Conserved Protein Domain Family
DisA

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COG1623: DisA 
c-di-AMP synthetase DisA, contains DisA_N, linker and DNA-binding domains [Signal transduction mechanisms]
Statistics
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PSSM-Id: 441230
Aligned: 112 rows
Threshold Bit Score: 411.065
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_127018056   1 MDEKLMEVLKIIAPGTPFREGLENILRAKTGALIVVGDSEE---VLGIVDGGFNINCELTPARLYELAKMDGAIILNKTA 77 
NP_603065      2 TKQDLMDIIVKVAPGSPLREGVDYILDAGIGALIIIGYDDE---VEKVRDGGFLIDCDYTPERIFELSKMDGAIILNDDC 78 
WP_012208214   1 mNEKLERIFELLAPGKPIRKGIDRIMEANLGALLFFCSQPEkhlKEGLIQLGFRVDSDFLPEKIYELSKMDGAIVLNSDG 80 
WP_015769716   8 EKKILEYIFGIVAPGTALREAIDKIQEAKLGALIVLGNPVD---LKDVIGGGFELNTVYSPQKVYELSKMDGGIILSTDI 84 
WP_012861904   3 RKEILTGIFSLVAPGTLLRDALGRIQEAGLGALIVIGDEES---LKYMIDGGFNLNVDFTPQKLYELSKMDGALMVSENL 79 
WP_014729964   2 ERSELIEKIKKIAPGTPLRHALDDIQDANVGGLLFFVDDYKk--YSHLMQIGFLLNCQFNPNKLYELAKMDGAIVVDDDL 79 
WP_013387948   3 NQKNLIDILSSVTPGTLLREGLDNILDAGTGALLIIGIDEN---IEAMLDGGFFINCEYNSQRIYELAKMDGAIILDYTA 79 
WP_052296041  11 KRKDWIKSLKLISPGNPLRDGVDLILDARGGALIVVGNPEK---TLPITVGGFPLDIEFTPARLFELSKMDGAIILNADA 87 
WP_014297200   3 PKNDITDILSLLAPGKKLRDGIDLIISANLGALIFLTDNAEehlSKGLIQLGFVIDTEFEPERMYELAKMDGAIVLNKDA 82 
WP_052670254   1 mNEKLGKIFNLLAPGKPIRKGVDRIMEANLGALLFFSSHPEdniKEGLIQPGFELNCDFLPEKIYELSKMDGAVVLNSDG 80 
WP_127018056  78 DRILIANAQLVPDPSIASFETGIRHRTAERVARQTGELIISISQRRDIISLYYGDSKYVLEDIRVILSKGNQAIQTLEKY 157
NP_603065     79 SKILYANVHVQPDNSYSTTESGTRHRTAERAAKHLKREVVAISERKKNVTLYKGNLKYRLKNFDELNIEVGQVLKTLESY 158
WP_012208214  81 TQILAANAQLNPDKSIPSSETGMRHKTAEKVSIQTGDLTVAVSKRRNIVSVYYNKMKYELLPENVLFARLNQEITIAQRY 160
WP_015769716  85 KTIYGANIQLQPNYSIQTDESGTRHQAAHRVAQQKGNLVVAVSERRNKITIYYGKFRYMLNEIGDLLTKSSQAITALEKY 164
WP_012861904  80 RKISYANIQLQPKATIHTDESGTRHRTADRVAKQTGNLVLAVSERRNKITIYKGSFRYEILDMKDILAKTSQALMALEKY 159
WP_014729964  80 TTIVGANVQLIPDHTIPTNQTGMRHRAAERMAKETGRMLVAISKRRNTMTIFLGDFAYTLNNVETLTSKITQTIRTAEKY 159
WP_013387948  80 DRILYANVHMQPDKNYTTDESGTRHRTAQRIAKQCNKLVIAISEKRNRITLYKGELRYKLRDIGEIMTEATQAIKTFERY 159
WP_052296041  88 KTILRANALLIPNPNIPTVNTGSRHQAAERFAKQTGELIIAISERRGVVTLYKGDLTYPLKSSASIMSRANQALTTLDSY 167
WP_014297200  83 TKILYANAQLNPSSNIPSFQTGMRHRTAERMAKQTDEILIAVSKRRNQVSIYYGTNSRVLYPETIILPRLNQEIAVAQRY 162
WP_052670254  81 TKILYANALLNPDKNIPSSETGMRHKTAEKIAIQTGDLTVAISKRRNIISVYYDKLKHELLPENVLFARLNQEITIAQRY 160
WP_127018056 158 RSVLDKVLNNLSSLEFDDLVTLADVTKVLQRIEMVLRIQKEIEGYICELGTEGRLLKMQLEELMANVREEGVLIIRDYIH 237
NP_603065    159 RHVLNRSLDSLTILELDDLVTVLDVANTLQRFEMVRRISEEITRYLLELGSRGRLVNMQVSELIWDLDEEEESFLKDYID 238
WP_012208214 161 RQSFMNLLDYLNIEETRGNVSLSDVVEILSKGLLTIKIVQRAEKYLLELGEIAGSAKLEYEEILRTVPKYVGAVIMDYSS 240
WP_015769716 165 SIAIEKNHINLSILEFDNMVTLYDIVECVRMYGLLFRMSEELIEYMAELGSEGRLIKIQYEEIMLNKNETFNALIKDYQV 244
WP_012861904 160 ATAIHHHLTNLTILEFDNMVTVNEVVEGIKKYGLLYRITDELDEYILELGSEGRLIVLQYEELMQGIKEDLYDLIRDYNN 239
WP_014729964 160 KEAFIEALQGIEFMERTGSLTLYDVVKTIQKGLMVALICEEAEFTIAELGNHGRFPSMQLAEILVNVNEEIESLILDFHE 239
WP_013387948 160 KTVLDKALANLTIMEFDDLATLYEVTTILQRFEMIFRIKQEVRNYVAELGVEGRLINLQLEELLQGLKDEKMNFIKDYYN 239
WP_052296041 168 KQVFNRSLEHLSVLEFTDSVTASDIANIITRAEMLKFIEEEIDTYIIQLGKDGLLTKWQLLELMSGVEEIEVLILKDYLS 247
WP_014297200 163 KQSFFELLSEINIAEMENRVILSTVVEAISKGFMTLKVAQKAEKYLLELGEAAESSKLEINEIYRITPRYLGALIMDYSK 242
WP_052670254 161 RQSFMGLLEYLNIEEIKEKVSLRDVVEVISKGMLTICITQKAERYLLELGEIAGSVRLEYEEILRSVPKLVGSVIMDYSV 240
WP_127018056 238 E-DLLAQkeeesdkldeesiaeektekiekerdkikkksremiAEEIIDELIDW-FSDDLLSLSTISKALGY---GSTLN 312
NP_603065    239 D---ETD------------------------------------TDSVRRYLHSL-SDSELLEVENVVVALGY---SKSSS 275
WP_012208214 241 EnLKYQR------------------------------------PEDATSIFKEL-DFNDLVDPFKIAKTLGYidvSSEDD 283
WP_015769716 245 N---NEK------------------------------------AEKIRVRLKSL-TKEELLDDEKIVSLLGF---DTDIT 281
WP_012861904 240 S---EET------------------------------------VDKIFSDIRKL-NKEELLELGKIAHIMGF---GKAYS 276
WP_014729964 240 ElLDQDS------------------------------------LEEVFDKMRSL-GEKEISSFGVILRNLGYd-iNTASQ 281
WP_013387948 240 SeKGEFD------------------------------------INHINLELDKL-TDEELLEQGKLSFILGY---GKNYS 279
WP_052296041 248 E-EKLAD------------------------------------IPKLLETLKQLkSEQDILDQFVVMKHLGF---NN--- 284
WP_014297200 243 DlLDFQY------------------------------------PQEALKLFDGF-KTEEFLNMKLISQKLGYd-iETEND 284
WP_052670254 241 EnLSYQR------------------------------------PEEALEIFNDF-GVDSLVRPLEVAKALGYndiESEDE 283
WP_127018056 313 VLDQFITPRGYRLLRKIPRLPMPVIENLVQTLGNFQRILNASIDELDDVEGIGEVRAKAIKEGLRHLRDRVG-------- 384
NP_603065    276 VFDNKIAAKGYRVLEKISKLTKKDVEKIVNTYKDISEIQEVTDEDFSAIK-ISKFKIKALRAGINRLKFTIE-------- 346
WP_012208214 284 LEETALTSRGYRILYST-KLPTSAVKKVVESFKNLQELMNATFEELTDISGIGKRRAEIILGTLNKKKREKEeieee--- 359
WP_015769716 282 NLDEKIEPRGYGLLSNITKISRKDREILVKEFSNVQSILMSTASDIAKLKGVSKFKAEHISKSLKRIKNKTI-------- 353
WP_012861904 277 NFDKRITPRGYRILSEIKRITKKDIELLIKAFNDLPEILDATSEDIAKIKGISKFKASSIVRGLKRLRNTLI-------- 348
WP_014729964 282 AVEYFIRSRGIRFARHIPRIPLQVAINLGKEFGTFSNLLESSEDELKDVDGIGEKRASAIRHAIDVYKKSGE-------- 353
WP_013387948 280 TLDNKVSPKGYRILGKITRLNKRDIEKIITEYDDLASIKDASVEDLYEIRGISKFKARSIKNGLKRLKFTLE-------- 351
WP_052296041 285 -PDQPLIPRGYRVLDNIPRLPSPIVEKIVGNYKNLNKLLGAKEEELDKIEGVGKIRAHQIVNCLMRMKEITKtfs----- 358
WP_014297200 285 LEEFFVTPRGFRLLYST-RIPSIIVRNVVETFKNLETLMKANMDELINVPGIGKKRAERINRAIRRKNEFSEkls----- 358
WP_052670254 284 LEEYGVSSKGYRLLYST-NLPSIVVRNVVETFKTLPELMKAKFEDLTTIPGVGKRRAEVILNALDKKKRNQEelnflans 362
WP_127018056 385 ------LDKYV 389
NP_603065    347 ------MQR-- 349
WP_012208214 360 --taqiISKEK 368
WP_015769716 354 ------VDRD- 357
WP_012861904 349 ------MER-- 351
WP_014729964 354 ------ITVPG 358
WP_013387948 352 ------LER-- 354
WP_052296041 359 ---srnINKIL 366
WP_014297200 359 ----seMEDHK 365
WP_052670254 363 eekapkVGT-- 371
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