Conserved Protein Domain Family
ArsO_flavin_mono

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NF040505: ArsO_flavin_mono 
ArsO family NAD(P)H-dependent flavin-containing monooxygenase
All members of the seed alignment for this HMM, including founding member ArsO (ABB70173.1), are encoded in arsenic resistance islands. However, protein functions in this family maybe both variable and promiscuous. ArsO is related to the flavoprotein CzcO (see PMID:12100555), which was found to modestly enhance the activity of cation diffusion facilitator CzcD.
Statistics
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PSSM-Id: 439724
Aligned: 37 rows
Threshold Bit Score: 497.899
Created: 11-Oct-2024
Updated: 3-Dec-2024
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_012480205  12 VDVVVIGGGQSGLSAGYFLRRSG----LSYVILDAEASPGGAWQHAWHSLHLFSPAGWSSIPGWPMPASQG-PYPARAEV 86  Stenotrophomona...
WP_010072861   7 VDVVVIGGGQAGLATGYYLRRQN----LGFVILDAQPSPGGAWRHTWDSLHLFSPAAYSSLPGWLMPAQDGaEYPDARHV 82  Streptomyces
WP_018491321   5 VDVVVIGGGQAGLAAGYHLRRGG----LDFVVLDAQATPGGAWQHMWDSLRLFSPAAYSSLPGRVMPGQPGeTYPDARHV 80  unclassified St...
WP_015034661   5 VDVVVIGGGQSGLAAGYHLRRLG----LDFVVLDAGAAPGGAWRHTWDSLHLFSPAAYSSLPGRLMPPQPGeTYPDAAHV 80  Streptomyces
WP_018382012   4 VDVVVIGGGQAGFAAGYHLRRQK----VDFVILDDQATPGGAWQHTWDSLHLFSPAAHSSLPGRPMPAQPGqTYPDARHV 79  Streptomyces vi...
WP_017944638   5 TQVVVIGGGQSGLAAGYHLRRLG----VDFTVLDAGTAPGGAWQHVWDSLRLFSPAAFSSLPGRLMPAVPGePYPDARHV 80  Streptomyces sp...
WP_017581277   8 VDVAVIGGGQAGLAAGYFLRRARrrleFDFAILDDGAAPGGAWSEYWDSLRLFSPAGHSMLPGWWMPEEEGqEYPSARHA 87  Nocardiopsis va...
WP_009885355   2 TDVVVIGGGQAGLAAGYFLRRTG----LEFVILDYHAGAGGAWQHGWQSLRLFSPAGYSPLPGWPMPAQKGeSFPTADHV 77  Brevibacterium ...
WP_019854389   3 CDVVVIGGGQAGLAAGYFLRRAG----WDFVILDAQSEPGGAWRHMWPSLRLFSPAEHSPLPGWPMPRQPGlDYPTRAHV 78  Actinopolyspora...
WP_005456477  17 YDVVVIGGGQAGLAAGYFLRRTG----LNFVILDDQQQPGGAWQHYWDSLRLFSPAEYSPLPGWWMPPQPGeDFPTAEHV 92  Saccharomonospo...
WP_012480205  87 LAYLAQYEQKYALPVLRPIRVQRVSHFG-ERLRVVARDgRQWLARAVISATGTWGEAYTPEYQGLESFAGIQLHSAHYST 165 Stenotrophomona...
WP_010072861  83 VQYLTAYEERYALPVQRPVRVKAVRRDG-ERLRVETDA-GVWSARAVVSATGTWWRPFLPAVPGRETFTGRQLHTVQYRN 160 Streptomyces
WP_018491321  81 VEYLTDYERRYELPVVRPVRVAAVHQDG-GHLRVETDA-GIWCARAVISATGAWWRPFIPAVPGRTEFTGVQLHTVGYRR 158 unclassified St...
WP_015034661  81 VAYLTEYEQRYELPAVRPVRVTGVHRDG-ELLRVETDS-GTWRARAVVSATGTWSRPFVPAIPGRADFRGAQLHTVAYEN 158 Streptomyces
WP_018382012  80 VAYLTDYDQRYDLPVRRGVRVRAVRGDG-DRLRVETDS-GDWRARAVISATGTWSRPFLPAVPGRDTFTGRQLHTVGYRR 157 Streptomyces vi...
WP_017944638  81 VDYLADYEKRYALPVQHGVQVRGVHRDG-PLLRVETDS-GAWRARAVISATGSWSRPFLPSVPGRASFRGEQLHTAGYRR 158 Streptomyces sp...
WP_017581277  88 ARYLAEYERRYDLPVHRPVHVDRVERDA-DGLLLHTGR-GDWRARYVISATGTWRAPHVPDLPGRGLFGGRQAHTADYRG 165 Nocardiopsis va...
WP_009885355  78 IDYLTRYEHRYDLPVHRPVHVSNVYQDR-GQLFVDTDT-GTLETTAVISATGTWQRPYVPAYPGCEDFTGRQLHTVEYDS 155 Brevibacterium ...
WP_019854389  79 VDYLTRYERRYALPVHRPVHVEGVRRDDtRSLVVSTDR-GTWRARVVISATGTWRAPHIPSYPGQDEFTGRQLHTVSYRG 157 Actinopolyspora...
WP_005456477  93 VAYLTAYEQRYQLPVHRPVRVQTVHQAG-KWLAVHSSQ-GVFNARAVISATGTWAAPHQPSLPGQQRYTGQQLHTVDYRS 170 Saccharomonospo...
WP_012480205 166 PAPFAGMRVAIIGGGNSGAQILAEVSTVAE-TTWITQHEPAFLADDVDGRVLFERATERWKAQQEGREPDLPPGGFGDIV 244 Stenotrophomona...
WP_010072861 161 PAQFSGRRVIVVGGGNSGAQVAADLAPHTD-LTWVTQRPARFLADDIDGGALFDAATARRRALDSGNPDTGGVASLGDIV 239 Streptomyces
WP_018491321 159 PADLAGQKVVVVGGGNSGAQIATDLVHATD-VIWATQRPPRFLADTIDGRALFDHATARRRALDEGRTDTGGAASLGDIV 237 unclassified St...
WP_015034661 159 PAAFAGQQVIVVGGGNSGAQIPADLAHAAH-LTWVTLREPRYLADDIDGRALFDHATARRRALDEGRTDTGGVASLGDIV 237 Streptomyces
WP_018382012 158 PADFAGQRVTVVGGGNSAAQIAADLLLDGVeVTWVTQHPPRFLADDVDGRALFAIATARRRALDEGRTDAGGVAPLGDIV 237 Streptomyces vi...
WP_017944638 159 PEDFTGKRVIVVGGGNSGAQIAADLAGHAD-VTWATRRPPRFLPDDVDGRVLFDVATARRTALDAGRTDPGGVASLGDVV 237 Streptomyces sp...
WP_017581277 166 PEEFAGQRVVVVGGGNSAAQILAELSLVAR-TRWVTLRQPRFLPDDVDGRALFSIATRRQQAAERG-EAAQGVSDLGDIV 243 Nocardiopsis va...
WP_009885355 156 PEDYTDQRVVIVGGGNSAAQIVAEVSTVAQ-TLWVTQRRPRFMPDDVDGRVLFDVATAREAAQRAGR-DHDGVSGLGDIV 233 Brevibacterium ...
WP_019854389 158 PDQFRGDRVVVVGGGNSAAQILAEVSAVAE-TLWVTRRPPRFMPDDVDGRVLFDVATRREAARRRGTEDTGGVAALGDIV 236 Actinopolyspora...
WP_005456477 171 PQHFTGQRVVVVGGGNSAAQILADISTVAD-TTWVTRRPPRFMPDDVDGRVLFDVATQREAARRAGIPDTGGASSLGDIV 249 Saccharomonospo...
WP_012480205 245 MVPPVLDARARGVLAAVPPPARFSPTGMQWADGTERAFDAVIWCTGFRPALSHLKGLDLVTPQGQVE-VDGSglRALAVP 323 Stenotrophomona...
WP_010072861 240 AVAPVRATRDAGLLKAQPMFARLNENGAEWADGARAEAAAIIWCTGFRPALSHLAPLGLRGERGHIP-TQGT--RAVGEP 316 Streptomyces
WP_018491321 238 AVPTVREARDAGLLKAQPMFRRLTATGIEWSDGTHAEADTIIWCTGFRPALSHLAPLGLRGSRGHIP-TMGT--RALGEP 314 unclassified St...
WP_015034661 238 AVPPVRAARDAGLLKAQPMFDRMTAAGVAWVDGTTAEADAVIWCTGFRPALSHLAPLGLRGARGRIP-TTGT--QAVDEP 314 Streptomyces
WP_018382012 238 AVPPVRAARDSGKLVARPMFTRLTATGIEWADGTRADADAVIWCTGFRPALAHLAPLALRGPQRHIP-TDGT--RAIGEP 314 Streptomyces vi...
WP_017944638 238 AVPAVRHARDHGLLTATPMFARLTADGAEWPGGTRAAADTVVWCTGFRPALAHLAPLGLRGPRGRIA-TSGT--RAADEP 314 Streptomyces sp...
WP_017581277 244 VVPSVRRARDRGALSAEPMFDRLTPTGVAWADGTVWECDAVLWCTGFRPVLDHLEPLVPAGPDGRIK-VEGT--RSVDEP 320 Nocardiopsis va...
WP_009885355 234 MVPPVRAARDRGDLNALPMFERLTSAGVSWADGSEYSCDAIIWCTGFKPHLNHLNGLELTWKNGHPV-TEGT--QSIDAS 310 Brevibacterium ...
WP_019854389 237 MTPSVLEARTRGALHAHPMFTRLTRDTVVWSDGTEHPAETVLWCTGFRPALRHLRPLGLRRRDGTIP-TEGT--RSVQEP 313 Actinopolyspora...
WP_005456477 250 MVPSVRDARDRGVLHAHPMFDSLTEHGIAYSDGTELACDAIIWCTGFRPHLTHLAPLGL-GQDGDVPlTEGT--RSINEP 326 Saccharomonospo...
WP_012480205 324 SVWLLGYGDWNGMASATLIGVTRYAREAVRQVTAYC 359 Stenotrophomonas maltophilia
WP_010072861 317 RLHLIGYGDWTGPASATLIGVGRPARDAVREIVALL 352 Streptomyces
WP_018491321 315 RLHLLGYGDWTGPASATLIGVGRPAREAAVEIAGLL 350 unclassified Streptomyces
WP_015034661 315 RLHLLGYGDWTGPASATLIGVGRPAREAARAIASLL 350 Streptomyces
WP_018382012 315 RLHLLGYGDWTGPASATLIGVGRPARDATAQITRLL 350 Streptomyces vitaminophilus
WP_017944638 315 RLHLLGYGDWTGPASATLIGVGRPARDAAREIAAVV 350 Streptomyces sp. CNS615
WP_017581277 321 RLHLLGYGDWTGAASATIIGAGRTAKGAVAEVVRGL 356 Nocardiopsis valliformis
WP_009885355 311 GLHLLGYGDWTGFASATIIGAARTAKSAVADVNKYV 346 Brevibacterium aurantiacum
WP_019854389 314 RLYLLGYGDWTGHASATLIGAGRTAKTTVTDITRQL 349 Actinopolyspora mortivallis
WP_005456477 327 RLHLLGYGDWTGWASATLVGAGRTAKAAVNHLTDQL 362 Saccharomonospora cyanea
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