Conserved Protein Domain Family
HECA

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pfam15353: HECA 
Headcase protein family homolog
HECA was characterized first in Drosophila where it regulates the proliferation and differentiation of cells during adult morphogenesis. In humans, HECA affects cell cycle progression and proliferation in head and neck cancer cells. It by slows down cell division of oral squamous cell carcinoma cells and may thereby act as a tumour-suppressor in head and neck cancers.
Statistics
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PSSM-Id: 464667
Aligned: 13 rows
Threshold Bit Score: 152.172
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEB14176              53 CACP--T-ECLKENntsvsgldtdpnIRLD-D---LHDVVRVICNNEQCTVGKYMHRECFESWEQAVLTYLKS------C 119 
EEN55086              33 CCVPgsSgCQLGSP------------VSLA-N---PEDVVKVVCNHDGCPEGPYMHKQCFEEWEETVLTFLRS------S 90  
XP_015792965          57 CCVP--TnCNLNQP------------IRME-D---LNDCVKVICNNENCNQGRYMHKSCFEDFQATVLTYLRS------T 112 
WGS:AAPU:GI23264-PA   67 CCYP--NgECTKLDt----------lIALD-DqsrLGDYVRVVCNNENCNEGQYMHRDCFEQWEAGVLQQLKA------S 127 
Q16RM2                45 CCVP--IgDCFKSSpvd------ygsINLE-D---LRDCVRVICNNDNCTAGQYMHRECFDHWEEGVLNYLKS------I 106  yellow...
XP_001951361          53 CCVP--TgDCIMRSa----------pIRPE-DpraAELYARVVCSDGGCPAGRYMHRECFDAWERLVLVYMKN------A 113 
XP_002407304          38 CCVP--TgCHLEQV------------IHMD-D---LNNTVKVICNNEQCSQGQYMHRLCFDEWESSVLTFLRS------T 93  
EKC42396              43 CCSP--TtCLFPDEt-----------IDTR-D---PGDAVRVYCNNDQCTLGNWMHGDCFIEWEDTVLAYLKS------C 99  
EFX73234              10 CCTP--AgCMTIVDgitstd------gssseD---GGEIVKVLCNNEHCPTSGLMHRQCFDQWEASVLHYLRS------C 72  
XP_022273281          32 CATP--LiCSFGRPv----------dL----D---KDDYQKVVCNNEHCPYSTWMHLQCFYEWESSILVQFNC------I 86  
XP_002599942         379 CCSP--KgCRHENSk----------------EvtdMASAVKVVCSVKTCKEGVFMHEDCFLAWEDDIIKNLQShhrpqqL 440 
XP_003384064          68 CCNP--RgCILGP-------------IETGsAtptQQEVVRMMCSNEKCPFSPYMHSECFDSFEEQILSCLRG------M 126 
1_pfamImport           1 CCFP--GvCPFGEDsa--------------aD---ESVMVKVICNSEACPLSQFMHAECFHQWEETILGHLRS------H 55  
EEB14176             120 GRAKS-----WSERQRHQNLWT------------KKGYDLAFKACGCKCGRGHLKKDLDW 162 
EEN55086              91 GRARS-----WSEKQRRQNLWT------------KKGYDLAYRACACKCGKGHLRKDLNW 133 
XP_015792965         113 GRARS-----WSEKQRLQNLWT------------KKGYDLAYKACGCKCGKGHLRKDLDW 155 
WGS:AAPU:GI23264-PA  128 ARGRS-----WSERQRVQQLWT------------KKGYDLVYKNCSCKCGRGHLRKDLEW 170 
Q16RM2               107 GRARS-----WSDKQRQQNLWT------------KKGYDLVFKACSCKCGRGHLRKDLDW 149  yellow fever mosquito
XP_001951361         114 AASYAngnapQSNSRRIKDLWTvnvnnnnvvnlnKKGYEMAFKACGCRCGRGYLKKDSEW 173 
XP_002407304          94 GRARS-----WSEKQRMQNLWT------------KKGYDLAYKACGCRCGKGHLRKDLDW 136 
EKC42396             100 GRARS-----WSEKQRLQNLWT------------KKGYDLAFKACDCKCSRGHLRKDLNY 142 
EFX73234              73 GRARS-----WSERQRSQNLWT------------KKGYDLAFKACGCLCGRGHLRKDCEW 115 
XP_022273281          87 GRARS-----WNEKQCRQNMWT------------KKGYDLAFRFCSCRCGQGHLKKDTDW 129 
XP_002599942         441 GRLRS-----WTLEQLQRDLWT------------KRVNDVTYKLCVCRCG-GYLKKDEDW 482 
XP_003384064         127 SRARN-----WSEKQRKQNLWT------------KKGYDLVFKFCACQCGKGNLRKDLNH 169 
1_pfamImport          56 GRARS-----WSEKQRRQNLWT------------KRGYDLAYRACACACRHGHLRKDLNW 98  
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