5W8S


Conserved Protein Domain Family
LpxB
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pfam02684: LpxB 
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Lipid-A-disaccharide synthetase
This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyze the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyze the fist disaccharide step in the synthesis of lipid-A-disaccharide.
Links
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Statistics
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PSSM-Id: 397004
Aligned: 7 rows
Threshold Bit Score: 426.089
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5W8S_A   9 IALVAGETSGDILGAGLIRALKEHVpn----aRFVGVAGPRMQA-EGCEAWYEMEELAVMGISESSGRSRRSSHIRADLT 83  Escherichia coli BL21...
O67420   4 IFLSLADRSASNYVYEILKEGFEEY-------EIYGLTDEKLEK-IGVKSVARYSEISTVGLIEALPKVFKFLKIYRKIL 75  Aquifex aeolicus VF5
O25537   4 ILVSALEASSNAHLEELRQNLPEDY-------RFIGVF-------EGKEVLYSPREFSIMGFRDVIGRLGFLLKAHKEMV 69  Helicobacter pylori 2...
O84416 228 CFISAGEHSGDTLGGNLLKEMHAKYpd----iHCFGVGGPQMRA-QNFHALFAMEKFQVSGFWEVLLALPKLWYRYQLLY 302 Chlamydia trachomatis...
Q9ZDK7   4 IYFIAGEMSGDFIGGHVIQNLKSNEg-----lEFTGIGGKYMEEaGNFKSLFTITAINLIGFIEIIPHLLKIKKLIDKTV 78  Rickettsia prowazekii...
P45011   8 IALVAGEVSGDILGAGLIRQLKAHYpn----aRFIGIAGPRMLA-EGCETLVDMEELSVMGLAEILKHLPRLLKIRKNVI 82  Haemophilus influenza...
Q57310   3 IFISTGEVSGDLQGSLLVGALRQQAeeqnlelELVGLGGEKMAA-AGLTLLANTAAIGSVGLTESLRFIIPTWQIQQRVK 81  Synechocystis sp. PCC...

5W8S_A  84 KRfgELKPDVFVGIDAPDFNITLEGNLKKQGIK--TIHYVSPSVWAWRQKR--VFKIGRATDLVLAFLPFEKAFYDKYN- 158 Escherichia coli BL21...
O67420  76 KN--LKNTDTLIACDAPALNLRLIKDARKLGVKr-IIYFISPQVWAWKPKR--AEIIANYCDHVIVILPFEKKIYRKFPn 150 Aquifex aeolicus VF5
O25537  70 Ql--AKQADMVLLMDSSSFNIPLAKKIKKQDPHkkIMYYILPQVWAWKKWR--AKSLEKYCDFLGAILPFEVGYYQKK-- 143 Helicobacter pylori 2...
O84416 303 RNilKTNPRTVICIDFPDFHFLLIKKLRSRGYKgkIVHYVCPSIWAWRPSR--KTVLEKYLDLLLLILPFEQNLFKDSA- 379 Chlamydia trachomatis...
Q9ZDK7  79 EHiiNSKADLLITIDSPGFTYRVAKRVRKLLPNlkMIHIVAPSVWAYKADR--AVNYAKIYDCLFALLPFEPPYFTKVG- 155 Rickettsia prowazekii...
P45011  83 QTmlQEKPDVYIGIDAPDFNLDVELKLKANGIK--TIHYVSPSVWAWRQNR--IHKIAKATHQVLAFLPFEKAFYDKFN- 157 Haemophilus influenza...
Q57310  82 RYlkTNPIDLLVLIDYMGPNLTIANYLRKTYPNlpILYYIAPQAWVWSPTKreTAQIMAVTDRLLAIFPGEAEFFQKQG- 160 Synechocystis sp. PCC...

5W8S_A 159 VPCRFIGHTMADAMPLDPD-KNAARDVLgiphDAHcLALLPGSRGAEVESLSADFLKTAQLLRQTYPDLEIVVPLVNAKR 237 Escherichia coli BL21...
O67420 151 LKVHYVGHPLVDLVKPQKTkEEFMKAFK----KEP-LPLLLGSREGEIRRHVKLLKGIIEELKKSFDVISPTFREFSKFI 225 Aquifex aeolicus VF5
O25537 144 --AQYVGHPLLDEIKHYKK-DIKGETLV----------FMPGSRKSEIAKM-FPLFVKAAQMLEQNEGFKRRVLVVPSFF 209 Helicobacter pylori 2...
O84416 380 LRTVYLGHPLSETIKSFSP-NLNWKDQLhlptDKPfIAAFPGSRRSDILRN-LTIQVQAFQASSLASTHHLLVSSANPEY 457 Chlamydia trachomatis...
Q9ZDK7 156 LDCRYIGHPIMEQEFYRDK-IALRKELKid-eNERiLCVTLGTRKGEILRHLPIFIDAIQEISKDYKNLTIIFPLAHPDH 233 Rickettsia prowazekii...
P45011 158 VPCRFIGHTMADAIPLKPN-RAEACQTLqidpAQRyLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQFLVPLVNEKR 236 Haemophilus influenza...
Q57310 161 LDVTWVGHPLLDRITKEAPsRGSAREKLgidhNETvITLLPASRIQELRYLLPSICGAAQQLQSQLPNVKLLLPVSLKDY 240 Synechocystis sp. PCC...

5W8S_A 238 REqferikaeVAPdLSVHLLDgMGREAMVASDAALLASGTAALECMLSKCPMVVGYRMKPFTFWLAKRLVKTDY--VSLP 315 Escherichia coli BL21...
O67420 226 ER--------ELK-VKTLTYEgASYDCFFYSKASLIASGTASLEAGIAGNPHVVYYKVNPITYFLGKRLVKVPY--ISLV 294 Aquifex aeolicus VF5
O25537 210 KGldl--kalYGEdIQLFEISyDAHKSLFEAEFAFICSGTATLEAALIGTPFVLAYRAKTMDFLIARMLVNLHY--IGLA 285 Helicobacter pylori 2...
O84416 458 DHlilevlqqNRClHSHIVPSqFRYELMRECDFALAKCGTIVLETALNLTPTIVTCQLRPLDTFLAKYIFNIILpaYSLP 537 Chlamydia trachomatis...
Q9ZDK7 234 EAiik--pflDNIqFNYLFLSnERLKAYAVSDLALAKSGTNTLEISASGTPMVVAYKVNIISFIIIMLLIKIKY--VSLI 309 Rickettsia prowazekii...
P45011 237 RIqfetikakITPnLDLHLIDgNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYFLAKRLVKTDY--ISLP 314 Haemophilus influenza...
Q57310 241 QPqieqtlkeFNLtVQLLEGK-ETLTAIAAADLAITKSGTVNLEIALLNVPQVILYRVSPLTMAIARRIFKFNLpfVSPT 319 Synechocystis sp. PCC...

5W8S_A 316 NLLAGRELVKELLQEECEPQKLAAALLPLLANG----KTSHAMHDTFRELHQQIRCNADEQAAQAV 377 Escherichia coli BL21(DE3)
O67420 295 NILLKEEVVPEFIQKSSDEILKGFEKVYKNEEE----IKEKLGTLKFILGERFVIRKLRELFLEIV 356 Aquifex aeolicus VF5
O25537 286 NIFYNALNNETPGLGESQLHPELIQHFLSVEGLlk-aYKEMDRERYFKESLRLREYLKHGSARKIA 350 Helicobacter pylori 26695
O84416 538 NIILGRTIFPEFIGGKKDFQYEDVAAALNILKTsqaqEKQKDSCRDVYQAINESASSMKECLSLIF 603 Chlamydia trachomatis D/UW-3/CX
Q9ZDK7 310 NIIAGSEIIPEFIQFNCKANLISNKLKELLSNSqk-rYNQVVKSKKILQKLGFESNRSPSYIAAKI 374 Rickettsia prowazekii str. Madrid E
P45011 315 NLLANEMLVPEMIQEECTPELLAEKLSVYLSDDesavKNRHVLIQHFTDLHQKIQCNADKQAAQAV 380 Haemophilus influenzae Rd KW20
Q57310 320 NIVLNRGIMPELLQEQATASNIAQAGLELLLNGdrqaKIAQDYQELREALGEPGVCERAAQAVLEF 385 Synechocystis sp. PCC 6803 substr. ...
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