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ER-bound oxygenase mpaB/B'/Rubber oxygenase, catalytic domain This is the catalytic domain found in the endoplasmic reticulum (ER) -bound oxygenases mpaB' (MPAB2) and mpaB (MPAB) from Penicillium roqueforti and Penicillium brevicompactum and in the rubber oxygenase (Lcp) from Streptomyces sp., which contains highly conserved arginine and histidine residues. Structural analysis from Lcp revealed that Arg164, Thr168 and His198 are crucial active site residues. The mpaB and mpaB' are part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA). Lcp (Latex clearing proteins) is a rubber oxygenase that catalyzes the extracellular cleavage of poly (cis-1,4-isoprene). This domain is also present in uncharacterized proteins from Mycobacterium sp. and hypothetical proteins, mainly from bacteria and fungi. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",