Conserved Protein Domain Family
Fe-ADH-like
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cd08183: Fe-ADH-like 
Iron-containing alcohol dehydrogenases-like
This family contains iron-containing alcohol dehydrogenase (Fe-ADH) which catalyzes the reduction of acetaldehyde to alcohol with NADP as cofactor. Its activity requires iron ions. The protein structure represents a dehydroquinate synthase-like fold and is a member of the iron-activated alcohol dehydrogenase-like family. It is distinct from other alcohol dehydrogenases which contain different protein domains. Proteins of this family have not been characterized.
Links
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Statistics
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PSSM-Id: 341462
Aligned: 83 rows
Threshold Bit Score: 390.324
Created: 29-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activemetal binding
Feature 1:putative active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    #                                                
SKA86171    8 ATRIIFGRGavsQLPVLTlgl--gkKLLVVTGrdpq----rfmPILQTLee-rGLEVVIFPLLt-EPTVDDIRRGSATAl 79  Prosthecobacter de...
AMV16784    8 PRRIVFGWGrraELPQWAasl--grRALLVSGsrtlsangtlaALKESLta-aGLATLDVAEIhrEPEVEDVDAAVSRLr 84  Planctomyces sp. S...
OHB86412   14 PRQIVFGWGrrrEVGALArgl--grRAFVICGsrtllaggaldEISEAIrs-eGVEPVRIATIsrEPEVDDVDRVAALVr 90  Planctomycetes bac...
EDL57328    8 PQQINFGWGrfqETGNLAasl--gtRAFIISGsrslaasgvieELRQLLsr-aSIKSEFIRTIsnEPEVTDVDQTTRVLr 84  Gimesia maris DSM ...
OIJ18822    8 PPRIVTGWGtisTIGSEVsti--geRVMVIHTkrlvn-sslieEILLDLkn-hGVYVICEHVSsgEPTVEQVEMVLKKVe 83  Bacillus alkalidia...
OGS22142   12 PTKIVFGKGsinKLTREIkpg--ekQVLLVTGrsairssgllaRLENILk---DKTVTLFDKVypEPDIDIVDEGVKVAr 86  Elusimicrobia bact...
OGV43441   24 PAHIVFSNGlidRVGELAfectdakEVLIVTGahssvqsgllaRVEALLrkagSKGIIVYSGVtgEPTPAMVMQAVDRAr 103 Lentisphaerae bact...
SHI95144   21 PEIIRFGRGrikDLPELVrsf-vapGATVVLLggvsy-krlleQLQARMaa-eGVQCELISGIsgEPTNESVDATTQQVr 97  Malonomonas rubra ...
ADG66447    9 PKLVKFGPRvrnEVIPLAkal--arRAIVLVGsrtlrqsslcqQWLEDFqk-qLPVECSLQLParEPQVDDVNHLAHSLr 85  Planctopirus limno...
OIO75663    7 PTRVIFGRNainTLAKNVkhl--gkTSLIVCGkqsikesgllkRVVEMLns-eNIKTTVFDRVfsEPDTKIVEEGISVAr 83  Elusimicrobia bact...

Feature 1                   ###  #  #                                          ## #           
SKA86171   80 kt---gaEVVIGLGGGSAVDAGKAIAAVArqph--dllhYLEIVGKAQPLdn----ppLPFIAVPTTAGTGAEVTRNAVL 150 Prosthecobacter de...
AMV16784   85 esgvqpgDFVLAVGGGSAIDLGKAVAALAtnrqsetvkdYLEGVGRGLKLdq----ppLPCLAMPTTSGTGSEATRNSVI 160 Planctomyces sp. S...
OHB86412   91 sqgvspgDFMLALGGGAAIDLAKAVAAMAtndqsptvedYLEGVGRGLKLaq----epLPILAMPTTAGTGCEATRNAVI 166 Planctomycetes bac...
EDL57328   85 nlgagagDFLIGIGGGSGIDLAKATSAMItnqesetvvdYLEGVGRGLKLte----apLPLMAIPTTAGTGSEATKNAVI 160 Gimesia maris DSM ...
OIJ18822   84 eq---ncDFVIGVGGGSVLDLAKAVAGLKfpnr---kpvKDYFYGEKIPQk------gIPWVAVPTTSGTGSEVTPNSVL 151 Bacillus alkalidia...
OGS22142   87 an---ncSVVVGVGGGSVIDVAKAIASMCrqenfvsvadYMEVDGTKQLQip-----gIPFIAVPTTSGTGSEVTKNSVL 158 Elusimicrobia bact...
OGV43441  104 qe---qpDLILSLGGGSVIDCGKAVAALTaneg--sveeYLEGVGSRQRLeh----spLPHLAIPTVAGTGAEMTKNAVI 174 Lentisphaerae bact...
SHI95144   98 el---qpKLVIACGGGSVIDTAKAGAALAtngg--mvedYLEGVGSGRKIea----dpLPMIAIPTTSGTGAEMTKNAVI 168 Malonomonas rubra ...
ADG66447   86 elsagpdDVVIVVGGGSSIDMVKAACGLAtqkevrscqdYLEGVGTGAKLiq----apLRWIALPTTAGTGSEATRNAVI 161 Planctopirus limno...
OIO75663   84 en---dcNLIIGIGGGSVLDTAKAISGLTkiknissvsdYLEIDGTKNLSeeisavgtACFVAVPTISGSGAEVTMNAVL 160 Elusimicrobia bact...

Feature 1                ##                  #       #      #   #                             
SKA86171  151 VSae----hgVKASLRhp-smLPAVALVDPELARtcPPSVTAASGMDALTQCLEAYVssRAQSMTDALCVDGIRRAIRSL 225 Prosthecobacter de...
AMV16784  161 SSra----egFKKSLRsd-amVPAVVLVDPELTVsaPRNVTVWSGLDAITQLIESYItrNARPVPQALCLEGLQKAVPAL 235 Planctomyces sp. S...
OHB86412  167 SSyd----ppFKKSLRdh-riMPRIALVDPELTVsvPRAITAASGMDAITQLFESFIsrKAQPIPQALAIEGLRLALPAI 241 Planctomycetes bac...
EDL57328  161 SSya----ppFKKSLRae-qmIPDIVLCDPQLACsvPPEITARTGMDAITQLLESYIscRAQPIPQALCLQGLKLAIPAL 235 Gimesia maris DSM ...
OIJ18822  152 SDek-----nVKLSIRgdnswLAKVVILDPQLTVssPANVTAWSGMDALTQAVEAHTskGANALTEPYSLKATTLIANSL 226 Bacillus alkalidia...
OGS22142  159 INkk----lgTKRSLRsd-liLARTALVDPELTLslNKNLTAEPGMDALTHILEAYAakNSSSFTDVMAREGIELVKSSL 233 Elusimicrobia bact...
OGV43441  175 GLye----rgVKRSMRfd-smMPTAALIDPALTVpvPPRVTAHGGMDAITQLIEPCIsgKRKPETTLLAHEGLRHTHQAL 249 Lentisphaerae bact...
SHI95144  169 SNyr----kqYKKSFRde-rmIPDAVILDPELTTdlPSGVTVATGLDALTQLLESAIsrRRTETTTALACEALVKVPEAL 243 Malonomonas rubra ...
ADG66447  162 SSddsststpFKKSFRsd-elYAQAVFLDPEWTLslPRQVTISSGLDALTQLLESAIssRATPYTFMLSQQGLAWGLPAF 240 Planctopirus limno...
OIO75663  161 INsk----tgKKRSLRnp-clFAGLALVDPELTLtlPADITAIAGIDALCHLIEGYIskESNIVCDALSIRGMELVLNSL 235 Elusimicrobia bact...

Feature 1                                        #   #         #                              
SKA86171  226 ERavtdghdveAREDLALAAMFSGMALANAGLGAVHGFAAPIGGsfkAAHGAVCAALLAPVWAMnwaaikrdgdclirer 305 Prosthecobacter de...
AMV16784  236 PRlvddpadraAREAMSHAALLSGIALANSGLGMAHGVAAALGVtcgIAHGLACAVMLPTAMDLnrrarepematlg--- 312 Planctomyces sp. S...
OHB86412  242 AEavrdgssreARERMSQAALLSGMCLGNSGLGMAHGVAPALGVhcrVPHGAACAVMLPVALRVnapirqaelarla--- 318 Planctomycetes bac...
EDL57328  236 PEavengnsrrGREAMAHAALLSGIALANSGLGMAHGVAPALGIhckISHGLACALMLPATLKAnysvrqqqyaeiy--- 312 Gimesia maris DSM ...
OIJ18822  227 MVaykhpedqkARTDMALGSLLAGVALANARLGIVHGVAHSIGLhfnVPHGLVCGTLLPWAIEYnqdvsrdkyq------ 300 Bacillus alkalidia...
OGS22142  234 LKavknpddyeAREKMSMASLYGGILLANAGLGLVHAIAPFVSVmynVSHGLAVAVLLPHVLEYnave------------ 301 Elusimicrobia bact...
OGV43441  250 PVcherpndleARAAMSLASMLSGTCLSNSGLAMVHGIAAAMGAlfeLPHGLLCGLLLPHTLRYnreaaaeplala---- 325 Lentisphaerae bact...
SHI95144  244 LTcfrqpyslvARERMMIASAVSGICLANSGLGLAHAVASALGAvhrVGHGIACGVMLPHVMEYnksgaademaqa---- 319 Malonomonas rubra ...
ADG66447  241 EQllqepenldARGKMLSAAYLSGVALANSGLGAAHGVAAGLGAilpVPHGLACAVMLPHTLAYnfstsqsaleim---- 316 Planctopirus limno...
OIO75663  236 PElikdrnnisARTDIALASLYGGIMIANSGLTLAHGLGSVIGPkfsIPHGLACGIVLPGVLEYnlshskgnip------ 309 Elusimicrobia bact...

Feature 1                                                                                     
SKA86171  306 feaasrlilnddeGTPEKAATFLKELSLRLKIp-----TLGSFGITHLDLPEIATKAAqsssmKGNPVPLSQEELLDILR 380 Prosthecobacter de...
AMV16784  313 -riftgddrlsgaAGADAAVRFIRDYCQRLSVp----tRLRDLGVTKDQVEPLVLGSQgn-smNGNPRPISECELSDTLE 386 Planctomyces sp. S...
OHB86412  319 hllfgedtsadpqEAVQTLIAQVEKLCDTVGAp----rRLSDLGVTREKIPAIAASSRgs-smSGNPRELSDEELLQILE 393 Planctomycetes bac...
EDL57328  313 -rflypeqalsaeQAAESLIDEIQKLNDRIQIp----rRLSDVGVSPLQIPALVQSSRgn-smSGNPREIPDEELTQILE 386 Gimesia maris DSM ...
OIJ18822  301 ----eiaqangvgTSASDLENWVRTINMELGIp----ySIKEFGVAKKDLDRIVEESMpsgslKANPRTTSREELYEFLA 372 Bacillus alkalidia...
OGS22142  302 ----------ckdKLTPGLIAQVKEIAQELGIp----kGISVFGVKKQDLPELARKSLtsvsvKNNPRNIDIDGMLELLS 367 Elusimicrobia bact...
OGV43441  326 -laaflhrdpsdqRVLDDGIAAIAELNCRLGIp----pDFKFLALSPQDLERIAENASgs-smSGNPIPMTPELTLKFLQ 399 Lentisphaerae bact...
SHI95144  320 -faamlgekqvtgETVDRGIAKLKQLLKALEVp----sSLRLLPLLDEDLRLLAEKAQgn-slSGNPVEMDSEAVYQFLK 393 Malonomonas rubra ...
ADG66447  317 -arsaglsatpntSAATQLIERITHLVHLCQIp----qRLRNLGVTQEMIPQLVELSQgn-slQGNPRPISPAELEQWLC 390 Planctopirus limno...
OIO75663  310 ----edkiailkeLFGKNPATKIQQFMSGVNLptrltgLENFHHLTGNDLKEIAEESLntgsaKKNPVQVNPETVIEIIK 385 Elusimicrobia bact...

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