3DAA


Conserved Protein Domain Family
D-AAT_like

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cd01558: D-AAT_like 
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D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.
Statistics
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PSSM-Id: 238799
Aligned: 26 rows
Threshold Bit Score: 316.462
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Citation:PMID 7748903

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
3DAA_A        4 LWNDQIVKDEEVKIDKEDRGYQFGDGVYEVVKVYn-------GEMFTVNEHIDRLYASAEKIritipyTKDKFHQLLHEL 76  thermophilic bac...
NP_682833     3 LCNLDGVITPEASISVLDRGFLYGDSVYEVIRTYr-------GIPFALPEHLARLRASAAYLymrlpwSDEYITQEVQRT 75  Thermosynechococ...
NP_243677     5 LYQDQLVPREQLKIDPEDRGYHFGDGIYEVVHVYh-------GKAFALSDHLTRFKESAEKLdlpmlySTDKLGELVQQL 77  Bacillus halodurans
NP_692004     8 LTQSEFKDKDSLNYPFEERGLQFGDGIYEVIRVYe-------GKYYLFEEHVDRLYRSAEAIkieipqSKKEMKELLLQL 80  Oceanobacillus i...
O07597        4 LVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYk-------GVLFGLREHAERFFRSAAEIgislpfSIEDLEWDLQKL 76  Bacillus subtilis
NP_347428     6 YYNGEYDLIENMKIPMNDRVCYFGDGVYDATYSRn-------HNIFALDEHIDRFYNSAELLrikipyTKKEMKELLKDM 78  Clostridium acet...
NP_841527     3 YLNGKFLPMEQATVPVLDRGFIFGDGVYEVIPVYs-------RKPFRLGEHLSRLQHSLDGIrlqnphTEEQWAGLIERI 75  Nitrosomonas eur...
ZP_00032528  14 YLNGELVPLSEARVPVLDRGFIFGDGIYEVAPLYahpahaggRTPFRFQQHLARLARSVDRIgivnplNDAGWRALIAQV 93  Burkholderia fun...
CAD90964      5 FVNGKYCCQSEAKISIFDRGFLFGDSVYEVLPVYh-------GQPYFVDQHLDRLFSNMKKIkm--iiPNYDWHGLIHRL 75  Legionella pneum...
ZP_00067067  20 WLNGTIIPASEASVSVLDHGLLYGDGVFEGIRFYn-------GKVFKLAEHLQRLFDSAKILqlampyNGQQLTRATQAL 92  Microbulbifer de...
Feature 1                                                                                       
3DAA_A       77 Vekn-------elnTGHIYFQV--TRGTSprahqfp-entvkpVIIGYTkenpr-plenlEKGVKATFVEDirw----lr 141 thermophilic bac...
NP_682833    76 Laa---------apAGEYYIRIvvTRGGDrrigllpepttqprLLIVLMgippe--ptlsEQGIRLAIPKRqrtstaald 144 Thermosynechococ...
NP_243677    78 Iekn-------kleHGMVYFQM--TRGISprnhly--trnetpVLTGFSkplp----dekRESVRLYLTDDirw----lr 138 Bacillus halodurans
NP_692004    81 Itkne------mttDGKVYMQI--TRGSAprdhif--pqsvepNMYAYVqdmpr-nkealQHGVSTITQPDirw----en 145 Oceanobacillus i...
O07597       77 Vqen-------avsEGAVYIQT--TRGVAprkhqy--eaglepQTTAYTftvkk-peqeqAYGVAAITDEDlrw----lr 140 Bacillus subtilis
NP_347428    79 Vkkv-------dsgEQFVYWQV--TRGTGmrnhafl-sedvkaNIWIVLkplk---vkdmSKKLKLITLEDtrf----lh 141 Clostridium acet...
NP_841527    76 Ieln-------egdDQYLYLHI--TRGVAkrdhaf--prevtpTVFIMSnplpappakllVSGVSAITARDnrw----gr 140 Nitrosomonas eur...
ZP_00032528  94 VaaneaggglragqDAIAYIQV--TRGVAkrghaf--pagiqpTVFVMVtplslpdaaqrAQGVRCVTAEDrrw----ln 165 Burkholderia fun...
CAD90964     76 Isen-------nggNLQVYIQV--TRGNQgvrkhdi-ptsitpSVIAFTmhnpfptledkEQGMSAKLVEDfrw----mr 141 Legionella pneum...
ZP_00067067  93 Ida---------cqWSNGYIRLvvTRGQGpmgldp--rpchspNVFIIVgqlsvvgddirKRGAKVIIASTrrlgadgld 161 Microbulbifer de...
Feature 1          #                                                                            
3DAA_A      142 cDIKSLNLLGAVLAKQEAhEKGCYEAILHR-NNTVTEGSSSNVFGIKD-GILYTHPAnnmILKGITRDVVIACANEINMP 219 thermophilic bac...
NP_682833   145 pAAKTGNYLNNILALLEAqQAGFEDALLLNaQGQITEATTSNFWIVRG-GVVETPPTtvgMLHGITRGTLLQIVADLGIP 223 Thermosynechococ...
NP_243677   139 cDIKTINLLGNVLAKREAtDHQCDEALLHR-DGTVTEGSSSNVFLIKN-ETLYTHPAtnlILNGITRQITIRLAKAKGYT 216 Bacillus halodurans
NP_692004   146 cYIKSLNLLPNVLAKQTAkEQGCYEAILHR-DGKVTECSASNVYLVKN-GKVYTHPTtnnILYGCVRMAVERFLKAANIE 223 Oceanobacillus i...
O07597      141 cDIKSLNLLYNVMTKQRAyEAGAFEAILLR-DGVVTEGTSSNVYAVIN-GTVRTHPAnrlILNGITRMNILGLIEKNGIK 218 Bacillus subtilis
NP_347428   142 cNIKTLNLLPSVIAAQKTeEAGCQEAVFHR-GDRVTECAHSNVSIIKD-EILKTAPTdnlILPGIARAHLIKMCKKFEIP 219 Clostridium acet...
NP_841527   141 cDIKAISLLPNILLRQLAvDAQAMETILLR-DGLLTEGAASNIFIVKD-DLLLTPPKdhrILPGITYDVVLELAETHGVP 218 Nitrosomonas eur...
ZP_00032528 166 cDIKSVSLLGNVLMAQYAaENDAFETIQFR-DGMLTEGSSSNVWMVKD-GVLSAPPRshkILEGIRYGLIEELAGECGIR 243 Burkholderia fun...
CAD90964    142 cDIKTTSLIANILLNDEAvSAGFHTAILAR-NGLITEGSSTNVFIVAQdGVIKTPPMnnfCLPGITRQVVIEIIKKLDLK 220 Legionella pneum...
ZP_00067067 162 pRIKSLNYLNHILARMEAnVAGADEAILLNaAGRVAEGSADNVFVVRH-GELLTPPViegALAGITRQTIIDLANALNIS 240 Microbulbifer de...
Feature 1                                                            
3DAA_A      220 VKEIPFTTHEALKMDELFVTSTTSEITPVIEIDGkliRDGKVGEWTRKLQKQF 272 thermophilic bacterium PS3
NP_682833   224 HREVILTPQDLAEASEGFLSSSVRLLMPIRQVNEv-iFPACPGPVTQQLWREL 275 Thermosynechococcus elongatus BP-1
NP_243677   217 VVEEPFPKEVIKDADEAFITSTIHEITPVTEVIGdetAHFPVGPVTKMLQQAF 269 Bacillus halodurans
NP_692004   224 LIEEAFQLEDISSADEIFLSSSTSEVTPIVRVDDkaiGDGKPGTITKQLQRAY 276 Oceanobacillus iheyensis HTE831
O07597      219 LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGqsiGSGKPGPVTKQLQAAF 271 Bacillus subtilis
NP_347428   220 VDETPFTLKELINADEVIVTSSGQFCMTACEIDGr-pVGGKAPDIIKKLQTAL 271 Clostridium acetobutylicum
NP_841527   219 HATREISELELRTAREIMLTSSTKEILPITQLDGqpiGNGTPGPVFQQLDRLY 271 Nitrosomonas europaea ATCC 19718
ZP_00032528 244 FEAREISEAELRAADEILVSSATKEVLPVAQIDGqpvGEGKPGAVFAALYAAY 296 Burkholderia fungorum
CAD90964    221 FREIEISISELFSAQEVWITSTTKEVFPITKINDsliNGGKVGEYWRIINDSY 273 Legionella pneumophila
ZP_00067067 241 CKEVALAPYDLYTADECFLTGTGAELIPVASVDGr-eISHCNGEITQRLSEAY 292 Microbulbifer degradans 2-40

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