Conserved Protein Domain Family
TIGR03491
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TIGR03491: TIGR03491 
RecB family nuclease, putative, TM0106 family
Members of this uncharacterized protein family are found broadly but sporadically among bacteria. The N-terminal region is homologous to the Cas4 protein of CRISPR systems, although this protein family shows no signs of association with CRISPR repeats.
Links
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Statistics
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PSSM-Id: 274603
Aligned: 13 rows
Threshold Bit Score: 447.93
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Download Cn3D
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_011610074   3 ITDSQLLSYQRCSRKVFLDVYG--DFRQQESPSDFRLKLIK-------D----S-SAFRSSIvgnynyqkpdypQGNF-- 66   Trichodesmium ...
WP_010871411   3 VTDSLLLDYKRCQRRAYLNTHG--SSEERRPERDFLLKLRQ-------E----S-QRHIQEV------------LEEQfp 56   Synechocystis ...
WP_011375842   1 MNTLYLKSFIRCKRKAWLDFKG--NKSCEIWSPHKAIDKIN-------Q----Y-HIFSEFC------------NGDI-- 52   Prochlorococcu...
WP_010997360   3 INAEHLLQYQRCKRRPILDIHA--DRSQRDAPSELLLKLQQ-------D----K-YAHQHSI------------LAKF-- 54   Nostoc sp. PCC...
WP_011131914   5 LNNLYLKSFIRCKRKAWLDYQG--NKSQRIWSPHQSIEIIK-------R----Y-KTFYKLS------------DGD--- 55   Prochlorococcu...
WP_011244352   3 LGDADLLDYLRCARRLYLNRWG--DRQQAEAPNAYLQRLRRlalerrrD----V-AAEWQAI------------AVDP-- 61   Synechococcus ...
WP_011294276   9 INDHLLRSWIRCRRKAWLDIYG--DKQKKLWTAHSTLQLNH-------Q----I-DCFHNLS------------QKSY-- 60   Prochlorococcu...
WP_011124464  11 ITDRLLISWIRCRRKAWLDLYE--ENKHKDWSAHRALQLDH-------Q----Y-KSFSALL------------SEAP-- 62   Prochlorococcu...
WP_011131237  11 LTDRLLRSWLRCRRRAWLDLYG--DGEQRLWTAHRTLQLDD-------Q----Q-RNFVALL------------PRKP-- 62   Prochlorococcu...
KDB61183      10 YAASDLVGFLACEHLTQLDLRAldAGQAPAAADDEQMALVQ-------A----KgQAHEQAW------------LERL-- 64   Bordetella bro...
WP_011596521  20 GTVIDASALTRCRHRVHLDAAF--PEQLAAAPEDPGVRQRQ-------DaaaaK-REDVRRI------------LTGH-- 75   Rhodococcus jo...
WP_004082671   3 ISYEDVENFLVCPRRYYLS-----KKISKEVSPNFSEELM---------------------------------------- 37   Thermotoga mar...
WP_011431114   1 --------------MPYLDRFG--PQEAKLPPDNLLEQWRR-------D----R-QALAAAV------------FERFpg 40   Synechococcus ...

WP_011610074  67 ------------I------------A--------------GAKATKLLMASG-----------------VDVIYQGVL-- 89   Trichodesmium ...
WP_010871411  57 hyrepetptylgQ------------E--------------RAQETKTLMAQG-----------------VDCIYRGCL-- 91   Synechocystis ...
WP_011375842  53 ------------------------------------------YTGLKACKKG-----------------SQGVIGLKI-- 71   Prochlorococcu...
WP_010997360  55 ------------AyhqpeypkrnweA--------------GQAATIELMQRG-----------------VEYIYQGVLla 91   Nostoc sp. PCC...
WP_011131914  56 -----------------------------------------LYSGEKACKRG-----------------SSGVIGLKA-- 75   Prochlorococcu...
WP_011244352  62 ------------S------------D--------------RAASTLDLMAQG-----------------VDCIEGGRL-- 84   Synechococcus ...
WP_011294276  61 ------------------------------------------GIGIRACEEG-----------------KNIAYGVRI-- 79   Prochlorococcu...
WP_011124464  63 ------------------------------------------NRGIEALKRG-----------------SNGVVGLRL-- 81   Prochlorococcu...
WP_011131237  63 ------------------------------------------CRGLDGCSQG-----------------CPGVVGLRL-- 81   Prochlorococcu...
KDB61183      65 ------------R------------A--------------RHPDLADVTRAGpdlaarlaatraamaagAPVIYQAAL-- 104  Bordetella bro...
WP_011596521  76 ------------A------------PerwvqidteqslrlRAEDTLAACEAG-----------------ADRIWGAVL-- 112  Rhodococcus jo...
WP_004082671  38 ------------------------------------------EAGFPLENPV-----------------IVCEFEG---- 54   Thermotoga mar...
WP_011431114  41 er-----------------------------------vapGNEALLAAMADG-----------------AERIYGGRI-- 66   Synechococcus ...

WP_011610074  90 -MiqksaiesslenqvqT-----DNFLS------------T-----------NFVSYP---------------------- 118  Trichodesmium ...
WP_010871411  92 -Y---------------H-----SLPVN------------LhtdnnghlpmlELLGHP---------------------- 116  Synechocystis ...
WP_011375842  72 -K---------------K-----NLFQN------------L-----------NVEIQP---------------------- 85   Prochlorococcu...
WP_010997360  92 nY---------------N-----ELIDTdd--------trY-----------TCLSRP---------------------- 110  Nostoc sp. PCC...
WP_011131914  76 -R---------------S-----KVINN------------I-----------NTEMQP---------------------- 89   Prochlorococcu...
WP_011244352  85 --------------------------QV------------E-----------PHWADP---------------------- 93   Synechococcus ...
WP_011294276  80 -K---------------Y-----PLIKN------------R-----------LIKANL---------------------- 93   Prochlorococcu...
WP_011124464  82 -K---------------G-----IGPQG------------L-----------KIEAHP---------------------- 95   Prochlorococcu...
WP_011131237  82 -K---------------G-----VGPAG------------Q-----------LLEAHP---------------------- 95   Prochlorococcu...
KDB61183     105 -C---------------H----------------------G-----------PYVGHA---------------------- 113  Bordetella bro...
WP_011596521 113 -P---------------L-----DRDAGrrarce-ilirdE-----------DHGGYI---------------------- 137  Rhodococcus jo...
WP_004082671  55 ----------------------------------------H-----------ELVSNP---------------------- 61   Thermotoga mar...
WP_011431114  67 -Aae------------lFwqpqeDLNCTaeaellqlasepV-----------PHSSSPrdpipapedcemvpalalppea 122  Synechococcus ...

WP_011610074 119 -------------DLLI-----KYP---GSSSFG----NW-IYIPTDIKLSKRPKLEYQIVTTFHAQILASIQKTWPEFA 172  Trichodesmium ...
WP_010871411 117 -------------HLLV-----KVP---GESRWG----PW-QYRPVSIQLGRRPKPEYKILAAFYAQLLAVHQGPLPRWV 170  Synechocystis ...
WP_011375842  86 -------------QLLV-----KTN---GRSKWG----TY-KYLPAVYKLGHKTTKEHLFDLAFSSIILETFQESKIEKG 139  Prochlorococcu...
WP_010997360 111 -------------DLLI-----KQP---GQSKFG----DW-VYEPVDIELGKRPKQEYQVVTAFHTQILAKVQEVQPKNA 164  Nostoc sp. PCC...
WP_011131914  90 -------------QLLK-----KVG---GHSKWG----EY-KYIPVVYKLGHRTTKEHLFDLAFSSMLLEPFQEAKIEKG 143  Prochlorococcu...
WP_011244352  94 -------------DLLV-----RQP---GQSIWG----DW-IYQPVAVKLAKKPKTEYLLQLAFQAELLTSIQGVWPEQG 147  Synechococcus ...
WP_011294276  94 -------------PILR-----KTS---GESIWG----NF-AYQPILARQGKKITREHKLTLALTGLLINNLQKFQVKKG 147  Prochlorococcu...
WP_011124464  96 -------------PLLK-----KIN---LGSPWG----DF-SYIPVVAQQGRRLTREHRLSLALWSYLLEQVQQIEVKYG 149  Prochlorococcu...
WP_011131237  96 -------------PLLQ-----RVE---GQSRWG----AF-AYRPVLARQGRRLTREHRLALALAGRLLAPLQSAPVPEG 149  Prochlorococcu...
KDB61183     114 -------------DFLL-----RTE---CPSALG----DY-GYEALDTKLARSPRASFVLQLSFYAWLLEHAQGVAPRSM 167  Bordetella bro...
WP_011596521 138 -------------PVIVvnhkvTDP---GRGALTsdmfEWqPREDATRKPRSQVRDQMRVAQVYRMLERHGFASPALVAG 201  Rhodococcus jo...
WP_004082671  62 -------------DLIV-----KDR--------D----GW---RIILRKSAKRFKDKYILESAYHALVFSR-AGLEVSGV 107  Thermotoga mar...
WP_011431114 123 vperrsvwvssslDLLI-----RDPalvGRSRHA----ARsSYLPVHIRIGKRPKPEYELVLALQAELLGSLQGNVPKRG 193  Synechococcus ...

WP_011610074 173 YLIL-R-NKGLYKVNLQQRIQAMQQAISELIFMLQNSLE----PEVFISR-QKCSLCAWYNTCHAVAKTEKHLSLLPGVT 245  Trichodesmium ...
WP_010871411 171 EIIL-R-RGNSYSVDLLEWLPRFHQTLADCVQTLIHQRE----PEVFISR-QRCNLCHWYDHCYAIAQEQQHLSLVPGVT 243  Synechocystis ...
WP_011375842 140 LVIS-S-FGNKVSIEEIYLNKKLRKKVFNVLLNLNASLEgf-iPEITQDR-KKCTICSWQNFCNKEAKENGYLSDIDGIG 215  Prochlorococcu...
WP_010997360 165 WLML-RgKETPYAVDLFKWIPQMQGILQEFTQDLESETA----PEVFIAR-QKCNLCLWHSQCYAIAQSEQHLSLLPGVT 238  Nostoc sp. PCC...
WP_011131914 144 LVIS-N-FSNRINIEKIDLNPRLRKKVIHTFLNLNEYLKrs-iPDITEDR-KKCTICSWQKFCDTEAKDNGYLTDIDGIG 219  Prochlorococcu...
WP_011244352 148 WLLL-R-DCHPKAYNLDLRRSQLQEHLAACAPILQNQQE----PELFISR-SRCDLCVWQTDCRDRARDQVHLSLLPGVS 220  Synechococcus ...
WP_011294276 148 LILH-K-ENEVIKVEKIKLSDNINTDLIGSLLHLEKDIEsrtpPPITSNR-KKCTICSWRKECDAVAIKEGSLSEVSGIG 224  Prochlorococcu...
WP_011124464 150 LAVSiR-NAGSLDIQEIAITKKLTNELFDSLKRLYKDIRkdvsPGLIADR-KKCTLCSWKKLCDEKANEEEDLSEISGIG 227  Prochlorococcu...
WP_011131237 150 LALA-G-AGRSLHMERVSLLGGLQRQLDDVLVKLAADLElsepPPLVADR-RKCKLCSWRGVCNAVASVEGHLSEVSGIG 226  Prochlorococcu...
KDB61183     168 HVVL-G-SGRELALRVADYAHYLRQVLRRFEAAIAAEPA----PPTYPEPcEHCPQCRWRVACEARRVADDHLSLVAGMS 241  Bordetella bro...
WP_011596521 202 AIGY-G-SDVIFVHDLTTILDDYDERFADRLAVARG--E----SATVPSRiGECRSCPWWPGCEEQLTQTHDVSLVA--T 271  Rhodococcus jo...
WP_004082671 108 EIVS---DSFSRKMENWKNLIPIVEDVLREMLTIDDDPH----PRV---G-RHCRYCDFLEDCEGKFFEEKSLLLVNGIG 176  Thermotoga mar...
WP_011431114 194 ILIL-K-DGKWHPVHLSRRRAQVRQLLQEYLHSLNQPEP----PQVFMAR-SRCHLCHWREHCRQLNAAAQPLSLLPGVT 266  Synechococcus ...

WP_011610074 246 SNRYAVLKRLNLTTLESLSQTNPNDL----ESy----pEFADGVAIEVVQQAQSVRENKVIlrN----Ekftkqleipal 313  Trichodesmium ...
WP_010871411 244 PSRYESLQMVGVLTIDSLARLQTQQV----AE------LMGTAIAEQLQQQALALVEKRAM--A----K----------- 296  Synechocystis ...
WP_011375842 216 SKTALLLKANGISNIQELSSYNEKEL----GDklskfkDQKYEKASKFIKQAQAYISGKPFciS----N----------- 276  Prochlorococcu...
WP_010997360 239 PIRYTQLQNLDITSVESLAHTSPNIL----ENl----vGFDTQVAAKLVVQAQSVVEGQPLllP----F----------- 295  Nostoc sp. PCC...
WP_011131914 220 SKTALFLQKNGISNIKELAATKKIDL----GKklfqfkEQRFEKASKFIKQSKAYLSGIPIriL----E----------- 280  Prochlorococcu...
WP_011244352 221 PSRFAILRDLKLDQLEALATADPQSL----AIa----aDWELGLAQRLVQQAAVFLSQQP--------Q----------- 273  Synechococcus ...
WP_011294276 225 AKREVLLNKIGINNIEELAKIKHYKL----QEkleifgTQHSDISKQIILQSQSQSTNRAIklN----P----------- 285  Prochlorococcu...
WP_011124464 228 AKRKIILQEIGIKNLSQLALIDKDDL----TNklspygESHKKIAGQLIRQAKVQKKLSPErlS----S----------- 288  Prochlorococcu...
WP_011131237 227 TRRRQMLQELGILGLQDLAAADPNEL----GSrlqhfgEQHGEVACELVAQARAQRDGRYErlD----S----------- 287  Prochlorococcu...
KDB61183     242 RQQARRLNAQGVATLAQLGALPEHAQvagiEAg----tLQRLRAQAALQWRARVDGARHYEllAaqdeG----------- 306  Bordetella bro...
WP_011596521 272 GSRADMLRDAGCHTIDDLAAWDREPL----ED-------WPHGAFEDAVVTAKAWLAGAPLv------R----------- 323  Rhodococcus jo...
WP_004082671 177 EETYRVLYGMGIETLEDLAEADQRIL----EK------VFGKEKGKRFVMAARAFLENRVImiT----P----------- 231  Thermotoga mar...
WP_011431114 267 GSRYPLLQEAGIHSIEALANARLEML----QAi----pKLGAGVALQLQLQARATLSRKPLwlQs---P----------- 324  Synechococcus ...

WP_011610074 314 sitDYKLTKL--V-N-APVELYFDIEAQP--EINLDYLHGVLVVNKRY------NT------E------KFYVHLAENP- 368  Trichodesmium ...
WP_010871411 297 ---EKKVYPL--P-R-SPVELYFDIEAEP--ERNLDYLLGVVVVDHGQ------KT------E------KFYGFMAKDP- 348  Synechocystis ...
WP_011375842 277 ---NNNSYDLieK-T-SSGFYIFDIESNP--DVRHDFLYGFLKINNLS------TKke---vR------IYEPILNLKN- 333  Prochlorococcu...
WP_010997360 296 ---PPPKGNL--VvN-SPVEIYFDIEAQP--DLNLDYLLGVLVVNKQT------NT------E------QFYSFVAEKP- 348  Nostoc sp. PCC...
WP_011131914 281 ---NKNLSYLlkN-K-DSGFFIFDIESNP--DDKHDFLYGFLKVNSLF------ENie---dD------FYDPILNLKN- 337  Prochlorococcu...
WP_011244352 274 ---PLQTYAF--P-D-SDVEFFFDIEAQP--DLDLCYLHGVLIRDRRQ------PE------S------QFRPLLAEQP- 325  Synechococcus ...
WP_011294276 286 ---EIELNNL--K-K-AKGLYIYDIESDP--DIRHDFLHGFIRLPKNI------KN------EislektKYSPLLNIEK- 343  Prochlorococcu...
WP_011124464 289 ---SMALPEL--N-S-AEGVFIYDIESDP--DAHHDFLHGFVSLAKRK------DGtwllddV------KYQPILNLSN- 346  Prochlorococcu...
WP_011131237 288 ---ASALPEL--A-T-APGVLLYDIESDP--DARDDFLHGFVRLGRRPdgswdlEG------A------QYHPFLVLYE- 345  Prochlorococcu...
KDB61183     307 ---PRGLARL--P-RpDPGDMFFDMEGDPleDGGLEYLFGLYVIDDGA------ER--------------FVPFWAHDR- 359  Bordetella bro...
WP_011596521 324 ---RFPEIRV--T-R-ADVEVDVDMESY---QEHGAYLWGTLLNVDGV------SA--------------YRPFVSWDPv 373  Rhodococcus jo...
WP_004082671 232 ---PEDLPEG--T--------IVDIEYHP--SEERDFLYGFLIGDE------------------------YRYFLEEDQ- 271  Thermotoga mar...
WP_011431114 325 ---PQALPTA-------PVELYFDIEADP--RHNVAYLLGLLVVEQAE------ENk----vV------NYYSCLAAEP- 375  Synechococcus ...

WP_011610074 369 --LDEELIWHQFLDL----VWKYPIA--------PI-YHFCEYE-----IQTVKKLAKLYNTP-TYKWKPLLK--RFVDI 425  Trichodesmium ...
WP_010871411 349 --EEEGLIWQEFVQL----IQTYPNA--------PI-YHFSEYE-----RETIKRLGKLYGTP-PKVREKILE--QCFDL 405  Synechocystis ...
WP_011375842 334 --NKEE-SHNQIIKM----LFSNKEW--------PV-LHYGETE-----KIAIINIAKKLNLR-IEEIEFLKS--RFIDL 389  Prochlorococcu...
WP_010997360 349 --SEEELIWRQFLDL----VWQYPEA--------PI-YHFCVYE-----LDTVKRLAKLYRTP-YTSVSPVLY--RFVDI 405  Nostoc sp. PCC...
WP_011131914 338 --NTKK-SNQEIIQK----LFSQKYW--------PV-LHYGETE-----KIAILNLARQSDLD-LKEIEILNS--RFIDL 393  Prochlorococcu...
WP_011244352 326 --DQEADTWQQLLQL----LDRHPQA--------PV-YHFCSFE-----VDSLRRLGQRYGCS-TRRLEALLT--RFIDI 382  Synechococcus ...
WP_011294276 344 --NTESFLWKRITKK----LSINQDY--------PI-IHYGETE-----PISLLKLGIRQGAN-PHEIEELKN--RFIDI 400  Prochlorococcu...
WP_011124464 347 --HTEEIAWGNIKRK----LKSHPNW--------PV-LHYGETE-----SLSICRMAKRQGEE-DKEINIIRN--KFIDI 403  Prochlorococcu...
WP_011131237 346 --HGEARCWQRLQRM----LKSYPDW--------PV-MHYGETE-----SLALRRMAKRQGVD-AAELSALSK--RMIDV 402  Prochlorococcu...
KDB61183     360 --RQEKQAFEAFMDFvaerLRRHPDA--------HI-YHYAPYE-----ATALKKLMSLHGTR-EAEVDHLLRagKLVDL 422  Bordetella bro...
WP_011596521 374 ptQDEARSFAEFWTW----LMAEREAaalsgrtfAA-YCYSRSAedkwlLDSARRFAGAPGIPtEADIREFIDspQWVDI 448  Rhodococcus jo...
WP_004082671 272 ---------GDLIAF----LNSLDDE--------SVfYHYHGPE-----KRKLISLIGRNKRM------------NFLDV 313  Thermotoga mar...
WP_011431114 376 --REEGQAWQQFLQL----VQRYPEA--------PI-YHFHSFE-----VQTCRRLGEQHQTD-PREVRQLLK--RFVDL 432  Synechococcus ...

WP_011610074 426 HKIITQTITLPIESYALKNIARWLGFEWRNPEANGAQSVCWYDQWLA--T-G--DRS---L---LDAIIIYNEDDCYATY 494  Trichodesmium ...
WP_010871411 406 HHYVVNHVICPVESYSLKSLASWLGFQWRDAQASGDQSVCWYDNWLT--T-G--DRQ---F---LELILRYNEDDCRATW 474  Synechocystis ...
WP_011375842 390 HTLIRKSWILPIKNYSLKTVSNWLGFEWEQKDVNGSKALYWWIQYQL--T-E--NEV---F---LKKIIKYNKDDCLATL 458  Prochlorococcu...
WP_010997360 406 YEHLTQSVALPIESYALKAIARWMGFEWRDKEASGAKCIYWYDQWLE--T-G--DRA---L---LEIIIRYNEDDCRATR 474  Nostoc sp. PCC...
WP_011131914 394 HLIVRGSWILPIRNYSLKTVANWIGFKWEQENVSGSKALYWWIQYKS--T-L--NDI---F---LKKIIKYNRDDCLATL 462  Prochlorococcu...
WP_011244352 383 HAVLTRSVLLPTESYALKSIARWLGFDWRDTEANGSQAILWYDYWLE--T-G--DRT---W---LDRILLYNEDDCRATA 451  Synechococcus ...
WP_011294276 401 HLLIREYWCLPVRNYGLKSIAEWIGFEWKQSNADGARALLWWRQWKK--S-RkiNKM---YsrnLNSIFEYNRDDCIATL 474  Prochlorococcu...
WP_011124464 404 HSRLKGSWVLPVNSYSLKEVAKWLKFEWSQKGSSGAKALLWWRQCQKaiS-Q--NNI---KpkqLELIMRYNQDDCIATW 477  Prochlorococcu...
WP_011131237 403 HDRVRRSWRLPLNSYGLKCVASWLGFCWRQVGVDGARALLWWRQWRG--S-GlqDRGssyS---LRWIFDYNHDDCLATW 476  Prochlorococcu...
KDB61183     423 YRVVREGLRISEPSYSIKYVERFYLPRRAGEVTNAGASIVYYERWKA--T-G--EPR---L---LQDIADYNRDDVISTW 491  Bordetella bro...
WP_011596521 449 YQAVSDQFICPGG-KGLKKIAPVAGFRWRDADASGEASMSWYREAVG--YdG--EPD---Lt-qRERLLQYNEDDVIATK 519  Rhodococcus jo...
WP_004082671 314 FTILRNHFVFPVMSYSLKRIAKYLGYDWR-TSLNGYEILRLYEKWKK--T-R--NEE---L---LKQMLLYNEDDVRATK 381  Thermotoga mar...
WP_011431114 433 HIWVQRSVVLPIESYSLKNIARWLGFKWQLPEGSGAHSIYWYSQWLE--T-R--DRR---Y---LEQSLIYNEDDCRATY 501  Synechococcus ...

WP_011610074 495 YVKEWL 500  Trichodesmium erythraeum
WP_010871411 475 ILKDWL 480  Synechocystis sp. PCC 6803
WP_011375842 459 HIAKFL 464  Prochlorococcus marinus
WP_010997360 475 KVKDWL 480  Nostoc sp. PCC 7120
WP_011131914 463 QIAKWL 468  Prochlorococcus marinus
WP_011244352 452 IVKDWL 457  Synechococcus elongatus
WP_011294276 475 MIAKWL 480  Prochlorococcus marinus
WP_011124464 478 KIAEWI 483  Prochlorococcus marinus
WP_011131237 477 AVAAWL 482  Prochlorococcus marinus
KDB61183     492 RLRDWL 497  Bordetella bronchiseptica A1-7
WP_011596521 520 VLREWM 525  Rhodococcus jostii
WP_004082671 382 LVLDFM 387  Thermotoga maritima
WP_011431114 502 CLKNWL 507  Synechococcus sp. JA-3-3Ab
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