Conserved Protein Domain Family
aceE
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PRK09405: aceE 
pyruvate dehydrogenase subunit E1; Reviewed
Links
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Statistics
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PSSM-Id: 236500
Aligned: 457 rows
Threshold Bit Score: 1326.31
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
158313696  16 LPSQLPDIDPSETSEWLESLDAVIEESGRGRARFLMLKLLERAREKAVGVPGLTs--TDFINTIPPEQEPWFPGDEHVER 93  
56708524    1 MSDFTKDIDVLETQEWLEAFEDVIKREGADRAKFLFEQLLAKGSELGIKSAYSTakvKNYVNSIDVSEQPSYPGDIELEQ 80  
110670995   1 MSDFTKDIDVLETQEWLEAFEDVIKREGADRAKFLFEQLLAKGSELGIKSAYSTakvKNYVNSIDVSEQPSYPGDIELEQ 80  
156501696   1 MSDFTKDIDVLETQEWLEAFEDVIKREGADRAKFLFEQLLAKGSELGIKSAYSTakvKNYVNSIDVSEQPSYPGDIELEQ 80  
89255740    1 MSDFTKDIDVLETQEWLEAFEDVIKREGADRAKFLFEQLLAKGSELGIKSAYSTakvKNYVNSIDVSEQPSYPGDIELEQ 80  
115314235   1 MSDFTKDIDVLETQEWLEAFEDVIKREGADRAKFLFEQLLAKGSELGIKSAYSTakvKNYVNSIDVSEQPSYPGDIELEQ 80  
118498065   1 MSDFTKDIDVLETQEWLEAFEDVVKREGADRAKFLFEQLLAKGSELGIKSAYSTakvKNYVNSIDVSEQPSYPGDIELEQ 80  
167627411   1 MSDFTKDIDVLETQEWLEAFEDVIKREGADRAKFLFEQLLSKGAELGIESAYSTakiKRYINSIDVSEQPSYPGDMEIEQ 80  
134301832   1 MSDFTKDIDVLETQEWLEAFEDVIKREGADRAKFLFEQLLAKGSELGIKSAYSTakvKNYVNSIDVSEQPSYPGDIELEQ 80  
187931238   1 MSDFTKDIDVLETQEWLEAFEDVIKREGADRAKFLFEQLLAKGSEFGIKSAYSTakvKNYVNSIDVSEQPSYPGDIELEQ 80  

158313696  94 RIRAYIRWNAAIMVSRANRPEYNVGGHIATYASSASLYEVGFNHFFRGKDHltSspgsDSGDQIFIQGHASPGIYARAFL 173 
56708524   81 KIEAINRWNSTVIVAAANKKDGSIGGHIGTGAGAMTLYEVGFNHFWKAPND--E----HAGDLIFYQGHLSPIVYARSFL 154 
110670995  81 KIEAINRWNSTVIVAAANKKDGSIGGHIGTGAGAMTLYEVGFNHFWKAPND--E----HAGDLIFYQGHLSPIVYARSFL 154 
156501696  81 KIEAINRWNSTVIVAAANKKDGSIGGHIGTGAGAMTLYEVGFNHFWKAPND--E----HAGDLIFYQGHLSPIVYARSFL 154 
89255740   81 KIEAINRWNSTVIVAAANKKDGSIGGHIGTGAGAMTLYEVGFNHFWKAPND--E----HAGDLIFYQGHLSPIVYARSFL 154 
115314235  81 KIEAINRWNSTVIVAAANKKDGSIGGHIGTGAGAMTLYEVGFNHFWKAPND--E----HAGDLIFYQGHLSPIVYARSFL 154 
118498065  81 KIEAINRWNSTVIVAAANKKDGSIGGHIGTGAGAMTLYEVGFNHFWKAPND--E----HAGDLIFYQGHLSPIVYARSFL 154 
167627411  81 RIEAINRWNSAVIVASANKREGSIGGHIGTGAGAMTLYEVGFNHFWKAPNE--N----HAGDLIFYQGHLSPIVYARSYL 154 
134301832  81 KIEAINRWNSTVIVAAANKKDGSIGGHIGTGAGAMTLYEVGFNHFWKAPND--E----HAGDLIFYQGHLSPIVYARSFL 154 
187931238  81 KIEAINRWNSTVIVAAANKKDGSIGGHIGTGAGAMTLYEVGFNHFWKAPND--E----HAGDLIFYQGHLSPIVYARSFL 154 

158313696 174 EGRLTEAQLDAFRREg--EPG--GLSSYPHPRLMPDFWEFPTVSMGLGPIDAIYQARFNRYLLNRQIKDTSRSKVWAFLG 249 
56708524  155 EGRITAEQLENFRKQa--FNGqnAVSSYPHPYLQPTYWQFPTVSMGLGPLQAIYQARFMKYLEARGLAKTSDRKVWAFCG 232 
110670995 155 EGRITAEQLENFRKQa--FNGqnAVSSYPHPYLQPTYWQFPTVSMGLGPLQAIYQARFMKYLEARGLAKTSDRKVWAFCG 232 
156501696 155 EGRITAEQLENFRKQa--FNGqnAVSSYPHPYLQPTYWQFPTVSMGLGPLQAIYQARFMKYLEARGLAKTSDRKVWAFCG 232 
89255740  155 EGRITAEQLENFRKQa--FNGqnAVSSYPHPYLQPTYWQFPTVSMGLGPLQAIYQARFMKYLEARGLAKTSDRKVWAFCG 232 
115314235 155 EGRITAEQLENFRKQa--FNGqnAVSSYPHPYLQPTYWQFPTVSMGLGPLQAIYQARFMKYLEARGLAKTSDRKVWAFCG 232 
118498065 155 EGRITAEQLENFRKQa--FNGqnAVSSYPHPYLQPTYWQFPTVSMGLGPLQAIYQARFMKYLEARGLAKTSDRKVWAFCG 232 
167627411 155 EGRITKQQLENFRRQafdKEN--AVSSYPHPYLQPTYWQFPTVSMGLGPLQAIYQARFMKYLEARGLAKTSDRRVWAFCG 232 
134301832 155 EGRITAEQLENFRKQa--FNGqnAVSSYPHPYLQPTYWQFPTVSMGLGPLQAIYQARFMKYLEARGLAKTSDRKVWAFCG 232 
187931238 155 EGRITAEQLENFRKQa--FNGqnAVSSYPHPYLQPTYWQFPTVSMGLGPLQAIYQARFMKYLEARGLAKTSDRKVWAFCG 232 

158313696 250 DGEMDEPESIGALGVAAREELDNLIFVVNCNLQRLDGPVRGNGKIMQELESLFRGAGWNVIKVVWGRDWDPLLAKDTDG- 328 
56708524  233 DGEMDEPESIGSITRAGREGLDNLIFVVNCNLQRLDGLVNGNGNIVEELADVFAGAGWNVINVLWSSDWDKLLQDPRGGk 312 
110670995 233 DGEMDEPESIGSITRAGREGLDNLIFVVNCNLQRLDGLVNGNGNIVEELADVFAGAGWNVINVLWSSDWDKLLQDPRGGk 312 
156501696 233 DGEMDEPESIGSITRAGREGLDNLIFVVNCNLQRLDGLVNGNGNIVEELADVFAGAGWNVIKVLWSSDWDKLLQDPRGGk 312 
89255740  233 DGEMDEPESIGSITRAGREGLDNLIFVVNCNLQRLDGLVNGNGNIVEELADVFAGAGWNVIKVLWSSDWDKLLQDPRGGk 312 
115314235 233 DGEMDEPESIGSITRAGREGLDNLIFVVNCNLQRLDGLVNGNGNIVEELADVFAGAGWNVIKVLWSSDWDKLLQDPRGGk 312 
118498065 233 DGEMDEPESIGSITRAGREGLDNLIFVVNCNLQRLDGLVNGNGNIVEELADVFAGAGWNVIKVLWSSDWDKLLQDPRGGk 312 
167627411 233 DGEMDEPESIGSITRAGREGLDNLIFVVNCNLQRLDGLVNGNGNIVEELADVFAGAGWNVIKVLWSSDWDRLLQDQKGGk 312 
134301832 233 DGEMDEPESIGSITRAGREGLDNLIFVVNCNLQRLDGLVNGNGNIVEELADVFAGAGWNVIKVLWSSDWDKLLQDPRGGk 312 
187931238 233 DGEMDEPESIGSITRAGREGLDNLIFVVNCNLQRLDGLVNGNGNIVEELADVFAGAGWNVIKVLWSSDWDKLLQDPRGGk 312 

158313696 329 VLVHRMNTTPDGQFQTYSTSSGDYIREHFFGADARLRRMVTDLADEDLSKLSRGGHDYRKLYAAYKAATEH-AGQPTVIL 407 
56708524  313 KLAQRLSELNDGQFHTIKAHGGAECRRVVFSGDEDLEALAKDMTDDDIQALRRGGHDPLKIYAAYKKAVENpNGRPTLIL 392 
110670995 313 KLAQRLSELNDGQFHTIKAHGGAECRRVVFSGDEDLEALAKDMTDDDIQALRRGGHDPLKIYAAYKKAVENpNGRPTLIL 392 
156501696 313 KLAQRLSELNDGQFHTIKAHGGAECRRVVFSGDEDLEALAKDMTDDDIQALRRGGHDPLKIYAAYKKAVENpNGRPTLIL 392 
89255740  313 KLAQRLSELNDGQFHTIKAHGGAECRRVVFSGDEDLEALAKDMTDDDIQALRRGGHDPLKIYAAYKKAVENpNGRPTLIL 392 
115314235 313 KLAQRLSELNDGQFHTIKAHGGAECRRVVFSGDEDLEALAKDMTDDDIQALRRGGHDPLKIYAAYKKAVENpNGRPTLIL 392 
118498065 313 KLAQRLSELNDGQFHTIKAHGGAECRRVVFSGDEDLEALAKDMTDDDIQALRRGGHDPLKIYAAYKKAVENpNGRPTLIL 392 
167627411 313 KLAQRLSELNDGQFHTIKAHGGAECRRVVFSGDEDLEALAKDMTDEDIQALRRGGHDPIKIYAAYKKAIEQaNGKPTLIL 392 
134301832 313 KLAQRLSELNDGQFHTIKAHGGAECRRVVFSGDEDLEALAKDMTDDDIQALRRGGHDPLKIYAAYKKAVENpNGRPTLIL 392 
187931238 313 KLAQRLSELNDGQFHTIKAHGGAECRRVVFSGDEDLEALAKDMTDDDIQALRRGGHDPLKIYAAYKKAVENpNGRPTLIL 392 

158313696 408 AHTIKGWTLGKDFEGRNATHQMKKLTKTELKELRDRLYLEIPDSALDGnlpPYYRPGPDSEEIQYMRERRAGLGGSIP-R 486 
56708524  393 PMTVKGYGLGEWGESKNIAHNVKKLDTDALEHIKNRFNVPASKEDIENy--RLIKLDENSPEMKYLHSKRKDLGGYIPkR 470 
110670995 393 PMTVKGYGLGEWGESKNIAHNVKKLDTDALEHIKNRFNVPASKEDIENy--RLIKLDENSPEMKYLHSKRKDLGGYIPkR 470 
156501696 393 PMTVKGYGLGEWGESKNIAHNVKKLDTDALEHIKNRFNVPASKEDIENy--RLIKLDENSPEMKYLHSKRKDLGGYIPkR 470 
89255740  393 PMTVKGYGLGEWGESKNIAHNVKKLDTDALEHIKNRFNVPASKEDIENy--RLIKLDENSPEMKYLHSKRKDLGGYIPkR 470 
115314235 393 PMTVKGYGLGEWGESKNIAHNVKKLDTDALEHIKNRFNVPASKEDIENy--RLIKLDENSPEMKYLHSKRKDLGGYIPkR 470 
118498065 393 PMTVKGYGLGEWGESKNIAHNVKKLDTDALEHIKNRFNVPASKEDIENy--RLIKLDENSPEMKYLHSKRKDLGGYIPkR 470 
167627411 393 PMTVKGYGLGEWGESKNIAHNVKKLDTDALEHIKNRFNVPATKEDIENy--KLVSLPEDSAEMKYLHAKRAALGGYIPaR 470 
134301832 393 PMTVKGYGLGEWGESKNIAHNVKKLDTDALEHIKNRFNVPASKEDIENy--RLIKLDENSPEMKYLHSKRKDLGGYIPkR 470 
187931238 393 PMTVKGYGLGEWGESKNIAHNVKKLDTDALEHIKNRFNVPASKEDIENy--RLIKLDENSPEMKYLHSKRKDLGGYIPkR 470 

158313696 487 RVVHaRTLPQPPKSIFDELRRGSGK-QPVATTMAIVRLLKDLMKTKEMGARFVPVIPDEARTFGMDAMFPTAKIYSPHGQ 565 
56708524  471 LENK-QALEIPSYKDFAKSLLDDSGdREFSTTTAFVRILSHLAKDKNLGKHIVPITVDESRTFGMEGLFRQLGIYNPHGQ 549 
110670995 471 LENK-QALEIPSYKDFAKSLLDDSGdREFSTTTAFVRILSHLAKDKNLGKHIVPITVDESRTFGMEGLFRQLGIYNPHGQ 549 
156501696 471 LENK-QALEIPSYKDFAKSLLDDSGdREFSTTTAFVRILSYLAKDKNLGKHIVPITVDESRTFGMEGLFRQLGIYNPHGQ 549 
89255740  471 LENK-QALEIPSYKDFAKSLLDDSGdREFSTTTAFVRILSYLAKDKNLGKHIVPITVDESRTFGMEGLFRQLGIYNPHGQ 549 
115314235 471 LENK-QALEIPSYKDFAKSLLDDSGdREFSTTTAFVRILSYLAKDKNLGKHIVPITVDESRTFGMEGLFRQLGIYNPHGQ 549 
118498065 471 LENK-QALEIPSYKDFAKSLLDDSGdREFSTTTAFVRILSHLAKDKNLGKHIVPITVDESRTFGMEGLFRQLGIYNPHGQ 549 
167627411 471 LENK-EPLAIPTYQEFAKNLLEDSGdREFSTTTAFVRILSHLAKDKKLGKHIVPITVDESRTFGMEGLFRQLGIYNPKGQ 549 
134301832 471 LENK-QALEIPSYKDFAKSLLDDSGdREFSTTTAFVRILSHLAKDKNLGKHIVPITVDESRTFGMEGLFRQLGIYNPHGQ 549 
187931238 471 LENK-QALEIPSYKDFAKSLLDDSGdREFSTTTAFVRILSHLAKDKNLGKHIVPITVDESRTFGMEGLFRQLGIYNPHGQ 549 

158313696 566 RYEAVDRELLLSYRESESGQMLHEGISEAGSMGSVIAAATAYSTHGQHMIPVYVFYSMFGFQRTGDQMWALGDQLGRAFL 645 
56708524  550 QYVPEDKQQVMFYKESVDGQILQEGINEQGGFCSWIAAATSYSVHKVPMIPFMIYYSMFGFQRFGDLAWAAGDSMAKGFV 629 
110670995 550 QYVPEDKQQVMFYKESVDGQILQEGINEQGGFCSWIAAATSYSVHKVPMIPFMIYYSMFGFQRFGDLAWAAGDSMAKGFV 629 
156501696 550 QYVPEDKQQVMFYKESVDGQILQEGINEQGGFCSWIAAATSYSVHKVPMIPFMIYYSMFGFQRFGDLAWAAGDSMAKGFV 629 
89255740  550 QYVPEDKQQVMFYKESVDGQILQEGINEQGGFCSWIAAATSYSVHKVPMIPFMIYYSMFGFQRFGDLAWAAGDSMAKGFV 629 
115314235 550 QYVPEDKQQVMFYKESVDGQILQEGINEQGGFCSWIAAATSYSVHKVPMIPFMIYYSMFGFQRFGDLAWAAGDSMAKGFV 629 
118498065 550 QYVPEDKQQVMFYKESVDGQILQEGINEQGGFCSWIAAATSYSVHKVPMIPFMIYYSMFGFQRFGDLAWAAGDSMAKGFV 629 
167627411 550 QYVPEDKEQVMFYKEAKDGQILQEGINEQGGFCSWIAAATSYSVHKVPMIPFMIYYSMFGFQRFGDLAWAAGDSMAKGFV 629 
134301832 550 QYVPEDKQQVMFYKESVDGQILQEGINEQGGFCSWIAAATSYSVHKVPMIPFMIYYSMFGFQRFGDLAWAAGDSMAKGFV 629 
187931238 550 QYVPEDKQQVMFYKESVDGQILQEGINEQGGFCSWIAAATSYSVHKVPMIPFMIYYSMFGFQRFGDLAWAAGDSMAKGFV 629 

158313696 646 LGATAGRTTLNGEGLQHQDGHSLLLASTNPACVSYDPAFAFEISHIVRDALDRMY--G-ErnENVFYYLTVYNEPVPQPA 722 
56708524  630 IGGTSGRTTLNGEGLQHEDGHSHIQAGLIPNCISYDPTYAYELAVILGEGMKRMY--VdG--DHVYYYITVMNENYSHRA 705 
110670995 630 IGGTSGRTTLNGEGLQHEDGHSHIQAGLIPNCISYDPTYAYELAVILGEGMKRMY--VdG--DHVYYYITVMNENYSHRA 705 
156501696 630 IGGTSGRTTLNGEGLQHEDGHSHIQAGLIPNCISYDPTYAYELAVILGEGMKRMY--VdG--DHVYYYITVMNENYFHRA 705 
89255740  630 IGGTSGRTTLNGEGLQHEDGHSHIQAGLIPNCISYDPTYAYELAVILGEGMKRMY--VdG--DHVYYYITVMNENYFHRA 705 
115314235 630 IGGTSGRTTLNGEGLQHEDGHSHIQAGLIPNCISYDPTYAYELAVILGEGMKRMY--VdG--DHVYYYITVMNENYFHRA 705 
118498065 630 IGGTSGRTTLNGEGLQHEDGHSHIQAGLIPNCISYDPTYAYELAVILGEGMKRMY--VdG--DHVYYYITVMNENYSHRA 705 
167627411 630 IGGTSGRTTLNGEGLQHEDGHSHIQAGLIPNCISYDPTYAYELAVILGEGMNRMYvkG----EHVYYYITVMNENYSHRA 705 
134301832 630 IGGTSGRTTLNGEGLQHEDGHSHIQAGLIPNCISYDPTYAYELAVILGEGMKRMY--VdG--DHVYYYITVMNENYSHRA 705 
187931238 630 IGGTSGRTTLNGEGLQHEDGHSHIQAGLIPNCISYDPTYAYELAVILGEGMKRMY--VdG--DHVYYYITVMNENYSHRA 705 

158313696 723 EPTGVDpTQIIAGMYRFRTAdaLTGGeetptgpvedgatesstttqAQLLASGTGMRWALAAQEMLAADYGIAADVWSVT 802 
56708524  706 MPEGCE-EGIIKGLYKLDEEk-KPASk------------------hVQLLGSGSILREVEATAKMLKEEYGITSNVWSMT 765 
110670995 706 MPEGCE-EGIIKGLYKLDEEk-KPASk------------------hVQLLGSGSILREVEATAKMLKEEYGITSNVWSMT 765 
156501696 706 MPEGCE-EGIIKGLYKLDEEk-KPASk------------------hVQLLGSGSILREVEAAAKMLKEEYGITSNVWSMT 765 
89255740  706 MPEGCE-EGIIKGLYKLDEEk-KPASk------------------hVQLLGSGSILREVEAAAKMLKEEYGITSNVWSMT 765 
115314235 706 MPEGCE-EGIIKGLYKLDEEk-KPASk------------------hVQLLGSGSILREVEAAAKMLKEEYGITSNVWSMT 765 
118498065 706 MPEGCE-EGIIKGLYKLDEEk-KPAAk------------------hVQLLGSGSILREVEAAAKMLKEEYGITSNVWSMT 765 
167627411 706 MPAGCE-EGIIKGLYKLEDTk-PADKh-------------------VQLLGSGSILREVEAAAKMLKDEYGITSNVWSMT 764 
134301832 706 MPEGCE-EGIIKGLYKLDEEk-KPASk------------------hVQLLGSGSILREVEAAAKMLKEEYGITSNVWSMT 765 
187931238 706 MPEGCE-EGIIKGLYKLDEEk-KPASk------------------hVQLLGSGSILREVEAAAKMLKEEYGITSNVWSMT 765 

158313696 803 SWNELRREALVCERRNLLNPEQPPAVPYISQILNGAPGPVIAVSDWMRAVPDQISRWVPQPYTSLGTDGFGRSDTRAALR 882 
56708524  766 SANELYREAKDVARANMLHPTAEKKESYIEKCFKNEQGPVIASTDYIKLYTDQLREFIPHTFVNLGTDGFGRSDTRAALR 845 
110670995 766 SANELYREAKDVARANMLHPTAEKKESYIEKCFKNEQGPVIASTDYIKLYTDQLREFIPHTFVNLGTDGFGRSDTRAALR 845 
156501696 766 SANELYREAKDVARANMLHPTAEKKESYIEKCFKNEQGPVIASTDYIKLYTDQLREFIPHTFVNLGTDGFGRSDTRAALR 845 
89255740  766 SANELYREAKDVARANMLHPTAEKKESYIEKCFKNEQGPVIASTDYIKLYTDQLREFIPHTFVNLGTDGFGRSDTRAALR 845 
115314235 766 SANELYREAKDVARANMLHPTAEKKESYIEKCFKNEQGPVIASTDYIKLYTDQLREFIPHTFVNLGTDGFGRSDTRAALR 845 
118498065 766 SANELYREAKDVARTNMLHPTAEKKESYIEKCFKNEQGPVIASTDYIKLYTDQLREFIPHTFVNLGTDGFGRSDTRAALR 845 
167627411 765 SANELHREAKKVARENMLHPDAERKESYIEKCLKNEQGPVIASTDYIKLYTDQLREFIPHTYVNLGTDGFGRSDTREALR 844 
134301832 766 SANELYREAKDVARANMLHPTAEKKESYIEKCFKNEQGPVIASTDYIKLYTDQLREFIPHAFVNLGTDGFGRSDTRAALR 845 
187931238 766 SANELYREAKDVARANMLHPTAEKKESYIEKCFKNEQGPVIASTDYIKLYTDQLREFIPHTFVNLGTDGFGRSDTRAALR 845 

158313696 883 RHFNVDAESVVVATLEALTRTGDVEQATVDDAIRRYGLRKDGANEAAL 930 
56708524  846 SFFEVDRYHVVVASLYALYLDGKVEASEVKTAIEKYNIDPERMAPFYS 893 
110670995 846 SFFEVDRYHVVVASLYALYLDGKVEASEVKTAIEKYNIDPERMAPFYS 893 
156501696 846 SFFEVDRYHVVVASLYALYLDGKVEASEVKAAIEKYNIDPERMAPFYS 893 
89255740  846 SFFEVDRYHVVVASLYALYLDGKVEASEVKAAIEKYNIDPERMAPFYS 893 
115314235 846 SFFEVDRYHVVVASLYALYLDGKVEASEVKAAIEKYNIDPERMAPFYS 893 
118498065 846 SFFEVDRYHVVVASLYALYLDGKVEASEVKAAIEKYNIDPERMAPFYS 893 
167627411 845 SFFEVDRYHVVVASLYALHLDGKVKASEVKDAIKKYNIDPERVAPLYC 892 
134301832 846 SFFEVDRYHVVVASLYALYLDGKVEASEVKAAIEKYNIDPERMAPFYS 893 
187931238 846 SFFEVDRYHVVVASLYALYLDGKVEASEVKAAIEKYDIDPERMAPFYN 893
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