Conserved Protein Domain Family
Bbox1_HOIP
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cd19815: Bbox1_HOIP 
B-box-type 1 zinc finger found in HOIL-1-interacting protein (HOIP) and similar proteins
HOIP, also termed RING finger protein 31 (RNF31), or zinc in-between-RING-finger ubiquitin-associated domain protein, together with HOIL-1 and SHARPIN, forms the E3-ligase complex (also known as linear-ubiquitin-chain assembly complex LUBAC) that regulates NF-kappaB activity and apoptosis. It also interacts with the atypical mammalian orphan receptor DAX-1, trigger DAX-1 ubiquitination and stabilization, and participate in repressing steroidogenic gene expression. HOIP contains a B-box motif that shows high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs). The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif.
Links
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Statistics
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PSSM-Id: 380873
Aligned: 20 rows
Threshold Bit Score: 57.3454
Created: 13-Sep-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C H HClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens Midline-1 (2JUN) binds two Zn2+ ions through its B-box motif.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #        #  #          #  #    #       #     
Q96EP0        216 PCFLCGSapGTLHCPSCKQA------LCPACDHLFHGHPsRAHHLRQTL 258  human
NP_001260159   89 KCTLCGSqnPWVTCAECAGQi-----FCASCDDMFHKHPkRKQHMRKAV 132  fruit fly
EFX70451       70 HCELCGSssPKVRCEKCLNQi-----FCLSCDDMYHRHPkRMNHSRKAL 113  common water flea
OQR67043       33 QCELCKSakAAIRCDRCENQv-----FCLQCDDIFHRHPkRKSHLRKSV 76   Tropilaelaps mercedesae
NP_001090429  203 GCFLCGTlaCSVFCCSCNEM------LCEECDKRAHSHPaRAEHVRLPC 245  African clawed frog
XP_006010093  262 LCALCGEasVSTHCPSCVYM------LCAECDVRYHKHPaRSTHVRLPV 304  coelacanth
XP_007884741  213 SCSVCGRhtFSVFCLTCDWH------LCQDCDCLYHQHPdRLTHHRLPA 255  elephant shark
PIK62631      216 SCFICGEenISVHCITCSEC------FCDECDSRYHRTSiRSSHDRKKI 258  Japanese sea cucumber
XP_011665886  462 NCDFCSTkpGKKFCASCEET------YCLECDDKRHSNQrRKSHKRQDV 504  purple sea urchin
PRP86453      719 NCDNCTEsvAVRECYQCSKEngtpvrMCTSCDQVMHKHPnKRNHHRQEC 767  Planoprotostelium fungivorum

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