Conserved Protein Domain Family
NTP-PPase_u4
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cd11541: NTP-PPase_u4 
Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea
This family corresponds to a group of uncharacterized hypothetical proteins from bacteria, showing a high sequence similarity to the dimeric 2-deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTP pyrophosphatase or dUTPase) and NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, members in this family consist of a single MazG-like domain that contains a well conserved divalent ion-binding motif EXX[E/D].
Links
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Statistics
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PSSM-Id: 212148
Aligned: 46 rows
Threshold Bit Score: 73.0291
Created: 12-Dec-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative metal
Feature 1: putative metal binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:E E E DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on sequence similarity to other superfamily members.
  • Comment:Most members of the NTP-PPase superfamily contain the well-conserved divalent ion-binding motif, EEED.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                              #  #                        #  #         
Q8Y5B6        5 EYQILANRTAath-------------eqaLTNYGLGITGEAGEVADLIKKyafhgh--dldkesLTKELGDVLWYVSQIA 69  Listeria monocyt...
NP_770574     7 EYAAWAASVAkvdeh---------psnerLSYLGLGLAGESGEVADHIKKllrddw---ldkagLVEELGDVIYYWACLC 74  Bradyrhizobium j...
CBW26318     17 EYVKLAIKTEstdfesmnt-rlqddglkrLLHAGIGLSTEAGEFLDALKKhifygk--eldrvnLAEEMGDLFWYLAIVA 93  Bacteriovorax ma...
EGT92009     13 ALVKKGQDILndmtp----------eqadLLHMGVGVSGESGELLDAIKKhaiygk--pldrenVIEELGDLEFYMERIR 80  Acinetobacter ba...
NP_640013    86 DDTKTLLMNGfdgkthniglgslaaidtrILHASLGVFTESAEICKALVNtiegqs---ldlvnLSEEFGDLNWYALGVF 162 Proteus vulgaris
BAJ72210     11 DYAAEIAATDvln-------------pndFNPVLQGLYGEVGGIMATAKKsvrertaypgfkkaAEEEFGDTLWYLAAIC 77  Acidovorax sp. K...
YP_737091    22 DYEQAVRDTDiin-------------qdeLNPILQGLFGEVGGIMSTAKKvtrdkeafpgstkaAEEEFGDTLWYLAALC 88  Shewanella sp. MR-7
ZP_01464698   6 EFAVAAEKTDtlvr-----------erdhKELLASGLLGEVGGVLAEFKKkkregpayplyegrLADELGDALWYFVRLA 74  Stigmatella aura...
AEQ53601     14 EYEQAIAPTDrfe-------------dseITPILLGLFGEVGSVMSTSKKlqrektaftgfqrdVEEELGDTLWYVAALC 80  Pelagibacterium ...
ZP_08872446   5 EYQRQANSTDqtadk---------netasWLTSVLGLAGRSGALATEYLRyvrdgaayqafnqhIGETLGDLLWYIANIA 75  Verminephrobacte...

Feature 1                                                                                       
Q8Y5B6       70 KWAdi--------------------------------------------------------------------------- 74  Listeria monocyt...
NP_770574    75 AATgq--------------------------------------------------------------------------- 79  Bradyrhizobium j...
CBW26318     94 DELgv--------------------------------------------------------------------------- 98  Bacteriovorax ma...
EGT92009     81 QIIgv--------------------------------------------------------------------------- 85  Acinetobacter ba...
NP_640013   163 PSAsg--------------------------------------------------------------------------- 167 Proteus vulgaris
BAJ72210     78 RRLqipleeifseaanhgnfknvgaasditegalayiavpvaatas---ldatlvrlgqsaaallgstparadliafara 154 Acidovorax sp. K...
YP_737091    89 RRLkypledifndatssampqrvgvasdfsegafgqifilpasqs----idktmfelghaaaalltdspsrdqivnfaks 164 Shewanella sp. MR-7
ZP_01464698  75 NVSasdllqtlpldtpgeagntaqtplvpilalgaaag------------------rvleaihranpdtlrvalqdtwhg 136 Stigmatella aura...
AEQ53601     81 RRLdvklsdmfarvldgngyavsiaanadpahpvaqvmtakdiapldsvllrlgeqaakllnldvtagtakdqvlsfvrv 160 Pelagibacterium ...
ZP_08872446  76 SKNnf--------------------------------------------------------------------------- 80  Verminephrobacte...

Feature 1                                  
Q8Y5B6       75 ----------sMETVAELNIEKLKRRY 91  Listeria monocytogenes
NP_770574    80 ----------qPSELLKASAAKIRRRI 96  Bradyrhizobium japonicum USDA 110
CBW26318     99 ----------nMDDVMERNIEKLKARY 115 Bacteriovorax marinus SJ
EGT92009     86 ----------sREETIAANMAKLGKRY 102 Acinetobacter baumannii ABNIH2
NP_640013   168 ---------ihYGRILETNIVKLAVRY 185 Proteus vulgaris
BAJ72210    155 yldaihaaelaFSEVARGNLRKARGAF 181 Acidovorax sp. KKS102
YP_737091   165 ylvslnaanmtFSNVVRSNIKKTRGAY 191 Shewanella sp. MR-7
ZP_01464698 137 lrvvaaaapieLVEASKRNRKKIESRW 163 Stigmatella aurantiaca DW4/3-1
AEQ53601    161 yieaiqaahvsFSAVLSSNMAKACGRF 187 Pelagibacterium halotolerans B2
ZP_08872446  81 ----------sLEHIAEVTVQPLEHES 97  Verminephrobacter sp. At4

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