Conserved Protein Domain Family
SLATT_4
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pfam18186: SLATT_4 
SMODS and SLOG-associating 2TM effector domain family 4
The SLATT domain contains two transmembrane helices. SLATT domains are generally predicted to function as pore-forming effectors in a class of conflict systems which are reliant on the production of second messenger nucleotide or nucleotide derivatives. SLATT domains are predicted to initiate cell suicide responses upon their activation. This SLATT family is often coupled to the SMODS nucleotide synthetase and is sometimes further embedded in other conflict systems like CRISPR/Cas or R-M systems.
Links
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Statistics
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PSSM-Id: 436335
Aligned: 27 rows
Threshold Bit Score: 201.722
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
KDN25757             8 LEGQLREFYGRVVYTHKTQEKCADILLKWNSRIKWGQIILSALLSGGLISLFLDgfvNYKKGIeFFSVLISTALLVLNSY 87 
jgi:Shel_02890      12 LKNQIRDEYGRLTYTYTCHNKDAAFYAIGEKAISWLQLVLSVVSTCSVMSLLVS---DGKVQL-WIAVVASAVLALISAF 87 
WP_021636468        13 LESQIREAYGRVTYTQTCHDKIISRLMKTNDRIKIWQIVLSAITTSGFIVAILS---EDKIAS-VLGAIISLVLLILNSY 88  Enteroclo...
Q4JWX5              21 LTGLLDARRDRMLYTYRTQEKAADRYQQWEKCRKTTSIILTALTAGAFLASLGGlffDPEVNA-VLVSGAAALATMLTFL 99  Corynebac...
EDQ03768            12 FEDQVRECFGRVVYTHKTHERMADRSADTLRRYKVLQITLSALTSAGAIGVVVG---EELWVE-VATVGISFMTLFVAAY 87 
CCG:RGR602_PA00012  15 LEDQIRECFGRVVYTHKTHEKMADRCSATLQRYKLCQIGVSVLTTSGALSVVFL---DQFWLK-LATAFLSIVGLWASGY 90 
WP_015459153         7 LEDQIRDCYGRVVYTHKTHEKMADRCSRTLRRFKIAQIVLTAVTASGAFSVVFL---DDTLLK-IATAVASIASLIISGY 82  Sphingomo...
jgi:Arch_1493       14 LLAQVRESFGRVVYSHKTHEKQADISFSRYKWQQATLIALTALGSGTFLTLVFGlfgNSTWSS-LATSFCALLVSWMSLG 92 
WP_068378368        19 LLAQVREAFGRVVYSHKTREKQADICFTKHRRQQGVLVALTAISSGTFLVAVVGlfgNPVLAS-LTTSSIALLVTWMSLG 97  Rhodococc...
KUF08611            15 LLAQVRESFGRVVYSHKTHEKQADICFAKHRWQQSLLIGLTAVSSGTFLAAVLGltgDPVVTS-MVTSSIALLVTWISLG 93 

KDN25757            88 TKDYDLGAIAQKHRQAATEIWLVREKYLSLLTALHMKVLPIDEICNQRDKLMMDLHSVYTGAPSTNFKAYKEAQKALQEM 167
jgi:Shel_02890      88 DKEKNFTAKANSHTEAANQIWLIREKYISLITDFDI--LTDQDVRQARDALLLETSGVYSSTPKTTPRAYRATRVALKND 165
WP_021636468        89 TKNFNLVEKAQEHKVASDTLWKIREEYVSLLTDFEI--LEPESIMKKRDELQERTAEVYSTSPRTDGKSYAEAQKALKND 166 Enteroclo...
Q4JWX5             100 GESVDWKKSVEAHRAAAVDLRTIHNRYESLTWDIEHDAISLEDALVKRDELERDERNLLSKSPRTTSGDYNKADEAINGK 179 Corynebac...
EDQ03768            88 LKNFDPGAIAQKHRDAAAKLWNVRECYLSLLTDLPR--LSHEAAVERRDELQAILSALYEGAPQTDGKAYEEAQRRLKEM 165
CCG:RGR602_PA00012  91 MKGFDPGGTAQKHRDAAANLWPIRESYLSLLADLRMGSLSSEEALKRRDELQKKLSAIYLGAPQTTAKAYADAQIALQKN 170
WP_015459153        83 MKGFDPGATAQKHRDAAASMWPIRESYLSLLTDLRMKRISDDEAVKERDALQAKLAAIYRGAPQTTGDAYTDAQDALKNK 162 Sphingomo...
jgi:Arch_1493       93 AKTFKFDENSAAHRDIASKLWDIRESYISLIADMMSGEVSDSDARKRRDELQILARDIYFTAPRTSGRAFTLAKDGLKNN 172
WP_068378368        98 ARTFKFADESDAHRVVATQLWGVRESYISLISDLMSGGNSHEQARTRRDELQEATSAAYADAPRTTAKAYTRAQKGLKHN 177 Rhodococc...
KUF08611            94 TKTFRFADESDEHRAIASQLWDLRESYISLIADLMAGSVSEAEGGRRRDELQEEVRGTYSSAPRTSPKAFARAQGGLKNN 173

KDN25757           168 EDMTFSDDE 176
jgi:Shel_02890     166 EEQFFTDDE 174
WP_021636468       167 EEQTFSENE 175 Enterocloster citroniae
Q4JWX5             180 EKPQSTQKE 188 Corynebacterium jeikeium K411
EDQ03768           166 EDMSFTADE 174
CCG:RGR602_PA00012 171 EDYTFNDEE 179
WP_015459153       163 EDLTFSDAE 171 Sphingomonas sp. MM-1
jgi:Arch_1493      173 EEMTFTAHE 181
WP_068378368       178 EEMTFTPRE 186 Rhodococcus sp. EPR-157
KUF08611           174 EEMTFTSRE 182
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