7D5I,5DOQ


Conserved Protein Domain Family
Cyt_bd_oxida_I

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pfam01654: Cyt_bd_oxida_I 
Cytochrome bd terminal oxidase subunit I
This family are the alternative oxidases found in many bacteria which oxidize ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II
Statistics
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PSSM-Id: 460282
Aligned: 526 rows
Threshold Bit Score: 173.379
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7D5I_A          6 LSRWQFGITTVYHFIFVPLTIGLAPLIAVMQTVWVATGNDTWYRLTRFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSR 85 
jgi:Vdis_1320  12 dvRVVTAVGVLAHLAMASSFLGTILLAVVAEYLYIRSHNQFWYNTARTFSVISTIFFGVGAAFGTLVEFGLVTLWSNFIS 91 
jgi:Cmaq_1686  17 aARWVSAIGILAHLSLASSFLGTILIAVIAEYLYLVKHDKDWYDKARMFSVVSTIFFGVGAAFGTLVEFGLVTIWSNFIT 96 
EQB65596       27 maelmtIVGIFVHAFFLIFALGFPIIVLTLESIGIVRKDNDFIKLARNASKLWGITFAAGAVTGTLVEFGLVVVWSGSIA 106
WP_013335786   21 namvmtiLGIYLHAVFVSFTLGFPLAILAWLIKWYRTGDALFLNYSKTLTMVWAVNFALGAVTGTIVEFGLLDIWPTSIL 100 Vulcanisaeta d...
Q9K5W2          9 MSRLLTILTLSFHIFYATIGVGLPFMIIIFHWLGIKKNDLHYILMARRLAKGFVVTVAVGVVTGTAIGLQLALLWPNFMQ 88  Bacillus halod...
WP_015881250    8 MSRALTALTLGFHVIFATLGVGVPLLILLAEFLGIRKKDPKYTLMARRWSRGYVVTVAVGVVTGTAIGLQLSLLWPNLMR 87  unclassified E...
WP_012957283    9 ySRILTGLTLGYHVIFATIGVGIPLLIALAEWIGIKRNDEHYRLLARRWARGFVITVAIGVVTGTAIGLQLSLLWPNFMQ 88  Alkalihalobaci...
WP_013486884    9 ySRILTALTLGFHVIFATIGVGIPLMIAIAEWMGIRRNDPHYTLMARRWARGFVITVAIGVVTGTAIGLQLTLLWPSFMQ 88  Evansella cell...
WP_013173429    9 fSRILTYVTLGFHVIFATLGVGVPLMIAIAEWMGIKRNDPHYTLMARRWARGFVISVAVGVVTGTAIAVQLALLWPNFMQ 88  Salisediminiba...
7D5I_A         86 FVGDIFGAPLAMEGLAAFFFESTFIGLWIFGWT--RL-PRWLHLACIWIVAIAVNLSAFFIISANSFMQ-HP--VG---- 155
jgi:Vdis_1320  92 LIGEAIVLPFYLE-LFAFLTEVIILPLYVFTWN--KIkNQVLHWIIGIAAAFGGYYSAYNILAVMASLSmRP--PG---- 162
jgi:Cmaq_1686  97 IIGSAIVLPFYLE-LFAFLTEVILLPLYVFTWG--KVrNGWVHWVIGLAAAFGGYWSAYNILAVMASLSmRP--PG---- 167
EQB65596      107 LIASMAAAPMIIE-LYAFLIEIVLIGTYLTTFNrfKK-WKGTHVLIGLGVLFGSNLSAYMILAVNSWMQ-VPwgTGsfva 183
WP_013335786  101 LFSSSAFIPLLYEATIAFIGEAVLVVLFIIAIG--RW-RAGYTLGILITAWLLGSLSGYFILTANAWMN-TPwgLGgiph 176 Vulcanisaeta d...
Q9K5W2         89 LAGHIIALPLFMEV-FAFFFEAIFLGIYLYTWD--RFdNQKKHLLLLIPVAVGGALSAFFITVVNAFMN-SP--SG---- 158 Bacillus halod...
WP_015881250   88 VAGQTIALPLFMET-FAFFFEAIFLGIYLYTWD--RFkNPWHHMLLGIPVAVGALFSGFFITTVNSFMN-QP--VG---- 157 unclassified E...
WP_012957283   89 VAGHAISLPMFMET-FAFFFEAIFLGIYLYTWD--RFkNKMYHFYLLIPVVIGASMSGFFITTVNAFMN-AP--TG---- 158 Alkalihalobaci...
WP_013486884   89 AAGHTIGLPMFMET-FAFFFEAIFLGIYLYTWD--RFkSKWKHFLLVIPIVIGATASAFFITSVNSFMN-VP--QG---- 158 Evansella cell...
WP_013173429   89 AAGHTIGLPMFMET-FAFFFEAIFLGIYLYTWD--RFkSKMKHFLLVIPIVIGATASAFFITSVNAFMN-YP--TG---- 158 Salisediminiba...
7D5I_A        156 -----------------------ARF--NPEt---------G------RAEL-E----SIFALF--TNNTAIAAF----- 183
jgi:Vdis_1320 163 -----------------------LEVinLYQ----------A------TGQN-VvgltDY--VVkwASPADAWNMfwwga 200
jgi:Cmaq_1686 168 -----------------------MIIqnL-A----------A------SNET-IagltSY--LVtwAKPTDAWNMfwwga 204
EQB65596      184 qtflpwvpslgpqvinpeklktlVTV--LPTig-------sGllsspgAFQLfSnftsNPWISL--FNPEQNVTY----- 247
WP_013335786  177 alypflpgy-gpdaanltatlnlAALllhyaingsgsvaltsmnftslVGTYlT----NPWLPM--VNPDAIVTT----- 244 Vulcanisaeta d...
Q9K5W2        159 -----------------------FEL--V-N----------G------Elt-----nmNPLLAM--LTVSMPTKV----- 184 Bacillus halod...
WP_015881250  158 -----------------------FDI--V-D----------G------Rla-----nvSPLEAM--FSPAMPTKM----- 183 unclassified E...
WP_012957283  159 -----------------------VEI--Q-N----------G------Vvt-----niNPLAAM--FNPATPTKV----- 184 Alkalihalobaci...
WP_013486884  159 -----------------------FNI--V-D----------G------Vlt-----dvSPLAAM--FNPATPTKI----- 184 Evansella cell...
WP_013173429  159 -----------------------FQL--V-D----------G------Vlt-----dvSPLSAM--FNPATPTKI----- 184 Salisediminiba...
7D5I_A        184 ----THAVSGAFLTAGVFVACVCAWWMVRs----------HrtggesaadAAT-MYRPATILGCWVTLVAAVALFF-TGD 247
jgi:Vdis_1320 201 nvfiFHGILAAVILTWSIIAAIYLYFYI------------R---------DKKpERLMMLKILVPTMAILTAIQGFvLGH 259
jgi:Cmaq_1686 205 nvfiFHGILAAAILTWSVVGAIYLYGYV------------R---------EHRpDQAKVLKVIIPGVAVMTAIEGFiLGH 263
EQB65596      248 ----FHNVLAALVITAFLTSSYLAYKILRg---------yG---------SKE-YNWKGLRVSFLIAAVASFLQAL-AGD 303
WP_013335786  245 ----LHTLFAAYAIGVGAVALAVSIRFF------------R---------THDnKYIKLLKPLLWILAVVLLIEPIvLGH 299 Vulcanisaeta d...
Q9K5W2        185 ----THVLATAYMTVAFTLAAIAAFRLMKgs-------etS-------------YYKKSLNVSMKIGFIFAIASAI-IGD 239 Bacillus halod...
WP_015881250  184 ----AHVLTSAILTSAFILAAIAAVQLLRqrrnqldkmsiE-------------YHKKGLRLTMTVALIFAIATAL-VGD 245 unclassified E...
WP_012957283  185 ----AHVLSSAYLTSAFVLAAIAAFALLKgk-------dhV-------------YHKKALHLTMTVAAVFAVATAL-IGD 239 Alkalihalobaci...
WP_013486884  185 ----AHVIITCYLTSAFILGAIAAYHIIKgn-------ahV-------------YHKKALHLTMVSAFVFAIGTAL-IGD 239 Evansella cell...
WP_013173429  185 ----SHVIITAYLTAAFILGMVAALKLLKns-------ksE-------------YHRKALHLNITAAAVFAIATAV-IGD 239 Salisediminiba...
7D5I_A        248 AQGKLMFEQQPMKMASAESLChSEQdP----SFSVLTVGTH------NNcDSVV---HLIEVPYVLPFLAEGKFSGVhLD 314
jgi:Vdis_1320 260 LQGELVLQDDPLKLAALEGMFwSG-----------------------------------LKVDPLTSFLAYGTFNHA-FW 303
jgi:Cmaq_1686 264 DQGELVLQFDPLKLAAIEGMFwKG-----------------------------------LKVDPLLSFFAYGTFNHA-FW 307
EQB65596      304 AQGRILYTFQRNIFNATEGIPaNGg-YdpivSLLLYGSPNHffpgsnY----------------LASLLPSGD-----TL 361
WP_013335786  300 FMGDDVVAYQPLKFTALTTLTgGS-------GVYGYEYYDP-----------------------VEALFAYGNPYHP-LY 348 Vulcanisaeta d...
Q9K5W2        240 FSGKYLAEYQPEKLAAAEWHFeTEErA----PLILWGILGE------DHev-----kYGIEIPYALSILAHSDPNAE-VI 303 Bacillus halod...
WP_015881250  246 FSGKYLAKYQPDKLAAAEWHFeTSSeA----ELILGGWLED------DG-QGGYevrGALKIPYALSILAGGVPNYE-VT 313 unclassified E...
WP_012957283  240 FSGKYLAEYQPEKLAAAEWHFeTSTeA----PLILGGVLDE------DQni-----rYALEIPYALSILAHGSPGAE-VI 303 Alkalihalobaci...
WP_013486884  240 LSGKYLHEYQPEKLAAAEWHFeTEAeA----PLILGGILTE------DNev-----kYALEIPYALSILAGGSPDTV-VV 303 Evansella cell...
WP_013173429  240 FSGKYLHEYQPEKLAAAEWHFeTEPgA----PLILGGILTE------DNdv-----rFALEVPYALSILAGGTPDTV-VT 303 Salisediminiba...
7D5I_A        315 G---VVDLqrsyee----------------------------kfgpgD-----YRPN------L-FVTYWSFRAMIGFLA 351
jgi:Vdis_1320 304 G---YFSWp-------------------------------------aY-----ERPPa----fV-FIFYWVF--MVIFGI 331
jgi:Cmaq_1686 308 G---YYSWp-------------------------------------aN-----VRPPlapfdfL-PIFYLGF--MVTLGV 339
EQB65596      362 GqltLSAT---------------------------------------N-----TYG---------PILHAIYYSMIISGV 388
WP_013335786  349 G---FQYYlsqcralgnttfgqlyseldpgmlgylgplanvtlaqncEaavlsMEP-------LaPLVSAFYYTMIGAGI 418 Vulcanisaeta d...
Q9K5W2        304 G---LNEFp-------------------------------------eE-----YQPp--------LIIHYFFDMMITIGM 330 Bacillus halod...
WP_015881250  314 G---LNEFa-------------------------------------kE-----DQPp--------LFVHYLFDAMVGIGM 340 unclassified E...
WP_012957283  304 G---LEEFp-------------------------------------qD-----ELPp--------LIVHYFFDAMVGIGM 330 Alkalihalobaci...
WP_013486884  304 G---LNDFd-------------------------------------eE-----YLPp--------LWVHYAFDLMVFIGI 330 Evansella cell...
WP_013173429  304 G---LNDFd-------------------------------------pD-----YLPp--------LWVHYFFDTMVFIGM 330 Salisediminiba...
7D5I_A        352 VPGLF---ALAAL---Wltrggr--------------ipdqrwFSWFALLTIPT-PFLANSAGWVFTEMGRQPWVVvpnp 410
jgi:Vdis_1320 332 LLGIW---SGA-LslwYlfpgffgsf--------swaralanfFERSGVYLMPFfAAFASIGGAVSAESGRYPFILvqad 399
jgi:Cmaq_1686 340 LLGVW---SGG-LslwYlfngffsrf--------nwarviasfLERTGPYAMPLfAALAAIGGAVTSESGRVPFILvdss 407
EQB65596      389 IIVILgvgYFG-LyskIlrgivqgi----------lrmkvetfVLYGSFAGAAL-GIIASVAGWATREMGRHPWTV---- 452
WP_013335786  419 LLAVA---AVLALftyLvrvpvlsaitdfinneilgvligadnVMPFLASAMAVlSAVAATAGWAAREIGRQPWTV---- 491 Vulcanisaeta d...
Q9K5W2        331 FMLAL---SFV-----Flvarwrnw-----------sfvdkngYRWLIVMGAPL-SFLAIQAGWWMAEVGRQPWIL---- 386 Bacillus halod...
WP_015881250  341 LLALI---SFL-----Fvlgryikr-----------lnqfskpMLFAIAAGGPL-AMAAIEFGWFFAEFGRQPWAL---- 396 unclassified E...
WP_012957283  331 FLALV---SVA-----Yvfiqrtkr-----------wnehnrlLLWAIFIGGPL-SIIAIEMGWFFAELGRQPWIL---- 386 Alkalihalobaci...
WP_013486884  331 YLAAV---SAI-----Fvfinwtkk-----------wnaftkpLLWAVVAGGPL-SMIAIEAGWFFTEVGRQPWIL---- 386 Evansella cell...
WP_013173429  331 YLALI---AVA-----Fslagvkhrlnp-----lknlnplspwLLKLIVAGGPL-SMLAIQSGWIMAEVGRQPWII---- 392 Salisediminiba...
7D5I_A        411 -------tgdQDIrLTVAQG-V-SD---HSVGLVVL-SLVAFTLVYAVLAVIWFFLLRRYIVQG 461
jgi:Vdis_1320 400 pnpngsppiitG--VPVGPGgLlNPtlyFPVWLAVL--VLIVEIAMPSLAVFMVYLYLRRApky 459
jgi:Cmaq_1686 408 pnpnggpptvtG--VPIYEGgLiNPnlsLPGWLVAL--IIIVEVAMPALAVYMVYLYTKPKEVK 467
EQB65596      453 ----------YGL-ITYNDV--------VNSHAITPvFTAAIIALEIAILLAGIWGIYMIYFKK 497
WP_013335786  492 ----------YGL-ITTNEV--------VTVDAITPgFVAFVVAVLLAIAVVGALAMYYVATRp 536 Vulcanisaeta distributa
Q9K5W2        387 ----------RGI-MTVDEA-A------TTAAYVDV-VFLGFVLLYLILGIGTIVVLRRMFRKR 431 Bacillus halodurans
WP_015881250  397 ----------YEL-MRTSEA-A------TTSANVGW-MLVAFAILYAVLGTVTVVVLSRLFKEN 441 unclassified Exiguobacterium
WP_012957283  387 ----------VGY-MTTAEG-A------TTSAHVDL-MLYLFIGLYLILTITCITVLRKLFSSN 431 Alkalihalobacillus pseudofirmus
WP_013486884  387 ----------NGV-MTVSEG-A------TTSQHVDI-LLYVFVVLYAILGVTCVVVLRRMFKTN 431 Evansella cellulosilytica
WP_013173429  393 ----------NGV-MTVSEG-A------TTSDNVDI-MLWLFIALYAVLGVTSYIVLQKMFKEN 437 Salisediminibacterium seleniti...
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