSGALFIQESLGWNLYVSVILLIG 167 house mouse

Feature 1                                                                                #    
P53794    168 MTALLTVTGGLVAVIYTDTLQALLMIIGALTLMIISIMEIGGFEeVKRRYMLASPDvtsill--------tynlsNTNs- 238 human
EDO43582  174 LACLCTITGGLAAVIYTDTLCTFLMTLGSLTVMSLGFAEVGGYEgLKSKYMVAVSNhtl--------------hsNTS-- 237 starlet sea anemone
CCD77070  166 LTGLITVTGGLAAVLYTDTLQFFVMIIGALILAIISYINAGGFGgVLSSYGRAIAPinissstdsdliislanvlNTTny 245 Schistosoma mansoni
P31637    168 MTALLTVTGGLVAVIYTDTLQALLMIVGALTLMIISMMEIGGFEeVKRRYMLASPNvtsill--------tynlsNTNs- 238 dog
Q9JKZ2    168 MTALLTVTGGLVAVIYTDTLQALLMIIGALTLMVISMVKIGGFEeVKRRYMLASPDvasill--------kynlsNTNa- 238 house mouse

Feature 1                                                                                     
P53794    239 ----------------cNVSPKKEALKMLRNPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIaHAKGSTLMA 302 human
EDO43582  238 -----------------CGWPRQDSFKLLRDPVYSDIPWPGFIIGETIVSIWYWCADQVIVQRTLSSKSLsHAQGACLFA 300 starlet sea anemone
CCD77070  246 tsltqlasspdvpsslkCSLPPENAFVLLRGINDPEMPWLGFLLGQTPASIWYWCTDQMMVQRVLAAKSLsHAQGATLMA 325 Schistosoma mansoni
P31637    239 ----------------cNVHPKKDALKMLRNPTDEDVPWPGFVLGQTPASVWYWCADQVIVQRVLAAKNIaHAKGSTLMA 302 dog
Q9JKZ2    239 ----------------cMVHPKANALKMLRDPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIaHAKGSTLMA 302 house mouse

Feature 1                                                                                     
P53794    303 GFLKLLPMFIIVVPGMISRILFTDDIACINPEHCMLVCGSRAGCSNIAYPRLVMKLVPVGLRGLMMAVMIAALMSDLDSI 382 human
EDO43582  301 GWIKVLPLFTMLIPGMISRVLSPERVACSTPEQCMAVCGSEVGCSNIAFPELVLKIMPSGLRGLMMAVMMAALMSDLTSI 380 starlet sea anemone
CCD77070  326 GLIKQLPLFLIVIPGMISRILFPDVIGCKPGPDCYRICGQKSGCSNLAYPKLVINIMPSGLRGLMLAVMLAALISDLTSI 405 Schistosoma mansoni
P31637    303 GFLKLLPMFIIVVPGMISRILFADDIACINPEHCMQVCGSRAGCSNIAYPRLVMKLVPVGLRGLMMAVMIAALMSDLDSI 382 dog
Q9JKZ2    303 GFLKLLPMFIIVVPGMISRIVFADEIACINPEHCMQVCGSRAGCSNIAYPRLVMTLVPVGLRGLMMAVMIAALMSDLDSI 382 house mouse

Feature 1                                                                                     
P53794    383 FNSASTIFTLDVYKLIRKSasSRELMIVGRIFVAFMVVISIAWVPIIVeMQGGQMYLYIQEVADYLTPPVAALFLLAIFW 462 human
EDO43582  381 FNSASTLFTIDVYGRFRSKasVRELMIVGRVMVAVMTGVGILWIPVIQnVQGGQLFVYIQAVTAYLSPPIASIYVLALFW 460 starlet sea anemone
CCD77070  406 FNSASTLFTVDVYMKIRKKakNMEIMVVSRIFVIVLILLSIAWIPVIQeFQGSQLYIYIQGVSAYLAPPVASVYLCAILN 485 Schistosoma mansoni
P31637    383 FNSASTIFTLDVYKLIRRSasSRELMIVGRIFVAFMVVISIAWVPIIVeMQGGQMYLYIQEVADYLTPPVAALFLLAIFW 462 dog
Q9JKZ2    383 FNSASTIFTLDVYKLIRKSasSRELMIVGRIFVAFMVVISIAWVPIIVeMQGGQMYLYIQEVADYLTPPVAALFLLAIFW 462 house mouse

Feature 1                                                                                     
P53794    463 KRCNEQGAFYGGMAGFVLGAVRLILAFAYRAPECDQPDNRPgFIKDIHYMYVATGLFWVTGLITVIVS----LLTPPPTK 538 human
EDO43582  461 KRTTEMGAFWGMMIGFVVGALRMILDFRYQSPRCGDADERPaITANVHYMYFAIVAFAISTVSIVIIS----LFTKPHPG 536 starlet sea anemone
CCD77070  486 KRTTERGAFYGLMYGLITGLIRLILTIIYHEPVCGEEDNRPwIIKDIHYMYFALFSFITCGLIVCLLSltekRLTNEQLY 565 Schistosoma mansoni
P31637    463 KRCNEQGAFYGGMAGFVLGAVRLTLAFAYRAPECDQPDNRPgFIKDIHYMYVATALFWVTGLITVIVS----LLTPPPTK 538 dog
Q9JKZ2    463 KRCNEQGAFYGGMAGFVLGAVRLILAFTYRAPECDQPDNRPgFIKDIHYMYVATALFWITGLITVIVS----LLTPPPTK 538 house mouse

Feature 1                                                                                     
P53794    539 EQIRTTTFWSKKNLvvkencspkeepyqmqeksilrcsennetinhiipngksedsikglqpedvnllvtcreegnpvas 618 human
EDO43582  537 ANTARLTWWTRHDAsassdhpeeerddeiamehvtlsrgkqas------------------------------------- 579 starlet sea anemone
CCD77070  566 HNYSTNQKHTSQSSswyk-------------------------------------------------------------- 583 Schistosoma mansoni
P31637    539 EQIRTTTFWSKKSLvvkescspkdepykmqeksilrcsenseatnhiipngksedsikglqpedvnllvtcreegnpvas 618 dog
Q9JKZ2    539 DQIRTTTFWSKKTLvtkescsqkdepykmqeksilqcsensevishtipngksedsikglqpedvnllvtcreegnpvas 618 house mouse

Feature 1                                                                                     
P53794    619 lghseaetpvdaysngqaalmgekerkketddggrywKFIDWFCGFkskslskrslrdlm-------------------- 678 human
EDO43582  580 --------cdsmtgsrdlenascpegtsegskqsrlrRFVSWVCGYeqvvsldtarrtave------------------- 632 starlet sea anemone
CCD77070  584 ----------------------------------ilkNICLWFCGCadhpcsnidiknhcqcnclqrlcnqftthfhsnh 629 Schistosoma mansoni
P31637    619 lghseaetpvdaysngqaalmgekerkketedggrywKFIDWFCGFkskslskrslrdlm-------------------- 678 dog
Q9JKZ2    619 mghseaetpvdaysngqaalmgerereketenrsrywKFIDWFCGFkskslskrslrdlm-------------------- 678 house mouse

Feature 1                                                                                
P53794    679 -----------------------------------eeeavclqmleetRQVKVILNIGLFAVCSLGIFMFVYFSL 718 human
EDO43582  633 ----------------------------------hqqrmrlitsleqdPRAKIFLNANLVVISIACISIFIYFSV 673 starlet sea anemone
CCD77070  630 hhshekiyiitsndiqliedksifnddqhqlntvddyykqpinslkqnSNIKLGLYIGLILTIILSIFGFIFFSV 704 Schistosoma mansoni
P31637    679 -----------------------------------eeeavclqmleepPQVKLILNIGLFAVCSLGIFMFVYFSL 718 dog
Q9JKZ2    679 -----------------------------------deeavclqmleetPQVKVILNIGLFAVCSLGIFMFVYFSL 718 house mouse

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