Conserved Protein Domain Family
7tmA_capaR
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cd15134: 7tmA_capaR 
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.
Links
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Statistics
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PSSM-Id: 320262
Aligned: 12 rows
Threshold Bit Score: 384.375
Created: 29-Jul-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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  next features
Feature 1:putative peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structure of Rattus norvegicus neurotensin receptor 1 with bound agonist neurotensin peptide, defined at 4A contacts
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                    #                 # 
Q8ITC7        69 VLITIIFGGIFITGVVGNLLVCIVIIRHSAMHTATNYYLFSLAVSDLLYLLFGLPTEVFLYWhq-yPDLFGmpfCKIRAF 147 fruit fly
AAN10042     108 TAFTVCYALIFVAGVLGNLITCIVISRNNFMHTATNFYLFNLAVSDLILLVSGIPQELYNLWyp-dMYPFTdamCIMGSV 186 fruit fly
ADG27752      39 LPITFTYGILFISGLFGNLAVCIVIAYNKSMHNATNYYLFSLAMSDLVLLLLGLPNDLSVFWqq-yPWILGllvCKLRAL 117 Rhodnius prolixus
NP_001073563  34 VPITLTYVVIFVTGFVGNIITCIVIWRNPSMQTPTNYYLFNLAVSDLLFLILGLPFELSVFWqq-yPWQWGlgiCKLRAY 112 honey bee
EKC39231      91 VCLLAIYCFIFVTGVVGNVCTAIVIVRNRYMQTTTDYYLCSLAISDILILVSCLPFEAYSIWqa-yPFSFGevfCIGKAL 169 Pacific oyster
EKC33871     116 IPVTIIYGILFVTGILGNICTCFVIARNKFMHTATNYYLFNLAVADLLLLVIGLPPDLYSVWsl-yPWVFGetlCVMRAF 194 Pacific oyster
ACC99623      62 IPMTLIYSVLLVSGVVGNVCTCIVIARNRYMHTATNYYLFSLAVSDLLLLVLGLPQELYQLWqr-hPYVFGeafCVLRGL 140 American dog tick
ELU05073       1 IVLTLAYSIIFFTGTVGNAFTCFVIVKNSYMHTATNYYLFSLAISDVLTLILGLPPELYTIWea-yPWRFGepyCLLKTF 79  Capitella sp. I...
CCD81490      35 ILIGIVYTAIFCTGLLGNLATCIVIARNSFMHTRTNCYLFTLSVSDLLLLIFGLPFELQTVLnksyPWTLGtvfCRFRIF 114 Schistosoma man...
XP_973937     35 IPLTVVNVLIFVSGFFGNVAVCIVIIKHRSLHTATNYYLFNLAISDLTLLIFGLPNDVMLYWhq-yPWPFGvefCKLRAL 113 red flour beetle
NP_493666     32 IPTVIIYGTIFLLGLFGNICTCIVIAANKSMHNPTNYYLFSLAVSDIIALILGLPMEFYQSLdysyPYRFSegiCKARAF 111 nematode
NP_001014620  21 IPVTVVYSLIFITGVVGNISTCIVIKKNRSMHTATNYYLFSLAISDFLLLLSGVPQEVSYIWsk-yPYVFGeyiCIGRGL 99  fruit fly

Feature 1                                                                                        
Q8ITC7       148 ISEACTYVSVFTIVAFSMERFLAICHPlhLYAMVg--------------------------------------------- 182 fruit fly
AAN10042     187 LSEMAANATVLTITAFTVERYIAICHPfrQHTMSk--------------------------------------------- 221 fruit fly
ADG27752     118 VSEMSSYVSVLTIVAFSVERYTAICYPlkSYTTDk--------------------------------------------- 152 Rhodnius prolixus
NP_001073563 113 VSETSSYVSVLTIVAFSIERYLAIYHPlrHYRSG---------------------------------------------- 146 honey bee
EKC39231     170 LTEMTSYASVLTITAFTVERYIAICHPlmSHKIAd--------------------------------------------- 204 Pacific oyster
EKC33871     195 VCEISTNTSILTITAFTVERYVAICFPmkAQKMSs--------------------------------------------- 229 Pacific oyster
ACC99623     141 TSETSTNASILTITAFTIERYVAICHPlrAHTMSk--------------------------------------------- 175 American dog tick
ELU05073      80 LTEMTSSASILTITAFTVERYFAICHPirSQTMSs--------------------------------------------- 114 Capitella sp. I...
CCD81490     115 LTELCPLVSILILTIFSVERYLSICHPfrKILRFsqydaghpcnrtlymhnanskashsseriskvinsqmrnstqiyys 194 Schistosoma man...
XP_973937    114 LSEMASYVSVLTIVAFSTERYLAICYPlyLHTMSg--------------------------------------------- 148 red flour beetle
NP_493666    112 LIEFTSYASIMIICCFSFERWLAICHPlrSKIFSt--------------------------------------------- 146 nematode
NP_001014620 100 LAETSANATVLTITAFTVERYIAICHPflGQAMSk--------------------------------------------- 134 fruit fly

Feature 1                                                    #                                   
Q8ITC7       183 -------------------FKRAIRIITALWIVSFISAIPFGLLSdiqylnypl-------------------------- 217 fruit fly
AAN10042     222 -------------------LSRAIKFIFAIWLAAFLLALPQAMQFsvvy------------------------------- 251 fruit fly
ADG27752     153 -------------------LNRVIKVIGTLWLISLGFAAPFAIYTtidyvdfpp-------------------------- 187 Rhodnius prolixus
NP_001073563 147 -------------------LKRAIRSIFGAWLIALIFAMPFATYVdinyveypq-------------------------- 181 honey bee
EKC39231     205 -------------------LRRSVLIIIGIWTVSFLIALPYPVHTrtlfyehsp-------------------------- 239 Pacific oyster
EKC33871     230 -------------------LPRAARVIACVWIVAVCTAIPIADQYgvvkikdp--------------------------- 263 Pacific oyster
ACC99623     176 -------------------LSRAVKFVVAIWVLSAVCAIPLAVQFgivhqtld--------------------------- 209 American dog tick
ELU05073     115 -------------------LSRAIKIIIAIWISACLAALPYPIHTrtyyylndp-------------------------- 149 Capitella sp. I...
CCD81490     195 nsqphykrghtpyivqinaLKSCFLLIFCVWIIGSCCAIVIAGLSnvfyavnlptidtfinntctdhyhtaviqfyltsd 274 Schistosoma man...
XP_973937    149 -------------------LQRAVRIIACLWLCAFVSALPFCIYTrvhylfypp-------------------------- 183 red flour beetle
NP_493666    147 -------------------LWRANVLIILAWTISFVCALPIAFIVqinklplpedakyqp-------------------- 187 nematode
NP_001014620 135 -------------------LSRAIRIIVLVWIMAIVTAIPQAAQFgieh------------------------------- 164 fruit fly

Feature 1                          ####                                                          
Q8ITC7       218 ---------dhsrieesAFCSMspk-----ivnEIPVFEVSFCIFFVIPMILIILLYGRMGAKIrsrtnqklgvqq---- 279 fruit fly
AAN10042     252 -------------qnegYSCTMen-------dfYAHVFAVSGFIFFGGPMTAICVLYVLIGVKLkrsrllqslp------ 305 fruit fly
ADG27752     188 --------gsgkaviesAFCAMlkqn----vpaDVPLYELSCTLFFICPAVILIFLYVRIGLTIknntklrgn------- 248 Rhodnius prolixus
NP_001073563 182 --------nskrnseesAICAMlke-----nmpEFPLYQLSCILFFLIPMVFIAVLYIRIGLRIqsdslaenve------ 242 honey bee
EKC39231     240 --------ttgkplhdsLVCTIppew----ifeMTVMFQISTFLFFIVPMTAIIILYVLIAITLrrtalnrans------ 301 Pacific oyster
EKC33871     264 ---------knrtieesAMCAFkh-------apITGWFLASTCFFFILPMIFISVLYSLIAVAIhrstieapkihrsssd 327 Pacific oyster
ACC99623     210 ---------gttvlpetAACTVkd--------pLEHAFELSTFVFFLLPMSVILVLYVCIALQLkrsdalsrqdvhhkcp 272 American dog tick
ELU05073     150 --------atkepiadsYICNIpvnw----mpmMTYVFQASTFVLFVLPMCIITGLYVVIGLTLrrsslarqt------- 210 Capitella sp. I...
CCD81490     275 cllnsemwtpgealpdsAVCAPsndsewaaylsIPVVLQLWTFLFFFTPMVIMSVLYGLMAIQLshsnlglraqsnskhr 354 Schistosoma man...
XP_973937    184 --------nstnilpdsAFCGMlyq------peGIPLTELSTLIFFIIPMLAIAVQYTKMGLEIakttrktlghgl---- 245 red flour beetle
NP_493666    188 --wtnkvstdgifvlhtEFCAMnqsr----pdqQKMIIIFAFTVFFVIPAIAIVIMYAHIAVQLesseidlkg------- 254 nematode
NP_001014620 165 -------------ysgvEQCGIvr-------viVKHSFQLSTFIFFLAPMSIILVLYLLIGVHLyrstlvegpasvarrq 224 fruit fly

Feature 1                                                                                       #
Q8ITC7       280 ------------------------------------------gtnnretrnsqMRKKTVIRMLAAVVITFFVCWFPFHLQ 317 fruit fly
AAN10042     306 -------------------------------------------rrtfdanrglNAQGRVIRMLVAVAVAFFLCWAPFHAQ 342 fruit fly
ADG27752     249 ---------------------------------------------vhgelqsiQSKKSIVSMLMAVVVAFFICWAPFHMQ 283 Rhodnius prolixus
NP_001073563 243 -------------------------------------------gyvhgetkqvQSRKTITRMLSAVVITFFICWAPFHVQ 279 honey bee
EKC39231     302 --------------------------------------------eestgghhsSHTRRVVRMLVAVVVAFFFCWAPFHTQ 337 Pacific oyster
EKC33871     328 tskas----------------------------kehgacirdgrrrsdgniqaRARRSVLKMLVAVVVAFFVCWAPFHAE 379 Pacific oyster
ACC99623     273 ssnntsssvvngkggadsssghkqgsaavqplpsklqrgcqlrksvrggaaasSSRKAVINMLIAVVVAFFICWAPFHAQ 352 American dog tick
ELU05073     211 ---------------------------------------------stayatqsQSRRAVLKMLVAVVVAFFISWAPFYAQ 245 Capitella sp. I...
CCD81490     355 -------------------------------------kvkssscsisktrssgSCRRGIVRMLVAVVVAFFICWAPFHLQ 397 Schistosoma man...
XP_973937    246 ------------------------------------------rgsvhrdsrrtQSNRSVIKMLSAVVIAFFLCWAPFHAQ 283 red flour beetle
NP_493666    255 --------------------------------------------dkmvkkrrnKSNRTVLKMLLSVVITFFICWLPFHIQ 290 nematode
NP_001014620 225 qlksvpsdtilyryggsg-tamsfngggsgagtaglmggsgaqlssvrgrlnhYGTRRVLRMLVAVVVCFFLCWAPFHAQ 303 fruit fly

Feature 1        #  ##                  #   #                             
Q8ITC7       318 RLIFLyaknmd-------nyldiNEALFSIAGFAYYVSCTVNPIVYSVMSrRYRVAF 367 fruit fly
AAN10042     343 RLMAVyglnlinigisrdafndyFRILDYTSGVLYFLSTCINPLLYNIMShKFREAF 399 fruit fly
ADG27752     284 RLIYVymsdyp-------wygivNVWLYYISGIFYYFSATINPILYNLMSlKYRKAF 333 Rhodnius prolixus
NP_001073563 280 RLLYVyedst---------yddiNQWVYPLTGCLYYFSTTINPILYNVMSaKYRNAF 327 honey bee
EKC39231     338 RLYTIyhakqwt-----pfelevQSHLFYISGVLYFVGSTVNPFLYNVMCkRYRQAF 389 Pacific oyster
EKC33871     380 RMMTVsisawt------epllriYRTLFYVSGIFYFINCTVNPVLYSVMSfKFRKGL 430 Pacific oyster
ACC99623     353 RLMAVyakvpt------paleiaFNLLTYVSGVTYYVSATINPILYSIMSlKFRQAF 403 American dog tick
ELU05073     246 RLMTVyikedq-------rpdiaLLFLLFPPGVLYFVSSTVNPILYNLMSkKYRQAS 295 Capitella sp. I Grassle & Grassle, 1976
CCD81490     398 RVLTSanvqm---------twffIDFLFYVSGFLYYMSATVNPILYSLMSaRFRRAF 445 Schistosoma mansoni
XP_973937    284 RLLVIygpd----------yseaNTYMFFITGILYYFSSTLNPILYNVMSdRMRSAF 330 red flour beetle
NP_493666    291 RLLSVyttwsettt-isppvqflSMIVFYISGFCYYSNSAANPILYNILSqKYRSAF 346 nematode
NP_001014620 304 RLIAIyapargak--lrdqhefvYTVMTYVSGVLYYLSTCINPLLYNIMShKFREAF 358 fruit fly

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