Conserved Protein Domain Family
PRK05277

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PRK05277: PRK05277 
H(+)/Cl(-) exchange transporter ClcA
Statistics
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PSSM-Id: 235385
Aligned: 122 rows
Threshold Bit Score: 391.562
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
269140120   1 MILAAIVGTLAGFIGVAFERCVDWVQQQRLAGLAEVANYWFIVWPAAILGSALLAMCGYYLVRRFAPEAGGSGIPEIEGA 80 
161579542  34 FPRALLAGLLAGCAAVGFHLGMDAGEAWRARLQDFAHGYGASGLAIAAAASALCVFLAAWLVERFAPEAAGSGIPHVKAV 113
289165222   9 YTLATLLGILTGTVGSLFQLAIHGVNKVLIHWFNFAGSKGYNIGIISALTTMVMVFITWSLVKWFVTEASGSGVQEIEGA 88 
289165593   9 YVVSVVLGIIVGLVGSTFRLSIDVLSALLDHFYHFLSINGWPSGIISGLVSMVMVYAAYLAVKHFAPEASGSGVPEIEGA 88 
296107323   9 YFVSVLLGILTGAIASLFQLTIQQMDHLLELLFHMTESYGLPVGIVSAMTSMVMLFIAWMMVKYIAPEAAGSGVQEIEGT 88 
81300385   33 LLWAAIAGLMVGLVGGAFRWLTSATLNGRVRWLASLPQG--PELVASVLLSSGMVALGFYLMRRFAPDTSGSGIPQIEGW 110
56750042   33 LLWAAIAGLMVGLVGGAFRWLTSATLNGRVRWLASLPQG--PELVASVLLSSGMVALGFYLMRRFAPDTSGSGIPQIEGW 110
16330386   32 LVAAIVVGLITGVLGAGFKSAVNNMLQWRSQLAQILAPIPPLAWLVTALISGGMVALSFWLMKRFAPDTSGSGIPQIEGH 111
172036162  42 LLWAALVGILTGGVGTLFQVAVSQLIQGREYLIQLVKNDAVLNWLVPTVLSAIMVYLAFGLMRRLAPETGGSGIPQIEGF 121
182414840  21 VLKAILVGVLAGALGAAFRLALQIAESARAQAIAAAAGPWALV--AGIAIGVVGGALGVWLVWRFAPHAAGSGIPHLKGV 98 
269140120  81 LEDLRPARwWRVIPVKFIGGLGTLGAGMVLGREGPTVQMGGNLGQMVYDLFRLpkrDNETRHTLLATGAAAGLTAAFNAP 160
161579542 114 LMGLRGFRwARVLAVKFLSGLIGMGGGLTLGREGPTVQMGGAVAEGVATACSS---SPDERRALIAAGAGAGLAAAFNAP 190
289165222  89 LLHKRPIFwRRLLPVKFVGGVMAIGSKMVLGREGPTIQIGGNLGEMLGEIFCL---TRKRRDSLIAAGAAAGLATAFNAP 165
289165593  89 LLHVRPIFwQRLLPVKFFFGILALGAKMILGREGPTIHIGGNLGEMLGSLFNL---ARRRKDSLIAAGAAAGLSVAFNAP 165
296107323  89 LLHVRPIFwKRLIPVKFFGGVLSISAKMVMGREGPTIQMGGNLGQMLGELFRL---TRRRRDTLIAAGSAAGLAAAFNAP 165
81300385  111 LAGFFSLFwWRVLPVKFLAGILTLGSGMVMGREGPTIQMGGAIGQMVSDWFRA---STEQARVLVAASAGAGLATAFNAP 187
56750042  111 LAGFFSLFwWRVLPVKFLAGILTLGSGMVMGREGPTIQMGGAIGQMVSDWFRA---STEQARVLVAASAGAGLATAFNAP 187
16330386  112 LEGKLPLVwQRVLPIKLVGGFLSLGAGMLAGFEGPTIQMGGSIGQMTGGWFKa---TQENQRILIAVGAGAGLATAFNAP 188
172036162 122 LDALLPLRwQWVLPVKFLGGLLALGSGMVLGREGPTIQMGGSIGKMVGSYFRS---SGEQIKILVAAGAGAGLASAFNAP 198
182414840  99 LERQAEPEwKRLLPVKFIGGVLGIGGGLALGREGPTIQMGGATGAMVASWLRVr-aGEGERRALMSAGAGAGLAAAFNAP 177
269140120 161 LAGILFIIEEMRPQFHYSLVSIKAVFIGVIMSCVVFRVFNGEHSVIEVGRLGVAELNTLWLYLVLGMVFGIVGVLFNMGV 240
161579542 191 LSGLIFVLEELRE--RCSSPEFFAAAVACLAADTVCRLALGELPAFRVGISGAPSLTMLPVFVGLGVSCGLLGVAFNRTL 268
289165222 166 LAGILFVLEEMRNEFNFSFTNFKVVAICCVFATIMLHVIIGPQPDIKMVVFAPPGLQSLWVFFAFGIIVGIVGLCFNKFL 245
289165593 166 LAGVIFVMEEMRNQFNYSFTSFSMVVICCITATVILDFMIGPQPTIPMNVFEFPQLDALWLFALFGIVVGLLGLLFNLSL 245
296107323 166 LAGVLFVMEEMRNQFNYSFTNFKMVVICCVMATIVLHLIIGSQPAIQMEVFELPTLGSLWLFFVFGILMGLAGLLFNVTL 245
81300385  188 LAGIVFVFEEMRPTFQNRLRAYQAVTIACITATIGLQLLLGKGPTIELAQFGAPPLSSLWVFVLLGLACGAIGYSFNRLL 267
56750042  188 LAGIVFVFEEMRPTFQNRLRAYQAVTIACITATIGLQLLLGKGPTIELAQFGAPPLSSLWVFVLLGLACGAIGYSFNRLL 267
16330386  189 LAGVALIGEEMHPRFRSQTLAYHSLLFGCVMATIILRMIRGQSAIISLTEFKRVPLDSLWMFIILGILFGVMGYTFNRGL 268
172036162 199 LAGILFVNEEMRPNFKDRISSYRAVALASVMATIVVRIFLGQGADIKITKFEAPPLVSLLGFALLGICLGIIGYVFNLCL 278
182414840 178 LSGLVFVMEELHGNF--TPVLFVAAFLASVSGDVVGRLMINELPVFHLSGIAAPGLSSLPWAALLGGALGLFGVAFNRVL 255
269140120 241 FRTQDMFlrmHGGNWRKLM--LIGAALGGLCGALGLIQQEAAGGGFALIPIAAEGNYTV--GMLLFIFIARVVTTLLCFG 316
161579542 269 LAVQRLCpgrPGSRKAFWL------GWGGSIGLVGWLAPDLLGGGQGLVGRILDGEASLapSLVALYFAARFALTIGSYA 342
289165222 246 MKLLYRLdklKPWMKDIYV-----LIIGLTVGYLAYIQPSVVGGGYDIIEQALIAYPDF--SVLMMLLIIRFIMTLLCYG 318
289165593 246 MKTLQLLdklTSRQKSYYV-----LIVGFLVGFLAVHHPASVGGGMDIIHQAITLSPSF--SLLCFLLIVRFIGMMACYG 318
296107323 246 MRTVGWLdkqNPKNKKYYI-----LAVGFLVGYLAYSYPATVGGGYVIISEALTMSPAF--SVLCSLIVIRFIMTMLSYS 318
81300385  268 VWSLNCFatlHGLPLR-----LTGLGVGGFIGLVSWLYPPATNSGENLVLWAFDTVEPI--HTLLLLCSLRFALTLLCYG 340
56750042  268 VWSLNCFatlHGLPLR-----LTGLGVGGFIGLVSWLYPPATNSGENLVLWAFDTVEPI--HTLLLLCSLRFALTLLCYG 340
16330386  269 FKVLDWFdrlPP---LATK--WKGFLLGSIIGILSLFPLPLTDGGDNAVLWAFNSQSHF--STLILVFCGRFLLTLICYG 341
172036162 279 FRTLDWFsnqRG---LSYL--VTGLYVGAAIGFLSWLYPPIIGGGDETIFWAFRNEAPG--YVLLSLFLLRFGLTMFCYG 351
182414840 256 LGSMNLHdr-----lRHWPgwVLGAIAGGTIGLAAWFLPGLAGSGGHLVQAALAGELAL--YLVPVFVLARFGATMLSYA 328
269140120 317 SGAPGGIFAPMLALGTLLGTAFGMAAAYL--FPHYGIDPGTFAIAGMGALFAATVRAPLTGIVLVLEMTDNYQLILPMII 394
161579542 343 TGAAGGIFAPILLLGALLGLGSGTLIQQM--APVLPVEPKVFAVAGMAALFTGVVQAPLTGVVLMIEMTGNYALILPLLA 420
289165222 319 TSVPGGIFAPMLALGTILGLAASHILQAI--SSDTTIHPGMLAVAGMGALFAASVRAPITGIILVVEMTQNYLLILPLMI 396
289165593 319 TAVPGGIFAPILSLGTLLGLAMFRILEFM--HIDFLTQPGMFAIAGMAALFAASTRSPITGAVLVVEMTHNYYLIFPVMM 396
296107323 319 SGVPGGIFAPMLALGTLFGLGFFHLFQWL--SMDFSIEPGMFAVAGMGALFAAAVRSPITGVVLVVEMTKNYSLILPLMV 396
81300385  341 SGAPGGIFAPLLSIATLFSLGLGQLTIDW--LPGLLLPPEVLAIAGMGAFVAATIQSPLTAILLTTEITSNYQLILPIMV 418
56750042  341 SGAPGGIFAPLLSIATLFSLGLGQLTIDW--LPGLLLPPEVLAIAGMGAFVAATIQSPLTAILLTTEITSNYQLILPIMV 418
16330386  342 SGAIGGIFAPMLGIASIVSVAMARHFHLL--FPSQIPEPAVMAIAGMGALVAATVRAPLTAILLTIEMTDNYFVILPLLV 419
172036162 352 CGVPGGIFAPMLALATTFSMGATQEVHDWfeFPFLLPEPDAFAVAGMGALVAATVRAPLTAIVLTIEMTDNYLLILPLLV 431
182414840 329 SGAAGGIFAPLLVLGALAGLWFGSGVHAL--VSNPGLTPAVFCVLGMGAMFTAVVRAPLTGIVLMVELTGTYGFMLPLLV 406
269140120 395 TCLGATLLAQFLGGKPLYSRILERTLHrQMQEQEAAQKRAEQSgqqtTNT 444
161579542 421 ACFAAQAVAARLHDLPIYEALLERELr-ESRGLRSR-------------- 455
289165222 397 TCLTSTTVVQLARQVPIYTQLLRRTLKnESCS------------------ 428
289165593 397 ACITATIVLQLAPNGPIYEQLLHRAIAsKKLR------------------ 428
296107323 397 SCITATIVVQLARNEPIYTQLLERTLRlNAK------------------- 427
81300385  419 SCSAATLIAHGLGSRPIYTVLLERQLAkAGIAVPT-PKAQNGA----IDL 463
56750042  419 SCSAATLIAHGLGSRPIYTVLLERQLAkAGI-----AVPTPKAqngaIDL 463
16330386  420 TCLVASVVAEALGGKPIYTVLLERTLAkQNRG------------------ 451
172036162 432 TCLTSTITAHALGGEPIYSVLLKRNLRrTQLEQSS--------------- 466
182414840 407 SCMAAYGVAELLGNMPIYEALRERSLR--------------------PSR 436
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