4TVX,4AN8


Conserved Protein Domain Family
casA_cse1

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TIGR02547: casA_cse1 
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CRISPR type I-E/ECOLI-associated protein CasA/Cse1
CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This model family, represented by CT1972 from Chlorobium tepidum, is found in Ecoli subtype CRISPR/Cas regions of many bacteria, most of which are mesophiles, and not in Archaea. It is designated Cse1.
Statistics
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PSSM-Id: 274192
Aligned: 13 rows
Threshold Bit Score: 411.417
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4TVX_U         2 NLLIDNWIPVRPRNg----GKVQIINLQSLYCSRdQWRLSLPRDDMELAALALLVCIGQIIA-P--AKDDVEFRH----R 70  Escherichia col...
AAL21823       5 SLLTTPWLPVRFKD-----GSTGKLAPVDLADEN-VVDIAATRADLQGAAWQFLLGLLQCSI-A--PKRYKNWED----I 71  Salmonella ente...
CAE13041       2 NLVQDPWLPFRLRD-----GSEKVLPINAICDHD-VMDFALPRADFQGAACQFAIGLLQTVF-A--PEDKYQWHA----L 68  Photorhabdus lu...
Q46901         2 NLLIDNWIPVRPRNg----GKVQIINLQSLYCSRdQWRLSLPRDDMELAALALLVCIGQIIA-P--AKDDVEFRH----R 70  Escherichia col...
AAR34761       2 NLLTEAWIPVRPLPa----GAACKLTLRQLLCEDgRWELCLPRDDMELAALQLLICMTQVFF-P--PQSTAALKQ----R 70  Geobacter sulfu...
BAC75253       7 NLFDEPWIPVRWTHaaplpHPERVGLRDLLLRSGdIATLTIADPPAHSALLRILYALTARVT-GldESGPGDWGErrlnI 85  Streptomyces av...
tigr:CT1972    6 NLIDEPWIPAIGKG---------LVSLADIFSDPrIPALGG-NPVQKIALTKLLLAIGQAAC-T--PETTEALEQ----- 67  Chlorobium tepi...
tigr:MCA0935   2 NLLTDPLFRVETPDg---iERLSLPQLLEALGQDrVESLLGLQRHQEDAFHIFLCYLAGAVL-AreARSEPRQPEd---F 74  Methylococcus c...
WP_001084082   5 SLLTTPWLPVRFKD-----GTTGKLAPVDLADEN-VVDIAAPRADLQGAAWQFLLGLLQSSF-A--PKDYRRWDD----I 71  Escherichia coli
WP_000366321   2 DLTKEKWLPVIFSN-----GDKKKISLRDLLD-NrIQDLAYPRADFQGAAWQMLIGILQCTV-A--PEDKEEWAD----I 68  Salmonella ente...
BAD59278       9 DLLDEPWIIVTDASg----KASEVSLRQVFRRADeYVAIGGEVPTQQFAILRLLLAILHRTV-AdrPGTAIDVWS----R 79  Nocardia farcin...
WP_011429628   7 NLTKEKWIPVLDPDf----RIQELSLVELFREWEsLKEMRGDNPPTTLALYRFLLAIMHRAYlG--PKDTDHWKE----I 76  Synechococcus s...
4AN8_A        12 NLIDEPWIPVL-KGg----RVVEVGIGEALLRAHeFARIETPSPLEEAVLHRLLLAVLHRALsG--PRCPEDVLD----W 80  Thermus thermop...
4TVX_U        71 IMNP-LTEDEFQQLIAPWIDMFYLNHAE--HPFMQTKGVK-ANDV---TPMEKLLAGVSGATNC-------AFVN----Q 132 Escherichia col...
AAL21823      72 WFDG-LHADVLHKALAPLEHAFQFGAET--PSFMQDFEPL-SGEK---VSIASLLPEIPGAQTT-------KFNKdhfvK 137 Salmonella ente...
CAE13041      69 YETS-PDKKVLQQNFNKVIHAFNVTGIG--PLFMQDFDPL-QTVKs--TTVAGLLIEAPGANGL-------RLNTdhfiK 135 Photorhabdus lu...
Q46901        71 IMNP-LTEDEFQQLIAPWIDMFYLNHAE--HPFMQTKGVK-ANDV---TPMEKLLAGVSGATNC-------AFVN----Q 132 Escherichia col...
AAR34761      71 IVAP-LSLDEFESGCAPYREWFRLDHPD--FPFMQVRNVS-AKDP---TPMDKLLAGLTGATNS-------CFVN----E 132 Geobacter sulfu...
BAC75253      86 LDAGqLPPEGITAYAGRYRQRFFLYDRDggRPWMQDARLTgQCDGgntAGVNKLIVTRPAGNAH-------AWFRh--gS 156 Streptomyces av...
tigr:CT1972   68 -LDAeTFRRACRAYLEKWRDRFWLFGDK---PFLQMPAILdWMES---QRAAGILSETENAKQIgpgfypsLPSEndsiL 140 Chlorobium tepi...
tigr:MCA0935  75 WREG---IRKLTGRDDDWAWTLIVDDVT--QPAFMQAPVPdKKDFg----AFKLKARTADALDIl------pTAKnhdvK 139 Methylococcus c...
WP_001084082  72 WEDG-LEAEKLREALLSLEHPFQFGPDS--PSFMQDFEVL-MGDK---VQVASLLPEIPGAQTT-------KFNKdhfiK 137 Escherichia coli
WP_000366321  69 WHES-IEFEQWEKALNTISLALQFGEQK--PSFLQSFDPL-DSEY---GSIAGLLVDAPGGNAL-------KLNKdhfvK 134 Salmonella ente...
BAD59278      80 LWRE-WPADDIDRYLLAHRDRFDLFHPS--TPFFQVADLRsAKDGv--SSLDKLIADVPNGDKY-------FTTRa---G 144 Nocardia farcin...
WP_011429628  77 FQDN---GKRVIKYLQDRQDCFDLFHPT--HPFMQDPALP-IEKA---VPVHSIHTMSTSEVFF-------HEHEwsgyS 140 Synechococcus s...
4AN8_A        81 WRKGgFPQDPIRDYLNRFRDRFFLFHPE--APFLQVADLP-EENP---LPWSKLLPELASGNNP-------TLFdh-ttE 146 Thermus thermop...
4TVX_U       133 PGQGEALCGGCTAIALFNQANQAPGFGG--GFK----------SGLRGGTPVTTFVRGI-----------DLRSTVLLNV 189 Escherichia col...
AAL21823     138 RGVTERFCPHCAALALFSLQLNAPAGGK--GYR----------TGLRGGGPLTTLVELQeyqg---erqtPLWRKLWLNV 202 Salmonella ente...
CAE13041     136 RGIGDVMSLEMATLALFTLQINAPSGGV--GHR----------VGLRGGGPLTTLVVPQqt-------daTLWQKLWLNV 196 Photorhabdus lu...
Q46901       133 PGQGEALCGGCTAIALFNQANQAPGFGG--GFK----------SGLRGGTPVTTFVRGId-----------LRSTVLLNV 189 Escherichia col...
AAR34761     133 PGLGACLCGGCAAIALFNQSSNAPSFGG--GFK----------GSLRGGAPVTTLVQGEh-----------LRQTVWLNV 189 Geobacter sulfu...
BAC75253     157 DARPDLPSAAEAVLSLLVWHYYGPSGRC--SARe--------vNGVKTASATAGPLRTAlsyh---pegdTLFETLLAGL 223 Streptomyces av...
tigr:CT1972  141 SQFQTLKAQTDAEKALFIVSVMNFAFGG--TQInkniypseekVKGKGKPAKPGPSLGRngylhtflfgsTIIDTLIMNL 218 Chlorobium tepi...
tigr:MCA0935 140 ASRSGATSPDGWVYALVSLQTMSGFFGQ--GNYg--------iARMNGGFGSRPAVAVYhae-----rmgMRWHCDVTRL 204 Methylococcus c...
WP_001084082 138 RGVTEHVCSHCSALALFSLQLNAPSGGK--GYR----------TGLRGGGPMTTLIELQeyqg---nqqaPLWRKLWLNV 202 Escherichia coli
WP_000366321 135 RGNVEQICPHCAAIALFAIQTNSPAGGA--GYR----------VGMRGGGPLTTLVVPQeed------kyPLWKKLWLNV 196 Salmonella ente...
BAD59278     145 RGLDHIDFGEAARWLVHAHAFDPSGIKT--GAVg--------dARVKGGKGYPIGVAWAgslggvyleggDLRRTLLLNL 214 Nocardia farcin...
WP_011429628 141 ISLPEAARLLVRLQGVDITSLRAFYVGQdsGNH----------SAVNTPTMNVANVLLKg---------rTLKETLMLNL 201 Synechococcus s...
4AN8_A       147 ENLPKATYAQAARALLVHQAFAPGGLLR--RYG----------VGSAKDAPVARPALFLpt-------gqNLLETLLLNL 207 Thermus thermop...
4TVX_U       190 LTlprlqkqfPNESHTENQ-PTWIKPIKS----NESIPASSIGFVRGLFWQPAHIELCD--------PI--------Gig 248 Escherichia col...
AAL21823     203 MPqdt--adlPLPDQCDATvFPWLAATRTseqaNAVTTPEQVNKLQAYWGMPRRIRLDF--------ATlqsgccdiC-- 270 Salmonella ente...
CAE13041     197 ISrse--whySEPDLTSAQvFPWLAPTKVsvneGTEIHATDVHPLHMYWAMPRRIRLIV--------EKgeni-ckiS-- 263 Photorhabdus lu...
Q46901       190 LTlprlqkqfPNESHTENQ-PTWIKPIKS----NESIPASSIGFVRGLFWQPAHIELCD--------PIgigk-cscC-- 253 Escherichia col...
AAR34761     190 LSeerltqiiPWHHATRSQqPTWVAPIKA----GETIPSQAIGVLRGLFWQPGHLELMP--------PQgeqa-cicC-- 254 Geobacter sulfu...
BAC75253     224 VP----------PEVTVRRsFDLCPWEREelpdPEAAPPLPCGPCSRLTACSQHALLLV--------PDen--------- 276 Streptomyces av...
tigr:CT1972  219 LSqe-----eIDNLPFWEKgIGTPPWENMpvsrECDAALSLKKSYMGTLVSLSRFVLLH--------DDg---------- 275 Chlorobium tepi...
tigr:MCA0935 205 VGi-------REELLAGPWgYRERGIVLVweqpWDLESSLSLNVLDPFYIEIARAVRLM--------GDgk--------- 260 Methylococcus c...
WP_001084082 203 MPqde--adlPLPKKFDDLvFPWLGPTRTselaGAVVTDDQVNKLQAYWGMPRRIRIDFntttvgncDI--------C-- 270 Escherichia coli
WP_000366321 197 LPqe-----ePPNVTQHPLiFPWLAPTKTsekaGNVVTPDNAHPLQAYWGMPRRIELDF--------THtvagicdlC-- 261 Salmonella ente...
BAD59278     215 VL--------ADPDGDRYPdHDLPPWERDpdgpAVRDITGPSGPVDLFTWQSRRVRLVN--------SG--------A-- 268 Nocardia farcin...
WP_011429628 202 MRys-----pEDEMPSVVAgEDVPTWETKvgytGQPKKEIPAGYIHYLTFPWRRLRLFS--------EA--------G-- 258 Synechococcus s...
4AN8_A       208 VPy----------TPEDDApIWEVPPLRLgdleGARTKWPLTGRTRVYTWPARGVRLLD--------E------------ 257 Thermus thermop...
4TVX_U       249 kcsccgqeS---NL---RYTGFLKEKFTFTVNGlWPHPHSPCLVTVKKGEVeEKFLAFTTSAPSWTQISRVVVDKIIQN- 321 Escherichia col...
AAL21823     271 --------GaesDE---LLGFMTVKNYGVNYDG-WRHPLTPYRAPVKDQNA-FFSVKPQPGGLIWRDWLGLSQNNQTEAn 337 Salmonella ente...
CAE13041     264 --------GkysEF---TVSEYRAQNYGGNYTGnWSHPLTPYKWDPKKLTP-PLSIKGQPGGVTYKIWDALVFTSHESGq 331 Photorhabdus lu...
Q46901       254 --------GqesNL---RYTGFLKEKFTFTVNGlWPHPHSPCLVTVKKGEVeEKFLAFTTSAPSWTQISRVVVDKIIQN- 321 Escherichia col...
AAR34761     255 --------GfveKQ---VYAGFNKAKFNYTIDGlWPHPHGPRISSVKKGEReEKFVSFTTAAPAWTHLSRFVVQRQTTNs 323 Geobacter sulfu...
BAC75253     277 -----------------sPGLVRDAYITWAYRTgRIPRDDNYLIWQISQQGnRYPRPADSRRALWRDLDALLLHEPPGTa 339 Streptomyces av...
tigr:CT1972  276 ----------------------IYYIDGLPYPShQEGWLEP-SMTIDNQQNpPKAILVNPEKRPWRELVSILAVFDSNKn 332 Chlorobium tepi...
tigr:MCA0935 261 ------------nV---RAFGASTKAARLAAGDaGGVLGDPWTPVNVADKKkGQSAMTVSASGLSPELIRNVLFEDGFRa 325 Methylococcus c...
WP_001084082 271 --------G---EQsdaLLSLMTTKNYGANYAM-WQHPLTPYRVPLKEG-GeFYSVKPQPGGLIWRDWLGLIETGKSENn 337 Escherichia coli
WP_000366321 262 --------GehhES---LLLQMRSKNYGVQYDS-WLHPFSPYRQALKDPSApWLAFKGQPGGLSYKDWLGLMLNREDKFn 329 Salmonella ente...
BAD59278     269 --------QvtgVV---LCNGDALESFNKQLLEpMTGWRYSENQSKKAGETrHYPMVHDPEKSLWRGLRSLLGDVASSEp 337 Nocardia farcin...
WP_011429628 259 ----------------------RVQQLAITMGNsLPNGVEARQWECSVAYKeDKPVRLSLHRQLWRDADSFLLTASKQTr 316 Synechococcus s...
4AN8_A       258 ------------------GDGVRFMGYGPGVEPlEATHRDPMVAQRLDAKGnLLVLRLSEERSFWRDFSAMLPRQGGKVa 319 Thermus thermop...
4TVX_U       322 -ENGNR--------VAAVVNQFRNIAPQSPLELIMGGYRNNQASILERRHDVLMFNq------gWQQYG-NVINEIVTVG 385 Escherichia col...
AAL21823     338 yESPAQ--------VVKVFNARSLTDVKAGIWGFGADFDNMKIRCWYEHHFPLLMTeg-----lIPDLR-KAVQTAARLL 403 Salmonella ente...
CAE13041     332 rCAPVVsh-----fYSLCCHFAELRRVMPRLWVFGYDMDNMKARCWYSVTVPLFFVlfeqqekiLYQVK-ELQKLAINMI 405 Photorhabdus lu...
Q46901       322 -ENGNR--------VAAVVNQFRNIAPQSPLELIMGGYRNNQASILERRHDVLMFNq------gWQQYG-NVINEIVTVG 385 Escherichia col...
AAR34761     324 kEEGQE--------PAAVVRQAQGLLN--KLRLAVGGYRNNQASILERRHELIFLNd------gWSGHT-EVVHALVGQA 386 Geobacter sulfu...
BAC75253     340 qPQRPK-----------VFDYASEVSEDLRVRALGFEQEGQAKDTQFVDADTPPVMgft--eqkAPATA-PAVGRMRQLG 405 Streptomyces av...
tigr:CT1972  333 nKFVCLfik---ygLSRWPKRYNKPGDKIGVWSGGLQVSFQTGEQYAKATNDFVESsveldpdmWNNLWyDKFFGEISIL 409 Chlorobium tepi...
tigr:MCA0935 326 aRMQCLl--------eENEGQSCLFSATVLVRGQGTTDGFHHVAIPVPARAHRLFRrs----seRDRLAsISKTALNDAK 393 Methylococcus c...
WP_001084082 338 tELPAL--------VVKLFNASSLKQAKVGLWGFGYDFDNMKARCWYEHHFPLLLNkke---gqIPKLR-LAAQTASRIL 405 Escherichia coli
WP_000366321 330 kMQPAK--------VVRAAGQR----NKMSLWCFAWDMNKAKVRCWYQHRIPLISVshe--eqfLAALN-IVLVLASESL 394 Salmonella ente...
BAD59278     338 vAGRAIapgvvewaATLLDAGALPPDQPIRLHAVGMHYINNLSIVGDIVDDAIGFRaam--lasDPRLR-ICAVAAVQIA 414 Nocardia farcin...
WP_011429628 317 pRIVDW--------LAEL-KSEELVNNLVVFEVLGMSADQAKPLGWSSARFSVPMQfvtd-selAQSLK-SAIGIAENHQ 385 Synechococcus s...
4AN8_A       320 aTLEH---------AENLQGELEDEGLEGRITLRVLGQVSDQAKVLDIRREVYPLPsg----llTPKAE-ENLEKALKMA 385 Thermus thermop...
4TVX_U       386 LGYKTALRKALYTFAEGFKNk----DFKGAGVSVHETAERHFYRQselliPDVLANVNFSQa----dEVIADLRDKLHQL 457 Escherichia col...
AAL21823     404 SLLRSALKEAWFADAKGARG-----DFSFIDIDFWNLTQGRFLNL-----IHDLENGHKPD------ERLNKWQRELWLF 467 Salmonella ente...
CAE13041     406 WLCRNQIKAAWFEKPVDVKG-----DTSFIDLTFWQQSESLFFSV-----VHQLIDNANSDapfltpEQAKHWLNTLRYL 475 Photorhabdus lu...
Q46901       386 LGYKTALRKALYTFAEGFKNk----DFKGAGVSVHETAERHFYRQselliPDVLANVNFSQa----dEVIADLRDKLHQL 457 Escherichia col...
AAR34761     387 VGYRDALNKALFVFSTGFK------EIKGAGVKVHELAKEQFYRRsedtvLDTLARIDFEQa----aLALLAMGDGLHGI 456 Geobacter sulfu...
BAC75253     406 EMYGRRLERAVKRAWAEYMNd-----PKANGDTWAAEAAARYWPGaeaefWDRFRHLDNTGhtlgagFDPAAARTAFLRL 480 Streptomyces av...
tigr:CT1972  410 EIMANKVKNGVINYYDSFEPkkekkPKERASTIMGKKAVELFWQLcerrfPELVDACGEPD-------KLPAIHEAINLL 482 Chlorobium tepi...
tigr:MCA0935 394 EIQNRVLKPSVIALLEAGPDk---iNFDRREVNLWLNEATQRFSAawsedYFPWLWRQAEQdd--adAARLEWLRALRDK 468 Methylococcus c...
WP_001084082 406 SLLRSALKEAWFSDPKGARG-----DFSFVDIDFWNKTQHRFLRL-----VRQIEEGQ--Da----dELLGKWQKEIWLF 469 Escherichia coli
WP_000366321 395 SLLRNALKSAKFDCPKEAKM-----DFSMVDIAFWQETEPAFRTLqealaVDPLRQDTQTRh------AVSQWEAELAHY 463 Salmonella ente...
BAD59278     415 EEAVDALANLAADLAAAAGGeptgaRMRAREEGFFALEAPYRRWLaglvpQSTGYARQAAEweqtafVIVRRLGTEYIAA 494 Nocardia farcin...
WP_011429628 386 QIFRSSKGSPYFSLAEVLKNg------ETEKLSKALDGESRYWAIldhafSMLLHDLPQDNqp--gaDGIIYYGLTTLPA 457 Synechococcus s...
4AN8_A       386 EELGQGLKHLAQEVAKAVVGe----RDRGHGRSPYLEELTK---LanslpLERLYWHALDG-------AFPRFFARVEEE 451 Thermus thermop...
4TVX_U       458 CEMLFNQSVAPYAHHP-KLIS---T---LALARATLYKHLRELKPQ 496 Escherichia coli K-12
AAL21823     468 TRHYFDDHVFTNPYESsDLER---I---MTARKKYFTTSAEKQSAK 507 Salmonella enterica subsp. enterica serovar Typhi...
CAE13041     476 CRDLFDEYVALSELGNeRSIA---K---RMKARQQLIIGLYGQKAL 515 Photorhabdus luminescens subsp. laumondii TTO1
Q46901       458 CEMLFNQSVAPYAHHP-KLIS---T---LALARATLYKHLRELKPQ 496 Escherichia coli K-12
AAR34761     457 VVGLFNESVAPYRNDP-ELIR---T---TAVARKTLYKHLNALKPQ 495 Geobacter sulfurreducens PCA
BAC75253     481 ATDAYDTVTASVTRTQrGAKA---V----AHARIDLYGGVRKKATs 519 Streptomyces avermitilis MA-4680 = NBRC 14893
tigr:CT1972  483 ALQSYDAYCPKETARQiDAWA---E------CQKDLKKFIRELMEA 519 Chlorobium tepidum TLS
tigr:MCA0935 469 AHKVLEEAIARYPSREgRRYR---Ar---VKAEGLFHGSLFKTFPQ 508 Methylococcus capsulatus str. Bath
WP_001084082 470 ARQDFDERVFTNPYEPvDLER---V---MTARKKYFTTSAEKQSAK 509 Escherichia coli
WP_000366321 464 LFHVFDRDALTNPDCPdDILQ---R---QLTARQDLASSYRKHKAR 503 Salmonella enterica
BAD59278     495 AGDVAWVGRPVREKWLdSSIA---ErwfYKKLRAVLPSAFTEHRDT 537 Nocardia farcinica IFM 10152
WP_011429628 458 WTKTVQDAARRAFTESiESIRnyqA---RAAALRTLERKLAELRAD 500 Synechococcus sp. JA-3-3Ab
4AN8_A       452 ASLDLWREALRg-----AALE---A---WKATRRFLGTGARHLKAL 486 Thermus thermophilus HB8
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