5YBB


Conserved Protein Domain Family
HsdM_N

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pfam12161: HsdM_N 
HsdM N-terminal domain
This domain is found at the N-terminus of the methylase subunit of Type I DNA methyltransferases. This domain family is found in bacteria and archaea, and is typically between 123 and 138 amino acids in length. The family is found in association with pfam02384. Mutations in this region of EcoKI methyltransferase abolish the normally strong preference of this system for methylating hemimethylated substrate. The structure of this domain has been shown to be all alpha-helical.
Statistics
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PSSM-Id: 463478
Aligned: 57 rows
Threshold Bit Score: 59.6184
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5YBB_A         10 LANEIWRACDIMRrDnnCtGIMEYVEHLAWLLFLRFLDAQEEEW-EAQAQI----AGR--PYtp----------iIDS-- 70  Caldanaerobact...
Q7VG99          6 IVAKVWNFATILR-DsgV-SYTEYVAQLSYLLFLKMESERESIGeHSKI---------------------------PT-- 54  Helicobacter h...
Q82S61          8 LKSKIDQLWNKFW-SggIsNPLTAIEQITYLLFMKRLDELDQKR-QADARDg---WSD--PYqskfeg-twippeERNwp 79  Nitrosomonas e...
jgi:Geob_2868   6 IKKKVDELWNRFW-AagLtNPLVAVEQITYLLFLKRLEDIDLKR-QQRG------------Lps----------iyADn- 60 
Q0VNH0          6 LKNDIDKLWEKFW-TggItNPLTVIEQISYLMFARMLDMQEEVA-ERKAAR----SKK--EFdrl-------fpnTPEg- 69  Alcanivorax bo...
Q0ATD0          6 LRRRVDALWTEFW-QggItNPLTVIEQITFLMFIRLLDVNETRD-EKHQ------NRTgyEFkr---------rfGPDe- 67  Maricaulis mar...
Q1GLF4          6 IRAQIDQIWNAFW-SggVsNPLSVIEQITYLLFIKRLDEIHTRE-EAKANm---lGSE--MErrifpegtftykvSDDpk 78  Ruegeria sp. T...
Q8XTZ9          6 LQRLVDRIWDAFH-TegIaDPVEIIEQLTCLLCLKRLDDLHVLA-RHLARRsrqpAAS--GArl---------pfREDq- 71  Ralstonia sola...
Q2SCB2         23 IKNQIDQVWTMFW-TggVsNPISVIEQISYLLFIRRLDEIQRNE-ERKAQa---tGES--LEnp---------ifSSQe- 85  Hahella chejue...
Q0AZK8          6 IRNKIDKIWTDMW-AggItNPLTVIEQLTYLMFIRSLDEKELEM-ESVEa----lSGE--EMpk---------ifPQDka 68  Syntrophomonas...
5YBB_A         71 ----------EYRW---RHwatkdwPAdeLLAFVHGrLIPYLRSLGG-----------Dpl--reTIRSLFsErn-viVC 123 Caldanaerobact...
Q7VG99         55 ----------SCKW---ERli--nlDGleLESAYNA-ALAQLAKSe------------------gVIGLVYnDaqn--ki 98  Helicobacter h...
Q82S61         80 vaeqrpidkrTLRW---GEfk--rmQAeeMLQHVQGkVFPFLKDLNga---------------esNFTHHMkNavf--ii 137 Nitrosomonas e...
jgi:Geob_2868  61 ---------eTCKWgyiRQ------EKtnPSHLINV-VFPWLRELDKhfkp---esdePse--laSLNNRMaDayfqlDP 119
Q0VNH0         70 ---------qLLRW---KNfk--nlSGkeLHKHLKNaVYPYFASLGQhaeeeglgsegSatqalgHIGEYMqDadl--ei 133 Alcanivorax bo...
Q0ATD0         68 ---------qNLRW---NEfr--hlGGdeMLVRVRDgVFPHLRKSSpt---------------gsSFAEFMkDaql--mi 116 Maricaulis mar...
Q1GLF4         79 ddetierpydDLRW---QRli--nfENreKMKLMDQhVFPFMRTMA------------Eeg---tAFATHMkDarl--gf 136 Ruegeria sp. T...
Q8XTZ9         72 ---------dDLRW---SVfr--tlSPqaMFDVVSTrGIPFLQALGdn---------------dpAAGRHMeDirf--tl 120 Ralstonia sola...
Q2SCB2         86 ---------aMLRW---NNfk--dkDPneMFDIVQNkVFPKIKNLQ------------Sqg----sFAEHMkDaif--mi 133 Hahella chejue...
Q0AZK8         69 --------gqDMRW---SKfk--tkDSraIYDIVGSkVFPFIKAMN------------Gkn--tsAFSRYMqDamf--li 119 Syntrophomonas...
5YBB_A        124 ASGYNLKDVIQIV 136 Caldanaerobacter subterraneus subsp. tengcongensis MB4
Q7VG99         99 KEPANLKKLFVLM 111 Helicobacter hepaticus
Q82S61        138 PKPALLVEAVKTI 150 Nitrosomonas europaea
jgi:Geob_2868 120 SKGKVLSDAIDAV 132
Q0VNH0        134 KNESVLVSAVEMV 146 Alcanivorax borkumensis SK2
Q0ATD0        117 QKPSLLVKAVSIV 129 Maricaulis maris MCS10
Q1GLF4        137 SSPALLDKVMRLL 149 Ruegeria sp. TM1040
Q8XTZ9        121 TTPALLARIVQLL 133 Ralstonia solanacearum
Q2SCB2        134 PSPKLLDQVVQML 146 Hahella chejuensis KCTC 2396
Q0AZK8        120 PTPQVLQKIITGL 132 Syntrophomonas wolfei subsp. wolfei str. Goettingen G311
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