3VQZ


Conserved Protein Domain Family
SMB-1-like_MBL-B3
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cd16313: SMB-1-like_MBL-B3 
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SMB-1, THIN-B and related metallo-beta-lactamases, subclass B3; MBL-fold metallo-hydrolase domain
MBLs (class B of the Ambler beta-lactamase classification) are a diverse group of metallo-enzymes that are capable of catalyzing the hydrolysis of a wide range of beta-lactam antibiotics. MBLs have been divided into three subclasses B1, B2 and B3, based on sequence/structural relationships and substrates, with the B1 and B2 MBLs being most closely related to each other. This subgroup of SMB-1- and THIN-B-like MBLs belongs to the B3 subclass. Subclass B3 enzymes are most active with two zinc ions bound in the active site, and have a broad-spectrum substrate profile. These B3 enzymes have a modified Zn2/DCH site (Asp-His-His).
Links
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Statistics
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PSSM-Id: 293871
Aligned: 4 rows
Threshold Bit Score: 470.114
Created: 20-Aug-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3VQZ: Serratia marcescens SMB-1 metallo-beta-lactamase binds the inhibitor mercaptoacetate and two zinc ions
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                        # # ##       
3VQZ_A      5 WSSPQQPFTIYGNTHYVGTGGISAVLLSSPQGHILVDGTTEKGAQVVAANIRAMGFKLSDVKYILSTHSHEDHAGGISAM 84  Serratia marcescens
AJP77057   79 WNAPQEPFALFGNSYYVGPHGVASVLITSNQGHILIDGGSDKSPPQIAARIRQLGFKPEDIRFILVSHEHIDHAGGVAEL 158 Massilia sp. SB1-3
ELX09746   25 WNKPVEPFQIYGGSYYVGVAGLSSVLVTSPQGHILIDGAFPDSPELIAASIRKLGFKLRDVKLILSSHDHWDHAGGIAAL 104 Janthinobacterium ...
KLU35050   25 WDAPQDPFPLYGNTYYVGTGGISAVLITSPAGHILIDGGPSGSSEQIAGHVRQLGFRVEDIRYILNGHDHFDHGGGIAEL 104 Oxalobacter sp. WF1

Feature 1                                 #                                    #              
3VQZ_A     85 QKlTGATVLAGAANVDTLRTGVsPKSDPQFGslSNFPGSAKVRAVADGELVKLGPLAVKAHATPGHTEGGITWTWQSCEQ 164 Serratia marcescens
AJP77057  159 QRlSNAEVLAGAAAVPVLHSGEaGRNDPQYGglPKMAPVARVRAVRDGEVVKLGPLAVTMHATPGHTQGGASWTWQSNEG 238 Massilia sp. SB1-3
ELX09746  105 QRmTGAQVVASPATAAALRRGSmGEDDPQFQgnTPYPKVASVRTVRDGEVVKLGPLAMTALYTPGHTTGGTSWTWNACEQ 184 Janthinobacterium ...
KLU35050  105 QKlSRAVVLGSPASIEVLRSGQpDKRDPQYPnlQAMTPIPSTRAVRDGEVVRLGPLAVTAHFTPGHTVGATSWTWRSSEG 184 Oxalobacter sp. WF1

Feature 1               # #                                        #                          
3VQZ_A    165 GKCKDVVFADSLTAVsadSYRFSDh---pEVVASLRGSFEAVEKLSCDIAIAAHPEVNDMWTRQQRaakegnsAYVDNGA 241 Serratia marcescens
AJP77057  239 GRTANMVYADSLTAFgsgGFRYSGdarypSARADVERSIAKVAALPCDILVSAHPEVSELWTRYERraaqgnaAFIDAGA 318 Massilia sp. SB1-3
ELX09746  185 GRCASIVFADSINPVssdGYKFSAh---pAVLKQYEQSYAALEKAACDIVVSGHPDFTGMWDKVKSgkp--haLLDGGEG 259 Janthinobacterium ...
KLU35050  185 GRIANMVYGDSLTAVaaeGRSFSRnplypQAQADVEHSIAAVESLDCDVLVSAHPEFSDLWERKAKqaalgnaAFIDRNG 264 Oxalobacter sp. WF1

Feature 1                      
3VQZ_A    242 CRAIAAAGRKRLETRLA 258 Serratia marcescens
AJP77057  319 CKAYAVKARVKLQEQLA 335 Massilia sp. SB1-3
ELX09746  260 CKAYVQQSREKLNKRLA 276 Janthinobacterium sp. HH01
KLU35050  265 CRNYAAKARAYLAKTLA 281 Oxalobacter sp. WF1

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