6UJ5


Conserved Protein Domain Family
Fumble

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pfam03630: Fumble 
Fumble
Fumble is required for cell division in Drosophila. Mutants lacking fumble exhibit abnormalities in bipolar spindle organization, chromosome segregation, and contractile ring formation. Analyses have demonstrated that encodes three protein isoforms, all of which contain a domain with high similarity to the pantothenate kinases of A. nidulans and mouse. A role of fumble in membrane synthesis has been proposed.
Statistics
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PSSM-Id: 460995
Aligned: 110 rows
Threshold Bit Score: 226.221
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6UJ5_A         29 LAIDIGGTLAKV-----------------VFSPIhs-------------------------------------------- 47   Saccharomyces...
PDM81676       20 FSFDIGLRVIKV-----------------VYTSRihrhpaivn--------------------------------ekfsk 50  
Q18580         23 ICFDACSKTVKI-----------------VYSSSvplshttlec------------------------------trilsk 55   Caenorhabditi...
A0DQ03         15 VCLDIGGTLTKL-----------------TFATKkgvslkcqtkk----------------------------elniine 49   Paramecium te...
EGR28327       21 VGIDIGGTLAKL-----------------CFALQkgspvdfkhie-----------------------------hlairs 54  
Q4U9L6        146 LSMDIGGTFVKIllnlpiknsenyhlfkdVYTSY---------------------------------------------- 179  Theileria ann...
XP_001913460   54 LSADMGGTMTKI-----------------VFWIPgdtdidlpkyvepeesvmsg-----------fdlypdpvlkvtmns 105 
Q384T6       1060 ISIDVGGTFAKL-----------------VYVQPpgdfkvphyvvkeaavlaegfnvr--mldlldnaegmkrllnddpf 1120 Trypanosoma b...
Q4Q8Q6       1048 VTIDIGGTFAKI-----------------AFIMPptggafptfpsiiheasslseklglrtfqffadeeaaeselrtrsh 1110 Leishmania major
XP_001030111   64 IGIDIGGTLAKL-----------------CFALKknsqvdfehie-----------------------------hlmins 97   Tetrahymena t...
6UJ5_A         48 ---nRLMFYT--------IETEK---------IDKFMELLHSIIKEHNNGCYRMt-------------HI-----IATGG 89   Saccharomyces...
PDM81676       51 eggtRLHCIH--------FPFTD---------LDKVCEYIAQKVGNLSGK---Tv-------------QF-----TSTHK 92  
Q18580         56 qsedRIYCIQ--------VQYPD---------FPLILNFFGENCPLLKGT------------------TVd---fVVTAS 97   Caenorhabditi...
A0DQ03         50 tedyEIHFIS--------HPNS----------LDKLIENLEGIGFIVDGKSYIQ--------------NF-----YITGG 92   Paramecium te...
EGR28327       55 ysdfDVFFQT--------FQTND---------VESLIDFIDQLNMNFITK------------------KF-----YITGG 94  
Q4U9L6        180 -----LHSIYisdrfselFGSTYkvnvenqrdLEDVLEFLHSIFLSIKVRDRVLvfkyfplsdfengyNIegrclNFTGG 254  Theileria ann...
XP_001913460  106 kgenELCFMK--------FPTSQ---------IPEFIHYAKTSKLKEIYGIGNLq-------------IL-----NVTGG 150 
Q384T6       1121 stvgTLQFAK--------MSSKC---------IPDFMSYIVESQMLSYYTKEYRn-------------TL-----RVTGG 1165 Trypanosoma b...
Q4Q8Q6       1111 slvgTLRFLK--------IPSQQ---------VPRFTDYLAGSHAINNFKPQYTt-------------KV-----RATGG 1155 Leishmania major
XP_001030111   98 yqefDIYFKT--------FESRN---------VEDMIDFIESLDMNFITK------------------EF-----YITGG 137  Tetrahymena t...
6UJ5_A         90 GAFKFYDLLYENF-PqiKGISRFEEMEGLIHGLDFFI-HEIPDEVFTYNdq-dGeriIPTSSgTmdSKA---IYPYLLVN 163  Saccharomyces...
PDM81676       93 DSEECVRIIRDTL-R--VKMERVNDMRCHVKGTNFLL-SNILDEVFVYDh--hNv-dCRYFFqTclNSPhssVYPYVLVN 165 
Q18580         98 QNAEIEEVIRKVL-D--VELRHVDAFNGLVNGTSFLL-RNIEAECFTYS----FdesQEYEFqTlnNDS---MFPYLLIN 166  Caenorhabditi...
A0DQ03         93 GSFKYYDQI-----SnyGKIIRINEFDALKFGFKLLDsIKCKNTYFTFNngie---------ylqlTAS---IYPFILVN 155  Paramecium te...
EGR28327       95 GAHKFEELFQKRL-K--VEIIKVQEFESLRMGFLLLDqLTPNDTVFTYSk-------QKGQQyIvkNKS---LFPFLLVN 161 
Q4U9L6        255 GAYKYTEFLNSTFvKhnVKVNVMDEFSAIVEASKFL--TKMDKSAVRYDl-------IHRIPeVvsLEP---VYPFIISN 322  Theileria ann...
XP_001913460  151 GAYKFANLLKDEM-D--LEVRQQDEMRCLVLGVNFLLlCCQEKLCFRFv--------NKTKLyRevTPE---IFPYLLVN 216 
Q384T6       1166 GAFKYAALA-KKM-D--LNFSVMREMSAVVHGLGVVI-GRAPETIFTVDpatgErhpHRLKSpPgePFS---PYPCLLVN 1237 Trypanosoma b...
Q4Q8Q6       1156 GAFKYASVARNVL-G--IEFDVVKEMDAVVKGLNLVL-RVAPESVFTVDpstgVhhpHQLVS-NgdGFS---PFPYLLVN 1227 Leishmania major
XP_001030111  138 GAHKFDELFQERL-K--VNVIKVQEFESLKMGFQLLEqLSPNDSIFNFSk-------QKGKDfFkgQGG---LFPFVLIN 204  Tetrahymena t...
6UJ5_A        164 IGSGVSILKVTEPN-NFSRVGGSSLGGGTLWGLLSLITGAQTYDQMLDWAQ---EGDNSSVDMLVGDIY-GT---DYNKI 235  Saccharomyces...
PDM81676      166 VGTGMSIVRVNSES-DFEYIGGSHCGGGAFFGLAQLLIGSADMDELLVMAE---DGDHRKVDSLVSDIY-GM---KYEGL 237 
Q18580        167 IRTGVSVVLVEGEN-QFKRLGGSSIGGGSFLGLTELITGVSDIEEMMDRAL---QGSPDEFDIFIRDIY-GD---RASNF 238  Caenorhabditi...
A0DQ03        156 IGSGVSILKFDNED-QFARISGTSLGGGMFLGLSHLFTGINDFDELLKMTK---QGSNAHTDLLMDEVHlGF---QSPTR 228  Paramecium te...
EGR28327      162 VGSGVSIIKFLDEG-TIQRVNGTSIGGGFFLGLAHLLTGENNFNSLLDISN---KGDNQNLDLYVSDIF-GQ---SNAPK 233 
Q4U9L6        323 IGSGTFYLKVESEN-ENKHVFGTSISGGTSFGLVNYLLPLKERRSFTKIFK---TGKYIYYDIIL--IK-G-------QI 388  Theileria ann...
XP_001913460  217 VGSGVSILKVTAPE-KYERVSGSLIGGGTFWGLCCLLTNYKSFDEMLQAAQ---YGQHQNVDLYVKDIY-GR---CYDSV 288 
Q384T6       1238 IGSGISIIKCLGPDgSHVRIGGSPMGGATFWGLVRTMTAVTSWEEITETMRldgPGDNRNVDLLVGDIY-GYnakDLPPM 1316 Trypanosoma b...
Q4Q8Q6       1228 IGSGISLIKCTGADgSHVRVGGSPIGGATFWGLIRTMTNLTSWEEVMEIMRldgPGDNKNVDLLVGDIY-GYnakDLPAM 1306 Leishmania major
XP_001030111  205 IGSGVSMIKFEGEG-VFTRVNGTSIGGGFFLGITHLLTGERNFDKLLEMSN---QGDNRNVDLYANDIY-GQ---VVPPE 276  Tetrahymena t...
6UJ5_A        236 gLKSSAIASSFGKVFQNRmtsnksleNNenklysshes------------------ieknngqmfKNPDICKSLLFAISN 297  Saccharomyces...
PDM81676      238 gLPPDLIAGSFGKCSNTKfadqvkndPD-------------------------------------YRKDCIRSLLLMISN 280 
Q18580        239 nMDPHLLAASFGRVTRGEtvrraenfDEq------------------------------------SKNNAILSLLRMILY 282  Caenorhabditi...
A0DQ03        229 nKNEKHVAVSMGKLDQNIni---------------------------------------------nkSDLVKSLLYMTTY 263  Paramecium te...
EGR28327      234 dIHGDALCVSMGKMTQKLkegq-----------------------------------------dvnkQDIVKSLLLMTSF 272 
Q4U9L6        389 vLIHSLIIKARTTIRMRKfkkeeiktDCe-----------------------------------lYPGELYKSLIDMVAY 433  Theileria ann...
XP_001913460  289 gLAADMMASSFGKIQKVPcgeaknhyS---------------------------------------EADIAQGLMMMVCG 329 
Q384T6       1317 -LSVDTVASTFGKLGTERfyesqgnvDRlyasssedlsgavssspdsnptlhdavaptlashgktSEIDIVRSLLNMISS 1395 Trypanosoma b...
Q4Q8Q6       1307 -LSSETVASTFGKLGTERfydmkrniCTahfadddaageilspkgs-kspsviselpvrngtkaaSAIDIVRSLLNMISS 1384 Leishmania major
XP_001030111  277 dIHGDALCVSMGKMSAKLkege-----------------------------------------dvnkNDLVKSMLLMASF 315  Tetrahymena t...
6UJ5_A        298 NIGQIAYLQAKINNIQNIYFGGSYTRGHLTTMNTL----SYAINFWSQGS-----KQAFFLKHEGYLGAMGA 360  Saccharomyces cerevis...
PDM81676      281 SIGQVVSLVLNNEKTNRLFFNGFMVRNHPIIMRTL----SYAINFWSKGA-----LQAHFLRHEAFNAAIGA 343 
Q18580        283 NVSQLAYMLSEISNVKRVFFNGFLVRNRPIVMKTL----SFACNYWSSGK-----LRAYFLRHENYTTGLGA 345  Caenorhabditis elegans
A0DQ03        264 NISQIAFLHSKLHNIERVFFSGHFIRNHEETLQCI----NEAFSYFSKLDqq--nRHPYFIKHDGFIGSLGS 329  Paramecium tetraurelia
EGR28327      273 NLSQIAFNQAKLEGIQNIIFAGNFVRNHPDTMDCI----DHAIDYFNQAQskqnqNQAFFVKHDGFIGALGS 340 
Q4U9L6        434 NKGCLGYVIAKANGVKRIIYNGNFICKN--TMDSIvagfAFTSDVYRDKS-----IELCFPLHGPYIAALGS 498  Theileria annulata
XP_001913460  330 SIAHLGFELTKLHHINRIFYTGGFVAHNPVVWEAI----TTMLTTWSSGS-----VDANFLEYDGYFGSIGA 392 
Q384T6       1396 NVTQLAYLHSRVQDVHNIFFAGGFVRNNPIVWSHI----SSFMAYWSKGE-----CHAHFLGHDSHLGALGA 1458 Trypanosoma brucei
Q4Q8Q6       1385 NVTQLAYLHARLHGVPNIFFAGGFVRDNAMIWSLI----STTMKYWSSGE-----CHAHFLEHDGYLGALGC 1447 Leishmania major
XP_001030111  316 NLSQIAFIQSKLEGINNIIFAGNFVRNHQDTMDCI----NTAIEFFNQNEdannqRKAFFVKHDGFIGALGS 383  Tetrahymena thermophi...
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