Conserved Protein Domain Family
NADase_NGA
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pfam07461: NADase_NGA 
Nicotine adenine dinucleotide glycohydrolase (NADase)
This family consists of several bacterial nicotine adenine dinucleotide glycohydrolase (NGA) proteins which appear to be specific to Streptococcus pyogenes. NAD glycohydrolase (NADase) is a potential virulence factor. Streptococcal NADase may contribute to virulence by its ability to cleave beta-NAD at the ribose-nicotinamide bond, depleting intracellular NAD pools and producing the potent vasoactive compound nicotinamide.
Links
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Statistics
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PSSM-Id: 462169
Aligned: 2 rows
Threshold Bit Score: 946.087
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_008089183   1 MRDSKLSLMNKLLKASTVIALAGTIGSGFLIDHTTYTVSDNDGKKSAVKYESTKVMEANATSNKEDNHIMHTLDSAMHTS 80  Streptococcus i...
1_pfamImport   1 MRDSKLSLMNKLLKASTVIALAGTIGSGFLIDHTTYTVSDNDGKKSAVKYESTKVMEANATSNKEDNHIMHTLDSAMHTS 80 

WP_008089183  81 WEENSPGGGVGEVLSYKFDSPMHIGRVLIANGDVSSKENFYKKNRIAKADVKYYNGDKLVLFQKVELGDTYTKKPHHIEL 160 Streptococcus i...
1_pfamImport  81 WEENSPGGGVGEVLSYKFDSPMHIGRVLIANGDVSSKENFYKKNRIAKADVKYYNGDKLVLFQKVELGDTYTKKPHHIEL 160

WP_008089183 161 EKKLDVDRIDIEITEVHQGENSDILAVSEVTFGNLERDTFEKAFKKRRENWVTPKKADEFIKTADKYADKAIQMNAVASR 240 Streptococcus i...
1_pfamImport 161 EKKLDVDRIDIEITEVHQGENSDILAVSEVTFGNLERDTFEKAFKKRRENWVTPKKADEFIKTADKYADKAIQMNAVASR 240

WP_008089183 241 AEYYRMYVSRKYTYGKDFLEKLKEIYKASGASHITSKKDLMAAFDNPQRKFTIGRQENGLFVTSFAEDMALLFNDKGQLK 320 Streptococcus i...
1_pfamImport 241 AEYYRMYVSRKYTYGKDFLEKLKEIYKASGASHITSKKDLMAAFDNPQRKFTIGRQENGLFVTSFAEDMALLFNDKGQLK 320

WP_008089183 321 PVDKITEAKGVEDGKYNDGVYQYEFDSELTKNIDKLGYIRTASGDTPGASSLNIPGCQTWAGEHIENSESELIFPSVDVK 400 Streptococcus i...
1_pfamImport 321 PVDKITEAKGVEDGKYNDGVYQYEFDSELTKNIDKLGYIRTASGDTPGASSLNIPGCQTWAGEHIENSESELIFPSVDVK 400

WP_008089183 401 GLKSKAVLAEIDAKGYFEIIDPTLVGPGGEHKKVTGRFKIKKMQDR 446 Streptococcus ictaluri
1_pfamImport 401 GLKSKAVLAEIDAKGYFEIIDPTLVGPGGEHKKVTGRFKIKKMQDR 446
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