Conserved Protein Domain Family
SpoU-like

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cd18096: SpoU-like 
SAM-dependent rRNA or tRNA methylase related to SpoU
RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Statistics
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PSSM-Id: 349969
Aligned: 18 rows
Threshold Bit Score: 175.867
Created: 9-Aug-2016
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative SAM
Feature 1:putative SAM binding site [chemical binding site]
Evidence:
  • Comment:based on homology to other SPOUT methylases

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
EIE23309      30 CYLIVHNVSKRHNIGTLVRSAAAFSvTEVCLVGAr-----------qFNTFGSHGSADy--VNYRHFpsLQECCHYLKqd 96  Coccomyxa subel...
XP_001428566   7 GYLLLHNIAKPKNIGTIIRNAAAFNlTKVFMIGKqgqtkkkfqiaegFSFFGNHGTYDq--MNFHLFnnLKEAKEYFVln 84  Paramecium tetr...
EER16467      15 SYLLICNVGKRQNWGQLLRSATAFGvTEVFVVGAkkm--------keLALFGNQGTTLh--ATFEFFdtIAEAKEELKrr 84  Perkinsus marin...
EGZ10614       3 HFLILNNVQKNKNIKNMLVSASAFGvEEVFVVGQk-----------kFDLQEQEPFLRslsCRVTRLatLKDCRAHCTer 71  Phytophthora sojae
Q8IJ98        53 TYVVIYNIGKKKNVGCIVRSCVAFNvHKIFIVGKrk---------keINFFGNMGTYDy--ITIEYFdnIYELKEYLTkh 121 Plasmodium falc...
ABD82724       3 FVLLIFNVQSNTNIGQLIRTANAFGaEEICVIGRk-----------kFSTYGNQKTASt--TKFRHFfqIDEAFEYYGqa 69  Saccharophagus ...
Q73T60        70 LHVAIENFGHDANIGSVVRTANAFAvHTVHIVGRr-----------rWNRRGAMVTDRy--QRLCHHdsTAELLDFAAaa 136 Mycobacterium a...
ADI66855      49 LEVAIENVGHDFNTGSIIRTANGLGvRHVHIVGRr-----------rFNRRGAMVTDRy--LHLHHHpeVQDLVSYAAqq 115 Mobiluncus curt...
ERI41553      50 LHVAIENWAHDLNIGSVVRTANAFNaAGVHVVGRr-----------rWNRRGAMVTDRy--LHVHHHasVADLADWAAge 116 Bacillus sp. EG...
CCK81972      38 CVIVLDHLKPTYNIGKIFRSADAFGaREIHLVGId-----------fFDPAPGMGAFKw--VPAVFHknFFSCYTSLVnn 104 Desulfobacula t...
Feature 1               # #                    ####  #              ## #      ## #  #        
EIE23309      97 kgcRIMGVEIaeDAQPIHahp-fsgPTAFMLGNEGsGLSPQQVQl-cDAFVYIPQYGagTASLNVTVAASIVLQHF 170 Coccomyxa subellips...
XP_001428566  85 -niFVCGVEIgeGSQNIItnp-fkgNTVFFLGNEGtGLIPEHKAl-cDHFVYIPQYTqkTASLNVGVASGIIFHHF 157 Paramecium tetraure...
EER16467      85 -giTLCGVEIhpSSEPIQdmh-wrgDTCFMLGNEGtGMTDKQIAa-cDQFTYIQQYTkaTASLNVAVAGSIVLHHF 157 Perkinsus marinus A...
EGZ10614      72 -giRIVGVEImhDAKSIAdqp-fsgDTAFIMGNEGsGMSSAQVAi-cDDFVYIPQYGggTASLNVTVAASIILQSF 144 Phytophthora sojae
Q8IJ98       122 -diLLYACEIsvNALSITtnpyehkDTAFLFGNEGtGIHDNVLKi-cDKIIYIPQYGkgTASLNVSVSCAIILQNF 195 Plasmodium falcipar...
ABD82724      70 -gyDFVGVEIteQAKSINkmr-ferDTLFIMGNEGdGIHENILKr-cHYCVYIPQYGt-GASINVNTACGIIFNVY 141 Saccharophagus degr...
Q73T60       137 -glTVVAVDNvpGAARLEett-lprECLLVFGQEGpGITDDTRTg-aTLTVSIAQFGs-TRSINAGVAAGIAMHAW 208 Mycobacterium avium...
ADI66855     116 -elTIVGMDNfpGAEPLEtvt-lpsRTLMVFGEESqGLTPAMQNa-lERLVQITQYGs-TRSLNVGHAAAISIWAW 187 Mobiluncus curtisii...
ERI41553     117 -glPLLGVDNvpGSVPIEgya-lpaSCVLLLGQESaGLTPEAVEa-cRAVLHITQHGs-TRSINAGAAGAIALHAW 188 Bacillus sp. EGD-AK10
CCK81972     105 -gyIPFILEPgkGQSITHtrm--plKSAFIFGHEEyGISFEPDLfpeVRPLTIPQFGk-SQSLNVSVAASIILYEY 176 Desulfobacula toluo...

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