Conserved Protein Domain Family
V_Cas12k
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NF038191: V_Cas12k 
type V CRISPR-associated protein Cas12k
Cas12k is the large effector protein of type V-K CRISPR systems, which belong to the class 2 systems. Cas12k has also been known as C2c5, and type V-K as type V-U5. Type V-K CRISPR systems have also been known as with the large Cas12k protein, has also been known as type V-U5, and Cas12k as C2c5.
Links
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Statistics
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PSSM-Id: 468404
Aligned: 52 rows
Threshold Bit Score: 717.055
Created: 11-Oct-2024
Updated: 3-Dec-2024
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_015172821   3 IITVECLLAASEETRQYVWSLMVQ-HAVLVRELLERAAQHPDFERWQSAGNLPAKAVERLAKESSneepplllEPRFSQL 81  Geitlerinema sp...
WP_045869560  14 HRTIRCHLHASEDVLRKVWEEMTQkNTPLIVQLLKSVSEQPEFETNQEKGTISKKEITKLRKALTn-------DSDLQQQ 86  unclassified To...
WP_010996846  14 LRTIRCHLHTKEDVLRKVWEEMTQkNTPLIVELLKSVSEQPEFETNKENGKITKKEITNLRKSLTq-------DS----- 81  Nostocaceae
WP_069072561  14 HRTIRCHLDASEDILRKVWEEMTQkNTPLILKLLKSVSEQPEFEANKEKGEITKKEIVKLRKNVTk-------NPELEEQ 86  Nostoc sp. KVJ20
WP_096553061  14 FRTISCDLSAKEDVLRKVWEEMSQkNAPLIVQLLKSVSEQPEFEANKENGTITKREITKLRRDITe-------NSDLKEQ 86  Nostoc sp. NIES...
WP_171575463   3 LITIHCRLIASEPVRRHLWHLMIEsNTPLINDLLKCVSQHPDFGIWQRRGTISESVVKGLCEPLK---------LVYPDQ 73  Leptolyngbya sp...
WP_088893327   3 IITIHCRLTAPESVRRHLWLLMSGrNTPLINDLLKRVSQHPDFETWQYWGTVPKVAIKELCEPLK---------ELYPGQ 73  Leptolyngbya oh...
WP_012628504   3 MYTIHCHLTASEPVRRHLWYLMAGsNTPLVNNLLKLVSQHPDFETWQRKGDISKSSVEALCEPLK---------ETYPGQ 73  Cyanothece sp. ...
WP_015183357   3 IITVQCQLKATKDSLRHLWSLMVEkNTLLVNELLKQINTHPDLENWLKVGNIKAEVIEGLCDNLRt-------ESRFQDM 75  Allocoleopsis f...
WP_073608258   3 IITIQCRLTASVATRQHLWNLMAHsNTPLVSELMRIIPLQPDFENWRQASKIPAKAIRDLCASFRk-------DERFAGQ 75  Phormidium tenue

WP_015172821  82 PDRFYKSAISTVQTTYKSWLALQHGRQQQRNRKQLWLD-IVEDDLLTEYD-ESQLDSIIKKAHEILSQLLSEmkKEANET 159 Geitlerinema sp...
WP_045869560  87 SGRLGSSADSLVTEVYTSWLTLSQKIKKQKEGKEYFLNnILKSDVELVQEsNCDLQTIRCKAQDILSQPKEFleQITNHD 166 unclassified To...
WP_010996846  82 -GRLYSSVDNLVQEVYSAWLTLYQKRKKQKEGKEYFLNnILKSDIELVEEsNCDLQILRAKAQEIISNPQDIlrQITIDN 160 Nostocaceae
WP_069072561  87 SGRLRSSAESFVKEVYSSWLTLYQKRKRQKEGKEYFLKnILKSDVELIDEsNCDLETIRSKAQEVLSQPEEFikQLTIND 166 Nostoc sp. KVJ20
WP_096553061  87 SGRLRSSADSLVTEAYSSWLRLYQVRKNQKEGKEYFLKnILKSDVELVEQsNCDLQTIRCKAKEILSQVEEFieQIK-NK 165 Nostoc sp. NIES...
WP_171575463  74 PGRFYASAILMVTYIYESWLSLQQNRRLRLDGKQRWLN-VVKSDAELLELsGSTLDALQHRAQDILSQRNTErqTQi--- 149 Leptolyngbya sp...
WP_088893327  74 PARFYASAILMVTYIYESWLSLQQTRRHRLNGKQRWLE-VVKSDAELLEMsSSTLETIRHRAQEILSRCNVEstPQSESS 152 Leptolyngbya oh...
WP_012628504  74 PGRFYSSAILRVTYTYKSWLALQKNRRYRLEGKQRWLH-VVESDSELLHRsGSSIETLKYRAQDILVQLNVEqqTQKTSV 152 Cyanothece sp. ...
WP_015183357  76 PGRFANAAEKLVKDIYKSWFALQEERRFRLWRKQRWFS-LLRSDLELEQEsGLSLEKLRTEATKILIKAQLEcsREAEPD 154 Allocoleopsis f...
WP_073608258  76 PGRFYSSASTMVAYTYDAWFALQASRLRRLYGMRRWLE-ILQSDTEMLKLcGVSWESFQERARAILQTATDQiqAKQPTP 154 Phormidium tenue

WP_015172821 160 SEDkkvrrkkatkkkDKAQTDSEEMqeerk------------fisiyKLNKLYN-SStDAVTRRAIAHLVRNHSQVNEE- 225 Geitlerinema sp...
WP_045869560 167 AVLnqtksa-rkkvqNSSNEINASKqrensdyqenv-dknipetlteILYKIHKiTQ-DILTQCAVAYLIKNHNQVSDLe 243 unclassified To...
WP_010996846 161 PKDkptksiqkrvrkNINASNSDTAknnilnsqektteenisksvieILYEIHKtTQ-DTIIRCAVTYLIKNYTKISDTe 239 Nostocaceae
WP_069072561 167 EDVkptksarkrvnkNINNKSTDAEqrkdssstnnv-dknkletltnILYEIHKqTQ-DILTRCTVAYLIKNHNKISNLe 244 Nostoc sp. KVJ20
WP_096553061 166 PKInqtkla-kkknnKSNKSNKAIDkilnrffig-----nldktltnTLYEIHRkSP-DSLTQCAVAYLIKNDNKVSEAe 238 Nostoc sp. NIES...
WP_171575463 150 ----------------------------------------------aHLFATYDaTN-DILSRCAISYLLKNGCKIPETe 182 Leptolyngbya sp...
WP_088893327 153 TKKrs---------kqQGQSSASSSksl-----------------mtRLFETYNsAD-DILSRCAIAHLMKNDCKVSATe 205 Leptolyngbya oh...
WP_012628504 153 TDIst---------itPEETPSSKNesl-----------------fpSLFRAYDsED-DILSRCAIAYLIKNGGKIPETe 205 Cyanothece sp. ...
WP_015183357 155 QATtdnss-----------------------------------alwdNLFTAYDkFK-SPRLRCVIAYLLKNGCQVNKVe 198 Allocoleopsis f...
WP_073608258 155 QPArrg------nkkQRKQSDKIVSrrr----------------lvdRLFQLYNeSP-ETLDRCAIVRLLKNGCTVPEQa 211 Phormidium tenue

WP_015172821 226 EDPDKIPLEIEKTRIEIERLDQQLK-SQLPK--GRDPFGTQYQKNLEFATELPSklstseEDVSEFIKWNAEEGQrriav 302 Geitlerinema sp...
WP_045869560 244 EDIKKLKKRRTEKQVQIKRLEEQIQkNKLPN--GRDITGERYNHAFDNLINQVP------QNNEEFAEWIASLLNkv--- 312 unclassified To...
WP_010996846 240 EDLNKLKERRAEKEIEIKRLEKQIQdSRLPN--GRDITGARYLEAFDKLINQVP------KNNEEFANWIADASRki--- 308 Nostocaceae
WP_069072561 245 EDIQKLKKRRNEKIVQIKRLENQIQdNRLPS--GRDITGERYSEAFGNLINQVP------KNNQEWEDWIANLSKki--- 313 Nostoc sp. KVJ20
WP_096553061 239 ENFTQLNKRRAAKEIEIKRLETQIQnTRLPIhyGRDITGEKYSQAFEKLVNQVP------QDNEEFAEWIAILLKkv--- 309 Nostoc sp. NIES...
WP_171575463 183 EAPEKFAHRIHRKQKEIEQLEAQLQ-ARLPK--GRDLTGEEFLETLEIATQQIS------ESVTQAREWQAKLLTrp--- 250 Leptolyngbya sp...
WP_088893327 206 EDPKEFAHRILRKQKDIEQLEAQLQ-ARLPK--GRDLTGEEFLKTLTIATQQIS------ASVAEARDWQGKLLTrp--- 273 Leptolyngbya oh...
WP_012628504 206 EDQEKFTQRVNSKREEIEQLEIELS-ARYPK--GRDLTGEEFLETLAIATQQLS------ETVAQAREWNDKILTqp--- 273 Cyanothece sp. ...
WP_015183357 199 EDPEAYQRRRRKKEIQIERLKEQLK-SRLPK--GRNLSEQEWLEALEQ-AQGLI------IDDEHLRQVQASLTRkq--- 265 Allocoleopsis f...
WP_073608258 212 EQPERYQRMLLAKQTGVSRIERELA-SRLPK--GRDLTDENFLNALELLTYQIP------TSTEEFAQWKSQLLRep--- 279 Phormidium tenue

WP_015172821 303 mrlpkSLPYPISFGSNTDLRWFQETQErktlkgkktnkprnqIIVRFQG------------------LKNHSFKILCDRR 364 Geitlerinema sp...
WP_045869560 313 ----sDLPYPIDYLYS-DLTWYKNEQRk--------------ICVYFNG------------------WAKFHFQICCNKR 355 unclassified To...
WP_010996846 309 ----sNLPYPIDYLYS-DLTWYKNQDGk--------------IFVYFNG------------------WSKYHFQICCNKR 351 Nostocaceae
WP_069072561 314 ----sHLPYPIDYLYG-DLSWYKNDVGn--------------IFVYFNG------------------WSEYHFKICCNKR 356 Nostoc sp. KVJ20
WP_096553061 310 ----sSLPYPILYCSG-DLSWYKDEKGn--------------IFVYFNG------------------WAEYHFQICCDKR 352 Nostoc sp. NIES...
WP_171575463 251 ----aFLPYPILYGSSTDIRWGKTANGr--------------IAVSFNGidkylkaadldikgwfkaHKEYPFRLYCDQR 312 Leptolyngbya sp...
WP_088893327 274 ----kSLPYPIIYGSSTDVRWGKTAKGr--------------ITVSFNGidkylkeadseiqewfktQKEYPFRLYCDQR 335 Leptolyngbya oh...
WP_012628504 274 ----kFMPYPIIYGSSTDVRWRKTSKSr--------------ITVSFNGidkylkaadpeikawfkdHQEYPFRLHCDER 335 Cyanothece sp. ...
WP_015183357 266 ----sPVPFSISYETSTDLRWSSNEQGr--------------ICVSFNGk----------------gISKHTFEVFCDQR 311 Allocoleopsis f...
WP_073608258 280 ----nPLPYPVLYSGNLNLTWFVEEVPrgksq-----kpkqqICVKLNG------------------LAKHVLKVQCDAR 332 Phormidium tenue

WP_015172821 365 QLPHFQQFVTDWKTYQELDrkgkadsekCSASLFLLRSARLIWRednRVPPKslrkkkgkqknnavvasgknvgsssdnr 444 Geitlerinema sp...
WP_045869560 356 QLHFFKRFLEDYKALKESEkge----ikLSGSLVTLRSVQLLWQ---QGEGA---------------------------- 400 unclassified To...
WP_010996846 352 QRHFFERFLEDHKAWKESEkge----vkLSGSLVTLRCVQLLWQ---QGEGK---------------------------- 396 Nostocaceae
WP_069072561 357 QRHFFERFLEDYKAFKVSQkge----ekLSGSLITLRSAQLLWQ---QGEGK---------------------------- 401 Nostoc sp. KVJ20
WP_096553061 353 QLRFFERFLKDYKALKPSKkee----ekVSGSLVTLRSAHLLWR---QGKGK---------------------------- 397 Nostoc sp. NIES...
WP_171575463 313 QLPFFRRFLEDWQAYQANKd-------tYPAGLLTLSSGILVWK---EGEGK---------------------------- 354 Leptolyngbya sp...
WP_088893327 336 QLPFFQRFLEDWQAYQANKd-------tYPAGLLTLSSATLGWR---EGEGK---------------------------- 377 Leptolyngbya oh...
WP_012628504 336 QLPFFQRFLEDWQFYQANKe-------tYPAGLLTLSSTLLGWR---EGEGK---------------------------- 377 Cyanothece sp. ...
WP_015183357 312 QLHWFERFYEDYKIFTQNKd-------qVPAGLLTLRSARLVWQ---EGEg----------------------------- 352 Allocoleopsis f...
WP_073608258 333 QHHYFQRFVQDWDIYNRGKg-------pISGSLLLLRTASILWKpvqQSRHRa--------------------------- 378 Phormidium tenue

WP_015172821 445 kTEPWNTHRLYLQCSIDTRLLTAEGTEEVRQEEIGQIIKQLEGDSkdSRKKkaVTdnqeltagqmadRKRKSSTLTRLNN 524 Geitlerinema sp...
WP_045869560 401 -GEPWKVNKLALHCTYDARLLTAEGTEEVRQEKTDTTQKQVTKAE--GNEN--IDsde------qknLNRNISSLSRLNN 469 unclassified To...
WP_010996846 397 -GEPWKVNKLSLHCTYDTRLWTAEGTEEARKEKINKIQRQVEQAE--ETEN--LDeqq------qkqLKKNKSSLSRLNN 465 Nostocaceae
WP_069072561 402 -GEPWKVHKLALHCTYDSRLWTAEGTEEVRKEKTDKAQKRVSKAE--ENEK--LDdiq------qtqLNKDKSSLSRLKN 470 Nostoc sp. KVJ20
WP_096553061 398 -GEPWKVNKLALHCTYDARLWTAEGTEEVRQEKTDKAQAKVNKAE--SNEN--LNseq------qkeLTKNKSSLSRLKN 466 Nostoc sp. NIES...
WP_171575463 355 -GDPWNVNHLSLHCTFDTRLMTAEGTLQVQQEKLAKTTKSLTLKT--LEHE--LTdhq------kkfHQRNASTLNRLTN 423 Leptolyngbya sp...
WP_088893327 378 -GEPWQVNHLVLYCSFDTRLMTAEGTLAVQQEKASK-----ALKN--LARE--NSd------------PRNLSTLNRLQN 435 Leptolyngbya oh...
WP_012628504 378 -GDPWNVNRLALYCTFDTRLMTAEGTLDVQKEKSEK-----ALKN--LAKA--KPd------------PRNHSTLDRLKN 435 Cyanothece sp. ...
WP_015183357 353 eGEPWQVHRLLLHCSVETRLWTAQGTEEVRAEKIAQTQAAIDRQK--AKGT--QSkkl------ntsLERLKTFQG---- 418 Allocoleopsis f...
WP_073608258 379 tGEPWSDHSLYLHCQIDTKLLTQEGIEEKRQKKLASAQSSEQTRH--------ATpvq------aarQQGSLDRLQRSAQ 444 Phormidium tenue

WP_015172821 525 KSAfsRPSKKPYQGQPDIVVGVSFSRHKPATAVVWDAKEDKILETQTVRQLLVdrkvqdkrgnqtivqlkfQQYRLVGRH 604 Geitlerinema sp...
WP_045869560 470 SFA--RPSKPIYRGQSNIIVGVSFHPVELATLVVVDIITKEKIICKTVKQLLG------------------DAFSLLSRR 529 unclassified To...
WP_010996846 466 SFN--RPIQPIYQGLSNMIVGVSFHPVELATVAVVDTTTQKVIAYKTINELLD------------------NAFHLLSRM 525 Nostocaceae
WP_069072561 471 SFN--RPGKLIYQSQSNIIVGISFHPIELATVAIVDINTKKVLACNTVKQLLG------------------NAFHLLSRR 530 Nostoc sp. KVJ20
WP_096553061 467 SFA--RPSKPLYRGQSNIIVGISFHPVELATLVVVDINTKEILICKTVKELLG------------------DAFPLLSRR 526 Nostoc sp. NIES...
WP_171575463 424 LPS--RPSQQPYQGNPEILVGLSIGLADPITAAVVNGRTGEVLTYCTPRTLLG------------------DHYHHLNRH 483 Leptolyngbya sp...
WP_088893327 436 LPE--RPSRKPYQGNPEILVGLSVGLTHPVTVAVVNGRTGDALTYRTPRTLLG------------------DRYPLLNRQ 495 Leptolyngbya oh...
WP_012628504 436 LPV--RPSRTPYQGNPEILVGLRVGLTNPITAAVVNGRTGEVLTYRTPSTLLG------------------DRYDLFNRH 495 Cyanothece sp. ...
WP_015183357 419 -FS--RPSRASYKGNCSIVIGVSFGRAKPATVAVVNVETGEVLAYRDVKQLLNkpikeg------ktkkkkTQYEYLKRR 489 Allocoleopsis f...
WP_073608258 445 HPIh-LPSRTPYQGQPQIILGVSFNLKHPVTVAVVDVQSQEVVKYHSSRQLLSttd------------pktDQSHLPQQQ 511 Phormidium tenue

WP_015172821 605 QRLRRNRLRRRNQERSRGMYQqSKSETNLGLYVDRLLAARIVELAIKWKAGSITLPKIENIRESVESEIRARAEKKFPGL 684 Geitlerinema sp...
WP_045869560 530 RRQQVHFRKEREKAQKKDSPC-NMGESQLGEYVDKLLAKRIVEVTKEYKASCIVLPRLKDTREIRTSVIQAKAEAKFPGD 608 unclassified To...
WP_010996846 526 RRQQIHFRKERKKAQKKDSPC-NLGESKLGEYVDKLLAKRIVEVAKEYQAICIVLPKLKDMKEIRTSVIQAKAETKFPGN 604 Nostocaceae
WP_069072561 531 RRQQVHLSKERKKAQKKDSPC-NIGESKLGEYIDKLLAKRIVEIAKFYQAGCIILPRLKDMKEIRTSAIQAKAEAKIPGD 609 Nostoc sp. KVJ20
WP_096553061 527 RRQQVHFRKEREKAQKKDSPC-HLGESKLGEYVDRLLAKRIVEVAKEYQASCIVLPGLKGIREIRTSAIQAKAETKFPGD 605 Nostoc sp. NIES...
WP_171575463 484 RHQQKQNALQRHKNQKRGVTY-QPSESELGQTIDRLLAKAIIQLAQTYRAGSIMMPNLTHLRELLASEIQAKAEQKCSGS 562 Leptolyngbya sp...
WP_088893327 496 RQRQKQNALQRHKNQKRGVAY-QPSESELGQYVDRLLAKSIIQLAQQYQAGSIVIPNLKHLRELLSSEITAKAEQKCSGS 574 Leptolyngbya oh...
WP_012628504 496 RHQQEQNALERHKYQKRGVTY-QPSESELGKYVDRLLAKAIIELAQTYKAGSIVIPCLTHLREILASEIAARAEEKCPGS 574 Cyanothece sp. ...
WP_015183357 490 QEQQRLNSHQRHNAQKNGAPC-NFGESKQGEYVDRLLAKAIVEVASQYRASSIVLPDLRNIEEAAESEVRARAEQKFPGN 568 Allocoleopsis f...
WP_073608258 512 MAQQQSHDHERHKALKKDHYAp-YKEANLGAYLNQVLAKRVVDIAIQFRVSSIVLPDTKGLRDKLEAQLRAKAASKIVGS 590 Phormidium tenue

WP_015172821 685 KEAQDKYAKEFRISFHQWSYGRLDTAIRSKAARVGVLIETAWQPVSGDLQDKAKDLAQAAY 745 Geitlerinema sp. PCC 7407
WP_045869560 609 VNAQKIYVKEYNRQIHNWSYGRLQESIKSKAAEFKISIEFGMQPSYDNLQEQAINLALSAY 669 unclassified Tolypothrix
WP_010996846 605 VNAQKLYVKEYNRQVHNWSYNRLQESIKSKAAELKISIEFGIQLSYDTLQAQARDLALSAY 665 Nostocaceae
WP_069072561 610 VNAQKLYVKEYNRQIHNWSYNRLQESIKSKAAEFKISIEFGIQPHYGTLEEQAKDLAFYAY 670 Nostoc sp. KVJ20
WP_096553061 606 INVQELYVKEYNRQIHNWSYSRLQESIKSRAAELKITIKFGKQPSHSTLQEQAINLALSA- 665 Nostoc sp. NIES-4103
WP_171575463 563 VEAQDQYAKEYRRTIHQWSYNRLIEAIHCKAQQLGIPVESGFQPIQFNPQKQARDLAISVY 623 Leptolyngbya sp. Cla-17
WP_088893327 575 VEAQDKYAKEFRQRIHRWSYNRLLEAICSKANQVGITIETGFQPSKGTFQEQAKDLAIATY 635 Leptolyngbya ohadii
WP_012628504 575 VEAQDNYAKEYRRKIHNWSYNRLISAICSKAEQLGIIVESGFQPYEGDSYQQAKDLAIAVY 635 Cyanothece sp. PCC 7425
WP_015183357 569 QKLQDSYAKDYRASIHCWSYSRLAQCIELKAGKAGIATEKVHQPHGDTPQEKARDLVLAAY 629 Allocoleopsis franciscana
WP_073608258 591 VAAQKRYARTASIRLHHWSYNQLAELIKNRAAKLGIPVEVVPGLVADSPQATARDVVFSAY 651 Phormidium tenue
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