1D0K,1D0M,5ANZ


Conserved Protein Domain Family
Slt35-like
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cd13399: Slt35-like 
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Slt35-like lytic transglycosylase
Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).
Links
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Statistics
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PSSM-Id: 381602
Aligned: 34 rows
Threshold Bit Score: 72.3412
Created: 3-Dec-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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sugar bindingcatalytic
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:sugar binding site [chemical binding site]
Evidence:
  • Structure:1D0K: Escherichia coli lytic transglycosylase Slt35 binds 2 murodipeptides; contacts at 4A
  • Structure:1D0M: Escherichia coli lytic transglycosylase Slt35 binds bulgecin A and (Glcnac)2; contacts at 4A
  • Citation:PMID 7823320
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    ### #   #                                                 #      ###
1D0K_A       109 YGVPPEIIVGIIGVETRWGRVMgktrildalatlsfnyprraeyfsgeletfllmardeqddplnlkgSFAGAMGYGQFM 188 Escherichia coli
WP_018685322  72 PEITAPILAAQIETESHWNPDAy--------------------------------------------nDGSKATGLSQFI 107 Actinokineospor...
ADH93376     246 PEVTPSIIAAQIDTESGWNPKAq---------------------------------------------SPVGAQGISQFM 280 Arcanobacterium...
NP_357505     59 HAVPPDYFARLIWRESLFRASAv---------------------------------------------SPKGAEGIAQFM 93  Agrobacterium f...
KDN74825      55 PEVSPNLLAALLTQESGFNPKAs---------------------------------------------SPVGAQGIAQFM 89  Streptomyces ol...
AII11085     404 PEVSPVLVAGIVQQESGFNEKAvskg---------------------------------------dgvNQGGAEGMSQFM 444 Rhodococcus opacus
ADB52950     322 WNVSAALLAAQLYAESGFNPFAv---------------------------------------------STAGAQGIAQFM 356 Conexibacter wo...
WP_020498852  73 TEITAPLLAAQIETESGWNPHAh--------------------------------------------nPSSGAEGLAQFL 108 Sciscionella ma...
EET74828      96 SGFRPGVLAAQIETESHWRVGVv---------------------------------------------SHQGAKGIAQFT 130 Rothia mucilagi...
KEJ95809      64 HGLDAGFFARLLWQESRFDPHAi---------------------------------------------SPAGAQGIAQFM 98  Sulfitobacter s...

Feature 1          #                                    #                                        
1D0K_A       189 PSSYKqYAVDFSGDGhi--------nlWDPVDAIGSVANYFKAHGwvkgdqvavmangqapglpngfktkysisqlaaag 260 Escherichia coli
WP_018685322 108 PSTWAaYGTDGDGDGka--------dpRNPFDAIKSQAVYMCHLVdfvkstk---------------------------- 151 Actinokineospor...
ADH93376     281 PGTWAsVGRDGNGDGka--------dpFDPADAIISQGHYMCGQVealkrh----------------------------- 323 Arcanobacterium...
NP_357505     94 PGTARlRGLEDSFNI------------IAALEASSRYLSELNVQFg---------------------------------- 127 Agrobacterium f...
KDN74825      90 PSTWEtHGIDGNGDGkr--------dvWDPEDAIPSSAKYLCTIAedvkd------------------------------ 131 Streptomyces ol...
AII11085     445 PETWKaFGTDSGLDRsgkaeppnaadpFNPYDAIASEGRYLCHIAdylrphhd--------------------------- 497 Rhodococcus opacus
ADB52950     357 PGTAQaYGLSDPFDA------------PSAIDAQARMMRDLLRQFg---------------------------------- 390 Conexibacter wo...
WP_020498852 109 PSTWNtYKIDGNHDGtt--------dpTDPADAIPTQANYMCAQVrtihahp---------------------------- 152 Sciscionella ma...
EET74828     131 DDAWS-GGHYSFGNGgn---------vLNPHDAIAAQARYLAELRtrlakya---------------------------- 172 Rothia mucilagi...
KEJ95809      99 PATAAlRGLSDAFNP------------AEAMERSAHYLGELQRRYg---------------------------------- 132 Sulfitobacter s...

Feature 1                                             ####                                       
1D0K_A       261 ltpqqplgnhqqasllrldvgtgyqywyglpNFYTITRYNHSTh------------------------------------ 304 Escherichia coli
WP_018685322 152 -------------------------glngeiVDLALASYNAGPgnvqkyggi---------------------------- 178 Actinokineospor...
ADH93376     324 --------------------------glsgsIDLALAAYNAGLgnvltfhgi---------------------------- 349 Arcanobacterium...
NP_357505    128 ------------------------------nFGLAAAAYNAGEaglrnfiatgrlptetrdyvfaitgypvenwkdnppe 177 Agrobacterium f...
KDN74825     132 --------------------------vpgnkQSNMLAAYNAGSgavrkyggi---------------------------- 157 Streptomyces ol...
AII11085     498 -----------------------sgavkgdfTDLIIAAYNGGEgavvtyggi---------------------------- 526 Rhodococcus opacus
ADB52950     391 ------------------------------tVPLALAAYNAGPgavsgcgci---------------------------- 412 Conexibacter wo...
WP_020498852 153 -------------------------glsgntIDLALAAYNAGPgrvlqyggvppfpettnyia--------kirkiiqky 199 Sciscionella ma...
EET74828     173 -------------------------snedelQDVVLAGYNAGPgsvekyggv---------------------------- 199 Rothia mucilagi...
KEJ95809     133 ------------------------------nPGLAAVAYNGGErradg-------------------------------- 150 Sulfitobacter s...

Feature 1                   #          
1D0K_A       305 -----------YAMAVWQLGQA 315 Escherichia coli
WP_018685322 179 ---ppfpettnYVTKIRNLANT 197 Actinokineospora enzanensis
ADH93376     350 ---ppfaetqnYVKRIKELAAT 368 Arcanobacterium haemolyticum DSM 20595
NP_357505    178 kaapalddnrsFLDACVRLADT 199 Agrobacterium fabrum str. C58
KDN74825     158 ---ppyketqgYVRAITSLANK 176 Streptomyces olindensis
AII11085     527 ---ppfgqtqaYVPAVREHMKK 545 Rhodococcus opacus
ADB52950     413 ---ppypetqaYVARILGLLRG 431 Conexibacter woesei DSM 14684
WP_020498852 200 aatqptqtpggTAGAVISAARK 221 Sciscionella marina
EET74828     200 ---ppyeetqnYVKSIRELANS 218 Rothia mucilaginosa ATCC 25296
KEJ95809     151 -------ftqeDKGLVQETWEY 165 Sulfitobacter sp. H3

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