3N6Q


Conserved Protein Domain Family
Aldo_ket_red

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pfam00248: Aldo_ket_red 
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Aldo/keto reductase family
This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Statistics
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PSSM-Id: 425554
Aligned: 30 rows
Threshold Bit Score: 184.437
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3N6Q_G         28 LSLGLWHNFGH-----VNALESQRAI---LRKAF-DLGIT--HFDLANN---------Yg----pPPGSAEEN-FgrLLR 82   Escherichia c...
Q2RNF0         23 LGFGAMRVTGPgvwgaGPQPVEALKT---LKMLP-EVGVT--LIDTADS---------Y------GPGISEAM-IaeALY 80   Rhodospirillu...
Q8G5I8         29 LGMGTMALAIEg---rPSNRDQAIET---IHAAL-DAGVR--YLDTAWS---------YylpsapGTGEPEDMgYgeYLV 90   Bifidobacteri...
Q8IM05        510 LCIGTNMYENDn----FISRDDVNVL---LNMAFyEYGIN--FFDICEYdpfpfdpdsY------RKGQNRNMnL--FLK 572  Plasmodium fa...
EAZ79723       13 MVVGTSSLGNLy---eAKSYQEKLDL---VKAAL-GCFQNqvMFDSAGK---------Y------GAGLALET-LgeALK 69  
Q113F2         16 VGLGTWQMSGD-----VWGKKTEAEYcrgIEVAI-EAGID--YFDTALE---------Y------GNGYCEQV-VgkVLQ 71   Trichodesmium...
Q03P61         16 VSLGTWQLGSKwg--dPFDATDAQNT---LAAAY-DAGVN--FYDTADI---------Y------QDGASEQA-LakFIK 71   Lactobacillus...
WP_012110268   15 LTLGGGGLGRVw---gETTREEAIAT---LRLAV-ERGIT--LIDLAPL---------Y------GRGEAESV-AgeAFG 69   Parvibaculum ...
EDN04437       73 IIFGTATFNSQ-----YNADPYALATtaiVHRAL-SAGIR--AFDTSPY---------Y--------GPAEEL-LgrALS 126 
EDO18352        7 LILGGATFNTQ-----YNDDPSSIPIadiLRTAF-KNGIN--AIDSSPY---------Y--------GPSEIL-LgnALF 60  
3N6Q_G         83 Edf----aAYRDELIISTKAgydmw-----------------pgpygSGGSRK-----YLLASLDQSLKRMGLEYVDIFY 136  Escherichia c...
Q2RNF0         81 Py-----eGANADLVIATKGglvrpa----------------pdvwiPLGRPE-----YLRQQAQVSRRTLKVEKIGLWQ 134  Rhodospirillu...
Q8G5I8         91 RdalhswhGPKDQVLVATKTgwlrtldg------------ngnygwqADARPE-----TMIANAKESARRLGVDTLDLLY 153  Bifidobacteri...
Q8IM05        573 D-------KKRENIIINLRMcssrnvnkle-------ygdyylswimEGLKDDtptfyNIEERLDKILKNLNTNYVDILT 638  Plasmodium fa...
EAZ79723       70 El-----mVPQEKVLISNKLgwkrtpligtepsfekdvwkdldhdavQDISYQ-----GILNCFEEGNDLLNGFETQLVS 139 
Q113F2         72 R---------YPSVVISSKIppqcdews-----------pkpqdnidDYFSPA-----WINKCCETTLRNLRRECIDILF 126  Trichodesmium...
Q03P61         72 D--------KKDKVFVSTKVgrkld------------------phvaSGYTAA-----NITKFVEASLQNLEVDALDNVL 120  Lactobacillus...
WP_012110268   70 G-------GWPEGVRVTAKCmvg---------------------grhVGDIES-----RLEKSLLRSLETMKREQADIFF 116  Parvibaculum ...
EDN04437      127 Ayfv-rsnFPRYTYRLLTKVgria--------------------aqsFNYSPA-----WIRKSIKRSLSRLDTSYLDVVY 180 
EDO18352       61 Elk---deFSRDQYKICTKVgrig--------------------mneFDYSKE-----NVRHSVQRSCERFHTSYLDLVY 112 
3N6Q_G        137 SHRVDENTP--------------------------MEETASALAHAVQ----SGKALYVGIS---SYS-PERTQKMvel- 181  Escherichia c...
Q2RNF0        135 LHRIDPKVP--------------------------RDEQFDAIKSLID----DGIIAHAGLS---EVT-IADIEEA---- 176  Rhodospirillu...
Q8G5I8        154 SHCNDPQVP--------------------------YEDQMGALKQLVD----EGVAKAVGISridNAD-IETARNI---- 198  Bifidobacteri...
Q8IM05        639 VDIPERYLPnnekgedtyiwgfenlnteqnknsisIEEQFDILEKLIL----KGKVRHIAVS---NESvWGIYQWCnlak 711  Plasmodium fa...
EAZ79723      140 IHDPDEYLDqasspkd------------yekrfqdILEGYAALDELKK----TGKVKAIGVG---SKS-WEVIQKIh--- 196 
Q113F2        127 LHTWNVAWGd-------------------------RTEWYEAMVKLKE----QGKIRAIGVSvgdRRA-SEANSHI---- 172  Trichodesmium...
Q03P61        121 LHCPPTAVYy-------------------------DPEVFFTLDQLKQ----AGKIKNYGVS-------VERVEEAm--- 161  Lactobacillus...
WP_012110268  117 LHSNICPDDyeyerdrdya------aygavpvsafMDEVVPVFEKLKA----RGLIGAWGIT---GTGlPRSIMDVl--- 180  Parvibaculum ...
EDN04437      181 CHDVEFVSP---------------------------AEVLGAVVELRRirdvEGSIRYIGIS---GYP-VDILCSLaemv 229 
EDO18352      113 LHDVEFTTVd------------------------eSIEACMELKKLKD----EGIIRNFGLS---GYP-LDYIYKLvyhl 160 
3N6Q_G        182 --lrEWKIPLLIHQPSYNLLn---------RWVDKSGLLDTLQN--N-GVGCI-AFTPLAQGLLTGKYLNGIPQDSRMHR 246  Escherichia c...
Q2RNF0        177 ----SDYFPVATVQNRYNML-----------DRASEPVLEYCEA--K-GIGFI-PWSPLGAGGLF--------------- 222  Rhodospirillu...
Q8G5I8        199 -----LGDRLVAVQNQFSPV-----------HRDPEHTLETCEK--L-GLAFV-CWSPLG-GFLDPFNE----------- 246  Bifidobacteri...
Q8IM05        712 -kkkKKYMKIVCVQNLYNLLh--------kNEVESSGLVEMILKenY-NVPLV-PYGLLAGGILTGKYLDPERYHTMGPE 780  Plasmodium fa...
EAZ79723      197 ---sHFKLDWVMIANSMTIY------------DHPAELFEFMNQleKeGVGIV-NSAVFHSGFLVGGEYFDYQKMNKNEV 260 
Q113F2        173 -----EAGRIDVVMAVYNVL----------EQEPEYTLLPMAKK--H-QVGII-ARCPFSSGALVSNWTSSHKFPEGDWR 233  Trichodesmium...
Q03P61        162 ---kALDYDISAVEIIYNMF----------RLRPAENFFKMAQA--K-NVGII-ARVPLASGLLSGKYTLDTTFGKDDHR 224  Lactobacillus...
WP_012110268  181 ----RSEPKPDAVQAVTNLLdspggmrryeEPAEPRNIIRTAKN--N-DVGVM-GIRAVQAGALTAAIDRELPPGDPEAK 252  Parvibaculum ...
EDN04437      230 leetGEPLDAVMSYANFTLQn---------TKLAVEGLSRLVAA----GVDVVpNASPLGMGLLRRKGVPIGSMGDFHPA 296 
EDO18352      161 ttnyKEEIGNLDVVLSYCNL-----------NLQNTMLNEYYQKlmNcNLKTIcNASILSMSLLRSNETRSFHPCSKELR 229 
3N6Q_G        247 EGNKVrglt---------------------------------pkmLTEANLNSLRLLNEMAQQ-RGQ-SMAQMALSWLLK 291  Escherichia c...
Q2RNF0        223 ---------------------------------------------------DAGSELAVLAKR-WSI-TPGQIALAWLLK 249  Rhodospirillu...
Q8G5I8        247 ---------------------------------------------------HLFDRFREVAKI-HDC-SYQRVTLAWELA 273  Bifidobacteri...
Q8IM05        781 KVLGDdqldhdlneargnipedygylsygpkngrcnkypnlykshRCVWAQDATGEYLKLARS-HGM-SLSQLSLSYVYS 858  Plasmodium fa...
EAZ79723      261 RDQ---------------------------------------------LKYQWRIDFFSLCET-HKI-DPAHACIQFALQ 293 
Q113F2        234 GLWTSh--------------------------------------dWVAKQMEMVDHIKPIVKN-TNL-PMWTIGLKYILN 273  Trichodesmium...
Q03P61        225 SFNRHgeafd------------------------------qgetfSGVDYATGVQAANELHERlGLAtPLAPLALRYILM 274  Lactobacillus...
WP_012110268  253 D-------------------------------------------------YAKAAPFRALCRE-LGE-DPAIVAHRYALA 281  Parvibaculum ...
EDN04437      297 PD----------------------------------------------GLRNAILAASEWVAH-QGE-KIEVVAIRYALE 328 
EDO18352      230 ---------------------------------------------------EAADRSSEYCKS-NGV-ELADLATRYALs 256 
3N6Q_G        292 d-------------D---------------------RVTSVLIGASRAEQLEENVQALnnlTFSTKELAQIDQHI 332  Escherichia coli D...
Q2RNF0        250 r-------------S---------------------PVILPIPGTSKRAHLQENIAAAa-iVLTDDDFSAFDQLA 289  Rhodospirillum rub...
Q8G5I8        274 q-------------Y---------------------QYLFTIPSARNPQEIQDSFKASe-lKLSDSEIGYLNGKD 313  Bifidobacterium lo...
Q8IM05        859 r-------------P---------------------FVGSSIIGPRTLGQLKDSIFAL---NYPIYQHTEWDIHE 896  Plasmodium falcipa...
EAZ79723      294 l-------------P---------------------GVNSIALNSSSLHRIQANAEYCn-tLISDSFWDACKEKG 333 
Q113F2        274 n-------------K---------------------TVTSVIPGSSSPEHIRDNASVTmlpDLSEEVLGHLQELW 314  Trichodesmium eryt...
Q03P61        275 a-------------D---------------------AVSTVIPGASKPEQIARNVAAAdlpAFTPDQMAIVRDVY 315  Lactobacillus brev...
WP_012110268  282 m-------------P---------------------GVDTLVLGVKNRAELTAILDAEargPLDAEMVKRIDALR 322  Parvibaculum lavam...
EDN04437      329 swlregspvgvlgpPlarfpdadpgftsavthgvgrRLGVSVMGVSNIDELDETLRVW-------------RSII 390 
EDO18352      257 q------------wY---------------------GKGPTVLGVSSVKELEHSLNSY---KKVKKQNGLLDESD 295 
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