Members of this family ligate (seal breaks in) RNA. Members so far include phage proteins that can counteract a host defense of cleavage of specific tRNA molecules, trypanosome ligases involved in RNA editing, but no prokaryotic host proteins . [Mobile and extrachromosomal element functions, Prophage functions, Transcription, RNA processing]
Jiyao W et al.(2023). "The conserved domain database in 2023.",