Conserved Protein Domain Family
Acs

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COG0365: Acs 
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]
Statistics
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PSSM-Id: 440134
Aligned: 833 rows
Threshold Bit Score: 319.75
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_011466223  74 RWFT-GARVNYAQQVL-RHV---AAadagGFPAILSHNEEtlgsAP-----ARQLSWPELRRQVASLALHLQAQGVLAGD 143
WP_068803103  39 RGLP-GGGINIAFEAVdRHVqngRG----GQVALRCLSRD----GV-----ASEFTYAGLAAETNRFANMLAAIGVGRGE 104
WP_011980657  39 EGLP-GGGLNIAHEAIdKHAngaLA----EKAALIWLGEN----SE-----KRTYTFAQMKRESAKFANVLKSLGFEKGE 104
WP_012395120  37 EGMG-DDKCNIAFAAVdRHCagpIA----TRTALRFVTDQ----SRedqppTQDVSYAELGRLVRKFTAVLRGLGVNKGD 107
WP_014433194  39 DGLPgGQGLNIAHEAVdRHAqgaRR----NHLALRWLGKD----GS-----VRDFTYADLAEQSNRFANVLRRLGVGKGE 105
WP_117413692  38 DGLP-DGRLNIAYEAVdRHVvhgAG----DKLALRWIGRD----DR-----VDDYTYDRLRLETNKFANVLRGLGIGKGD 103
WP_025312318  28 DGL--GDGLNIAHEALdRHVaagHG----DQVALRWLGKS----GE-----RRDLTYAALSTEAARFANVLAAHGVQRGD 92 
WP_004513280   1 -mlieNGQYNIGDICTsRQCrlgRG----DRVAMRWLTPG----ME-----RRDYTFNELDGLSGRFANVLASLGVGAGE 66 
WP_004322106  40 AGLP-GGGLNIAHEAVeRHAhgpLR----ERIAFRFLGEN-----S-----LRDVGYGELSRLTSRFANVLRTLGVRRGE 104
WP_013250344  39 DGLPeGQGLNIAHEAVvRHAtgsLG----QQTAIRWLGKS----GQ-----VEDYSYARLDDLTNRFANALQGLGVVKGD 105
WP_011466223 144 RVAAYLPNSAETMVAFLATVSIGAVWSVCAPDMGSNAVLDRFQQIEPKVLIACDGVTYggreldrrAV-LAELCAALPSV 222
WP_068803103 105 RVFSLLGRVPQLYVTALGTLKAGAVFCPMFSAFGPEPIRARLELGGARVLVTTPQLY---------QRkVAALREQLPKL 175
WP_011980657 105 RVYTLSTRLPELYIGTMGILKNGSVMCPLFSQFGPEPILQRMQRGDARGLLTTQRLY---------EKkIAPQMDQLPEL 175
WP_012395120 108 RVFTIMGRIPELYITMLGALRNGSVVSPLFSAFGPEPIATRVEIGQADVLVTTAAIY---------RRkIAKIRERLTSV 178
WP_014433194 106 RVFVLAGRIPELYITVLGTLKNVSVLCPLFSAFGPEPVEQRLKIGEGKVLVTTERLFR--------QRkIAEMWERLPSL 177
WP_117413692 104 RVYSLLGRVPELYVAVLGGLKCGCVFSPLFSAFGPEPILARMSIGEATVVVTTAALY---------KRkIAPIRDKVPSL 174
WP_025312318  93 SVFAMTGRVPALYACALGTLKAGMVFTPLFSAFGPEPVRTRMEIGSANVLLTTAAIY---------KRkIAAWRDAIPSL 163
WP_004513280  67 VFFTYLPKQPEQFVAFLGALKLTAVAGTLFSNFGEEALLDRLADARACGIITKKSLL---------RK-IIRIRPQLPDL 136
WP_004322106 105 RVFVLTGRIPELYIAVLGGLKAGCVVSPLFSAFGPEPIATRIGIGEGAVLVTTDLLY---------ERkVAKLRDRLPSL 175
WP_013250344 106 RVFVLAGRIPELYIAALGTLKHRALFCPLFSAFGPEPIRARLTIGQAKVLVTTESLY---------QRkVAGILETLPHL 176
WP_011466223 223 RHLILQSNLGLPtDTiktvASQACFTEATgqnDAKTDAFEPLWLPFDHPLWVVYSSGTTGLPKPIVHGHGGTILVALAlK 302
WP_068803103 176 EHVLLVGDAAGA-G-----IGTRSLATLM---AKASDSFEIPPTGGEDMALLHFTSGTTGRPKGAVHVHAAVLQHYVT-G 245
WP_011980657 176 RTILLIDAEEDV-N-----EKVLSLPRLM---EKASDSFEIVHTEPEDMSLLHFTSGTTGMPKGVIHVHKAMYTHWVT-G 245
WP_012395120 179 RHILVVDAQSSG-DQl---PGTLSLWELM---AAADDNAPAEPTTADDPALLHFTSGTTGTPKGAIHVHGAVTMHYVT-G 250
WP_014433194 178 EFVLLTDAESHI-N-----EDVLSLPRLM---EEASPEFTIPPTDPEDMALLHFTSGTTGRPKGAIHVHKAVIMHYMT-A 247
WP_117413692 175 RHVLVIDAHGAP-P-----QGTLDLADLM---RNTSSHFDIEPTGPEDMALLHFTSGTTGKPKGAVHVHEAVVAHTVT-G 244
WP_025312318 164 KLVLILGDNA---P-----EGCVALAPAM---AAAAPEFETVPMRPDDPALIHFTSGTTGKPKGAVHVHDAVAYHAYS-G 231
WP_004513280 137 RFIILVDSDDHQ-A-----DGIFSYSRLM---AEASPAFVTPLTPADAPSVLHYTSGSTGKPKGVLHRHGAVTMINST-A 206
WP_004322106 176 RHVLLVGEEDGA-TAi---PATQDLAMLM---AQAADTFETVATRPEDLALLHFTSGTTGTPKGAMHVHGAVLTHWAT-G 247
WP_013250344 177 EHVLLIGDEGRP-TAi---PGTQNFHELL---EQHPHTYRIGPTDPEDAALLHFTSGTTGTPKGALHVHGAVAAHHIT-G 248
WP_011466223 303 NLHNDIGCsydpntlGERYHWYSTTGWVM--WNAQASGLLSGTTCCLFDGSpggrsvdaagskvApDWTTLWRFAAELKV 380
WP_068803103 246 RLALDLHP-------GDVFWCTADPGWVTgtSYGIIAPLVIGATLIIDAEE-------------F-DAERWYGILQEQKV 304
WP_011980657 246 AYVLDLHP-------DDMYWCTADPGWVTgtSYGIIAPWLHGVTNVVDEAE-------------F-DAERWYGILQEHKI 304
WP_012395120 251 LYALDLHP-------DDIYWCTADPGWVTgtSYGIISPLLHGVTSIVDQAE-------------F-DAERWYRILQDQNV 309
WP_014433194 248 LYALDLHP-------EDIYWCTADPGWVTgvSYGISAPLCHGVTMIVDEAE-------------F-DAERWYRILEEQKV 306
WP_117413692 245 RYALDLHE-------DDIFWCTADPGWVTgtSYGIISPLAIGCTMIVDQAE-------------F-DAERWYRILQDQKV 303
WP_025312318 232 RHALDLTP-------GTIYWCTADPGWVTgtSYGIISPLVNRVTLLIDEAE-------------F-DLDRWYGILQDEAV 290
WP_004513280 207 QLVLGLRE-------DDVYWCTADQGWVTgtSYGIIGPWSMGVTQVHFGGG-------------Y-AAEQWFEILEREEV 265
WP_004322106 248 RYALDLHD-------GDIFWCTADPGWVTgtSYGIVAPLLHGVSSIVDVAD-------------F-DAERWYRILQEQRV 306
WP_013250344 249 KLALDFHP-------TDIFWCTADPGWVTgtSYGIIAPLTNGLTCIVDEAD-------------F-DAERWYGILQDHRV 307
WP_011466223 381 TFFGAGAAFYANCLKADVNLGECGDLSRVRALGSTGSPLSPEAQAWGTEQFAhlranaaapgrpkqgmassggsdphavg 460
WP_068803103 305 DVWYTAPTAIRMLMRLGDELPARFDLSRLRFMASVGEPLNSEAVIWSQRALG---------------------------- 356
WP_011980657 305 SVWYTAPTAIRRLMRLDIEPLESYDLSHLRLVQSVGEPLNPEAVIWGVEKLK---------------------------- 356
WP_012395120 310 SVWYTAPTGIRMLIKAGAELAAQYCFPHLRFIASVGEPLDPEAVWWGKRVLG---------------------------- 361
WP_014433194 307 TVWYTAPTAIRRLMRMDIEPLKRYDLSHLRFIASVGEPLNPEAVVWGMKMLH---------------------------- 358
WP_117413692 304 TVWYTAPTAIRMLMKIGGDIIGQYDLSHLRFMASVGEPLNPEAVTWSNEVFG---------------------------- 355
WP_025312318 291 EVWYSAPTAIRMMMRAGPEAAARFDFSSLRFLASVGEPLNPEAVTWSAEVFG---------------------------- 342
WP_004513280 266 SVWYTAPTALRMLMREEPLLFARFDLGMLRHICSVGEPLNPEVIHWARRVLA---------------------------- 317
WP_004322106 307 SVWYTAPTAIRMLMKAGPELARGFSFPRLRFVASVGEPLNPEAVWWGRDVLG---------------------------- 358
WP_013250344 308 SVWYTAPTAIRMMMKVGVDLVRKYDLRPLRFLASVGEPLNPEAVVWGEKAFG---------------------------- 359
WP_011466223 461 erggdIWWCNISGGTDFCGAFIGGNReLPLIPGEMQCRLLGCAVEARN--EQGE---P-V-I-DEVGELVCTQpiPSMPL 532
WP_068803103 357 -----RPFHDNWWQTETGGIMIANFAaMDIKPGSMGKPLPGIEAAIANvtRDGRl--EfVdSpDEQGQLVLKSgwPSMFR 429
WP_011980657 357 -----MPIHDNWWQTETGGIMIANYLcQDVKPGSMGRPLPGIVAAVVRqnGDGTv--TeIrEpGKDGDLALKPgwPSMFR 429
WP_012395120 362 -----LPIHDNWWQTETGGIMIANTPaFDIKPGSMGRPLPGVDAHILRhnDDGTt--SvIdDpDEEGELALEPgwPSMFR 434
WP_014433194 359 -----LPIHDNWWQTETGGIMIANFAaMDIRPGSMGKPLPGVEAAIVEklEDGHv--RvVtEpNVEGHLALKPgwPSMFR 431
WP_117413692 356 -----RPFHDNWWQTETGGIMIANYAaMDVWPGSMGKPLPGIAASVVErtDEGLr--E-ItKpNTVGELALRPgwPSMMR 427
WP_025312318 343 -----QPFHDNWWQTETGGIMIANLPgMEVRPGSMGKPLPGIVAGIVE--RDGDrllE-L-GaGKVGELALRPgwPSMMR 413
WP_004513280 318 -----KEVYDTWFQTETGAIMIANRPgIPVKPGSMGKPVDGIEAVVIS--TEGE---L-L-GsGQQGDLCLKPgwASMFS 385
WP_004322106 359 -----KPIHDNWWQTETGGIMIANLPaLDIKPGSMGKPLPGVEAAIVRprEGGGv--EfVdApDEEGELALKRgwPSMLR 431
WP_013250344 360 -----RPFHDNWWQTETGGIMIANYAaMDVHPGSMGRPLPGIEAGIVKktESGGv--EvVdQpDVQGELALRPgwPSMFR 432
WP_011466223 533 YLWGDVgkQRYLASYFDtypGVWRHGDWLKIGRNGGCVIYGRSDATINRHGLRMGTSELYSAVEALPEVLDSMVVDLEYL 612
WP_068803103 430 GYLGEE--ERYRKCFIG---DWYLSGDLARRDADGYYWFVGRADDVIKTSGHLIGPFEVEDVFMQHPAVAECGVIGKPDP 504
WP_011980657 430 GYLHNE--EKYKKSFVD---GWYISGDLAYRDEDGYFWFVGRADDIIKTSGHMVGPFEVESALMEHPAVAEVGVIGKPDP 504
WP_012395120 435 GYLHAE--DRYRKCFSD---GLYLTGDLAKKDADGYFWFVGRKDDVIKSAGHLIGPFEVESALTDHPAVAEAAVIGKPDP 509
WP_014433194 432 GYLHDE--ERYAKCFVD---GWYISGDLAELDEDGYFWFIGRADDIIKTAGHMVGPFEVESALMEHPAVAEAGVIGVPDP 506
WP_117413692 428 AYLHED--ARYRKCFDD---GWYLSGDLAMRDKDGYFWFVGRADDVIKSAGHLIGPFEVESALMEHEAVAEVGVIGIPDP 502
WP_025312318 414 AYLHEQ--ARYDKCFVE---DWYLSGDLAMRDGDGYFWFVGRADDLIKTSGHLIGPFEVESALIEHAAVAEAGVIGIPDE 488
WP_004513280 386 SYLNNA--GAYASKFRN---GFYCTGDVAYRDTDGYFWFVGRSDDVINTAGHLISPFEIESALIEVHEVAEAGVIGAPDE 460
WP_004322106 432 GYLNNE--ERYRKCFAG---DWYLTGDLARRDADGYYWFVGRSDDVIKSAGHLIGPFEVESALMEHPAVAEAGVIGKPDD 506
WP_013250344 433 GYWNEP--ERYKKCFAG---GWYLTGDVARKDADGYFWFVGRADDVIKTSGHLIGPFEVESVLIEHTAVAEAAVIGKPDP 507
WP_011466223 613 GRESYMPLFVVLREGLALDDTVRAKLVNAIKTALSPRFVPDEIFQVAEIPRTLSGKKQELPIKKLLLGQPLDKvlnREAM 692
WP_068803103 505 VAGEIIKAFVALKPGFEPDAALHDALLAHARKRLGAVVAPKEIEFAPSLPKTRSGKIMRRLLKARELGLPEGD---TSTL 581
WP_011980657 505 LIGQMVKAFVSLKSGYEPTEKLKRELIGFGRKKLGAAVAPKEIEFQENLPKTRSGKIMRRLLKARELGLPEGD---TSTL 581
WP_012395120 510 TVGAIIKAFVVLKDGFTADDDLRLELLGHARKHLGAAVAPKEIEFADALPHTSSGKIMRRLLKARELGLPEGD---TSTV 586
WP_014433194 507 VIGEVVKAFVSLKPPYKPSEELRLELLGWGRTRLGSAVAPKMIEFQDNLPKTRSGKIMRRLLKARELGLPEGD---LSTL 583
WP_117413692 503 VAGEVVKAFVGLKPGYTPSDDLAKELLGHARVQLGPAVAPKQIAFRTNLPKTRSGKIMRRLLKARELGLPEGD---TSTL 579
WP_025312318 489 TAGEVVKAYVTLNPGFDPSDALERVIRGHARKRLGPAVAPREVVFRQTLPKTRSGKIMRRLLKARELGLPEGD---ISTL 565
WP_004513280 461 LLYEKVVAFVSLHLGYALTDELQLKIRLHLANKLSSVATPHEIHCLERIPKNKSGKIMRRYLKATYLGQDAGD---ISTM 537
WP_004322106 507 MVGEVVKAFVSLKQGFEPSEALRKELLGHARKKLGAAVAPKEIDFLPVLPRTRSGKIMRRLLKARELGLPEGD---TSTL 583
WP_013250344 508 VAMEIVKAFVSLKDGHEPSDALRRELLGFARARLGAAVAPKEIAFLPTLPKTRSGKIMRRLLKARELGLPEGD---TSTL 584
WP_011466223 693 ANPACLDWYVA 703
WP_068803103 582 ENA-------- 584
WP_011980657 582 EK--------- 583
WP_012395120 587 VGFPEPKPQGV 597
WP_014433194 584 EKATEEEEKAV 594
WP_117413692 580 ESEER------ 584
WP_025312318 566 ETDET------ 570
WP_004513280 538 EE--------- 539
WP_004322106 584 EAGA------- 587
WP_013250344 585 EA--------- 586
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