Conserved Protein Domain Family
DUF6365

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pfam19892: DUF6365 
Family of unknown function (DUF6365)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001960) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the hiroshidine biosynthetic gene cluster from Streptomyces hiroshimensis.
Statistics
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PSSM-Id: 437724
Aligned: 11 rows
Threshold Bit Score: 342.443
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
PZW22846      22 VAQQLQRRGAEVLFLTPPEQQAYAEAAGMQVRVLPLK-------LHQQIQEVIEDFRPDAVVLAD--------YYLLDIE 86 
WP_065482214  22 LAGQLAPAGITAHFVVDTHNAPQIRAAGVPGTVIDTAmg---agVRKVIEDAVRAERPDVIVLSDylsywlmmHRVYRTD 98  Streptomyces sp...
PLW74052      22 LADQLVPAGVKSHFVVDAGNEAMLRSSRHAYTTVTSAlg---rrVEDVVAGVVRDFAPDAIVLCDytahwmthVVSYDTD 98 
RKT74708      22 LAAQLAGAGIRSHFVVDLFNEEQLKAADLPHTLLDPSmg---paVRDVVRGAVHDFRPDAIVLADylghwmtfDVGYSVD 98 
WP_073892151  22 LMTQLEAAGVRCHFVIDAFNEDQLKAAGFPYTLVDPVmg---aaVRTVVEDVAREFRPDAVVLADyvghwmtlEVTYGCD 98  Saccharothrix s...
OZV13163      23 FAKGLNKNQYSMDFLIPEEKNVFFE-KDCEFRVHTISrnygvthNQRHIISLIKSNNYDLIILFDaftmey------aqy 95 
OZV13166      22 FADELIKSGEKICFIAPPTHKNTILKKGYICISLVPKsr---qlNRILFNEVKYSFKPDLVILSDflnynf------adr 92 
RRJ87583      24 LAKRL-PEGWRAEVLVSAKHLDYAQAAGVATRVLPrg-----raAAAAVREAVSDAEVSGILLAD--------HHLLGLE 89 
WP_072329845  22 LARQLEEQDVRAHFLTSPNHIDYVRQAGMSATSLRka-----tmQTAPIQALVEEFQPNAIVIAD--------YHNLDLE 88  Thermoactinomyc...
EWC63339      22 LTNQLRAAGVRSHYVITASSENLLRHHGYPHTVLDPAgg---qdVRAEVDAVVRRFRPDAIVLADylnhwgtlIRQFDTD 98 
RKT55614      22 LAEQLRRAGVESHFVHPPVTSGAVEHFGFDHTVVDYAdcpkgpsARAFVDELVASVAPDAIVLCDynvfirnvRFHFQLD 101
PZW22846      87 SEILDleallRLPVPCATFDSFRWAPEPRTVEnrlirp----qderlFKGKfdRLARVRALPEGVQILRACPVNVP---- 158
WP_065482214  99 PWFVE-----RLNVPVIPLDLYEWENTDFRID---------------HFGL--DLEVDRRILGMPVQLRPAPWARPd--- 153 Streptomyces sp...
PLW74052      99 PWYVE-----RFGVPVIPIDLYDLTRTGREVE---------------ILGR--TMRVSDRILHMEAHLWPVPGVRPh--- 153
RKT74708      99 PWFID-----EFDLPVIPIDLYDLENTTREVE---------------VLGR--TVQVSDRILGMGRHLQPVPMSRPt--- 153
WP_073892151  99 PWFID-----GLGLPLIPMDLYDLANTSRTVE---------------ILGK--STQVSDRLLDLPCHLQPVPMNRPq--- 153 Saccharothrix s...
OZV13163      96 wtgINmdvlkALDIPISSLDEYDYINAGYKLD---------------YYGIfvK-KLPDLLSEVDIILKNCPLSMPkggq 159
OZV13166      93 hygITkedlnIFDTTLCTFDNFYWNYPRKCMD---------------TYGFksDIPKKIVLEDYGARIVPCPIVNPd--- 154
RRJ87583      90 RVGFGyddlaSRTAPLVAFDSLAFGVGPTRLKlavsrg----sedpmLRRWfpPEVDLDRVPDGVPLLRPVPVAAPise- 164
WP_072329845  89 SPLIDldyvlQLGIPCATIDSLSWAPNSRILRnrlfdgtinkrpnanIKGE----VHLREVPEQMKIIRTCPINSP---- 160 Thermoactinomyc...
EWC63339      99 PWFID-----DYRLPVLPIDIWEWENTAFRFD---------------VCGRrhEREVSRRILDMPAHLRPVPVCHLd--- 155
RKT55614     102 PVFID-----DYGLPVLPVDLMEWEDTDFEID---------------LCGAp-PLPVDRGILAYPAHLRPVPPLHLd--- 157
PZW22846     159 ----TKPEGRVISLKMYE--QPFTITEA---RRREVRQRLGVrEDGEKLVMFAKASWALKAMYYrmlqsggrAARLTYSY 229
WP_065482214 154 ----PGPGSRALTYPFMR--PLPRPTDE---ARRAVRSALGL-REGDRLLSLSVSGWQRYAQTV--------ENPVTRGL 215 Streptomyces sp...
PLW74052     154 ----AAPDGPAFPYRADP--TVRPLSAA---ARQEVRDGLSV-HARHRLLTVPTLPWQHLMQTR--------AGPLTREL 215
RKT74708     154 ----AVPGRLGRPYRVTR--STEPLTAA---RRAEVRRSLGL-GERDRLLMVPTLPWQESMRLH--------AGPATREL 215
WP_073892151 154 ----VTGDGPGKPYRATL--AVEPPTAE---HRRAVRRSLGL-REGDRLLMVPTLPWQQLMARH--------AGGPAKVL 215 Saccharothrix s...
OZV13163     160 dlikEAEEKGQFYYQVIQ--EIRKLDKN---HIFNIRKRY-V-KDDEKIVFLTLSKWELEGAYS---------FTSQSTL 223
OZV13166     155 ----SVEGENVYTYSLIS--DFVDISNL---KKRKNRIKYGFdNDEDKIILVSYAKWQNEHIED----------RGVSEF 215
RRJ87583     165 -tleTSRTARIRSLDLYG--ESGPWGDAavtEPERIRSRLGV-EPHRKLVVVAMSNWASMAMTKpgl---ggPNRERDAY 237
WP_072329845 161 ----KDVGDRIKAVTLYK--EPFHIDED---VKQQMRQRFGCgHKDDKLVMVSKAAWASLLVKMrmle-sklHMQASYSY 230 Thermoactinomyc...
EWC63339     156 ----PGPAGYGHPYRVLP--PEPALTAA---RRREVRAALGV-GERHRLVMLPMAAWQHQRGDRp------gMTEMVGRL 219
RKT55614     158 ----RGGSTRALPYRVVApeSVDPATSA---R---IRADLGL-GGRDRLVMLPVSAWQRPPGGRg------lWSDMMTTL 220
PZW22846     230 EDFLQELLIHYIAEVDAP--VTVVGvmpQGKGEVYRQEQRR--FvsMPFLPMNEFTELVLSCDLFVTDNMPSSATTRAVF 305
WP_065482214 216 ARQVPERVAAMLRRLSSTtrFLVIG---PDLEGLEGLPAERthR--VPACAPDRYQELLDASDAVLSLHVPASALVRSVF 290 Streptomyces sp...
PLW74052     216 ARRVPHLVAGYLAKLPDDtrFLFLG---PWFDGFDRLPRERvrH--RPSCTAGEYTRLIGASDAVLALFLPSFALERAIL 290
RKT74708     216 AARVPELVVRYLRRLPADthFLLTG---PVFAGVEGLPPDRvhL--RPAYGAREYDELVGTSDAVWSFHLPSFALERAVF 290
WP_073892151 216 ASRLPGLVTHYLRQLPGQthFVFTG---PVFEDVGGLPPDRvhL--FSHYTVAEYDDLLGASDAVMSFHVPSFAIERAVF 290 Saccharothrix s...
OZV13163     224 CRYLLPLIYNYLSELDTKicLIHVG---DSCWNESEFKNPKikYihYSSLPVDIFEELLQSSDLFVTYNLVSITLTKAVD 300
OZV13166     216 VKLSNNFFNKLISKLAEEfhIICVG-------SKEKIQGDNihH--YSSVHTETFDELVSISNIYISRNMTSTSMVRIAL 286
RRJ87583     238 LQLRFTWLHELMRRLDEP--IALVGvsaEGFDA----EGADvqTiaTGFLPLAEFTELLAAADLYLTDNLTSGAMARAVL 311
WP_072329845 231 EYFIQELIGQYLGTRSLPskVVVVGiasEK-GFLERDPHSKlsFvsLPFMDLDEYEDLLFSCDLFITDNITSCSMAKALF 309 Thermoactinomyc...
EWC63339     220 GRRVPELLADYLRRLPSDahLLFIGgnvP--EPFLALPAERvhL--LPLCAPDRYDELLASVDAVLSLTTTGLTVSRAIL 295
RKT55614     221 TDHVPDLVVRYLGRLPEHvhFLVIGqapP---AFDRLPAGRlhV--RPPCAIDRYTEYLGASDAVVLLSPPSVTGARAVL 295
PZW22846     306 GRVPVIVLTNTLLTGTQDGSpltfpehlrlseegaaliqkwnsLLHGGIYPFTIYPNGWIDELRPLFQNNPYCTTLVQAE 385
WP_065482214 291 SDLPAVHIVHSGPDTGAAHA-----------------------EGPGGLEPYSMWPLRWNSVVRPLLSDNPLAAAFRRAE 347 Streptomyces sp...
PLW74052     291 ADVPGLFTVNSHRL-DPADAaglpdglt-------pdvrswlsAFPGTVPPFHMWPLQWNRVVGPLLEDNPFTATAVRTE 362
RKT74708     291 ADVPGMLSVNGFDVAGPADAdrlaeafggl----sptvarwlaDYPGAVPSFHMWPLRWNSVLAPLMVDNPFGDAVERVE 366
WP_073892151 291 VDVPGVVCLNGFDVAGPEDLarldaefggl----tptvaawlrTNPAPVPAFHMWPLSWNGLLGPMLADNPFTEVLHRAE 366 Saccharothrix s...
OZV13163     301 FGVPSIVLNNDKIIDFKTLEkkcmekplw---------yqymakdlKKIYPFTASMFGWNHFLKGIMKDNIYMKSFERIQ 371
OZV13166     287 SGVRCVNIINSISDIGTIEKiaakdef----------------nmtikpYRYFMFPVGWYSFLKPIFDNNPYAELIIQIE 350
RRJ87583     312 LGTPAVTLTReaewhtedaf-------------vtawlaqmraGFPASDFDYLVNPFGWIDELQPLLANNAYLAALPRIH 378
WP_072329845 310 GYVPTLSLINTKVVSSPDEGvpilpqlssep--ikeilerwsrVLPQGLYPFLTFPNGWVEELAPLLEDNPFFDAIDIAE 387 Thermoactinomyc...
EWC63339     296 ADTPAMLLTNRFTVPDTAAVdtveselggmd-----pvvrrwlldtAPVEPFRMWPKGQHAFLEPLLKDNPHLDALVHRE 370
RKT55614     296 MDKPVLIMQNRFPVRDGAELaavaaevdl-----tpfvrdwlaAT-GPIDRFRMWPKGSFRALDAVFTANDYTNALITTE 369
PZW22846     386 MYALSETAHCFAELLC-NR----KAREVLQARQQAYIEQVV----GLPPTYDLFETWIATMK 438
WP_065482214 348 LLDTEGTVEMLDAVLN-DP----WTRAGLSEARGRYLAALD----ALPPVPEIFAEAVHRAS 400 Streptomyces sp. PTY087I2
PLW74052     363 LFDEEAVVSGLEAVLH-DT----ATRDALAAGRAGFRRAVD----LLPDTPDVFFAAARRVG 415
RKT74708     367 LFDEAAVVGGLHDLLH-DP----GTRDRLAAARARYRDLID----ALPPTPEVFLAATRELG 419
WP_073892151 367 IFDERSVLDRLDRVLY-DT----RTALELAEARARYRGLID----DLPPTPEVFDSVARRLG 419 Saccharothrix sp. CB00851
OZV13163     372 VFNTEQVNSTLKEILYgDL------CEKMIDNINIFKRELS----KIPNVNEVLNNAFQYLL 423
OZV13166     351 QFEIERGIETIKDILYgDN----SDHTILTNK---LRRKLS----ELMTPKEIVRSILSYDL 401
RRJ87583     379 AHDLDGQVRACRTALDsTA--------------QLARAALNaargALPSGSEALLAALDAAS 426
WP_072329845 388 MFCVDQTGEKIWNMLY-DE----STKQHILDKQERYIEKII----HLPGAMEMLCFITEQKV 440 Thermoactinomyces sp. DSM 45891
EWC63339     371 LFDGGGVVAALTALLF-DP----GTRDDLAARRAGYAAAVA----ALPPTEEVFAAAAGRAA 423
RKT55614     370 LLDETGTVRALHDLVA-GPddpsGAAERLAKSRARYLEAVA----ALPDAVEVIREAVGRGP 426
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