Conserved Protein Domain Family
TFIIIC_delta

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pfam12657: TFIIIC_delta 
Transcription factor IIIC subunit delta N-term
In humans there are six subunits of transcription factor IIIC, and this one is the 90 kDa subunit; whereas in fungi the complex resolves into nine different subunits and this is No. 9 in yeasts. The whole subunit is involved in RNA polymerase III-mediated transcription. It is possible that this N-terminal domain interacts with TFIIIC subunit 8.
Statistics
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PSSM-Id: 463658
Aligned: 42 rows
Threshold Bit Score: 77.1004
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EHS64598       72 IDSSPSCLEWSNDGQAFAVTKANIYLLTPILGYlvspedrhthtqaqptengshsqdapsTPSRSNPSGIQESIAds-tT 150 
Q5KPU4         20 PDPTYRGISWSNEGQCMVVTPRTITILTPHIASslppprnplt-------sqqsmkiseaQKLSNIKPGIQATDSgynnN 92   Cryptococcus ...
XP_002426494   25 HISKTFCISWSENNKISVIADGGVFIFELWPTSlt-----------------------enQTVSLRKFFISVSDMtp-lQ 80  
XP_003425560   14 LVTRSFACKWSEDNRLSIVTEKGVQIIEIVPSAtq-----------------------asPILHLARSFFNPPEAmp-cA 69  
XP_012059392   14 LVVNPFAIQWSPDNHISIITEKGVHVLELQPSPms-----------------------pnPFFKFSRSFIYHSDTlp-aY 69  
EFN83604       14 LVTIPFAVQWSPDNQISLITEGGVH--ELQPSPms-----------------------pnPIVKFTRSFVNATDIlp-aC 67  
EFN61867       14 LVTIPFATQWSPDNQISIITDKGVHVFELQPSPms-----------------------pnSTIKFARSFIYPPENlp-aC 69  
Q6C759         70 PSATGGALAWSDDGDLSIAAGSDAVVLNVNGPItsr-------------------------------------------- 105  Yarrowia lipo...
EDK40866       12 ASSRCDPAQWSSNSQLAINSGSQITLLDPQVPL----------------------------------------------- 44  
XP_004201730   13 VSSTCDPVQLSENQQLAVNNGYQLTLLDPKLPL----------------------------------------------- 45  
EHS64598      151 KSAgGQPKIPFfttiieINKQLGVNWSTHSNDISTITPPNDD-------------------------------------- 192 
Q5KPU4         93 NQQ-LKARRLEgggvqwWSTAINVEINEEREWLYGWGDVSDNylsmve-------------------------------- 139  Cryptococcus ...
XP_002426494   81 SKS-F--------------DTSNWLSNQKKKGTYEIPIDSTLffstdkc------------------------------- 114 
XP_003425560   70 QYE---------------KYVLSNIFEWPKEEIYSYFLQDALtptfpk-------------------------------- 102 
XP_012059392   70 AFK---------------SEVDSSIWDMIREEIYSLLMDDVItpkldg-------------------------------- 102 
EFN83604       68 AFE---------------NEIESMVWKLERKEVYSLLMEEAItpklen-------------------------------- 100 
EFN61867       70 SFA---------------NKIDSLIWNLDRENIYSILMEETItpiidg-------------------------------- 102 
Q6C759        106 --------------ddeIDSVRDRNWAQFPETNFTINKSDTMdaipvtaggsts------------------------ip 147  Yarrowia lipo...
EDK40866       45 ----------------------------IHQSVYAIPDQETQnksldpkglfhistpihpdilqewpiyrpnsfllddgt 96  
XP_004201730   46 --------------------------IHQSTVNSSLGQDNKGtsileskrifdisgildveareklslgnldkilietld 99  
EHS64598      193 ----------RFWRAATWSPSGLSALGSCLLAGLSTTCDVFVYSPCqnyqAGLWAikETLNLSEELLTIFydfypsiigh 262 
Q5KPU4        140 -----tdskgATVRQATWSPSGLSNLGSCLLVVLTTSLQVSVYAPVenplTQRWV--EIADLTMLTKELLpp-------- 204  Cryptococcus ...
XP_002426494  115 ----ssninsSQIIQIEFSPL---INNQSYLSCLTNNGLLEIFtk----eYSKWI--SIISITELWNSYCndvf------ 175 
XP_003425560  103 -----alpatADIVDVFWSPCRLLHPLECLLAVVTTTGAIQLVaq----iDRTWI--LIYEFNAVLAENIeediqq---- 167 
XP_012059392  103 -----vidkfPKIIKVSWSPKNLISPSQCILAILNSAGAVELLhk----vSNNWY--SICDIFSLRLKIIedeiktg--- 168 
EFN83604      101 -----vndtvLRIIKVEWSPKNLIYPSQCILAILTAAGAIELLhk----vSNEWY--SICDISALRLNIVqktikssln- 168 
EFN61867      103 -----vndmnHRIVNIMWSPKNLISPSQCVLAILTTAGTVELLhk----vFNVWY--SICDISSLRLKNMkdniisn--- 168 
Q6C759        148 gnqiqygsgdRHVADIAWSPTGLGKMHGCLIGLLNTTHELFIYDHRgqveKHSWT--LCHNVADVLYKRVkketgetnge 225  Yarrowia lipo...
EDK40866       97 epfaiggigePIITGHMWSPIR-SETRDCMLGILINTGELFVLERAtt-tKESYC------IKHCFFDVLcwqngi---- 164 
XP_004201730  100 eefsfgrinePIIVNHAWSPVN-PTSRDCLLGVLYNTSELLLLERQgt-nTNDYV--VKYNVFDELLKNLgisp------ 169 
EHS64598      263 qedptk--------------sidvspetawdiseegEEKRSRFTAGVLRTQATCIAWS 306 
Q5KPU4        205 -----------------------------------kEILNGLTSRGMLEMRASSISWS 227  Cryptococcus neoformans
XP_002426494  176 ---------------------------------nvqDLDIDDLNTKMLDLKISGMKWF 200 
XP_003425560  168 -------------------------------lkcnkKIDSQELKEQLYRLLVTTATWS 194 
XP_012059392  169 -----------------------------lnksnfhENQSARIVESIKKLQACSMTWS 197 
EFN83604      169 ----------------------------kcvnspnnVNKYVRITDSMRMLQACSMAWS 198 
EFN61867      169 -----------------------------ldkckksKDKYTVIVENMRQLQACAMTWS 197 
Q6C759        226 dhptvveeptngdssmidhgedtpkgsragtpsvpgITEQEYTREQYYSFQIHSFAWS 283  Yarrowia lipolytica
EDK40866      165 -------------------------------asntsADDTKIPVQLYQALRVRSFAFG 191 
XP_004201730  170 --------------------------------dvftNGEYTLSKMQYMSLKVESFCFN 195 
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