4JHY


Conserved Protein Domain Family
DUF4468

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pfam14730: DUF4468 
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Domain of unknown function (DUF4468) with TBP-like fold
A large family of (predicted) secreted proteins with unknown functions from human gut and oral cavity. Typically forms a N-terminal domain with FMN binding domain at the C-terminus. Experimentaly determined 3D structure of this domain shows a variant of a TATA box binding - like fold, but no detectable sequence similarity to other proteins with this fold
Statistics
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PSSM-Id: 434164
Aligned: 54 rows
Threshold Bit Score: 58.0538
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4JHY_A          22 SDDVEIENTSKL-EIFNAINAWAKKSYGKDVFL--------SNVN-SNKNKGTIFVSSKVELLLND-----TD----KTI 82  Parabacteroid...
WP_013253034    33 EVILELSNMPKN-EIFLKANKWFISNFSSEN----------SIILiSDKEYGYIIGTIFDSFVDVNt----------FYQ 91  Sediminispiro...
CDB09654        62 VQIIPAEGKTKD-ELYVLLNYWFTATFNDAN----------SVIKlNDKELGTIIAQGYVADIAQHaggtnSY----NVN 126
WP_002986232    46 VRVIEAPGISKE-DIYNRALNYFTYNYGSGK----------SVIQtQDKESGLVVGKGIYKDVHIGmslitT-----YVD 109 Myroides odor...
jgi:Solca_0833  42 TGVVIVDSVKMK-ELFVRAKEWTALTFNSAQ----------DVIQmDDKEAGKLIIKAIDKVNISSkslgmENi--tTYS 108
CDD90216        27 SKVIEVKDVDKT-SIYISLRDWISTYYRDTQ----------EVLQmDDKDAGIIIGKAIFLYSMNNlayaaY-----EGK 90 
CAL42880        27 KNVIKVDSLKKSsQLYMLSRSWFAEKYNSAK----------DVIQfEDKEEGKIIARGSFNYNSNVfvysnAT----KGH 92 
WP_014679119   427 vggIRLDSMSTKvELFQRAKDWITLNFQLEN----------QVLHrDDLHNGVLIAKGF------AgyttkLNakdfQHK 490 Solitalea can...
WP_044000657    49 rgmlPAAGLPQT-EVYGRAQEWLARQFEQYD----------QVVRfADAGRGVLIGQAIVQAVGPAqknleAR----RFN 113 Hymenobacter ...
WP_011734774    32 QTVVDAPTVSKE-RIFEKSKIWFAQTFRQSMAGgwqqnstrTVIQyENGEKGVLIANAAILYPLGRyseayKE----GWE 106 Pelobacter pr...
4JHY_A          83 IKYKXRITCFDNRYTIEASDIV 104 Parabacteroides distasonis ATCC 8503
WP_013253034    92 MKFDVNIEIKGNRVRMTFENPH 113 Sediminispirochaeta smaragdinae
CDB09654       127 IRPVIKCDIKDGRVRVTYTIPF 148
WP_002986232   110 AWHILRVDAKDGKARAIITLTQ 131 Myroides odoratus
jgi:Solca_0833 109 LYFTLNLTFKDNKYKYELNNFR 130
CDD90216        91 IWYSIKLQVKDGRFKVEMLNFV 112
CAL42880        93 ITYTLTIIVKDGRYKYEASNFT 114
WP_014679119   491 LTWTMTITVKNGGYTYEMTDIY 512 Solitalea canadensis
WP_044000657   114 LLFRFQFRAQAGGLQYELTDLS 135 Hymenobacter swuensis
WP_011734774   107 VRFTLREEVKEGKARLTFSNLN 128 Pelobacter propionicus
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