5Z1W


Conserved Protein Domain Family
PKD_channel

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pfam08016: PKD_channel 
Polycystin cation channel
This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.
Statistics
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PSSM-Id: 462341
Aligned: 11 rows
Threshold Bit Score: 205.203
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5Z1W_C  280 RYVNNWDFFIVGcEVVFCVFIFYYVVEEILEIHLHr-LRYLS-SVWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLL- 356  house mouse
Q9Z0T6 1829 DFNRKTSSEIYL-YAAILIFFCAYVVDEGYIIRQEr-ASYIR-SVYNLLNFSLKCMFALLIVLFFWKYFLATKMVQLYL- 1904 house mouse
Q9NTG1 1956 DFDRKASAEIYL-YVAILIFFLAYVVDEGCIIMQEr-ASYVR-SVYNLLNFALKCIFTVLIVLFLRKHFLATGIIRFYL- 2031 human
Q9VVZ8  364 EQLREFTKFGMLmVFVFVVTWLQFTKAFFLKVWYD--PRQLK-TLWVQVDAMIVALSLVVGMIMSVRDNLVQKMIKSVEi 440  fruit fly
Q9W4X5  370 ENVDQMPYTGLLaLLIYVLVFIQFAQTLAVKLWYE--PHLLK-SVWNKLDLFIFMVNVLVVVLVVLRESLVASMMKKVEg 446  fruit fly
O08852 3882 RLSTGLSLPLLT-SVCLLLFALYFSMAEVQTWRKDgcACTARpDTW--ARCLLVILTAATGLVRLAQLGIADRQWTHFVq 3958 house mouse
Q95V80 2420 RYAANYKLFVILcEILFVVALFFVMYREYVRYKPIgiRKYLS-DKWNLLEIAIIVNCIVSAGLYIYRYVITKQLFKQMR- 2497 purple sea urchin
Q9U1S7  314 TYQTSGGTRMMIfEGIFCGFILYFIFEELFAIGRHr-LHYLT-QFWNLVDVVLLGFSVATIILSVNRTKTGVNRVNSVI- 390  Caenorhabditis elegans
O35245  462 RYVTAFDFFLAAcEIIFCFFIIYYVVEEILEIRIHr-LSYFR-SFWNCLDVVIVVLSVVAMVINIYRMSNAEGLLQFL-- 537  house mouse
Q9VK95  579 SFFTDRSMLMTViYIFWYIMVIYYTIYEITEIRKSgiKIYFC-SMLNILDCAILLGCYLALVYNIWHSFKVMSLTARA-- 655  fruit fly
Q8T8Z2  369 GNVETRSNSELLiLFVYTVLVILFARGVFTKIWHH--PAAAH-EAWTMVDLAIYILNVFLTVLAIMRDIETDALLQIIEt 445  fruit fly
5Z1W_C  357 QQPDTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLF 436  house mouse
Q9Z0T6 1905 ADPEAFIPFHAVSRVDHFMRIILAFLLFLTILKTLRYSRFFYNVRLAQKAIQAALPGICHTALVVSIYSFMYVAFGYLVF 1984 house mouse
Q9NTG1 2032 SNPEDFIPFHAVSQVDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMAFVVSVYFFVYMAFGYLVF 2111 human
Q9VVZ8  441 AVVVDFLDFREPAQLAYLEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFVITVIFIIAIGIATVTIN 520  fruit fly
Q9W4X5  447 ASKMEFIDFRRPSRMHQLTTITIGFLICITTLRLWRVLQFASVFKLFTRTLYLAWSAVASTAIAIVIFLIGFCFAVVTIN 526  fruit fly
O08852 3959 DHPRHFTSFDQVAQLGSVARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELMGATLGLVLLGVAYAQMAILLI 4038 house mouse
Q95V80 2498 DESVRFVGFRTAATSDNALGYSLAVIIILSCVKFLYLLRLNPRMYLLTSVISDCYHEVIAFTFLIFILILSFAFPMTIMF 2577 purple sea urchin
Q9U1S7  391 ENGLTNAPFDDVTSSENSYLNIKACVVFVAWVKVFKFISVNKTMSQLSSTLTRSAKDIGGFAVMFAVFFFAFAQFGYLCF 470  Caenorhabditis elegans
O35245  538 EDQNSFPNFEHVAYWQIQFNNISAVMVFLVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFTIMFSIIFLAYAQLAYLVF 617  house mouse
Q9VK95  656 HSDVTYQSLDVLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLF 735  fruit fly
Q8T8Z2  446 ATKGQYLDFQRPLRLHQMLFIVKGFLVCITTLRLWKVLQFASVFQHFTQTLFSAWRAVASLGVIILVVLMAIGITLAVPN 525  fruit fly
5Z1W_C  437 GTQVENFSTFVKCIFTQfr-----iILGDFDYN------AIdNANRILGPVYFVTYVFFVFFVLLNMFLAIINDTYSEV 504  house mouse
Q9Z0T6 1985 GQHEWNYSNMIHATQTIfs-----yCVSAFQNT------EF-SGNKVLGVLFLSSFMLVMICIFINLFQAVILSAYDEM 2051 house mouse
Q9NTG1 2112 GQHEWNYSNLIHSTQTVfs-----yCVSAFQNT------EF-SNNRILGVLFLSSFMLVMICVLINLFQAVILSAYEEM 2178 human
Q9VVZ8  521 GNYTSNFRDFPKGIVTV--------TCFAFGYTnlvyppDIfYGGEWLGILLYTIMGFVVKYMLINLIVSMMRDQMASV 591  fruit fly
Q9W4X5  527 GNYSSNFNKLVKSMVMC--------MCYSFGFSaqvkpsELfHGGKWLGILCYGVLAFVIIVLLINVFVSLINDYFTva 597  fruit fly
O08852 4039 SSGADTLYNMARAFLVLcpgarvptLCPSESWY--------------LSPLLCVGLWALRVWGALRLGAILLRWRYHAL 4103 house mouse
Q95V80 2578 GSNLPDYRDITKTALNLfi-----tLPDNFVYE------DLkSVQRVLGPLILLLFQFLSCYLFLDLLIAALNESMVTI 2645 purple sea urchin
Q9U1S7  471 GTQIADYSNLYNSAFALlr-----lILGDFNFS------ALeSCNRFFGPAFFIAYVFFVSFILLNMFLAIINDSYVEV 538  Caenorhabditis elegans
O35245  618 GTQVDDFSTFQECIFTQfr-----iILGDINFA------EIeEANRVLGPLYFTTFVFFMFFILLNMFLAIINDSYSEV 685  house mouse
Q9VK95  736 GTKHPDFRNFITSILTMir-----mILGDFQYN------LIeQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYNTV 803  fruit fly
Q8T8Z2  526 GNNAVVFSHMVQSVVTC--------MWYSMGFNgdihpaDFfHGGRILGILLYLALVFLLAIILMNVFASVIYDYFNET 596  fruit fly
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