Conserved Protein Domain Family
hppA

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PRK00733: hppA 
membrane-bound proton-translocating pyrophosphatase; Validated
Statistics
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PSSM-Id: 234827
Aligned: 338 rows
Threshold Bit Score: 573.241
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
225620277   1 MRKQDEGNETMKEIASHVRSGAIAYLKQQYKVIAFFFAGAFIIFail-----syaLKVQNPFIPIGFLTGGFFSTLSGFL 75 
302864951  43 VLAAGKGTTNMQEISGAVQEGASAYLLRQFRTLAIFVVIAVVLLfllpvhdtdgnETLVKAGRSAFFVVGALFSAFIGGA 122
271962068  45 VLAAGQGTERMQNIARAVQEGASAYLARQFRTLAVFVILIPFLLyll-----paeSTGVAIGRSVFFVVGAVFSALTGFI 119
297564247  45 VLAAGQGTERMRGIALAVQEGAAAYLKRQFRTLAVFVVLIPLLLlll-----padSWAIAIGRSVFFALGALLSAATGFI 119
269129011  46 VLAAGQGTEKMRNIARAVQIGAGAYLKRQFRTVAIFVVLIPLLLlll-----padDMAVRIGRSVFFVIGALFSAITGFA 120
72160538   73 VLAASQGTERMQNIARAVQEGAAAYLKRQFRTLAVFVIIIPLLLlll-----padTEAVRWGRSIFFAIGALFSAMTGFL 147
145596541  43 VLAAGRGTTNMQEISGAVQEGASAYLLRQFRTLAIFVVVAVLLLfllpvhetdgsETAVKIGRSAFFVIGALFSAFIGGA 122
159039926  43 VLAAGRGTTNMQEISGAVQEGASAYLFRQFRTLAIFVVVAVLLLfllpvhdtdgsETAVKIGRSAFFVVGALFSAFIGGA 122
291298029  42 VLATGKGTKKMQEIAGAVQEGASAYLKRQFRTLAIFVVIAMVLLwflpvhdvgdsETMVKAGRSAFFVVGAGFSAFIGWA 121
296268216  44 VLSAGQGTERMQNIARAVQEGAAAYLARQFRTLVVFVVVIPLLLlll-----papSTSVQIGRSVFFVVGALFSALTGFM 118
225620277  76 GMKTATYASARTANAA--SK--SLNEGLTIAFRSGAVMGLTVVGLALFDISLWFIVLNvwldnslfgtdflnlaatgiak 151
302864951 123 GMWLATRANLRVAAAAreREg-GREAAMKIAFRTGGVVGFLTVGLGLFGAALVVLIFR---------------------- 179
271962068 120 GMWLAVRGNVRVAAAAreS---GEKVAMRIAFRTGGVAGMITVGLGLLGAAIVVIVYG---------------------- 174
297564247 120 GMWLAVRGNVRVAAAArgGDdaSNRTAMRIAFRTGGVAGMITVGLGLFGAALVVLLYR---------------------- 177
269129011 121 GMWLAVRGNVRVAAAArdGDaaAERRAMRLAFRTGGVAGMFTVGLGLFGAAVVVLSYQ---------------------- 178
72160538  148 GMWLAVRGNLRVAAAAraG---EARAAMRIAFRTGGVAGMFTVGLGLLGAALVVLIYR---------------------- 202
145596541 123 GMWLATRANLRVAAAAreRVg-GRETAMRIAFRTGGVVGFLTVGLGLLGAALVVLFYR---------------------- 179
159039926 123 GMWLATRANLRVAAAAreRAg-GREAAMRIAFRTGGVVGFLTVGLGLLGAALVVLFYR---------------------- 179
291298029 122 GMGLATRANLRVASAArdG---SRTGAMAIAFRTGGVVGFLTVGLGLLGAAVVVMVFK---------------------- 176
296268216 119 GMWLAVRGNLRVAAAAkdQ---GEKAALRIAFRTGGVAGMFTVGLGLLGAAIVVLVYK---------------------- 173
225620277 152 gtaeytaakmHFVTTTMLSFGVGASFQALFARVGGGIFTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDVAG 231
302864951 180 ----------GDAPTVLEGFGFGAALLAMFMRVGGGIFTKAADVGADLVGKVEQGIPEDDPRNAATIADNVGDNVGDCAG 249
271962068 175 ----------GDAPAVLEGFGFGAALLAMFMRVGGGIFTKAADVGADLVGKVEQGIPEDDPRNAATIADNVGDNVGDCAG 244
297564247 178 ----------GDAPIVLEGFGFGAALLAMFMRVGGGIFTKAADVGADLVGKVEQGIPEDDPRNAATIADNVGDNVGDCAG 247
269129011 179 ----------GGAPGVLEGFGFGAALLAMFMRVGGGIFTKAADVGADLVGKVEQGIPEDDPRNPATIADNVGDNVGDCAG 248
72160538  203 ----------ADAPIVLEGFGFGAALLAMFMRVGGGIFTKAADVGADLVGKVEHHIPEDDPRNAATIADNVGDNVGDCAG 272
145596541 180 ----------GDAPTVLEGFGFGAALLAMFMRVGGGIFTKAADVGADLVGKVEQGIPEDDPRNAATIADNVGDNVGDCAG 249
159039926 180 ----------GDAPTVLEGFGFGAALLAMFMRVGGGIFTKAADVGADLVGKVEQGIPEDDPRNAATIADNVGDNVGDCAG 249
291298029 177 ----------GNAATVLEGFGFGAAMLAMFMRVGGGIFTKAADVGADLVGKVEQGIPEDDPRNAATIADNVGDNVGDCAG 246
296268216 174 ----------GDAPNVLEGFGFGAALLAMFMRVGGGIFTKAADVGADLVGKVEQGIPEDDPRNAATIADNVGDNVGDCAG 243
225620277 232 MGADLYESYAGSILAAMSLGSaafgyinpDVSPIFAVSLPMILAAIGTLSSIIGVFFVKTKEGatmGELLKSLRVGVYVS 311
302864951 250 MAADLFESYAVTLVAALILGR--------AAFGETGLVFPLIISTIGVLVAIVGVFITRLRASd--RNGLTAINRAFYLS 319
271962068 245 MAADLFESYAVMLVASLILGK--------VAFGTEGLVFPLIVPMVGVITAIIGIFTTSPRKGd--RNGMAAINRGFFIS 314
297564247 248 MAADLFESYAVVLVASLILGR--------VAFGTEGLVFPLLVPMIGVLTAIVGIFLVAPRARd--KTAMSAINRGFFIS 317
269129011 249 MAADLFESYAVTLVAALILGT--------VAFGTHGLVFPLIVPMIGVITAMIGIFAVAPRARd--RSGMTAINRGFFIS 318
72160538  273 MAADLFESYAVVLVASLVLGR--------VAFGTEGLVFPLLVPMIGVITAIIGIFVVSPRARd--ANAMAAINRGFFIS 342
145596541 250 MAADLFESYAVTLVAALILGR--------AAFGEQGLVFPLIVSGIGVIVAIIGVFITRLRTSd--RSGLTAINRAFYAS 319
159039926 250 MAADLFESYAVTLVAALILGR--------AAFGEEGLVFPLIVSGIGAIVAIIGVFITRLRASd--RSGLTAINRAFYAS 319
291298029 247 MAADLFESYAVTLVASLILGQ--------IAFGDTGLVLPLIIGAVGIVTAIFGVFITKLRASd--KNGLTAINRAFFIS 316
296268216 244 MAADLFESYAVTLVASLILGK--------AAFGTEGLVFPLLVPMIGVLTAIIGIFAVRTRSGd--RSGMAAINRGFFIS 313
225620277 312 SAIIIIVAFLLVKALLP-------------------------NNLGL----------FVSIIVGLIAGNVVGFFTEYYTA 356
302864951 320 ALIAAVLVAIAAFAYLPatf-------------------aelEGGLTdvdrnprlvaIGAVVIGIVLAAAIQALTGYFTE 380
271962068 315 AVISAVLVGVAVFLYLPssfag----------------ltgvSPEIAaitsdprliaIGAVLIGLVLASAIQILTGYFTE 378
297564247 318 AAISAVLVVGTAFWYLPssfdqlsgvspqvlaeieeagtnpdPRILA----------VAAVLIGLVLAAAIQLLTGYFTE 387
269129011 319 AIISALLVAVAAYGYLPssfael--------------ggvtdPQITAleadp-rlvaLGAVLIGIVLASAIQLLTGYFTE 383
72160538  343 AVISAVLVVGAALLYLPdtfael--------------egvpaDIAALdgnp--qliaIGAVLIGLLLAAAIQLLTGYFTE 406
145596541 320 ALISAVLVAIAAWTYLPasf-------------------aelTQGLAdvdqnprvvaIGAVVIGIVLAAAIQALTGYFTE 380
159039926 320 ALISAVLVAIATWAYLPatf-------------------gelAGGLTgvnenprvvaLGAVVIGIVLAAAIQALTGYFTE 380
291298029 317 AVLAAVLSAGAILATVPntwaalgvee------avhkgvpfsPQVTA----------IVAVVIGIVLAAAIMALTGYYTE 380
296268216 314 AVISAILVAVAAFAYLPssfael--------------sgvseEIRALtadp--rliaLGAVLIGLVLASLIQLLTGYFTE 377
225620277 357 AEYRPTQWVAEQSKTGPATVIIGGLAVGMQSTLIPVVTVVISIILAFGFaggfgaeasafsQGLYGIALASVGMLSTLGI 436
302864951 381 TNRRPVQDIGKSSQTGPATVILAGISVGLESAVYSALLIGAGVFGAFLLggs------sitLSLFAVALAGTGLLTTVGV 454
271962068 379 TNRRPVKDIGESARTGPATVILSGISVGLESAVYSALIIGAAVYGAFLLgfg------nvtIALFAVALAGTGLLTTVGV 452
297564247 388 TDRRPVREIGDSSETGAATVILSGISVGLESAVYSALLIAGAVYAAFLLggg------sitLSLFAVALAGTGLLTTVGI 461
269129011 384 TTRRPVREVTASARTGPATVVLSGISLGLESAVYSALVIGAAVYGAFLLgfg------nttVALFAVAMAGTGLLTTVGV 457
72160538  407 TNRPPVREIGESSRSGPATVVLAGVSVGLESAVYSALLIAGAVYAAFLLggg------nitVSLFAVALAGTGLLTTVGV 480
145596541 381 TDRRPVQDIGRSSQTGPATVILAGIGVGLESAVYSALLIGAGVFGAFLLggs------sitLSLFAVALAGTGLLTTVGV 454
159039926 381 TNRRPVQDIGRSSQTGPATVILAGIGVGLESAVYSALLIGAGVFGAFLLggs------sitLSLFAVALAGTGLLTTVGV 454
291298029 381 TEKRPVSDVAKTSLTGPATVILSGVSLGFESAVFSALVIGAGVYGAFLLggat-----amfVSLFAIALAGCGLLTTVGV 455
296268216 378 TNRRPVREIGESALTGPATVILSGVAVGLESAVYSALLIGAAVYGAFLLgfg------nvtVALFAVALAGTGLLTTVGV 451
225620277 437 TLATDAYGPIADNAGGNAEMS-GLPESVRERT-DALDSLGNTTAATGKGFAICSAALTAMALIAAYIEEIktslgrmint 514
302864951 455 IVAMDTFGPISDNAQGVAEMS-GDIDEHGARTlTELDAVGNTTKAITKGIAIATAVLAATALFGSYTDTLrsay------ 527
271962068 453 IVSMDTFGPVSDNAQGIAEMSgDVDGEGARVL-TSLDAVGNTTKAITKGIAIATAVLAATALFGAFRTAIetqlan---- 527
297564247 462 IVAMDTFGPVSDNAQGIAEMSgDVEGPGAEIL-TGLDAVGNTTKAITKGIAIATAVLAATALFGAFRTSVq--------- 531
269129011 458 IVSMDTFGPVSDNAQGIAEMSgDVHGEGAKVL-ERLDAVGNTTKAITKGIAIATAVLAATALFGAYRTTVetalag---- 532
72160538  481 IVAMDTFGPVADNAQGIAEMSgDVEGSGAEVL-NSLDAVGNTTKAITKGIAIATAVLAATALFGAFRTAV---------- 549
145596541 455 IVAMDTFGPISDNAQGVAEMSgDIDADGARTL-TELDAVGNTTKAITKGIAIATAVLAATALFGSYTDTLriay------ 527
159039926 455 IVAMDTFGPISDNAQGVAEMSgDIEADGARTL-TELDAVGNTTKAITKGIAIATAVLAATALFGSYTDTLrtay------ 527
291298029 456 IVAMDTFGPISDNAQGIAEMSgDIDEEAARTL-TDLDAVGNTTKAITKGIAIATAVLAATALFGSYTSAInval------ 528
296268216 452 IVSMDTFGPVSDNAQGIAEMSgDVDGEGAQVL-TSLDAVGNTTKAITKGIAIATAVLAATALFGSFRTAVetelaa---- 526
225620277 515 gnltsidigtvqytansakelydkvvysLGMNEFMNAFNIHLMNPKVLIGIFIGAMLVFFFCALTMKAVGRAAAGVVEEV 594
302864951 528 ------------------------edagVGDVGTEILNSLNVSNPRNLVGLIIGAAVVFLFSGLAINAVSRSAGAVVMEV 583
271962068 528 -----------------------asqgvKDVLGSFGTFSLSVDSPNVLVGLIIGAAVVFMFSGLAIMAVGRAAGRVVFEV 584
297564247 532 ----------------------------AQLGDADEAFSLSLDQPDVLVGVIIGASVVFFFSGLAIMAVGRAAGRVVMEV 583
269129011 533 -----------------------asagvRDALGTYADFSLSIDSPNVLIGLIVGAAVVFLFSGLAIMAVSRAAGRVVIEV 589
72160538  550 -----------------------------EAELGATEFSLSVDQPDVLVGVIIGAAVVFLFSGLAIMAVGRAAGRVVHEV 600
145596541 528 ------------------------adagITDVGGEILNSLNVANPRNLVGLIIGAAVVFLFSGLAINAVSRSAGAVVMEV 583
159039926 528 ------------------------adagIADVGGEILNSLNVANPRNLVGLIIGAAVVFLFSGLAINAVSRSAGAVVMEV 583
291298029 529 -------------------------aegGKLADGGIDVLLNIANPANIVGVIVGAAVVFLFSGLAVNAVSRSAGAVVFEV 583
296268216 527 -----------------------atqgvKDVLGSFASFSLSVDAPNVLVGLVIGASVVFLFSGLAINAVGRAAGRVVIEV 583
225620277 595 RRQFREIKGLLAGEkgVKADYEKAVQICTKSAQKEMIVPSVLAIIVPVVVGFLFGVPAVIGMLVGGLTAGFAMAVMMSNA 674
302864951 584 RRQFRELPGIMDRT--QRPEYGKVVDICTRDAQRELMTPGLLAILAPIAVGFGLGPGALAAYLAGAIGAGTLMAVFLANS 661
271962068 585 REQFRTKPGIMAGT--ELPDYGRVVDICTRDSLRELATPGLLAVLTPIAVGFALGYAPLGAFLAGAIACGTLMAVFLANS 662
297564247 584 RDQFRTRPGIMDGT--EKPEYARVVDICTKDSLRELVTPGLLAVLAPIAVGFALGYAPLGAFLGGAIAAGVLMAVFLSNS 661
269129011 590 REQFRSKPGIMNHT--QEPDYDRVVDICTRDSQRELATPGLLAIMTPIAVGFGLGYAPLGAFLGGAIAAGVLMAVFLANS 667
72160538  601 REQFRTRPGIMDGT--EKPEYGRVVDICTRDSLRELITPGLLAVLTPIALGFALGYAPLGAFLGGGIAAGALMAVFLANS 678
145596541 584 RRQFRELPGIMDRT--QRPEYGKVVDICTRDAQRELLTPGLLAIMAPIAVGFGLGPGALASYLAGAIGAGTLMAVFLANS 661
159039926 584 RRQFRELPGIMDRT--QRPEYGKVVDICTRDAQRELMTPGLLAILAPIAVGFGLGPGALASYLAGAIGAGTLMAVFLANS 661
291298029 584 RRQFREFPGIMDGT--QRPEYGRVVDICTRDAQRELMTPGLLAILAPIAVGFGLGAGALAAYLAGAIACGVLMAIFLANS 661
296268216 584 RDQFRNKPGIMDGT--EKPDYGRVVDICTRDSLRELATPGLLAVLTPIAVGFALGYAPLGAYLAGAIAAGTLMAVFLANS 661
225620277 675 GGAWDNAKKYIEAGNLGGKkiidektgekiTNPNHAAAVIGDTVGDPFKDTSGPSINILIKLMSLISVVFAGAIVA 750
302864951 662 GGAWDNAKKLVEDGAYGGK-----------GSDAHSATVIGDTVGDPFKDTAGPAINPLIKVMNLVSLLIAPAVVA 726
271962068 663 GGAWDNAKKLVEDGHHGGK-----------GSSAHEATIIGDTVGDPFKDTAGPAINPLLKVMNLVALLIAPAVVT 727
297564247 662 GGAWDNAKKLVEDGHHGGK-----------GSEAHAATVIGDTVGDPFKDTAGPAINPLLKVMNLVALIVAPSVVI 726
269129011 668 GGAWDNAKKLVEDGKLGGK-----------GSEAHAATVIGDTVGDPFKDTAGPAINPLIKVMNLVSLLIADAIVT 732
72160538  679 GGAWDNAKKLVEDGHYGGK-----------GSEAHEATVIGDTIGDPFKDTAGPAINPLLKVMNLVALLIAPSVVI 743
145596541 662 GGAWDNSKKMVEDGAYGGK-----------GSEAHAATVIGDTVGDPFKDTAGPAINPLIKVMNLVSLLIAPAVVA 726
159039926 662 GGAWDNGKKMVEDGAFGGK-----------GSEAHAATVIGDTVGDPFKDTAGPAINPLIKVMNLVSLLIAPAVVA 726
291298029 662 GGAWDNAKKAVEDGAHGGK-----------GSEAHDATVIGDTVGDPFKDTAGPAINPLIKVMNLVSLLIAPAVIM 726
296268216 662 GGAWDNAKKLVEDGHHGGK-----------GSEAHAATVIGDTVGDPFKDTAGPAINPLIKVMNLVALLIAPAVVA 726
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