Conserved Protein Domain Family
aceK

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PRK02946: aceK 
bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated
Statistics
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PSSM-Id: 235089
Aligned: 180 rows
Threshold Bit Score: 659.647
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
89902599    6 LD------------------------------SSLAYDIAKAMMDGFNRHYRLFRTESARAKHRFETADWHGQQRAQRDR 55 
39933424   10 ARplgaseiehatriaepdfdlldalyrtddpDDQARLLARVVLSAFDNYYAVSRRIPALAQAAFEARDWPVTVRLSKIR 89 
91974857    5 AHlfsasdleaatriaepdfelldalirtddpDDQAHTLARVALSAFDNYYAVSRRIPALAKAAFYARDWPATVRLSKIR 84 
192288781  10 ARplgaseiehatriaepdfdlldalyrtddpDDQARLLARVVLSAFDNYYAVSRRIPALAQAAFEARDWPVTVRLSKIR 89 
153004637   1 ----------------------------maepNDVAAAGAAAIAASFEAYQEERARITRRARERFEKRDWAAGQADARER 52 
190576094   1 -------------------------msrpdiaAELAPRIAVAIRDGFEQYHARFAAITARARQRFEQRDWAGARQDAVER 55 
194367451   6 IA------------------------------TVLAPRIAGAIRDGFEDYHARFAAITVRARLRFEQRDWAGARQDAVER 55 
197122246   1 ---------------------------mlderGALARGAAEAIRAGYEAYQAERARITARARARFEARDWAGAQRDARER 53 
220917028   1 ---------------------------mlderGALARGAAEAIRAGYEAYQAERARITARARGRFEARDWAGAQRDARER 53 
86158461    1 ---------------------------mlderGALARGAAEAIRAGYEAYQAERARITARARGRFEARDWAGAQRDARER 53 
89902599   56 IEFYDLRVRECFMRLAREFKADEQPMEVWQQVKLHYIGLLVDHHQPELAETFFNSVTTKILHHS----YFQNDFIFVRPA 131
39933424   90 IGLYTACIDQLVPLLKAGLPELTTDEQLWPTAEAELLAAIEGRYEADFAFAFWQSLRRKLVSDEwrpvSYDAGSTARRTT 169
91974857   85 IGLYTACIDQLVPLLKAGLPELANDEQVWVRAEAELLAAIAGRYEADFAFAFWQSLRRKLVSDEwrpvSYDTGPAARPPA 164
192288781  90 IGLYTACIDQLVPLLKAGLPELTTDEQLWPTAEAELLAAIEGRYEADFAFAFWQSLRRKLVSDEwrpvSYDAGSTARRTT 169
153004637  53 LDLRDRLVNACVGTVRAELGGAAHDHGLWRAMKELYEARVESRPDREIGQSFFNSVTRRVFVTV----GVDPAIEFLAAD 128
190576094  56 IALYDLCIAEQMDALRRLAGDAIGERALWLRVHARYSALLQGLIDAELYKTFYNTLSRRLFAIR----GVDPALEFIAFD 131
194367451  56 IALYDLCIAEQMDALRRLAGEVIGERALWLQVHAEYSALLQGLIDAELYKTFYNTLSRRLFATR----GVDPALEFIAFD 131
197122246  54 LDLRDGVVHRTVGEVRAELGGAVQDREVWRRAKEAFEAAAGSRPDFEVAGSFFNSVTRRVFTTV----GVDPAIEFLAAD 129
220917028  54 LDLRDGVVHRTVGEVRAELGGAVQDREVWRRAKEAFEAAAGSRPDFEVAGSFFNSVTRRVFTTV----GVDPAIEFLAAD 129
86158461   54 LDLRDGVVHRTVGEVRAELGGAVQDREVWRRAKEAFEAVAAARPDAEIAGSFFNSVTRRVLTTV----GVDPAIEFLAAD 129
89902599  132 VSTEYIEndeSETSPTYRSYYPTh-DSLAEVLVQMVLDFDLRCPFADLDSDAARVQAAMVEQl--------GE-V-KLRA 200
39933424  170 SPAAVLK---TTATTL---------PITAEVIAGILDEAGFRVPWRDRDGDAALAAQAIETAl--------EPlSpRPGE 229
91974857  165 AIAAVVR---TIAATL---------PIQPEVIRNVLDAAGFTGPWRDLDGDAALAAAAIEAAl--------EPlSpRAGE 224
192288781 170 SPAAVLK---TTTTTL---------PITAEVIAGILGDAGFRVPWRDRDGDAALAAQAIETAl--------EPlSpRPGE 229
153004637 129 GPAVR-----EGPVPVYARYRRE--VSTEALLRTVLRACAFAAPYEDLERDARIAAIELDSH---------LReLdDGQP 192
190576094 132 VEPSD-----AITHPVARHTYAVspTRPVEALQRVLADYRFDIPYAHQLRCAAAIAVRLQDDlahwgdtpvRS------- 199
194367451 132 VEPSD-----AITHPVARHTYAVspTRPVEALQRVLADYRFDIPYAHQLRCAAAIAVRLQDDlthwgdtpvRS------- 199
197122246 130 APPPRED------PPQHRTFPRE--ATTEALLARVLRATPISAPFEDLARDARLAALELDAH---------VRgLpDRQP 192
220917028 130 APPPR-----EDP-PQHRTFPRE--ATTEALLARVLRATPISASFEDLARDARLAALELDAH---------VRgLpDRQP 192
86158461  130 APPPRED------PPQHRAFARE--ATTEALLARILRAAPISAPFEDLARDARLAALELDAH---------VRgLpDRQP 192
89902599  201 NFQLQVLSGLFFRNKGCYIVGKLINGFN----E--FPFALPVLYGRAGQLVIDAVLFGEDDLLMLFSFARAYFMVDMEIP 274
39933424  230 PVKIEIADSGFLRNRGACLVGRIKLRDRgdmpMrnLPLLIALL-NEKDGLVVDAVLTDSDELQYAFSSTLANYHATNPRY 308
91974857  225 TAKIEIAESGFFRNRGACLVGRIRLRDRgdmpPrnIPLLVALL-NEDDGLVVDAVLCDSDELQFAFSSTLANYHATNPRY 303
192288781 230 PVKIEIADAGFFRNRGACLVGRIQLRDRgdmpMrnLPLLIALL-NEKDGLVVDAVLTDSDELQYAFSSTLANYHATNPRY 308
153004637 193 IEALELVKAVFYRGKGAYLVGRLRRGRY----T--TPLVLALVHGERG-VVLDAILFTQEDVSIVFSFTRSYFHVEVERP 265
190576094 200 ---IELLDTVFYRERRAYLVGRVFGEHR----F--SPCVIALV-NDERGLRADAVLTRRRDVAHLFGVSRSYFQANLATV 269
194367451 200 ---IELLDTVFYRERRAYLVGRVFGEHR----F--SPCVIALV-NDERGLRADAVLTRRRDVAHLFGVSRSYFQANLATV 269
197122246 193 IEAVELARPVFYRGKGAYLVGRIRRGRH----L--TPLVLALA-HGERGVALDAVLFTEEDVSIVFGFTRSYFHVALERP 265
220917028 193 IEAVELARPVFYRGKGAYLVGRIRRGRH----L--TPLVLALAHGERG-VALDAILFTEEDVSIVFGFTRSYFHVELERP 265
86158461  193 IDAVELARPVFYRGKGAYLVGRIRRGRH----L--TPLVLALA-HGDRGVALDAVLFTEEDVSIVFGFTRSYFHVALERP 265
89902599  275 SAYVQYLRSMMPRKPRNEIYNALGLAKQGKTLFYRDFLHHQRHSTD-KFRIAPGIKGMVMLVFDLPSFPYVFKVIKDFYP 353
39933424  309 HELARLLYELMPKRPLGTQYSCIGFHHLGKVAVMSEILAEHRKTKE-KLATAPGFKGTVAIAFTMPSSAYVLKIIRDHPT 387
91974857  304 HELARLLHELMPKRPLGTQYSCIGFHHLGKVAVMNEILTEHRRSKE-KLATAPGFKGTVAIAFTMPCSAYVLKIIRDHPT 382
192288781 309 HELARLLYELMPKRPLGTQYSCIGFHHLGKVAVMSEILAEHRKTKE-RLATAPGFKGTVAIAFTMPSSAYVLKIIRDHPT 387
153004637 266 RELVAFLSTLLPLKRVSELYIALGFNKHGKTELYREIARHIAETGE-AFVPARGDKGLVMSVFTLPGLDVVFKVIKDEFK 344
190576094 270 GDAVVFLRSLLPGKPIDEIYTVLGRAKQGKTERYRTFFRHFNEHPQeRLVHAEGTPGMVMAVFTLPSYPLVFKLIRDRFA 349
194367451 270 GDAVVFLRSLLPGKPIDEIYTVLGRAKQGKTERYRTFFRHFNEHPQeRLVHAEGTPGMVMAVFTLPSYPLVFKLIRDRFA 349
197122246 266 RAMVAFLSTLLPLKRRSELYTGLGYHKHGKAELYREVTLHLAEGED-RFVPARGDRGLVMCVFTLPGLDVIFKVIRDRFA 344
220917028 266 RAMVAFLSTLLPLKRRSELYTGLGYHKHGKAELYREVTLHLADGED-RFVPARGDRGLVMCVFTLPGLDVIFKVIRDRFA 344
86158461  266 RAMVAFLSTLLPLKRRSELYTGLGYHKHGKAELYREVAQHLAEGDD-RFVPARGDRGLVMCVFTLPGLDVIFKVIRDRFA 344
89902599  354 PPKDTTR----EQIKAKYLLVKQHDRVGRMADTLEYSEVGFPRARFDDELIAELEKFAPSQLEisdrdgDGRIEVIIKHV 429
39933424  388 DDYKFDYfdglDEVLRKYNLVHEIDRAGSMLDNIIYSNVKLDRAMFAPELLDELLEAGIGTVT------LDRGALVFRHL 461
91974857  383 DDYKFDYfdglDAVLRKYNLVHEIDRAGSMLDNIIYSNVKLARTMFAPDLLDELLEAGIGTVT------LERDALVFRHL 456
192288781 388 DDYKFDYfdglDEVLRKYNLVHEIDRAGSMLDNIIYSNVKLDRAMFAPELLDELLEAGIGTVT------LDRGALVFRHL 461
153004637 345 PPKQTTR----REVMDKYRHVFRHDRAGRLVDAQEFEHLAFPADRFSPEVLRELSEECRGSIE------IGRAEISVKHL 414
190576094 350 WPKAMSR----QQVEEKYALVFNLDRVGRLLDAQPYRHLRFPRDRFAPALLGELLQQCAQSVR------IDGDEVEVALC 419
194367451 350 WPKAMSR----QQVEEKYALVFNLDRVGRLLDAQPYRHLRFPRDRFAPALLEELLQQCAQSVR------LDGDEVEINLC 419
197122246 345 PPKQTTR----REVMDRYRHVFRHDRAGRLVDAQEYEHLAFPAGRFAPALLEELRTECGDGVR------VADGEVAIRHL 414
220917028 345 PPKQTTR----REVMDRYRHVFRHDRAGRLVDAQEYEHLAFPAGRFAPALLDELRTECGDGVR------VADGEVAIRHL 414
86158461  345 PPKQTTR----REVMDRYRHVFRHDRAGRLVDAQEYEHLAFPAARFSPALLEELRTECGDGVR------VAGGEVAIRHL 414
89902599  430 YIERRMIPLNIYLQEAfdagganpddtspaalrAREQIERGVIEYGNALKDLVAANIFPGDMLWKNFGITRHGKVVFYDY 509
39933424  462 IVQIKLTPLPLYLANA-----------------SAAESRAAVINLGDCIKNNAAADIFNKDLDGRNYGVSRIRKVYLFDY 524
91974857  457 IVQIKLTPLPLYLTTA-----------------AAADARAAVINLGDCIKNNAAADIFNKDLDGRNYGVSRIRKVYLFDY 519
192288781 462 IVQIKLTPLPLYLANA-----------------SAAESRAAVINLGDCIKNNAAADIFNKDLDGRNYGVSRIRKVYLFDY 524
153004637 415 YAERRVTPLNLFIREA-----------------DEWTARQAVLDFGRALKDLAATNTFPGDLLLKNFGVTRHGRVIFYDY 477
190576094 420 YVQRRFRPLNLYLREQ-----------------GAEAVRAAVLDYAQAITDMARNNIFPGDMLPKNFGVSRHGRAVFYDY 482
194367451 420 YVQRRFRPLNLYLREQ-----------------GGEAVRAAVLDYAQAITDMARNNIFPGDMLPKNFGVSRHGRAVFYDY 482
197122246 415 YAERRVTPLNLFVREA-----------------DEWTARQAVLDFGCALRDLAATDTFPGDLLLKNFGVTRHGRVIFYDY 477
220917028 415 YAERRVTPLNLFVREA-----------------DEWTARQAVLDFGCALRDLAATDTFPGDLLLKNFGVTRHGRVIFYDY 477
86158461  415 YAERRVTPLNLFVREA-----------------DEWTARQAVLDFGCALRDLAATDTFPGDLLLKNFGVTRHGRVIFYDY 477
89902599  510 DEIEYITDCNF-RKVPQA------------RNEEDEMSGEVWYRVGPKDVF--PETFAPFLLGNPFVREVFMKHHAELLD 574
39933424  525 DAVEPLTSVTVsRDGAAP------------------------GEFDNGMVFrpQEMLEGLRIDDPGLRRAFRDAHPELMQ 580
91974857  520 DAVEQLTEVKV-RSTPPM------------PRAEDE----------DGVVFrpAQMLEGLRIDDPGLRRAFRDAHPELMQ 576
192288781 525 DAVEPLTSVTVsRDGAAP------------------------GEFDNGMVFrpQEMLEGLRIDDPGLRRAFRDAHPELMQ 580
153004637 478 DELTRVTDCVF-RDLPTPsg------------ddEETSGEPWFYVGQDDVF--PEELLPFLGLAGRLREVFLQAHGDLLT 542
190576094 483 DELCLVSDCVF-RAWPQP------------RTPEEAMSDEPWFHVGPRDVF--PERFGPFMGLPAAELAAVREHYRHLFD 547
194367451 483 DELCLVSDCVF-RAWPQP------------RTPEEAMADEPWFHVGPRDVF--PERFGPFMGLPASELAAVREHYRHLFD 547
197122246 478 DELTRVTDCNF-RDLPGAgpgdggedgwggGPDAGYDGGDPPFYVGPADVF--PEELLPFLGLTGRLREVFLRAHGELLT 554
220917028 478 DELTRVTDCNF-RDLPAAgggdd---gwggGPDAGYDGGDPPFYVGPADVF--PEELLPFLGLTGRLREVFLRAHGELLT 551
86158461  478 DELTRVTDCNF-RDLPGAgpgdgd-dgwggGPDAGYDGGDPPFYVGPADVF--PEELLPFLGLTGRLREVFLRAHGELLT 553
89902599  575 AAFWQSHKERIQAGHVYDVFPYDQGKRFHPEIS 607
39933424  581 ADYWEGMQQALRDGKVPKVMNYPASRRLRR--- 610
91974857  577 PDYWEGMQHALRAGKVPKVMNYPTSRRLRR--- 606
192288781 581 ADYWEGMQRALRDGKVPKVMNYPASRRLQR--- 610
153004637 543 ARYWRAIQERIREGEIVDIYPYREEQRLVHGYE 575
190576094 548 PGWWQGLQERFARGDYPDTPPYAGAHRLA---- 576
194367451 548 PAWWQGLQERFARADYPDTPPYAGAHRLA---- 576
197122246 555 GRWWREIQARLRAGEIVDIFPYREEQRLRHArp 587
220917028 552 GRWWRGIQARLRAGEIVDIFPYREEQRLRHARP 584
86158461  554 GRWWRDIQARLRAGEIVDIFPYREEQRLRHAhp 586
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