Conserved Protein Domain Family
DUF4157
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pfam13699: DUF4157 
Domain of unknown function (DUF4157)
This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. This domain contains an HEXXH motif that is characteriztic of many families of metallopeptidases. However, no peptidase activity has been shown for this domain.
Links
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Statistics
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PSSM-Id: 433412
Aligned: 94 rows
Threshold Bit Score: 48.3716
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
jgi:Pmen_2644     77 PIPLMIRAQLAPFYDDAlLDEVRFRVGitdemDAATVMLQNPDVQAVTLVDVVVF---RDAEAAASDAALWAHELWHVQQ 153 
jgi:RoseRS_1661  708 LLSESNRRFLRAAVGVD-PATVRLSRG-----QDAGRLTSAYRADAVTFGDDVALapgR-GDETAEGLGLLAHELTHVAR 780 
jgi:Afer_1419    610 PLPA-VLEPLASALGVR--GPVEVQSG-----PLTRRSLRALGTVAATVGQTIFLe--RPVDRSPGALGVIAHELVHVAS 679 
jgi:Amir_4350     91 PLPLGVRREAEAFYGVD-LSPARVHDD-----VVAQRATEAFDAKALTVGAHVFL-----PPKVANDRTVVGHELSHVSS 159 
WP_013006022     111 ALPSSVVAKAGAFFQNDrLSATRVHRG-----EVAQRATTAMGAEAMTIGHHVFL-----SATAAADERLMGHELSHVDK 180  Streptomyces
Q9L0N6           113 TLPGSFLDKAVPFYDNPaLAGARMHTG-----PVAQRATAAMGAEAMTIGMDVFL-----GPSAIGNEEILAHEASHLDK 182  Streptomyc...
WP_013006449      74 PLPGAFLTKAKAFYGNDaLSAGRVHDN-----ATAQRATAALGAQAVTIGSHIFL-----GASAVGDTETLAHETSHLDK 143  Streptomyc...
WP_011958492      82 NPEDDLRERASRATNYD-LSHAAIHRN--------SPLAAASGVEAFALSQEIHVapgRYQPETPHGAHVLLHELAHVAQ 152  Roseiflexu...
jgi:Hoch_1195    223 SLPARFRARMERAYGQR-LEHVRIRQD----------SDLTADQQAVTRGRDIFLa-pEVRPDSPEGERVLAHELAHVAQ 290 
Q82QW5            49 EVPTAARTLIERATDLS-LGHVRLHTG-----PAVRTAARAAGVAGFTLGPDIAV---ATGPGEGAPDRLLRHELMHAAQ 119  Streptomyc...

jgi:Pmen_2644    154 YRDWG 158 
jgi:RoseRS_1661  781 RRDPT 785 
jgi:Afer_1419    680 G-DTG 683 
jgi:Amir_4350    160 NLAGV 164 
WP_013006022     181 NLKGV 185  Streptomyces
Q9L0N6           183 NSRGI 187  Streptomyces coelicolor
WP_013006449     144 NLRGI 148  Streptomyces scabiei
WP_011958492     153 QGNDS 157  Roseiflexus sp. RS-1
jgi:Hoch_1195    291 QARPN 295 
Q82QW5           120 QTMTR 124  Streptomyces avermitilis
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