Conserved Protein Domain Family
PTP_fungal
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cd18533: PTP_fungal 
fungal protein tyrosine phosphatases
This subfamily contains Saccharomyces cerevisiae protein-tyrosine phosphatases 1 (PTP1) and 2 (PTP2), Schizosaccharomyces pombe PTP1, PTP2, and PTP3, and similar fungal proteins. PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. PTP2, together with PTP3, is the major phosphatase that dephosphorylates and inactivates the MAP kinase HOG1 and also modulates its subcellular localization.
Links
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Statistics
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PSSM-Id: 350509
Aligned: 35 rows
Threshold Bit Score: 219.042
Created: 8-Dec-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active sitecatalytic site
Feature 1: active site [active site], 10 residue positions
Conserved feature residue pattern:x x C x x x x x R xClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
266860       467 YINANYLKLtqin------------pdfKYIATQAPLps--tmDDFWKVITLNk---------vKVIISLNSdde----- 518 baker's yeast
131684       324 YINASFIKTet----------------sNYIACQGSIsr--siSDFWHMVWDNve-------niGTIVMLGSlfe----- 373 fission yeast
XP_002173223 464 YINASHITLgt----------------dRYIACQAPKes--tvLDFWEMIWFSid-------kvGTVVKLANvve----- 513 Schizosaccharom...
XP_001591318 151 YINASPVTLtstaekqs---tmkkgiqdKYICMQGPKsq--tvDHTWHMMWHSitvpd--naapGVIIMLSPlvgpnpak 223 Sclerotinia scl...
131557        79 YINASYVKVnvpgq---------siepgYYIATQGPTrk--twDQFWQMCYHNcpl------dnIVIVMVTPlve----- 136 baker's yeast
XP_001936723 145 YINASPIILectes----------gtllKYIATQGPKad--twSHIWRMIWKEnp-------efAVIVMLTQtwe----- 200 Pyrenophora tri...
XP_002839516 111 YINASPIVLkgrn-----------gsikRYIATQGPKeg--qfNHIWRMVWQEts-------dvAVIVMLTKtfe----- 165 Tuber melanospo...
XP_001595509  84 YINASPIALrtangs--------geeqeNYIATQGPRdngydgGLFWEMCWQEn---------vEVVVMLTRpve----- 141 Sclerotinia scl...
CAF05891     196 YINASPIVLpptvlttadgetsntqepdRYIAMQGPKqc--ttDHVWRMAVEQle-------spGVIVMLTEthe----- 261 Neurospora crassa
XP_506073     86 YINANRVTLvakknt--------ktyhkTYIATQGPLrq--taGHFWQMVHDTtteqgqesdkpTVVIQVTPfed----- 150 Yarrowia lipoly...

Feature 1                                                                                        
266860       519 --lnLRKWDIYWNNls-----------------------ySNHTIKLQNTWENICni---------------ngCVLRVF 558 baker's yeast
131684       374 --agREMCTAYWPSngigd-----------------kqvyGDYCVKQISEENVDNs-----------------rFILRKF 417 fission yeast
XP_002173223 514 --ggRERCTQYWPTaidqpl---------------midprSGFIIELFEHTELPDl-----------------nAIMNVF 559 Schizosaccharom...
XP_001591318 224 peemMEKCYQYYPMseddpplmv--------neagtlgetFKAQVRFVKREENIEgt----------------gIEVRKL 279 Sclerotinia scl...
131557       137 --ynREKCYQYWPRggvddtvriaskwespggandmtqfpSDLKIEFVNVHKVKDy------------------YTVTDI 196 baker's yeast
XP_001936723 201 --anREKCYPYYPQs------------------------lDAPDMRVNEQDEFQDglihnlhla-sytmdedarTQVREI 253 Pyrenophora tri...
XP_002839516 166 --lgRDKCFQYFPEklddkpwtv--------dgdeefgdgFKATISLLEKTKDKRs-----------------sCTVRKI 218 Tuber melanospo...
XP_001595509 142 --egKEKCGVYYAEdvee------------------vkriGEWEVRCVGKEEEGG-------------------TVRRTL 182 Sclerotinia scl...
CAF05891     262 --gdFEKCYQYFPRt------------------------tEDPPLEINEGDEFGDgfratvrcagiedtpagdaIELRKM 315 Neurospora crassa
XP_506073    151 --nhGERCCQYYISrkgqvf--------------evdgegDVLTVEVKDNSEVGP-------------------TKVTEF 195 Yarrowia lipoly...

Feature 1                                                                                        
266860       559 QVKktapqndnisqdcdlp----------------------------------------hngdltsitmavsepFIVYQL 598 baker's yeast
131684       418 EIQnanf----------------------------------------------------------------psvKKVHHY 433 fission yeast
XP_002173223 560 YMKrnn-----------------------------------------------------------------capKCVYQI 574 Schizosaccharom...
XP_001591318 280 AMSvege----------------------------------------------------------------deeKIIWHF 295 Sclerotinia scl...
131557       197 KLTptdpl--------------------------------------------------------------vgpvKTVHHF 214 baker's yeast
XP_001936723 254 DMTtddg----------------------------------------------------------------sesRKVWHL 269 Pyrenophora tri...
XP_002839516 219 SLKvge------------------------------------------------------------------keKIVWHL 232 Tuber melanospo...
XP_001595509 183 KLRrvgraarsvstasgasigngtvgtiet-----------------veehseeeketeikieelqeeeaqieeRTIHHF 245 Sclerotinia scl...
CAF05891     316 VIHvhksagrksvdgksngsqskrqtpepenatteepkitspltqmaketeenltisepeetvgrnseeeeveeRIVWHF 395 Neurospora crassa
XP_506073    196 LVTkgst----------------------------------------------------------------gkvKRVVHY 211 Yarrowia lipoly...

Feature 1              ##                                                               #######  
266860       599 QYKNWLDSCGVd----mNDIIKLHKVKNSLLFNpqsfitslekdvckpdliddnnselhldtanssPLLVHCSAGCGRTG 674 baker's yeast
131684       434 QYPNWSDCNSP------ENVKSMVEFLKYVNNShg-----------------------------sgNTIVHCSAGVGRTG 478 fission yeast
XP_002173223 575 CYVAWPDHGAP------EDTKCVVDFTRLVNQFer-----------------------------dgPLIVHCSAGVGRTG 619 Schizosaccharom...
XP_001591318 296 FYPLWPDMGSLnnq-nvKSVLTLMDLSRAKNQEee------------------------------nPRVVHCSAGVGRTG 344 Sclerotinia scl...
131557       215 YFDLWKDMNKPee---vVPIMELCAHSHSLNSRg-------------------------------nPIIVHCSAGVGRTG 260 baker's yeast
XP_001936723 270 LFAGWPDFSVPegd-drAGMLKLIEISHEKNGGep-----------------------------anPRIVHCSAGIGRSG 319 Pyrenophora tri...
XP_002839516 233 LFKGWPDFNVPegd-nrSALLEAIKLANEKNSGpq------------------------------nPLIVHCSAGVGRSG 281 Tuber melanospo...
XP_001595509 246 LFESWPDNDIPqspadiHSLLTLLDVSRAANNHsi------------------------------tPRVVHCSAGVGRTG 295 Sclerotinia scl...
CAF05891     396 LYKKWPDFGVPdla-dlDSFFTLMSLSREKNAGph------------------------------nPRIVHCSAGVGRSG 444 Neurospora crassa
XP_506073    212 YYPNWADFSAPgv---nTDIDDIVKSAGPITDS---------------------------------PPIVHCSAGVGRTG 255 Yarrowia lipoly...

Feature 1                                                                                 #      
266860       675 VFVTLDFLLSILspttnhsnk--------------------------idvwnmtqDLIFIIVNELRKQRismVQNLTQYI 728 baker's yeast
131684       479 TFIVLDTILRFPesklsgfn----------------------------psvadssDVVFQLVDHIRKQRmkmVQTFTQFK 530 fission yeast
XP_002173223 620 TFIAIDHLMHLSsqqlpds-----------------------------avvrdeeDVVFQTVNLLRSQRmkmVQNFKQFR 670 Schizosaccharom...
XP_001591318 345 TFVALEFLMGELqggawegw---------------------------dqseekgnDAIYETVDQLRQQRktmVQAVEQYI 397 Sclerotinia scl...
131557       261 TFIALDHLMHDTldfknitersr---------------------hsdrateeytrDLIEQIVLQLRSQRmkmVQTKDQFL 319 baker's yeast
XP_001936723 320 TFIALDWLVQELeegald-------------------------------evpeseDPVMDVVQKLRDQRpgmVQSDSQFQ 368 Pyrenophora tri...
XP_002839516 282 TFITLDHFLREIdagtis--------------------------------adereDPVFEVVNRLREQRmymVQSQVQYE 329 Tuber melanospo...
XP_001595509 296 TFIALDHLLRELdmghld-------------------------------glskdkDPVLETVKRLRDQRmlmVHKVAQYV 344 Sclerotinia scl...
CAF05891     445 TFIALEHLMRELdagvlenwdertagvgeslsspvrtsqeevmspigstkglednDLIFQVVNQLREQRktmVQAESQYL 524 Neurospora crassa
XP_506073    256 TYIVADFLTTFQkel-------------------------------------qgeDIVCSLVDQMRQQRshmVQTISQYE 298 Yarrowia lipoly...

Feature 1            
266860       729 ACYE 732 baker's yeast
131684       531 YVYD 534 fission yeast
XP_002173223 671 FVYD 674 Schizosaccharomyces japonicus yFS275
XP_001591318 398 FLYE 401 Sclerotinia sclerotiorum 1980 UF-70
131557       320 FIYH 323 baker's yeast
XP_001936723 369 FIYD 372 Pyrenophora tritici-repentis Pt-1C-BFP
XP_002839516 330 FLYQ 333 Tuber melanosporum Mel28
XP_001595509 345 MIYN 348 Sclerotinia sclerotiorum 1980 UF-70
CAF05891     525 FIYQ 528 Neurospora crassa
XP_506073    299 YLHS 302 Yarrowia lipolytica CLIB122

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