1DBS,1HYQ,6IUC


Conserved Protein Domain Family
CbiA
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pfam01656: CbiA 
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CobQ/CobB/MinD/ParA nucleotide binding domain
This family consists of various cobyrinic acid a,c-diamide synthases. These include CbiA and CbiP from S.typhimurium, and CobQ from R. capsulatus. These amidases catalyze amidations to various side chains of hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many plants and animals and is primarily produced by bacteria. The family also contains dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family.
Links
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Statistics
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PSSM-Id: 426369
Aligned: 79 rows
Threshold Bit Score: 66.2152
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1DBS_A   4 YFVTGTDTEVGKTVASCALLQAAKAAGYRTAGYKpVASGSEKTPe-------GLRNSDALALQ--RNSSLQLDYATVNPY 74  Escherichia coli
Q57908   5 IMVVGTSSNSGKTTITAGLCRILANKGYKVAPFK-SQNMSLNSRv------aKEDGEIAIAQYtqSLACRVEPSVHFNPI 77  Methanocaldococcus ja...
O33475   5 LMVQGTMSGAGKSLLVAALCRIFTNLGYDVVPFK-SQNMSLNSAps----ieGGEISRAQYLQ--ALACRKKPSVKFNPI 77  Thermococcus kodakare...
D5AV13   4 LMIQGAGSNVGKSMLVAGLCRAARRRGLTVAPFK-PQNMSNNAAvt----adGGEIGRAQALQ--ALACGLEPVTDMNPI 76  Rhodobacter capsulatu...
P29932   5 IMLQGTGSDVGKSVLVAGLCRLAANQGLKVRPFK-PQNMSNNAAvs----ddGGEIGRAQWLQ--ALAARVPSSVHMNPV 77  Sinorhizobium sp.
Q05597   5 VMLQGTASDVGKSVLAAGLCRIFYQDGLRTAPFK-SQNMALNSGit----pdGKEMGRAQIFQ--AEAAGITPDVRMNPV 77  Salmonella enterica s...
P9WP95   4 LLVAGTTSDAGKSAVTAGLCRALARRGVRVAPFK-AQNMSNNSMvcrgpdgtGVEIGRAQWVQ--ALAARTTPEAAMNPV 80  Mycobacterium tubercu...
Q9RJ20   5 LLVAGTTSDAGKSVVTAGICRWLVRQGVKVAPFK-AQNMSLNSFvt----rdGAEIGRAQAMQ--AQACRVEPTAHMNPV 77  Streptomyces coelicol...
Q55860   4 IMVVGTTSHAGKSFLTTGLCRLLRRRGDRVTPFK-GQNMALNAFvt----idGGEMGHAQAVQ--AWAAGTVPRVAMNPI 76  Synechocystis sp. PCC...
O28931   4 LMVGGTTSSAGKSLLAAAFCRILARRGYDVAPFK-AQNMSLNSFvt----skGKEIAIAQAYQ--AFAAGIEPDERMNPV 76  Archaeoglobus fulgidu...

1DBS_A  75 TFAEPTsphiISAQEGRPIESLV----------------MSAGL-RALEQQADWVLVEGAGGWF--TPLSDTFTFADWVT 135 Escherichia coli
Q57908  78 LLKPKGnf-iSQVIVHGRPYKDMnyneyrkn-kdfflkkIKESL-EILDREYDYVIMEGAGSCCeiNLLKDDIANLRIAE 154 Methanocaldococcus ja...
O33475  78 LLKPEGnm-rSQVVFMGRPIGSVsardymlskkaelfekAIEVLkELMRE-HDLVIIEGAGSPVeiNLKDYDIANMRVAK 155 Thermococcus kodakare...
D5AV13  77 LLKPESdv-gAQVVVQGKRLTTTrarvyatl-kpqlmgaVLESF-NRLKATHDLVIVEGAGSPAevNLRAGDIANMGFAR 153 Rhodobacter capsulatu...
P29932  78 LLKPQSdv-gSQIVVQGKVAGQArgreyqal-kpkllgaVMESF-EQISAGADLVVVEGAGSPAeiNLRPGDIANMGFAT 154 Sinorhizobium sp.
Q05597  78 LLKPTSdr-qAQVVLMGKVATNMdavsyhdy-kprlreqILAVYnSLAQE-YDVIVLEGAGSPAeiNLRDRDIVNMGMAE 154 Salmonella enterica s...
P9WP95  81 LLKPASdh-rSHVVLMGKPWGEVassswcag-rralaeaACRAF-DALAARYDVVVAEGAGSPAeiNLRAGDYVNMGLAR 157 Mycobacterium tubercu...
Q9RJ20  78 LLKPGGer-sSQVVLLGRPVGEMsargyhggrqerllgtVLDSL-AELRGTYDAVICEGAGSPAeiNLRRTDIVNMGIAR 155 Streptomyces coelicol...
Q55860  77 LLKPQGdm-tSQVIMLGQAVGTTraqeyyqnyfdrgwqaIANSL-ETLAQDFDVVVCEGAGSPAeiNLKHRDLTNMRVAT 154 Synechocystis sp. PCC...
O28931  77 LLKPKGnf-vSQLVVMGEAVGDVdsrkyygvkvewlkrvVEEAY-LSLAEEYDFVVIEGAGGMAeiNLYERDLPNIHIAR 154 Archaeoglobus fulgidu...

1DBS_A 136 QEQLPVILVVGV-KlGCINHAMLTAQVIQh--aGLTLAGWVANDVTPPGKRHAEYMTTLTRmiPAPLLGEIPWLAENPEN 212 Escherichia coli
Q57908 155 LVNAKAILVADIdR-GGVFASIYGTIKLLpenwRKLIKGIIINKFRGNVEVLKEGIEKIEEltGIPVLGIVPYDENLVLP 233 Methanocaldococcus ja...
O33475 156 AVNAPVILVADIdR-GGSFAQIVGTMELLseeeRELVMGFIFNKFRGDASLLKPGFEFLEKrcGKPVLGVVPYIEH--RL 232 Thermococcus kodakare...
D5AV13 154 AADVPVVLVGDIdR-GGVIAQIVGTQAVLdpadAEMISGFLINKFRGDVTLFDDGYRLIGArtGWRGFGTLPWFPLAHKL 232 Rhodobacter capsulatu...
P29932 155 RANVPVVLVGDIdR-GGVIASLVGTHAILpeedRRMVTGYLINKFRGDVTLFDDGIAAVNRytGWPCFGVVPWLKAAARL 233 Sinorhizobium sp.
Q05597 155 MAQCPVILVADIdR-GGVFAAIYGTLALLhkqeRDRVKGVIINKFRGDVALLYSGIEQIESltGVPVLGVMPW-LDVDLE 232 Salmonella enterica s...
P9WP95 158 HAGLPTIVVGDIdR-GGVFAAFLGTVALLaaedQALVAGFVVNKFRGDSDLLAPGLRDLERvtGRRVYGTLPWHPDLWLD 236 Mycobacterium tubercu...
Q9RJ20 156 GAGLPVLVVGDIdR-GGVFASFFGTVALLapedQALVAGFLVNKFRGDVSLLEPGLDMLHGltGRRTYGVLPFRHGLGID 234 Streptomyces coelicol...
Q55860 155 HLQAATILIADIdR-GGVFAHVVGTLQLLepeeRKLIKGIVINKFRGQRSLLDSGITWLEeytGIPVLGVIPYGQNLFSA 233 Synechocystis sp. PCC...
O28931 155 FARPDILIVGDIdR-GGVFASLYGTYALLpddvKPLVKGFVINRLRGREDVLESGIRELErltGIRVLGVLPYLD--YNF 231 Archaeoglobus fulgidu...

1DBS_A 213 AATGKyIN 220 Escherichia coli
Q57908 234 EEDSQ-VL 240 Methanocaldococcus jannaschii DSM 2661
O33475 233 PEEDS-LA 239 Thermococcus kodakarensis KOD1
D5AV13 233 PAEDAlDI 240 Rhodobacter capsulatus SB 1003
P29932 234 PAEDSvVL 241 Sinorhizobium sp.
Q05597 233 DEDGV-AL 239 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
P9WP95 237 SEDAL-DL 243 Mycobacterium tuberculosis H37Rv
Q9RJ20 235 EEDGL-RV 241 Streptomyces coelicolor A3(2)
Q55860 234 EDSLD--I 239 Synechocystis sp. PCC 6803 substr. Kazusa
O28931 232 PSEDSlNI 239 Archaeoglobus fulgidus DSM 4304
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