2NV4,1XQB,3OKX


Conserved Protein Domain Family
UPF0066
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cd09281: UPF0066 
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Escherichia coli YaeB and related proteins.
Uncharacterized protein family UPF0066. This domain includes Escherichia coli YeaB, Archeoglobus fulgidus AF0241, and Agrobacterium tumefaciens VirR. Proteins with this domain are probable S-adenosylmethionine-dependent methyltransferases but they have not been functionally characterized and the substrate is unknown.
Links
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Statistics
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PSSM-Id: 187753
Aligned: 192 rows
Threshold Bit Score: 122.6
Created: 20-Nov-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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cofactorhomodimer
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:cofactor binding site
Evidence:
  • Structure:2NV4_A; Archaeoglobus fulgidus AF0241 binds S-adenosylmethionine. Contacts determined at 4A distance.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                          # ##                         #
2NV4_A         5 PIGVVKspfktqndaprqgrfsdaVSEIAIFDeyadGLHKIEnlRHIIVLYWXDkasrdklrv--vppgeteerGVFTTR 82  Archaeoglobus f...
XP_001322060   7 PVGYVHsdckqmcevplngkddilGGVIEILPqfseCILGLEkvKYIWVFSFLHladrsiqqvqpvhrrhlhprGVFATC 86  Trichomonas vag...
XP_001306267   7 FLGIAHtsfktvpevprcakdcteESTVTFYPeysdCLVGLEnfSHVFVFAWMHqsdrdlqlvrphfgaakkdiGVFATR 86  Trichomonas vag...
ZP_07332797    7 VLGTVRsvltdpataprfetenapPAELVLDPayraAAESLEvgQEILVFTWFHlanrscqqvhprrdktrpltGVFSTR 86  Desulfovibrio f...
ZP_07017367    5 SIGLARtnyldpedcprqgrgdmpACTIELDPeyapGLHRLRqgQEVVVLTWMHlarrdvyrlrprndparplhGVFCTR 84  Desulfonatronos...
ACU90551       5 VIGTVRshlvsreqcpkygdasmpPVWIELAPdfepAATDLQvgDSILVLTWMHqgdqsvlrchpqgnrelpmrGIFSTR 84  Desulfomicrobiu...
ACS80449       7 IIGYLRsdikerekapkqgseggiEATVEINEkyseALEGLEagAEILLFTWLHkadrsyqkvhprgdesrpkrGVFSTR 86  Desulfovibrio s...
YP_003197097   8 PVAVVRtvypsreacprqagsdaePARIEVASefqpALDGVRpgQHLLVLTWLEqgdraclrchprgdvnrpqrGVFTTR 87  Desulfohalobium...
Q30VD4         7 FIGVVRsslkdigdcpkqgdeggvEAWVDIHEeyraGLDSLRagQGLTLLTWLHeadrsvlsvhprgdtgrprrGVFNTR 86  Desulfovibrio d...
YP_003769854   3 PVAHIEspltdrsaapkqgdegapPSRVVFAPeftpAAADLRpgDRLILLTWLHeadrdvqavhprgdrdrpstGVFSTR 82  Amycolatopsis m...

Feature 1               # #                  #    #        
2NV4_A        83 SPSRPNPIGLCvvEILEVErnrLKVRWLDalDGSPVIDIKKY 124 Archaeoglobus fulgidus
XP_001322060  87 SPVRPNPIGKSfmEIQKIDglkIYVKGLDlvDGTPILDIKLY 128 Trichomonas vaginalis G3
XP_001306267  87 SPARPNPIGMTlvKVNKIEgitLYVTGLDllDGTPIIDIKKY 128 Trichomonas vaginalis G3
ZP_07332797   87 SPDRPNPIGLHkvRIAAIDdakITVEALEavDGTPVIDIKPL 128 Desulfovibrio fructosovorans JJ
ZP_07017367   85 SPHRPNPIGLHqvKILKIHdcrIVVHPLEvvDKTPVVDIKPV 126 Desulfonatronospira thiodismutans ASO3-1
ACU90551      85 SPDRPTPIGLHavRILGREglrLKVHPLEviDGTPVIDIKPD 126 Desulfomicrobium baculatum DSM 4028
ACS80449      87 SPDRPNPIGLHpvTITAINgckIKVRPMEaiDGTPLVDIKIG 128 Desulfovibrio salexigens DSM 2638
YP_003197097  88 SPDRPNPIGLHevRVLGWEngvLTVSGMEvvDGTAVVDIKSV 129 Desulfohalobium retbaense DSM 5692
Q30VD4        87 SPARPNPVGLHevRLTAVEdgrLKVAPLEalDGTPVIDIKTS 128 Desulfovibrio desulfuricans subsp. desulfuricans str....
YP_003769854  83 SPDRPNPIGLHtvTVTAIEgaaLTVTGSEaiDGTPVLDVKPV 124 Amycolatopsis mediterranei U32

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