1LRZ


Conserved Protein Domain Family
FemAB

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pfam02388: FemAB 
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FemAB family
The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan. These proteins are also considered as a factor influencing the level of methicillin resistance.
Statistics
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PSSM-Id: 426751
Aligned: 22 rows
Threshold Bit Score: 374.685
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1LRZ_A   6 LTAKEFGAFTDSMPY-SHFTQTVGHYELKLAEGyETHLVGIKNNnNEVIAACLLTAVPVMKVFkYFYSNRGPVIDYENQE 84 
Q2FVL5   6 LTSDEFNAFTTKH-F-SHYTQSAIHYNHRVDLKgDVHLVGVKDDnGQVIAGCLLTEARTLKFFkYFYTHRGPVMDYTNQS 83  Staphylococcus aureus...
Q5HLI6   6 LTSEEFEQFTSEN-F-SHYTQSSIHYNNRSKTKgDVHLVGVKDDqEDVIAACLLTEARSLKFFkYFYTHRGPVMDFNNLV 83  Staphylococcus epider...
Q2FYR1   6 LTVTEFDNFVQNPSLeSHYFQVKENIVTRENDGfEVVLLGIKDDnNKVIAASLFSKIPTMGSY-VYYSNRGPVMDFSDLG 84  Staphylococcus aureus...
Q830W0   8 IPAEVHDTFVKNHPL-CNLLQSSSWAKVK--DNwGSEIVGVYEKdTLVASSLVLIKPLPA-GFtMLYTPRGPVMDYTNER 83  Enterococcus faecalis
Q8E152   8 ISEKEYDAFAIASSQ-TNLLHSSKWAQVK--SNwQNERLGFYKDdQLVAVASILIKSLPL-GFtMLYIPRGPIMDYSNKE 83  Streptococcus agalact...
Q8E153   5 ITAVEHDRFVSESNQ-TNLLQSSNWPKVK--DNwGSQLLGFFDGeTQIASASILIKSLPL-GFsMLYIPRGPIMDYSNLD 80  Streptococcus agalact...
Q8DV07   8 ISKEEHDNFIKNSSQ-TNLLQSSSWAKVK--DEwENERIGFYQDsKLVASASILIRPLPL-GMtMFYIPRGPVMNYQDKD 83  Streptococcus mutans
Q5M449   8 LSTSEHDRFVIDSPQ-TNLLQSSSWAKIK--DSwGNDRLGFYQDdKLVAVASVLIQPLPL-GFsMIYIPRGPIMDYQDKE 83  Streptococcus thermop...
Q8DQR1   8 ipTLEYDQFVKEHEL-ANVLQSSAWEEVK--SNwQHEKFGVYREeKLLATASILIRTLPL-GYkMFYIPRGPILDYGDKE 83  Streptococcus pneumon...
1LRZ_A  85 LVHFFFNELSKYVKKHRCLYLHIDPYLPYQYLNHDGEITg--NAGNDWFFDKMSNLGFEHTGFHKGFDpvLQIRYHSVLD 162
Q2FVL5  84 LVAFFFKALTSYLKKHNCLYVLVDPYLIENLRNADGEIVk--SYDNRAFVRTMDKLGYKHQGFPVGYDsmSQIRWLSVLD 161 Staphylococcus aureus...
Q5HLI6  84 LVRFFFKSLTAYLKKHNCLYVLVDPYVLENLRQPNGEIIe--SFDNRALIKTMEELGYKHQGYTVGYDtmSQIRWLSVLN 161 Staphylococcus epider...
Q2FYR1  85 LVDYYLKELDKYLQQHQCLYVKLDPYWLYHLYDKDIVPFe-gREKNDALVNLFKSHGYEHHGFTTEYDtsSQVRWMGVLN 163 Staphylococcus aureus...
Q830W0  84 LVSYFMAELKKFGKKKRALFIKMDPAVHYQDFHLGEEHQp--HAEATSIIETLKEAGAKYQGLTMDMGatIQPRFQANIY 161 Enterococcus faecalis
Q8E152  84 LVNFVLKTLKNFGRKKRAVFAKFDPALLLRQYHLKEENVaeeIDESRQAIDNLKSAGAQWIGPTKAISetIQPRFQANIY 163 Streptococcus agalact...
Q8E153  81 IVTKVLKDLKAFGKKQRALFIKCDPLIYLKMVNAKDFENspdEKEGLIAIDHLQRAGADWTGRTTDLAhtIQPRFQANLY 160 Streptococcus agalact...
Q8DV07  84 LVNFVLTSLKKFAKRKRALFIKFDPFILLNHHQIDEEAIn--NPQAQTIIDTLKHLGCEWLGQTSDMGetIQPRFQANIY 161 Streptococcus mutans
Q5M449  84 LLAFVITSLKKYAKTKRALFVKFDPSLFVTKNLISQEVNi--NEDTLSIAKDIQALGVEWTGLTEDMAenIQPRFQANIY 161 Streptococcus thermop...
Q8DQR1  84 LLNFAIQSIKSYARSKRVVFVTFDPSICLSQSLINQEKTe--FPENLAIIDSLQQMGVRWSGKTEEMGdtIQPRIQAKIY 161 Streptococcus pneumon...
1LRZ_A 163 LKDKTADDIIKNMDGLRKRNTKKVKKNGVKVRFLSEEELPIFRSFMEDTSESKAFADRDDKFYYNRLKYYKDRVLVPLAY 242
Q2FVL5 162 LKDKTEDQLLKEMDYQTRRNIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLAY 241 Staphylococcus aureus...
Q5HLI6 162 LKDKSEDQLLKEMDYQTRRNIKKTYEMGVKVKTLPIEETNTFFELFKMAEEKHGFKFREEPYFVEMQKTYEDHAMLKLAY 241 Staphylococcus epider...
Q2FYR1 164 LEGKTPETLKKTFDSQRKRNINKAINYGVKVRFLERDEFNLFLDLYRETEERAGFVSKTDDYFYNFIDTYGDKVLVPLAY 243 Staphylococcus aureus...
Q830W0 162 REDFSEE----QLSKSTKKMIKTAEKKGVVVQQGHVDFVDEFEKVIQSTMERQHISLRNSDYFKKLLNIYPEDSFIMLAQ 237 Enterococcus faecalis
Q8E152 164 TKANIEE----NFPKHTKRLIKDAKHRGVQIYRANIDDLPKFATVVALTENRKGVALRNENYFHQLMTIYGEDAYLYLAK 239 Streptococcus agalact...
Q8E153 161 ANQFGLD----KMSKKTRQAIRTSKNKGVDIQFGSHELLEDFAELMKKTEDRKGINLRGIDYYQKLLDTYPNNSYITMAS 236 Streptococcus agalact...
Q8DV07 162 AEGFSEA----NLSKKIRQSIRTAKNKGVSIRFGGYELLADFSDLMKKTEDRKSIHLRGIDYYRKLLDNYPQHSFITLAS 237 Streptococcus mutans
Q5M449 162 KEDFTEE----QLSKSTKQAIRTARNKGISVQFGGTELLDQFADLMKKTEARKNIHLRGIDYYEKLLTTYPESSYITLST 237 Streptococcus thermop...
Q8DQR1 162 KENFEED----KLSKSTKQAIRTARNKGLEIQYGGLELLDSFSELMKKTEKRKEIHLRNEAYYKKLLDNFKDKAYITLAT 237 Streptococcus pneumon...
1LRZ_A 243 INFDEYIKELNEERDILNKDLNKALKDIEKRPENKKAHNKRDNLQQQLDANEQKIEEGKRLQEEHGNEl-PISAGFFFIN 321
Q2FVL5 242 IDLNEYLKTLQLKQQQLTAELSGVEEALEESPNSKKNKTKRTQLEQQLNSNKRKIDNTIEQIEQDGAVl-NLASALFIYN 320 Staphylococcus aureus...
Q5HLI6 242 IDLQDYLDTLQTKHQNLNQQLKDVEKTLEENPNSKKNKTKHTQVKQQFDSNARKIRQTKEKIAEEGQVl-HLAAALYIYN 320 Staphylococcus epider...
Q2FYR1 244 IDLDEYVLKLQQELNDKENRRDQMMAKENKSD---KQMKKIAELDKQIDHDQHELLNASELSKTDGPIl-NLASGVYFAN 319 Staphylococcus aureus...
Q830W0 238 VNLKERLDSTRQRYDKNQKDLSNLKE---------NQVKKRHNLEELDASLTRELKELEENIAEAGEIv-TVAGALAVTF 307 Enterococcus faecalis
Q8E152 240 VNLPKRLAQFKEQLLQIQKDLSETPS---------HQKSRLTRLNQQEASVKQYILEFQEFSKKYPDEp-VIAGILSIRF 309 Streptococcus agalact...
Q8E153 237 LDVAKRLEKIEKECQIAQSERIKSLEL--------NREKKVKQHQGTIDRLNKEIDFLKEAQKAYDRDiiPLAATLTLEF 308 Streptococcus agalact...
Q8DV07 238 LNLKERLTELESQRKKAQNNLAKFGDN--------VKPSKIDNTKKEIERLSDEIAFLQEHLSQGKDTv-PLSGTLSLEF 308 Streptococcus mutans
Q5M449 238 LDLPARLKDLNKQLEKNIADAAKFTEK--------TKPGKIENNKQEYKRLSEEIAFLQEKVDAGNKIv-PLSGTLVLEF 308 Streptococcus thermop...
Q8DQR1 238 LDVSKRSQELEEQLAKNRALEETFTES--------TRTSKVEAQKKEKERLLEELTFLQEYIDVGQARv-PLAATLSLEF 308 Streptococcus pneumon...
1LRZ_A 322 PFEVVYYAGGTSNAFRHFAGSYAVQWEMINYALNHGIDRYNFYGVSGKFTedaEDA---GVVKFKKGYNAEIIEYVGDFI 398
Q2FVL5 321 EHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHIDRYNFYGITGDFS---ESSedyGVQQFKKGFNAHVEEYIGDFI 397 Staphylococcus aureus...
Q5HLI6 321 DHEVYYLSSGSNPKYNAYMGAYRLQWDMIQFAKEHNIDRYNFYGVTGDFS---ENAedaGVQKFKEGFNAKIYEYIGDFI 397 Staphylococcus epider...
Q2FYR1 320 AYEVNYFSGGSSEKYNQFMGPYMMHWFMINYCFDNGYDRYNFYGLSGDFT---ENSedyGVYRFKRGFNVQIEELIGDFY 396 Staphylococcus aureus...
Q830W0 308 GPTSEILYAGLDDRYKRYMPTYVTWRDAIQECFNRGCESCNMGGLEGSLN---D-----GLIKFKANFNPTINEFIGEFD 379 Enterococcus faecalis
Q8E152 310 GNVLEMLYAGMDDSFRKFYPQYLLNARVFEDAFKNDIVSANLGGVEGSLN---D-----GLTKFKSNFNPMFEEYIGEFN 381 Streptococcus agalact...
Q8E153 309 GNTSENIYAGMDDYFKSYSAPIYTWFETAQRAFERGNIWQNMGGIENDLS---G-----GLYHFKSKFEPIIEEFIGEFN 380 Streptococcus agalact...
Q8DV07 309 GKTSENVYAGMDDEFRRYQAAIYTWFATANHAFERGSHWQNMGGIENDLS---G-----GLYNFKSKFKPEIEEFIGEFN 380 Streptococcus mutans
Q5M449 309 GNTAENIYAGMDEDYRRYQPAILTWFETANHAFERGAEWQNMGGIENSLD---G-----GLYNFKSKFNPRIEQFIGEFN 380 Streptococcus thermop...
Q8DQR1 309 GTTSVNIYAGMDDDFKRYNAPILTWYETARYAFERGMVWQNLGGVENSLN---G-----GLYHFKEKFNPTIEEYLGEFT 380 Streptococcus pneumon...
1LRZ_A 399 KPINKPVYAAYTALK---K 414
Q2FVL5 398 KPIKPLLYKVQTYLN---H 413 Staphylococcus aureus subsp. aureus NCTC 8325
Q5HLI6 398 KPIKPLFYKVKQELE---S 413 Staphylococcus epidermidis RP62A
Q2FYR1 397 KPIHKVKYWLFTTLD---K 412 Staphylococcus aureus subsp. aureus NCTC 8325
Q830W0 380 LPVNKLLFKASEYAY---K 395 Enterococcus faecalis
Q8E152 382 LAINPLLYKLANLAYtirk 400 Streptococcus agalactiae serogroup V
Q8E153 381 IPVNRLLYKASNYVYalrk 399 Streptococcus agalactiae serogroup V
Q8DV07 381 LPVSP-LYKLANIAYtirK 398 Streptococcus mutans
Q5M449 381 LPVSP-FYGLANFAY---K 395 Streptococcus thermophilus LMG 18311
Q8DQR1 381 MPTHP-LYPLLRLAldfrk 398 Streptococcus pneumoniae R6
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