1FI4,2GS8


Conserved Protein Domain Family
mevDPdecarb

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TIGR01240: mevDPdecarb 
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diphosphomevalonate decarboxylase
This enzyme catalyzes the last step in the synthesis of isopentenyl diphosphate (IPP) in the mevalonate pathway. Alternate names: mevalonate diphosphate decarboxylase; pyrophosphomevalonate decarboxylase [Central intermediary metabolism, Other]
Statistics
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PSSM-Id: 130307
Aligned: 5 rows
Threshold Bit Score: 400.094
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1FI4_A    26 ASVTAPVNIATLKYWGKRDTKLNLPTNSSISVTLSQddLRTLTSAA-T-APEFERDTLWLNG-EPHSIDNERTQNCLRDL 102 baker's yeast
AAG02451   6 ITVTSYANIAIIKYWGKENQAKMIPSTSSISLTLEN--MFTTTSVSfL-PDTATSDQFYINGvLQNDEEHTKISTIIDQF 82  Streptococcus pyogenes
P32377     6 ASVTAPVNIATLKYWGKRDTKLNLPTNSSISVTLSQddLRTLTSAA-T-APEFERDTLWLNG-EPHSIDNERTQNCLRDL 82  Saccharomyces cerev...
AAG02446   4 GKARAYTNIALIKYWGKKNEELILPMNNSLSLTLDA--FYTETEVI-F-SDSYMVDEFYLDGtLQDEKATKKVSQFLDLF 79  Enterococcus faecium
2GS8_A     9 ITVTSYANIAIIKYWGKENQAKXIPSTSSISLTLEN--XFTTTSVS-FlPDTATSDQFYINGiLQNDEEHTKISAIIDQF 85  Streptococcus pyoge...
1FI4_A   103 RQLRkeXEskdaslptlsqwKLHIVSENNFPTAAGLASSAAGFAALVSAIAKLYQLPQSTSEISRIARKGSGSACRSLFG 182 baker's yeast
AAG02451  83 RQPG--QA------------FVKMETQNNMPTAAGLSSSSSGLSALVKACDQLFDTQLDQKALAQKAKFASGSSSRSFFG 148 Streptococcus pyogenes
P32377    83 RQLRkeMEskdaslptlsqwKLHIVSENNFPTAAGLASSAAGFAALVSAIAKLYQLPQSTSEISRIARKGSGSACRSLFG 162 Saccharomyces cerev...
AAG02446  80 RKEAglSL------------KASVISQNFVPTAAGLASSASGLAALAGACNTALKLGLDDLSLSRFARRGSGSACRSIFG 147 Enterococcus faecium
2GS8_A    86 RQPG--QA------------FVKXETQNNXPTAAGLSSSSSGLSALVKACDQLFDTQLDQKALAQKAKFASGSSSRSFFG 151 Streptococcus pyoge...
1FI4_A   183 GYVAWEXgkaedGhDSXAVQIADSsdwPQXKACVLVVSDIKKDVSSTQGXQLTVATSELFKERIEHVVPKrFEVXRKAIV 262 baker's yeast
AAG02451 149 PVAAWDK-----D-SGAIYKVETD---LKMAMIMLVLNAAKKPISSREGMKLCRDTSTTFDEWVEQSAID-YQHMLTYLK 218 Streptococcus pyogenes
P32377   163 GYVAWEMgkaedGhDSMAVQIADSsdwPQMKACVLVVSDIKKDVSSTQGMQLTVATSELFKERIEHVVPKrFEVMRKAIV 242 Saccharomyces cerev...
AAG02446 148 GFVEWEKgh--dDlSSYAKPVPSDsfeDDLAMVFVLINDQKKEVSSRNGMRRTVETSNFYQGWLDSVEGD-LYQLKQAIK 224 Enterococcus faecium
2GS8_A   152 PVAAWDKd------SGAIYKVETD---LKXAXIXLVLNAAKKPISSREGXKLCRDTSTTFDQWVEQSAID-YQHXLTYLK 221 Streptococcus pyoge...
1FI4_A   263 EKDFATFAKETXXDSNSFHATCLDSFPPIFYXNDTSKRIISWCHTINQfyGETIVAYTFDAGPNAVLYYLAENESKLFAF 342 baker's yeast
AAG02451 219 TNNFEKVGQLTEANALAMHATTKTANPPFSYLTKESYQAMEAVKELRQ--EGFACYFTMDAGPNVKVLCLEKDLAQLAER 296 Streptococcus pyogenes
P32377   243 EKDFATFAKETMMDSNSFHATCLDSFPPIFYMNDTSKRIISWCHTINQfyGETIVAYTFDAGPNAVLYYLAENESKLFAF 322 Saccharomyces cerev...
AAG02446 225 TKDFQLLGETMERNGLKMHGTTLAAQPPFTYWSPNSLKAMDAVRQLRK--QGIPCYFTMDAGPNVKVLVENSHLSEVQET 302 Enterococcus faecium
2GS8_A   222 TNNFEKVGQLTEANALAXHATTKTANPPFSYLTKESYQAXEAVKELRQ--EGFACYFTXDAGPNVKVLCLEKDLAQLAER 299 Streptococcus pyoge...
1FI4_A   343 IYKLFG 348 baker's yeast
AAG02451 297 LGKNYR 302 Streptococcus pyogenes
P32377   323 IYKLFG 328 Saccharomyces cerevisiae S288c
AAG02446 303 FTKLFS 308 Enterococcus faecium
2GS8_A   300 LGKNYR 305 Streptococcus pyogenes M1 GAS
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