Conserved Protein Domain Family
CysQ
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cd01638: CysQ 
CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine biosynthesis (a principal route of sulfur assimilation).
Links
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Statistics
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PSSM-Id: 238816
Aligned: 55 rows
Threshold Bit Score: 170.099
Created: 9-Jul-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active site
Feature 1:active site [active site]
Evidence:
  • Comment:by similarity to other families in this hierarchy
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                   #                      ##           
P22255        1 MLDQVCQLARNAGDAIMQvydgtkpm----dvvskadnSPVTAADIAAHTVIMDGLRTLtpdVPVLSEEDPpgwevrqhw 76  Escherichia coli
YP_001584     6 YLQSAVDSVLEAGKIVLEiyhsdfk------vkdkgknDPVTEADLKASSHISESLRFLn--IPILSEEDSekkdv-skl 76  Leptospira inter...
AAF11261      6 ELQTAVRLAREAGALLLRhraagltv-----ehktsadDPVTAADREASALIVAGLHAAfpgDGLLSEEEVdspgr-lrh 79  Deinococcus radi...
NP_384914    15 DLELILTAAVAAGDTALGyfrktldv-----rwknegrSPVSEADLAANDILKGRLLGArpdYGWLSEETDddesr-lvr 88  Sinorhizobium me...
ZP_00290290   8 ECQLMTQAAQQCHDTIMQhfrlgqtvgeganvqdkginNPLTAADLAVDGYLHDTLLTArpdYGWLSEETVdnpsr-lkn 86  Magnetococcus sp...
ZP_00304839   3 DYDRLHAIVRAAGDMALAlwpghghap---evwektpgSPVCEADIAVDTFLKRELGVLlpsAGWLSEETVdhper-ler 78  Novosphingobium ...
AAL54274     13 ELDLLREAAREAGRIAMHyfgrspe------vwlkdgvSPVSEADLAVDRFLKETLLAArpdYGWISEETVderaa-aer 85  Brucella meliten...
NP_419127     3 DLDLIIAAAREAGELALGaresglt------iwskeggSPVTDADLAVDTLLRTELRAErpdYGWLSEETAddpar-lat 75  Caulobacter cres...
ZP_00007616  29 DLALLSEPPGGGPFALRYwknapra------wekdgnaGPVTEADLAVNQALEQRLRSArpdYGWLSEESAdsger-qga 101 Rhodobacter spha...
ZP_00193836  11 ELSLIVEAAREAGRIAMGyfrrdpe------vwwkdgrSPVSQADLDVDLFLRRVLLEErphYGWLSEETAdnker-lna 83  Mesorhizobium sp...

Feature 1             ###### #                                                                  
P22255       77 qrYWLVDPLDGTKEFIKRNGEFTVNIALIDhgKPILGVVYAPVMNVMYSAAe-gKAWKEEcgvrkqiq-----------v 144 Escherichia coli
YP_001584    77 qtVWILDPIDGTREFIHKNPEFAISLGLSIlgKAVLGVVFNPVTLELIYGAedlGVVYQKlenipdffsvklqnftkils 156 Leptospira inter...
AAF11261     80 erVWIIDPIDGTKEFTTGSPDFCVSIGLAVrgEAVMGVVYAPATDELFSGVvgeGVQKNSepveps-------------- 145 Deinococcus radi...
NP_384914    89 etVFVVDPIDGTRAFIAGKDLWCVSVAIVHrgQPVAGVLYAPSLNEIFQATrdgEARKNGkaiavrea------------ 156 Sinorhizobium me...
ZP_00290290  87 qrVWVVDPIDGTKEFIAGIPQFAISIGLVDngQPVAAVVYNPALQEMFSAHlggGAQLNGtpihtstr------------ 154 Magnetococcus sp...
ZP_00304839  79 glCWLVDPIDGTRDFVRGRPGWAVSVALVSegRPLIGVLSAPAREEYWSAVagrGATRNGlplaa--------------- 143 Novosphingobium ...
AAL54274     86 srAFVVDPIDGTRAYIGGQDQWCVSIAIIEngSPVAGVLECPVREELLEAGkglGARQNGcrihtkvp------------ 153 Brucella meliten...
NP_419127    76 grQFVVDPIDGTVAFMKGKPWFAVSIAVVEdgQPIAAVVHAPALDETYAATlqgPATLNGapiapsdt------------ 143 Caulobacter cres...
ZP_00007616 102 erVFIVDPIDGTRAFMAGEDTFAVSLAVAEagRIVAAAVYLPALDRLYTAGesaPALRDGqpiaasqr------------ 169 Rhodobacter spha...
ZP_00193836  84 prTFVVDPIDGTRAFIDGRSSWCVSIAVVEngRAVAGVLDCPACGEIFSAVrggGAHRDGraisikt------------- 150 Mesorhizobium sp...

Feature 1                 #  #                            #           #        ##               
P22255      145 rdarpplVVISRSHadaelkey---lqqlgehQTTSIGs-sLKFCLVAEGQAQLYPRFgptnIWDTAAGHAVAAAAGAHV 220 Escherichia coli
YP_001584   157 dfkpiqkVLISRTEekeglfsssmipfgwefvAMGSIA---YKLGLVAAGKAALSISLkpknDWDICAGIALINSSGGSD 233 Leptospira inter...
AAF11261    146 -tpttfrLSVSDTEyqrelhr----hdipgmfPSGSIA---LKLARMAAGEADATFSMspraEWDICAGDALLRAAGGEL 217 Deinococcus radi...
NP_384914   157 esgavlkVAAAEDVmgrlalpy--rntmmrvsHVPSLA---YRLAMIADGRIDGTIVKrnshDWDLAAADLILSRAGGAL 231 Sinorhizobium me...
ZP_00290290 155 tslqgarCLASRSEtkrgewd-----sftselQLTTMGsiaYKLALVAMGRYDMTFTLtpknEWDFCAGHLLVTEAGGAI 229 Magnetococcus sp...
ZP_00304839 144 ---strqVLAGARVpadslpra--dadlvtvdKPNSIA---LRIAMVGANEADLLATLrwgfEWDIAAATLIAREAGAAV 215 Novosphingobium ...
AAL54274    154 lageeitIAFARNQinalpeqw--rgpvrvhpYVPSLA---YRIAMVARGDIAGTFIRpnshDWDLAAADLILSESGGAI 228 Brucella meliten...
NP_419127   144 dalegaaMLGDAKMfahpawre--pwptmrieTRNSIA---YRACLVAAGAFDAAVALspksEWDVAAADLICQRAGAAL 218 Caulobacter cres...
ZP_00007616 170 tetqgatLLATRHTlgdshwpg--gvpdvkrsFRASLA---FRLCLVAEGRHDGMLMLrqawEWDIAAGSLIAARAGAAV 244 Rhodobacter spha...
ZP_00193836 151 -pgrelsLAGPKNMikalppei--yskvaphpYVPSLA---YRIALVASGALDATFVKpsshDWDLAAADLILEEAGGSI 224 Mesorhizobium sp...

Feature 1                                   
P22255      221 HDWQ-GKPLDYTp----RESFLNPGFRV 243 Escherichia coli
YP_001584   234 LEIKtGEPYKFQtlngkGEGLIAGHTRS 261 Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130
AAF11261    218 RRRD-GRPIVYNa---pRPSLEQGIIGG 241 Deinococcus radiodurans R1
NP_384914   232 CGLD-GEPLSYN-----RPTVTHGVLGA 253 Sinorhizobium meliloti 1021
ZP_00290290 230 SHKE-GSPFIYN-----QAQPKTRSVVA 251 Magnetococcus sp. MC-1
ZP_00304839 216 SDAF-GQPLAYN-----KRDPRAFGLLV 237 Novosphingobium aromaticivorans DSM 12444
AAL54274    229 LTSK-ALPLVYG-----GPTRSHGALVA 250 Brucella melitensis 16M
NP_419127   219 SDHK-GRPYAYN-----RPVPQVPSLVC 240 Caulobacter crescentus CB15
ZP_00007616 245 SDRF-GQPLTFN-----GSPPQTPGVIA 266 Rhodobacter sphaeroides
ZP_00193836 225 VDGA-MRRPHYA-----GPDPRRGPLAA 246 Mesorhizobium sp. BNC1

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