Conserved Protein Domain Family
T7SS_Rv3446c

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TIGR03931: T7SS_Rv3446c 
type VII secretion-associated protein, Rv3446c family, C-terminal domain
Members of this protein family occur as part of the ESX-4 cluster of type VII secretion system (T7SS) proteins in Mycobacterium tuberculosis and in similar T7SS clusters in other Actinobacteria genera, including Corynebacterium, Nocardia, Rhodococcus, and Saccharopolyspora. This model describes the better-conserved C-terminal region. [Protein fate, Protein and peptide secretion and trafficking]
Statistics
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PSSM-Id: 274863
Aligned: 14 rows
Threshold Bit Score: 117.189
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_003940733 295 DSRLTGSVTATAEDEVEIVEASKEQ-----------------ETPA--------PKTSI-------------SSIesga- 335 Rhodococcus ery...
WP_005524358 189 PGSPPPTLPQASARPSPTSQLAAVP-----------------QKPA--------STSNT-------------STI----- 225 Corynebacterium...
WP_010934380 158 dAALNSDDTKVAVGESKASEQAAAS-----------------ATTS--------APIHL-------------AGD----- 194 Corynebacterium...
WP_011013742 138 FTGPVDSRPVDKVAEISTQGETSIS-----------------NQPQ--------PQP----------------------- 169 Corynebacterium...
WP_006769743 158 GG----DTPVTTQEVEPQAAVTGTT-----------------QAPA--------PPTAT-------------AGTgvega 195 Corynebacterium...
WP_005322753 198 EGDAAPDASHPQPRAAEPSGDGAAE-----------------FAPA--------SPQPGmpgasdsgseelnPGE----- 247 Corynebacterium...
WP_005509753 283 GGIASENEGKQKHREASHAQAPPVT-----------------TPPVttppstskPVPDS-------------APV----- 327 Corynebacterium...
WP_011274106 255 NTASTGNTGIADSAASATGSLSVESeesfadepgsektgeeaTEPF--------PEPHR-------------RGV----- 308 Corynebacterium...
WP_011558539 159 qvvqvptppvaappprrsgrraipvlagalvaaagvgaavathgPA--------PPPAE-------------PS------ 211 Mycobacterium
WP_011727727 187 vdvlqravtdtpareperrprkvtvgvaavaimgmcttlaaheRPT--------DTVT---------------------- 236 Mycobacterium s...
WP_003940733 336 -----tpelTrVDVGSVAAEVP-----SDWk--LLSRGTSSGRTDLVPGSGADRKIVVIEKRLAeG-VGFDSVEAVLRQQ 402 Rhodococcus ery...
WP_005524358 226 ---------T-MEHGNIQVGLP-----HDY---RIEEQPDKPGMLIGRGADENLRVTMAIDPLF-D-ADPTAIFAELDAT 285 Corynebacterium...
WP_010934380 195 ---------MiAEHERIRVTLP-----RGY---VLALKPNDPSTVVATGPDPELRILLSAEPID-A-ADPPLIHQEIRNT 255 Corynebacterium...
WP_011013742 170 ---------TvLVTEDLLIEAP-----FGF------EMRSDEQSRYLEGPDPNLRIHVGVDPLH-G-ADAALVAEELRRL 227 Corynebacterium...
WP_006769743 196 ststvaaapAvLEGEGFLVAAP-----HGY---RLDSDDGDPGMHVLTGRDPDLRIHIALDPLH-G-LEPHLVAEEMELV 265 Corynebacterium...
WP_005322753 248 ---------KrLDVEGMSVVVP-----SGF---HT---KVEDGLVTATGKDPNLRILLAADEMF-N-VPADALFKEIHAQ 305 Corynebacterium...
WP_005509753 328 ---------VtLANAGVEARFP-----GGW---ELDSASPFDRLIAVDGGD--MRVLVLANPLS-QdMALEHLAAALSSS 387 Corynebacterium...
WP_011274106 309 ---------TtADQSSRRADIPisvnvDGW---HLGGATRAREEYIGDDEGMRVLVAAKETPLKtQ-EEMDAAMLGALND 375 Corynebacterium...
WP_011558539 212 ---------TlLVEGRAGVVVP-----ALWtvrRITDGGGSARVQITSPADPAVALHVTQSPLPrA-QSLEEVGGTLLGA 276 Mycobacterium
WP_011727727 237 ---------TgLVEGRVAVQIP-----RGWrveRVTDDAGSPRLQVFSPSGTDPVIHITQSPV-----GAGDVADTLRYA 297 Mycobacterium s...
WP_003940733 403 fsTFEDPLr-F-AE-FAVLDDAAGKRaVVYVEFPDDFSEVRWRVYVDNGRQVSIGCQYL-IGEWGSLEADCLRMWQSVEF 478 Rhodococcus ery...
WP_005524358 286 --INGDPT--L-TP-AESLGIGRGQE-KNYIENPGDGSTVHWIVWIDAGHVFSLGCHTRtAAANLPQRATCRKAAETLTI 358 Corynebacterium...
WP_010934380 256 --IDLDPA--L-S--LREDRLAKNVPvLAYQETPDDGSTIAWWAWVENKHLFSVGCHSK-TAQKVAHKAACRKAAETVHI 327 Corynebacterium...
WP_011013742 228 --ITEDPS--L--E-EIPAGEWGEKTtIDYRETPGDGSHVLWVTWFDTDRQLNVGCHSK-AAETLVHKAQCRNVIEHLTL 299 Corynebacterium...
WP_006769743 266 --IAQDPT-------LERQPTVDGR--IIYTEDPGDGSKVAWTTWFEADQQVSVGCHTR-LGANVVQQAACRTVLDSLRI 333 Corynebacterium...
WP_005322753 306 --VDEDPT-------LRDATDEAGR--LTYTEDPGDGSLVEWTTWEDRGHQMSVGCHTR-HNSNAVQKAACRMATESLVK 373 Corynebacterium...
WP_005509753 388 --VAGDET--K-SA-PERRQVLGTDVvVVEERLPSGNSIVLWHHKVMDGTQVSVGCQFR-GRTIASVRPICDQAVVSARP 460 Corynebacterium...
WP_011274106 376 --VSAGDS---------EVTVVSTQPvSYEENYPS--STTLWHVRLVDGHQISVGCQYR--QWNEQREKVCQEFVATARP 440 Corynebacterium...
WP_011558539 277 --LEAQPPgvF-TD-FHARDERGGRAvVTYRERRA-RHQTDWVVLVDDTLRIGIGCQSP-PDRTDAVRSACDAAVHSAHA 350 Mycobacterium
WP_011727727 298 --LEQAPA--GvFVdFDPDDRIADRPaITYREVRA-HREVRWAVVVDGPVRIAIGCQGR------EFHAACSAAVASAHA 366 Mycobacterium s...
WP_003940733 479 T 479 Rhodococcus erythropolis
WP_005524358 359 R 359 Corynebacterium matruchotii
WP_010934380 328 K 328 Corynebacterium diphtheriae
WP_011013742 300 K 300 Corynebacterium glutamicum
WP_006769743 334 g 334 Corynebacterium efficiens
WP_005322753 374 K 374 Corynebacterium pseudogenitalium
WP_005509753 461 V 461 Corynebacterium amycolatum
WP_011274106 441 E 441 Corynebacterium jeikeium
WP_011558539 351 V 351 Mycobacterium
WP_011727727 367 A 367 Mycobacterium smegmatis
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