Conserved Protein Domain Family
MetH2

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COG1410: MetH2 
Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]
Methionine synthase I, cobalamin-binding domain is part of the Pathway/BioSystem: Methionine biosynthesis
Statistics
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PSSM-Id: 441020
Aligned: 542 rows
Threshold Bit Score: 954.401
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_013043882  346 TTPAQRLSGLEALNIEADTGFINVGERTNVTGSPRFKKLIKADDFTAALAIAQSQVDKGAQIIDINFDEGMLDGEACMTR 425 
WP_011685902  320 SKHRAYYSGIDLVEAEDSNRPLLVGERTNVIGSRLFKNLIADEKWEEATDIARRQVRNGAHVIDVCLQSTDREELEDIRP 399 
WP_015769679  326 NKDFNDVSGLITLETP-KDRPIYVGERTNVIGSRIFKNLIASEKFDEATEVARLQIKGRADVIDICLANPDRDEIADMKA 404 
WP_013074393  329 ADHPPAVSGVEAVFLEGDNRPLLVGERTNVIGSRKFRELIQSGRFEEAAEIARAQVRGGAQIIDVCLADPDRDEYADMDQ 408 
WP_013505619  320 PATPFALSGIEYLPIE-PGELYLVGERTNVIGSRKFKRLIAEGNLDEAVEVARKQIRGGAHIIDVCLANPDRDEHTDMQA 398 
WP_013625903  313 QKAESAVSGIEPLWLEKTGRPILVGERSNVIGSRLFRDLIVGEHYEEGSEVARGQVKKGAHVVDICVANPDRDEYHDMVN 392 
WP_015254625  315 GSHPPAVSGIETVYIEPENRPYFVGERTNVLGSRMFKRLIAEGKYEEAAEIARAQVKNGAHVIDVCLQDPDRDELADMTR 394 
WP_015043771  322 AAERSSVAGLEAVWPEEENRPLLVGERANVIGSRKFKELIADEYYEEGSEIARNQVKKGAQIVDVCVANPDRDELKDMVS 401 
WP_102993344  315 TTHAPAVSGIEAVFLE-DNRPILVGERTNVIGSRKFKRLIAEGSYEEASEIARKQVKGGAQVIDICLADPDRDELADMER 393 
WP_123040654  315 GEHPPAVSGIETVYIEDANRPYMVGERTNVLGSRKFKRLIAEGKYEEASEIARAQVKNGAHVIDVCLQDPDRDETSDMKE 394 
WP_013043882  426 FLNLVASEpdiSRVPIMIDSSKWSVIEAGLKCVQGKCIVNSISLKGGEDEFKAQAKKILRYGASVIVMAFDE---KGQAA 502 
WP_011685902  400 FYEKLIRK---IKAPIMIDTTDPKAVELALTYCQGKSIINSVNLEDGEEKFERLCPIAKLYGAALVVGSIDEdklQAQAF 476 
WP_015769679  405 FLDKVAKF---AKVPLMIDSTDINVVKEGLTYLQGKGIINSINLEDGEKKFTDMAKVIKDFGASVVVGLIDE---EGMAV 478 
WP_013074393  409 FLKYVTRM---VKVPLMIDSTDPRVVELALQRSQGKAIINSINLEDGEKRFAQVAPLARRYGAAVVVGTIDE---EGMAV 482 
WP_013505619  399 FMAALMRS---IKVPFMIDSTDAAVVEVALQYSQGKAIINSINLEQGTERLDEVVPLLKTYGAAVVVGTIDEdpeHGMAV 475 
WP_013625903  393 FLSYVVKK---VKVPLMLDSTDAQVVEAGLKMIQGKAIINSINLENGLERFEQIVPLIHKYGAAIVVGLIDE---QGMAL 466 
WP_015254625  395 FLEQVVKK---VKVPLVIDTTDPRVIEASLKFSQGKAIINSINLEDGEEKFERVVPLVKKYGAAVVVGTIDE---RGQAI 468 
WP_015043771  402 FLPHVVNK---VKAPLMLDTTDPAVLEAGLRLIQGKAIINSINLENGRERFDEVVPLLRKFGAAVVVGLIDE---QGMAL 475 
WP_102993344  394 FLSFVTKK---VKAPLMIDSTDPQVIARALTYTQGKAVINSINLEDGEERFQEVLPLVKRFGAAVVVGTIDE---RGMAV 467 
WP_123040654  395 FLAFVTKK---VKVPLMIDSTDPNVVEMSLKYIQGKSIINSINLEDGEEKFERVVPVLHRYGAAVVVGTIDE---RGQAI 468 
WP_013043882  503 NQADKVAIAERSFKILtEEVGMDPQDIIFDLNILTVATGMEEHNNYAVDFIEAVREVKQKCPGARCSGGLSNISFSFRGN 582 
WP_011685902  477 TRERKVAVAERSYRLLtEKYGIPGEDIIIDPLVFPCATGDVNYIGGAVETIEGIRLVKQALPYAKTVLGISNISFGLPAA 556 
WP_015769679  479 SVERKLEIARRSYELLtKKYGIDERDIIFDTLVFPVATGDQKYIGSATATIEAIRQIKDEMPNVKTILGVSNISFGLPIA 558 
WP_013074393  483 TRERKLAVAQRSYQLLtEEYGIPPEDLIFDPLVFPVGTGDENYVGAAAETVAALRMLKERFPRSATILGISNVSFGLPPA 562 
WP_013505619  476 TAQRKLEIARRSYDILvNRYGLRPENIVFDPLVFPVATGDEQYRTSARETIEGIALIREEFPHCAITIGLSNVSFGLPPA 555 
WP_013625903  467 SREDKLRVAERSCQLLtERYALQPGDIIFDPLTFPVGTGDPKYLGSAKETIEGLRLIKEKIPACKTILGVSNVSFGLPTV 546 
WP_015254625  469 AREAKLEVARRSYDLLvNKYGLQPEDIIFDPLVFPVGTGDEQYIGSAKETIEGIRLIKQEMPRCQTILGISNVSFGLPPA 548 
WP_015043771  476 TRERKLEVAGRSYNLLvNEYGLSAADIIFDPLTFPVGTGDVKYLGSAVETIEGLRLIKAKYPECKTILGISNVSFGLPAA 555 
WP_102993344  468 SRERKLEVALRSYELLvEKYGIAPEDIIFDPLVFPVGTGDEQYIGSAVETVEGIRLIKEALPGTATILGVSNVSFGLPLA 547 
WP_123040654  469 TRQDKLEVAIRSHDLLvNKYGLQPEDIIFDPLVFPVGTGDEQYIGSAKETVEGIRLIKQALPKCQTILGISNISFGLPEA 548 
WP_013043882  583 npVREAMHAAFLHHACEAGLDMAIVNPGLLMDYQEMDPTLKTLVEDVLLNRN-----DEaT------------------- 638 
WP_011685902  557 --AREVVNSVFLYYCTKAGLDLAIVNAEKLERFASIPEEERRLAEHLLFNTPpagaeDEsLrtaaedwraqspeqkaain 634 
WP_015769679  559 --GREVLNTYYMQKAYEAGLDYAIVNTEKVIPMSEISDEEKELSENILFHTD-----DEnV------------------- 612 
WP_013074393  563 --GREVLNAVFLYHCTKAGLDYAIVNPEKLQRYASIPEEERRLAEALLFETG-----QEtL------------------- 616 
WP_013505619  556 --AREILNAVFLKHCVDAGLTMPIINPEMMVRYASIEAEDLQLAENLIFARG-----EDpI------------------- 609 
WP_013625903  547 --GREVLNAVFVHHNTLAGLDYAIVNAEKHKSYADIPEEERKLAEDLLFQTN-----DRtL------------------- 600 
WP_015254625  549 --GREVLNSVFLYECTKAGLDYAIVNTERLERYASIPEHERKLAEALIYDTN-----DEtL------------------- 602 
WP_015043771  556 --GREVLNAVFVYLNTVAGLDYAIVNSEKLERYATIPHEEKKLAEDLLLNTN-----DQtL------------------- 609 
WP_102993344  548 --GREVLNAVYLYECTKAGLDYAIVNTEKLERYASISEEERRLAERLLFDTNqa-nyDAvL------------------- 605 
WP_123040654  549 --GREVLNSVFLYECTKAGLDYAIVNTEKLERYASIPEEERRLSEELLYNTN-----DGtL------------------- 602 
WP_013043882  639 ----EKLIEHAEAIKE-GkitlgagtpeerinaamvqgmetlralferataeknpeilerfltsgtdavpaaaEKktadv 713 
WP_011685902  635 qfhiAAIAEHFRKAGA-R-------------------------------------------------------VK----- 653 
WP_015769679  613 ----SKFANFYREKKAiQ-------------------------------------------------------KV----- 628 
WP_013074393  617 ----ARFHDRFKDRPA-G-------------------------------------------------------PP----- 631 
WP_013505619  610 ----TPFADKFRERKT-Q-------------------------------------------------------QK----- 624 
WP_013625903  601 ----KNFTDFYRDKKA-V-------------------------------------------------------PV----- 615 
WP_015254625  603 ----AAFVAAFRDKAV-E-------------------------------------------------------KK----- 617 
WP_015043771  610 ----KAFTDFYREKKV-T-------------------------------------------------------EQ----- 624 
WP_102993344  606 ----AEFTAFYRDKKV-E-------------------------------------------------------EK----- 620 
WP_123040654  603 ----AEFVAAFREKKV-E-------------------------------------------------------KK----- 617 
WP_013043882  714 aSDWR-SGTVEERLSHALVKGIVAHVDADTEEARQKYARPLEVIEGPLMDGMKVVGELFGAGKMFLPQVVKSARVMKKAV 792 
WP_011685902  654 -KAAA-DMPLDQRLANYIIEGTKDGLIADLDRKRAEGATPLEIINGPLMAGMSEVGRLFNNNELIVAEVLQSAEAMKAAV 731 
WP_015769679  629 -VDTS-NMTMEERVANLVVEGSKKDLKICLDELLKKYS-PIEIINGPLMDGMDEVGRLFNNNDLIVAEVLQSAEVMKASV 705 
WP_013074393  632 -VRRE-TLSLNERLARCVVEGSKEGLLDDLSEALQSAS-PIEIINGPLMAGMDEVGRLFNDNQLIVAEVLQSAEVMKAAV 708 
WP_013505619  625 -ATSDeSLPVAQRLQSNIVEGSRENLHPRLDEAMAQMP-PLDVINGPLMAGMAEVGRLFNDNKLIVAEVLQSAEVMKASV 702 
WP_013625903  616 -HVQE-QLSWDQRLARNIVDGSKEGLEADLSEGLKTHT-PLELINGPLLKGMDEVGRLFNRNMLIVAEVLQSAEVMKAAV 692 
WP_015254625  618 -AKNTeSLTLEERLANYVVEGSKDGLFADLDEALKKYA-PLDIINGPLMRGMEEVGRLFNNNELIVAEVLQSAEVMKASV 695 
WP_015043771  625 -KQTS-GLSVEERLAGAIVEGSKEGLENDLYEALTKYR-PLEIINGPLMKGMEEVGSLFNRNQLIVAEVLQSAEVMKAAV 701 
WP_102993344  621 -KQSV-HLTLEERLARYVVEGSKDGLFSDLDEALTKYK-PLDIINGPLMAGMDEVGRLFNDNQLIVAEVLQSAEVMKASV 697 
WP_123040654  618 -QKAV-NLPLEERLASYVVEGSKEGLIPDLDEALGKYP-PLEIINGPLMAGMTEVGRLFNNNELIVAEVLQSAEVMKASV 694 
WP_013043882  793 AYLLPYMEAEKEgssgSSAGKFLIATVKGDVHDIGKNIVAVVLACNNYEVKDLGVMVDCETILKEAEEWGADIIGLSGLI 872 
WP_011685902  732 NHLEQFMEKADT----AARGKVLLATVKGDVHDIGKNLVEIILANNGYEVINLGIKVPPDVLIQAFREHMPDAIGLSGLL 807 
WP_015769679  706 SHLEQFMEKDES----SVKGTVIMATVKGDVHDIGKNLVGIIIGNNGYKVIDLGINTPAEKIREAIIEHKADFLGLSGLL 781 
WP_013074393  709 AYLEPHMEKAET----AKKAKILLATVKGDVHDIGKNLVEIILSNNGFEVVNLGIKVAPEVLIEAVRREEPDAIGLSGLL 784 
WP_013505619  703 DYLSQFMEADQV----TTRGTMVLATVKGDVHDIGKNLVDIIMTNNGYKVINLGIKIPSEQIIEAIEKHKPDFVGLSGLL 778 
WP_013625903  693 GILEKHMDKTEE----AIKGKLILATVKGDVHDIGKNLVEIILSNNGYQVINLGVKVSPEEIIKACREHKPDAVGLSGLL 768 
WP_015254625  696 SYLEPHMEKTET----SVKGKIMLATVKGDVHDIGKNLVEIILSNNGYEIVNLGIKVPPEAIIEAQRRENADIIGLSGLL 771 
WP_015043771  702 TILESQMEKAEE----AVKGKILLATVKGDVHDIGKNLVEIILSNNGYKVVNLGVKVSSEQLIEAARKEAPDAIGLSGLL 777 
WP_102993344  698 AYLEPHMDKAKT----HARGKVILATVKGDVHDIGKNLVEIIMANNGYEVVNLGIKVPPEQLIEAARRERPDMIGLSGLL 773 
WP_123040654  695 AHLEPHMEKSDS----ALKGSIMLATVKGDVHDIGKNLVEIILSNNGYKIINLGIKVPPEQLIEAYRAEKPDAIGLSGLL 770 
WP_013043882  873 TPSLDEMIFNAQEMQKRGFKQPLLIGGATTSKAHTAIKIAPHY-EQPIVRVGDASLVTEVCNNLLTEDsdrRTAYIAEVA 951 
WP_011685902  808 VKSTQQMVITATDLKAAGIDVPLLVGGAALSEKFTRTKIGPAY-SEAVCYAKDAMTGLSLMNRLMDPAe--REALIATST 884 
WP_015769679  782 VKSATEMVNTMEVLHEAGIDIPIFVGGAALTEKFTVNKIEPAYkNNIVIYSRDAMTALADLNKMIDEIk--FREFKEYLQ 859 
WP_013074393  785 VKSAQQMVVTAQDLRAAGVSLPLLVGGAALTAKFAYTRIAPEY-EGLVLYAKDAMEGLEIANRLVDPEg--RPELERKTA 861 
WP_013505619  779 VRSAQQMTTTAADMKAAGIDIPLMVGGAALSENFTSQKIQPQY-EGLAIYCRDPMECLALAGRLLDDDq--RQSVVEELW 855 
WP_013625903  769 VKSVQQMLVTAQEMRAENIKVPLILGGAALSRKFTEEKIAPAY-DAPAFYCQDAMEGLKVLQEYLYAHk--DTVIKANQD 845 
WP_015254625  772 VKSAQQMVTTAQDLKAAGIDTPILVGGAALTRKFTKTRIAPEY-DGLVLYAKDAMNGLELANKLMDPDa--RRELEEEHR 848 
WP_015043771  778 VKSVQQMLLTAQDLQAAGINTPLILGGAALSRKYTEEKIAPQY-GGPVLYARDAMVGLNLLNGLKRKPv--NDSGSYNAA 854 
WP_102993344  774 VKSAQQMVVTAQDLRKADIHVPMLVGGAALSRKFTDTRISPEY-NGPVLYARDAMNGLELANRLMNPEe--RDALEAELR 850 
WP_123040654  771 VKSAQQMVVTAQDLRAAGIDAPILVGGAALTRKFTKTRISPEY-DGVVLYAKDAMDGLDLANKLNDPEq--RSKIEEEHR 847 
WP_013043882  952 AEQEKQRQRFaARAkdtef--------lsledARAKrftCDwSKa----------------QLKAPNRPGITVDDHIDLE 1007
WP_011685902  885 TLEAPAAVEA-PAeplgp---------lstrrSRK----VR-TEl----------------PVPPAPYLERKVRDVPNLA 933 
WP_015769679  860 KRRELVTIKD-AKKleql----------kvkpTVSD---IK-DAdgtfdfskvelpkydfeKIYKPQTLNKQIITNIKAK 924 
WP_013074393  862 ELRASLTDRP-Aapavs----------tgsrpRRSS---VS-RTv----------------PVAVPPDCRRHLWRDYPFD 910 
WP_013505619  856 NKRLKREELS-QEaastr---------paastASQR---VQ-PVe----------------RVPLPPDLKRHVHMESDLQ 905 
WP_013625903  846 KGIDRRDEEA-RKRktfaqesrdthplnetglLRSQtdqIArPlp---------------gPIYVPSDLQRHVLLDFPLQ 909 
WP_015254625  849 ELKASLDNAR-EReqeet----------apaavRSN---VS-QDa----------------PVFTPPDFERRVLRDIPIS 897 
WP_015043771  855 KNNDQVGNAG-TISgnipdsisgsisdnhienKFSP---VS-FDg----------------PVCRPQHTAREILLDYPLT 913 
WP_102993344  851 AKRVKSQAANtevkas----------vqvaerRVSD---IN-RQa----------------PLFVPPDYEKHVYRDVPLA 900 
WP_123040654  848 AALAKLAEEEekpkel----------peatrtRRSN---IS-QDa----------------PVFTPPDFERHVLRNYPLA 897 
WP_013043882 1008 ALSEYFDYSPLFW-TWELKGVYpyile------------hkkyGEE-AQKIYADAQALLKRIIAEKRFRARSVVGLFPAN 1073
WP_011685902  934 DVWSYINPFMIYGrHLGYKGNFeka---------------laeHEEkALELFHNVEELKHEA--AQFMHVKAVWQFFEAE 996 
WP_015769679  925 DVFPFINLQMLIGkHLGMKWIVnnl---------------iekQDPrTIKLYNEILDIIENG--DEYFDIKAIYKFFPVR 987 
WP_013074393  911 HVQPYINLQMLLGrHMGLRGNVdkl---------------laeRDPkAVEWVERLNALIAEAKGEGLLRLHAVYQFFPSQ 975 
WP_013505619  906 TIFDHINPHMLYGkHLGYKG-Fpea---------------larGEAkAVQLQKQVQEIMDEIQRRGDIQPGAVYRYFQAH 969 
WP_013625903  910 EIIRDIDVKSLMKfYLGIGKKKpdtlqe---------mgsgfvRDTrEEELAHTIQQLFNEIVDQKMIKARGVYRFLPAR 980 
WP_015254625  898 QIVPYINMQMLLGhHLGLRGTVsdl---------------laaGDEkAVQLKEAVDGLIREAAEKKTLRLDAMYRFFPAQ 962 
WP_015043771  914 EIVPNLDLPFILRrYLGVKNKLrhpsqeeikaaesllldsadvPKDkSAEIQKFVQKFLEEIQEHKLITVNGVFAFYPAC 993 
WP_102993344  901 QLRPYINEQMLLGkHLGLKGNVael---------------laaGDEkACQLKAQVDELFAAAISDRLIRPHGCYRFFPAQ 965 
WP_123040654  898 HVLPYVNLQMLMGhHLGLKGNVeel---------------laaGDEkAVQLKESIDGILREAEGNSWLKPQAMYRFFPAQ 962 
WP_013043882 1074 -SVGD-----DIELYT--------DTersGVLNTLHSLRQQKkkdkgDTYFALADFVapk--dsGQ---VDACGAFAACI 1134
WP_011685902  997 -RDGN-----AIHLFA--------PGgasP-IHTFRFGRQRR-----EDGLCLSDYIlds--pdGK---RDHLALFVTTA 1051
WP_015769679  988 rKAGEkkedfKIEVLS---------DdlsTVLETFDFPRQKY-----GQYLSLNDYVnp--------dgIDYIGFFVATA 1045
WP_013074393  976 -SEGD-----DILIYD--------PEqpgRVIERFTFPRQGR-----EPYLCLSDYVrpv--esGE---MDYVAFFAVTA 1031
WP_013505619  970 rSSEN-----SITLLDsl----------eQPLRTISFPRNPG-----LD-LCLADYVhp---------eRDYLCLFIVST 1019
WP_013625903  981 -SAGN-----LVRILN--------PEnheEIQAEFLFPRQTA-----EPFLSPADYIqnp--inGK---TDYLGLFTVTT 1036
WP_015254625  963 -SDGN-----DILIYD--------PAgsgEIIERFSFPRQRT-----EPFLCLADFLkpv--esGV---MDVVGFLVVTA 1018
WP_015043771  994 -ANGN-----TVAILNsdpnpnlsPKasnIVLEELSFPRQQK-----DNGLCLADYVrpwnkldGQeqaYDYLGMFALTT 1062
WP_102993344  966 -ADGD-----TILIYD--------PNdhsRVIERFTFPRQTK-----GSYLCLADFVrpv--esGE---MDTVGFFAVTA 1021
WP_123040654  963 -SEGN-----DVIVYD--------PQdttKVLKRFSFPRQQV-----EPFLCLADFLksv--esGV---MDTVGFLVVTA 1018
WP_013043882 1135 E-GVDAFAQEFEDAHDDYSSIMVKAIGDRFAEALAEYTHARVRKElWGYaPDealdndqliqeeyRGIRPAAGYPSQPDH 1213
WP_011685902 1052 GaGIRERSEQWKKAGEFFKAHAIQALAIETAEATAEWLHRRIRED-WGFpDPptttmhdrftskyHGKRYSFGYPACPNL 1130
WP_015769679 1046 GeKSRLVSNELKEKGEFYRGHIVNSVGLELAEAASEYIHKMMRQD-VGIiDKdislne-ilnaqyQGNRYSFGYPACPDL 1123
WP_013074393 1032 GaGIRDKAEEWKARGEYVKSHFLQALALETAEAFAERLHGMIRDL-WGFpDPpdmtmrerfqakyRGIRVSFGYPACPNL 1110
WP_013505619 1020 GpKLGQLAQQEKEKGNYQRSHIMASLALEMAESLAEILHIRLRHM-WGIgEQsplpkqdlfgaryRGKRYAPGYSALPDL 1098
WP_013625903 1037 GvGLREKAQALKDGGQYLKSYLLQVISLKMAEAMAEKVHEIMRKE-WGLpERevsgnkeknrrryQGIRLSPGYPLCPDL 1115
WP_015254625 1019 GrGVRGLAEEAKERGDYFRSHALQALALETAEGLAERVHQMMRDV-WGFpDPpemtmkqrfaaryQGIRVSFGYPACPNL 1097
WP_015043771 1063 GlGIREKAENYRDKGEYLKSFLLQVLALELVEGFADIMHEKMRKI-WGId---------------NGIRVSPGYPIYPAL 1126
WP_102993344 1022 GlGVREQAEKWKEQGDYLRSHLLQALALETAEGFAERIHQVMRSA-WGFpDPvtmtmkerfaaryQGIRVSFGYPACPDL 1100
WP_123040654 1019 GqGARGQAETWKQNGDYLRSHVLLATALETAEGLAERVHQIMRDN-WGFpDPadmtmkqrfgaryQGIRVSFGYPACPDL 1097
WP_013043882 1214 TEKAIIWDLLQAeANTGATLTESFAMHPGSAVSGLYFGHPDAKYFQV 1260
WP_011685902 1131 DDQQGVWKLINP-DDIGVKLTEGMMMEPEASVSAIVFHHPDCAYFTA 1176
WP_015769679 1124 SDQRKLFNLLKP-ERYGISLTEEFMMYPEATVSAIVFSQPFCKYFNM 1169
WP_013074393 1111 EDQAKLFRLLRP-EEIGIRLTDGFMMDPEASVSALVFSHPEAVYFRA 1156
WP_013505619 1099 SVQEDLFALLHP-DELGVKLTESHMMDPEASTSGFVFHHPQARYF-- 1142
WP_013625903 1116 EAQRQIFKLLQP-EDIGITLTESLMMDPEASVSALVFAHPEARIFSL 1161
WP_015254625 1098 EDQEKLFKLMHP-EDIGVELTEGYMMEPEASVSAMVFAHPEAQYFNV 1143
WP_015043771 1127 EEQAKLFRLLKP-EEIGITLTENFMMDPEASVTAVVFSHPEAKIFNI 1172
WP_102993344 1101 EDQVKLFRLLEP-EEIGVALTEGFMMEPEASVSAMVFAHPEARYFSV 1146
WP_123040654 1098 EMQGPLFELMHP-EDIGVELTEGFMMDPEASVSAMVFAHPEAQYFNV 1143
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