Conserved Protein Domain Family
STD1

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pfam17235: STD1 
STD1/MTH1
This family of proteins includes the known homologs STD1 (also known as MSN3) and MTH1. Both STD1 and MTH1 are involved in modulating the expression of glucose-regulated genes in yeast, but have been shown to function by slightly different methods. It has been suggested that both STD1 and MTH1 are required to repress the hexose transporter genes in low glucose conditions. STD1 has also been shown to stimulate SNF1 kinase through interaction with the catalytic domain of SNF1, antagonising auto-inhibition and promoting an active conformation of the kinase.
Statistics
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PSSM-Id: 435802
Aligned: 40 rows
Threshold Bit Score: 129.786
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001526403          96 SSLT-NNGK------RSIRSAPSIYSSStatipedfePITTTVEQLI-----------NDIALHEQHFErefeakkq--- 154
XP_002618154           5 DFLPsRTSS---------ESPPpfip-------hkgeSPELQMESLLylfkrlrinrlSSFSQGNTLKysdnkeesiqd- 67 
ABN66869               5 NLFSsGSRA----------TIPRFHQDEnh------dSIDLQIKSLLylfkrcqiaklAHFLNSDGSFrynesgsgsvnf 68 
Q6BMY6                 5 SLFGtSANK--------TAKVPNFEQGEnh------dSVDLQVKSLLyvfkrlrlnklSSFLGKDGTTysfkyvdgdkql 70  Debaryo...
CCE40396               5 NAFIaLDST----------SIPTFDPSId--------SINLQVKSLLylfkrlrinklLPLLKNGELTytdslvgdr--- 63 
XP_002547586           5 DLLSfSSSSss--tsTSSSIIPTYDQNQd--------SINLQIKSLLylfkrlqidklSTLPNKDGTLryivkknelv-- 72 
EMG50569               5 DILQfQTPA--------KQSIPTYDPTId--------STNLQVKSLQyifkryrinnlSSFLTKDNHLqyttntkidl-- 66 
Q6CY44                 7 SALFsIEDG------TTESVTPKYGHGVqe------dDIDLQLRALIycyqrlkvkemSPFYPVDSTTEdgetlg----- 69  Kluyver...
XP_011273530           5 KSLWpNSST-------NVITIPQHIEGEle------dDLDLKIKSLTylfkrlnienlPAFINDENGIydlrndeann-- 69 
LoveMIT:GQ68_05016T0   6 SWGGtESSQeqkhirNAIHNIPNYLEGEne------dPIDLQVKSLTyvfkrlkadrwGPFLQADESNgygysmkvdnt- 78 
XP_001526403         155 -----realplynSPTFDPDETFKISLGsgltfqndlqSnfLIDWNLNVTRCKLIL--INLpmis----sastTQQqlcy 223
XP_002618154          68 ---saqepevsrwDKIYQTTEMKRRLLGq--------kErvLIDWSKNKFRSLCILqrEPGpslrnkdyeledgf----- 131
ABN66869              69 --gqeestyyqklDQVYNIEGFKHSLIKd--------eYrvMVDFCKNKFRSFCIV--SDLps----------------- 119
Q6BMY6                71 nsdsgvhnyfqklDAMYNVKKFKQVMINd--------eYrvMIDFTKNKFRSFCIL--SEYpskgtlssqgigNGEfpnf 140 Debaryo...
CCE40396              64 -----sdptfaklDKTYNVIRFKEMLLDd--------eYrvLVDFIKNKFRSMCFI--DDLpt----------------- 111
XP_002547586          73 ---vdddptfnklDKIYDVDKFLNILLNd--------eYriLVDFIKNKFRSMCMI--VEYps----------------- 122
EMG50569              67 ----endpmisklDQVYDVNGFMRMYLGd--------eYriLVDFMKNKFRSMCIL--SSLpd----------------- 115
Q6CY44                70 -------dgsvalDKVYNLEQFIAMLQEd--------pHhiLVDWCKNKARLMCIL--SSTpvrtvn------------- 119 Kluyver...
XP_011273530          70 ----edtyyntklDTIYNKIEFERVLINd--------eHriLVDWFKNRFRSICIL--SNYpsksnl------------- 122
LoveMIT:GQ68_05016T0  79 --lssgnygndklDVIYNIKRFEEKLFTd--------eHriLIDFPKNKMRSLLIL--SDNtdssiipslgkeN------ 140
XP_001526403         224 nqhyppqlvGDLAKv---------------------------------VQLIIIQP--HITDKELIFTLV-QSNIYKEH- 266
XP_002618154         132 -----------------------------------pvfkdykdrktgsFVFFVIPIdqQLNFTELAFELA-QSTLYVEHh 175
ABN66869             120 -------anLSRPNspvkgagineesgd------fpsfrdskdrkvrhFRFVLLPLe-GLTVEFVANTLS-GSDIYHEHf 184
Q6BMY6               141 kdy--------------------------------------kdrdvkhFRFSIIPLq-DTSIAFIANTLS-TSDIYVEHh 180 Debaryo...
CCE40396             112 --------nLSRPRsptrnsstdavsavdvdddflppfldykerntklFKFTLFSIsqPHTTESIASILS-GSNIYIEH- 181
XP_002547586         123 -------nlSSRPSspikgqstnnptmif----pdfkdykdrnmngknFKFVLFPLn-DVSIDKIAQILV-NSDIYIEH- 188
EMG50569             116 --------fQSRPGspvkgkssngsncg-------lelrdykdrsvsgFRFVVMELq-MTNRERIVEVLT-SSDIYMEH- 177
Q6CY44               120 -------------------------------------------klpkgFSYLILEP--DSSEDLYFQRLVyDSKLYHEH- 153 Kluyver...
XP_011273530         123 ------------------------------------------nslgkhFKFIVLKP--DSSDEDYLKILI-NSDIYYEH- 156
LoveMIT:GQ68_05016T0 141 ------------------------------------------------FQFHVLKP--NGSDEEYYSVLIeKSNIYEEH- 169
XP_001526403         267 -NLDLAFRKSVAEILVKQSRLLQINSlrqntnselqhnlsintnvlnehHDFLKFKYKEIaVRNYLINLAAAATTAHEYK 345
XP_002618154         176 sYVSVAARIQCAKEAISKCLGQKFTSes--------------------vVILSEETHTQV-ISAYVSSLAFIVQLFRIYD 234
ABN66869             185 sYMDFSSRHQNAIDSIKKVIRDDRIDmksp----------------akeFSISENEKAAI-IREYLIAVAFNVQVMRIYE 247
Q6BMY6               181 nKIDFNCRYQYAMDSINKVLDMERSMsdi-----------------dssISITDAEKASI-IQYYLKRVAFFIQLNRIYV 242 Debaryo...
CCE40396             182 -KVPFLKRYNIALTATNKVIGKPLTTk----------------------FTIDQKQKLKI-IRNYLTLLATHVQVMRIYH 237
XP_002547586         189 -KVSYSKRYSIALESIKSVISINQ-------------------------KRITINEKNQI-IRNYLIKLSFHVQLLRIYQ 241
EMG50569             178 -NVEYAKKYSIAVESVNKVLGNRGVDedee----------------edrFDVSIPQKNEI-VRNYLTGLAFYVQLMRIYE 239
Q6CY44               154 -DVPLSWKIQCLREIIKKQYTLVPTRr----------------------KSFNKQDRWQI-MIRYLSKLAEHVQIERVYK 209 Kluyver...
XP_011273530         157 -PIDPILKTDILLEILKNQKLLKPSYk----------------------KNFNKNDRSII-ILKYVRKLSEIIQIERIYK 212
LoveMIT:GQ68_05016T0 170 -QVSYRTKSSILGSAIRYLDGMKPR------------------------DEFTKDDRAWI-IRQYVNKLAIHVQTQRIYR 223
XP_001526403         346 LRVDEIK 352
XP_002618154         235 SHIKHNS 241
ABN66869             248 EYIKHHP 254
Q6BMY6               243 EYLKHHA 249 Debaryomyces hansenii
CCE40396             238 EYTKMHP 244
XP_002547586         242 EYIKLNS 248
EMG50569             240 EYNKQHP 246
Q6CY44               210 AYRSQPP 216 Kluyveromyces lactis
XP_011273530         213 ASLLTKL 219
LoveMIT:GQ68_05016T0 224 ESKRQAS 230
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