5U2A


Conserved Protein Domain Family
MACS_like_2
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cd05973: MACS_like_2 
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Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS)
MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Links
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Statistics
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PSSM-Id: 341277
Aligned: 5 rows
Threshold Bit Score: 744.339
Created: 21-Sep-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 35 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:based on the active site of related family members with structure
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                 #                      
5U2A_A        75 LTFEDLRDMSARVGNMLADAGIsAGDVVAGLLPRTPELVATILGAWRIGAIYQPLFTAFgPKAIEQRFGTSgAKLVVTNL 154 Brucella canis ...
EAY72148      67 FTFAQMRALSARVANLLVAHGVkPGDVVAGLLPRTPELVATILGTWRAGAVYQPLFTAFgPKAIEHRLRMSdARLIVTNV 146 Burkholderia do...
NP_251245     58 YTFSELKALSGRFANFLQAQGVrPGDCVAGLLPRTPELLVTILGAWRLGAVYQPLFTAFgPKAIEHRVATAgSKVLVTDA 137 Pseudomonas
YP_888272     50 LTYGQLREQSTKFAAALSELGIgPGDHVATLMGKSAELVVALLGIWRRGAIHVPLFTAFaPPAITHRLRASdARLVICDA 129 Mycobacterium s...
YP_003767503  46 LSYGELAARSHRYARALQELGVgPGDRVATLMGKSTDLVTLILAIWRLGAVYVPLFTAFaPQAIALRLDGSgAHVVVVDA 125 Amycolatopsis m...

Feature 1                                                                                        
5U2A_A       155 ANRSKLAevencprvatilapgeslpegd-----idfraavaaastecepvmrkgSDLFMMMSTSGTAGLPKGVPVPLRA 229 Brucella canis ...
EAY72148     147 ANRAKLDeiadcppvatvrerdeplperd-----idfraaldaqsdvfepvprkgTDLFLMMSTSGTTGLPKGVPVPLRA 221 Burkholderia do...
NP_251245    138 ANRDKLDeladpplavtvggpkgqgirrg----dfsfwaelerypaefepvprsgEDPFLMMFTSGTTGLAKPVPVPLKA 213 Pseudomonas
YP_888272    130 DQLHKIThddsapspapwrvvvagpsttddvlelaglirrhdgvstaemtavtggSGTLVELFTSGTTGSPKGVAVPLRA 209 Mycobacterium s...
YP_003767503 126 DQRHKLDpgpdlphdprrhvvtgasl----------adlaaatspepvprvttsgDGPLVHMFTSGTTGKPKGVIHPVSY 195 Amycolatopsis m...

Feature 1                                   ###                      #                   # #   # 
5U2A_A       230 LMAFGAYMRDAVGLRsDDIFWNIADPGWAYGLyYAVTGPLLLGVPTILNEGGFTAENTYDIIERLGVTSLAGSPTAFRLL 309 Brucella canis ...
EAY72148     222 LLAFGAYMRDAVDLRdGDRFWNIADPGWAYGLyYAITGPLLLGHATTLYEGAFTVDSTYDVIERLGITSLAGSPTAYRML 301 Burkholderia do...
NP_251245    214 ILAFVGYLREAVDLRpEDAFWNLADPGWAYGLyYAVAGPLAMGHPTTFYEGPFSVESTCRIIRDYGITNLAGSPTAYRLL 293 Pseudomonas
YP_888272    210 LASFHAYQEFGLDVRrEDVFWNAADPGWAYGLyYAILSPLATGTRSILLHAGFSPPLVWRVMERFGVTNFTAAPTVYRSL 289 Mycobacterium s...
YP_003767503 196 IAGWQSYLEYALGVTpDSSYWCAADPGWAYGLySAIVAPLAAGIPSLLLAGGFSVETTWRTLVEHAVTDFTAAPTVYRGL 275 Amycolatopsis m...

Feature 1                            ####                  ######  ##                  #         
5U2A_A       310 IAAGpesaarvkgRLRVVSSAGEPLNPEVIRWFDACLGAPIHDHYGQTELGMVVNNHHGle--hpVRQGSAGYAMPGYRV 387 Brucella canis ...
EAY72148     302 MAAGaeaaarikgKLRVVSSAGEPLNPEVVRWFDATLGVPIYDHYGQTELGMVVNNHHGla--hvVHAGSAGLAMPGYRV 379 Burkholderia do...
NP_251245    294 MAAGaaaetalkgRLRAVSSAGEPLTPEVIRWFADRLGTTIHDHYGQTELGMVLCNHHAla--hpVRVGAAGFACPGHRV 371 Pseudomonas
YP_888272    290 LTDPtsvp--ptvRLRRASSAGEPLTPDVISWSRANLGVLVRDHYGQTEHGMFIANAWAdglrdeVHEGSMGAVLPGWRC 367 Mycobacterium s...
YP_003767503 276 RSSSvpvp--pglSLQRASSAGEPLTPEVNDWAGAALGLAVHDHFGQTEVGMPLANHHHpelarpLKAGSMGRPVPGWSV 353 Amycolatopsis m...

Feature 1                                                               #           #  #     # ##
5U2A_A       388 AVLDEAGKEVGp-NEPGVLAIDIdNSPLLWFTGYYKKDTps-----isGGYYRTGDTVEFEPDGSISFIGRADDVITSSG 461 Brucella canis ...
EAY72148     380 AVLDDAGRELGp-GEPGNLAIDIaRSPLLWFGGYWQQDTpa-----iaGGYYRTGDNVELEPDGTVSFIGRADDVITSSG 453 Burkholderia do...
NP_251245    372 VVLDDDLNELPp-GQPGILALDRrRSPLMWFPGYQGLETaa-----fvGDYYLSGDTVELNEDGSISFVGRADDVITTSG 445 Pseudomonas
YP_888272    368 NVLDLNTVTAApsRRMGRVAIDAhNSPLMWFNGYTNAPDktaerftpdGHWYLTGDIGHVDDEGKFHFCGRDDDVIIMAG 447 Mycobacterium s...
YP_003767503 354 TVLADDKDEPVepGVLGRVAIDVaASPLMTFRGYQLPGQsdak-ftadGRWYLTGDAGRFDADGEFFFSSRDDDVIIMAG 432 Amycolatopsis m...

Feature 1        ##                            #                            #    ## # #          
5U2A_A       462 YRIGPFDVESALLKHPAVNEAAVVGVPDPqRTEIVKAFVILApgfegtpeLAEELALHVKKQLSAHAYPRQIDFVAELPK 541 Brucella canis ...
EAY72148     454 YRIGPFDVESALIEHPAVSEAAVIGVPDPeRTEIVKAFVVLSnnyegtpaLADELALHVKRRLSAHAYPRAIEFVDALPK 533 Burkholderia do...
NP_251245    446 YRVGPFDVESALIEHPAVMEAAVIGKPDPeRTELVKAFVVLCaghrptpeLADALQRYVRQRLSAHAYPREIEFLEELPK 525 Pseudomonas
YP_888272    448 YRIGPFDVESVLVMHPSVIEAAVVARPDHlRGEVLEAFVVLRegtegsedLEKELQTLVKKKYAAHAYPRTVHFVTELPK 527 Mycobacterium s...
YP_003767503 433 YRIGPFEIESVLAQHPAVAECSVIGAPDDvRGEVIEAYVVLRgghdastaLAAELQQFVKTRYAAHAHPRTVHFIDALPK 512 Amycolatopsis m...

Feature 1                     
5U2A_A       542 TPSGKIQRFLLRK 554 Brucella canis ATCC 23365
EAY72148     534 TPSGKIQRFVLRK 546 Burkholderia dolosa AUO158
NP_251245    526 TPSGKIQRFLLRN 538 Pseudomonas
YP_888272    528 TSSGKVQRHLLRR 540 Mycobacterium smegmatis
YP_003767503 513 TPSGKTQRYLLRR 525 Amycolatopsis mediterranei

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