1G3U,4TMK


Conserved Protein Domain Family
TMPK
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cd01672: TMPK 
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Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).
Links
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Statistics
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PSSM-Id: 238835
Aligned: 79 rows
Threshold Bit Score: 82.7016
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ATP-bindingTMP-binding
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP-binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #                                                                 
1G3U_A      1 MLIAIEGVDGAGKRTLVEKLSGafra------------------agrSVATLAFPRyg--qsVAADIaaealhgehgdla 60  Mycobacterium tube...
NP_950940   2 KLIIFEGLDGSGKTGLIKSVKHglkk------------------qgkEVIVIRGLGsstigeSIRETflth-------nk 56  Onion yellows phyt...
NP_950596   2 KLIVFEGLDGSGKTTLIQKIRKqlek------------------qghEVITLQGLGsssigqPLRDIfltn-------aq 56  Onion yellows phyt...
NP_950682   4 KLIVFEGLDGIGKTTLINKLKNslin------------------kgnKVKVFQSLGsssiekEIRKLflhq-------rk 58  Onion yellows phyt...
AAK54673    2 KLIVFEGLDGSGKTTLIQELQQklkk------------------qkiNNKIYQGLGsssigtEIRNLflny-------nq 56  LfWB
Q46843     15 RVIAIVGCDGSGKSTLTASLVNelaarmptehiylgqssgrigewisQLPVIGAPFg----rYLRSKaahvhekpstppg 90  Escherichia coli
Q46844      7 PLIAVIGSDGSGKSTVCEHLITvvekygaaerv---hlgkqagnvgrAVTKLPLMGk-----SLHKTiernqvktakklp 78  Escherichia coli
NP_954341   5 KLIVIEGISGSGQQVKAGIVALhntlv----------------enkyDVVECANPDsgrakeLGITNllnwp------fg 62  Geobacter sulfurre...
NP_107196   1 MIIELFGPPGAGKTTLLRGLCQgmakhgin----------vktvngyRLIEYGSAQed--gpEVRHGigrig------kk 62  Mesorhizobium loti...
NP_906438  54 IIIILEGRDGAGKGGTIKALTEhlnp------------------rgaRVVALQKPS------DVEKTqw----------- 98  Wolinella succinog...

Feature 1                                                                                     
1G3U_A     61 ssVYAMATLFALDRAGAVhtiqgl--crgydVVILDRYVASNAAYSAarlhe-------naagkAAAWVQRIEFarlg-- 129 Mycobacterium tube...
NP_950940  57 lhNLTRYFLSFANMIQTQeelikp-hletnkIILVDRWLGSNFAYRVypnr----------idkKYYFFNNLTKlfi--- 122 Onion yellows phyt...
NP_950596  57 lkPLTRYLLSFANMQQIQeeeikp-hletnkIILIDRWLGSNFAYQAyprn----------idkNYQLFNLLNKqfi--- 122 Onion yellows phyt...
NP_950682  59 tsPKNKYFLSFANMIQVQdeliip-nllnghLVLIDRWYGSTLAYQSnd-------------vdCDDVITSKIInqyl-- 122 Onion yellows phyt...
AAK54673   57 vdYITRFYLSITNMAQIQkeliyp-hlkqnqLIILDRWLPSTYAYQLfpylkq-----tkscfdLKELFDITHKklf--- 127 LfWB
Q46843     91 niTALVIYLLSCWRAYKFrkmlck--sqqgfLLITDRYPQVEVPGFRfdgpqla---kttggngWIKMLRQRELklyqwm 165 Escherichia coli
Q46844     79 gpVPALVITAFVARRLLRfrhmla-crrrglIVLTDRYPQDQIPGAYdgtvfpp----nveggrFVSWLASQERkafhwm 153 Escherichia coli
NP_954341  63 rtPRADFLFESAVRTEVFknvvep-alqqdkIVLCKQSSVSSLANAWvsgyt--------khfdVLRHIDKISRgflfe- 132 Geobacter sulfurre...
NP_107196  63 iaTSGPVLLSTLPKDGVAarllas--iplrsLTWSWRMKVDIALLCEswrqaqesegyfifeegIIQALCALVVlartps 140 Mesorhizobium loti...
NP_906438  99 yfQRYINELPVGGEIVFFdrswynragvekvMGFCTNEQYKEFIYQVp---------------nLEQMLLGSGFl----- 158 Wolinella succinog...

Feature 1                                  #                                                  
1G3U_A    130 ----------lpkpDWQVLLAVsAELAGERSRGRaqrdpgrar------dnyerdaeLQQRTGAVYAELAaqgw------ 187 Mycobacterium tube...
NP_950940 123 ------------kpNLTVYLKIdPQTGLNRKANQtnhtldv---------ietsplsYFYQVEKGFQEFLnkk------- 174 Onion yellows phyt...
NP_950596 123 ------------kpDMTVYLKIkPQLGLERKQNQkdhkldv---------iethplsYFRQVSQGYELFLeikn------ 175 Onion yellows phyt...
NP_950682 123 -----------ikpHLTFYLDIyPKIGLKRKQNQsnhkldl---------ieqkplnYFENVRQNYLNQHk--------- 173 Onion yellows phyt...
AAK54673  128 -----------iqpHLLIYLDInPLIGKERKQTQknhqldi---------ieqksltYHQTVHKGYYHYLthyq------ 181 LfWB
Q46843    166 ---------asylpVLLIRLGIdEQTAFARKPDHql-------------------aaLQEKIAVTPQLTFng-------- 209 Escherichia coli
Q46844    154 ---------ashkpDLVIKLNVdLEVACARKPDHkr-------------------esLARKIAITPQLTFgg-------- 197 Escherichia coli
NP_954341 133 ---------deifpDLTIFIDVpAQEAFERIEDVlqihh-------------eggidYYNQMREFYLKEIsr-------- 182 Geobacter sulfurre...
NP_107196 141 idvvrdclaflprpDLLIQLDApQETLRRRLMDRhaqqpl------------levllFELGVDRGLRQADisrdigkclr 208 Mesorhizobium loti...
NP_906438 159 --------------VFKYFLDVgQEEQLKRIERRktdplrmwklspidekslglwdeYTEAFQKMFARTHtpy------- 217 Wolinella succinog...

Feature 1               #                   
1G3U_A    188 --ggrWLVVGAd-------vDPGRLAATLA 208 Mycobacterium tuberculosis
NP_950940 175 --lgpQIILNAmepktwksnTKQIIKKIGE 202 Onion yellows phytoplasma OY-M
NP_950596 176 --lghKLILKEmnskttltnQNQIIKQIGA 203 Onion yellows phytoplasma OY-M
NP_950682 174 ----yCKKPNCnh-----qnCKNIMINTTT 194 Onion yellows phytoplasma OY-M
AAK54673  182 --nnkQLILNGidsl--qsnVTKIMKLIRD 207 LfWB
Q46843    210 ---akILELDGrhpa--deiLQASLRAIHA 234 Escherichia coli
Q46844    198 ---aqLVDIDAnqpl--eqvLVDAEKAITD 222 Escherichia coli
NP_954341 183 ---wrGVRIDAsagrhpeiiNAEIWDVVKK 209 Geobacter sulfurreducens PCA
NP_107196 209 qdgwpLIKVNGaep----hdLDKIITRILE 234 Mesorhizobium loti MAFF303099
NP_906438 218 ---apWVVIDSndk---kraRLNIARDLLS 241 Wolinella succinogenes DSM 1740

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