2R6U,3OXH,3OXH


Conserved Protein Domain Family
SgaA_N_like

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cd07247: SgaA_N_like 
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N-terminal domain of Streptomyces griseus SgaA and similar domains
SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.
Statistics
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PSSM-Id: 319911
Aligned: 68 rows
Threshold Bit Score: 80.3861
Created: 23-Feb-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2R6U_A     26 IVHFEIPFDDGDRARAFYRDAFGWAIAeip-----dmdYSMVTtgpvgesgmpdepgyiNGGMMQrge-------vtTPV 93  Rhodococcus sp. RHA1
NP_232809   7 INYVEFAAKDLESTKAFFSKVFGWSFVdyg------peYAAFSne------------glDGGFFKaelss--rtengGAL 66  Vibrio cholerae O1...
NP_386042  10 IDYVEFNVTDIAASKAFYGSAFGWTFTdyg------peYCEFAdg------------rlTGGFTTlgpv-----rsgGPL 66  Sinorhizobium meli...
NP_746166  10 IDNIEFNVSDISRSKAFYGSVFGWAFTdyg------ptYTEFSdg------------rlTGGFTTgepv-----rpgGPL 66  Pseudomonas putida...
NP_865438   8 INYIEIPATDMAKTKVFFETCFGWKFTdyg------peYTAFDkst-----------glDGGFYQsdkss--ltsngSAL 68  Rhodopirellula bal...
ACB13608    5 VVWTEIPVTDLQKSTDFYGKVFGWNMQitnmgpnevatFNALTda-------------dPNSVARhlypgt-paarsGST 70  uncultured alpha p...
EDX86605    7 INYLKLPTKDIEKTKAFFTQIFDWKFKdfg------sdYTVFSna------------gvEGGFFQsdksv--stesgSVL 66  Synechococcus sp. ...
EDY86981    6 IDYVELPASDLHAIKAFYQAAFGWRFIdyg------deYCALDga------------glDGGFFKaplss--stangAAL 65  gamma proteobacter...
EDZ47319    9 LVWGELPVSDLDAAVTFYSKVTGADLSidts---gpnpIAMFKta------------deASGVALhlypgrpagdgrGPT 73  Rhodobacterales ba...
EEE44268    9 NVWMEIPVSDLDKAIVFYNNVFQTELNlvtdm--gpnpFAMFPtse----------engVAGHLYpgkpa---dkgtGPT 73  Labrenzia alexandr...
2R6U_A     94 VTVDVES-IESALERIESLGGKTVTGRTPvgnmGFAAYFTDSEGNVVGLWE 143 Rhodococcus sp. RHA1
NP_232809  67 LIFYSSD-IEATLEKVVKNGGHIIRPIFEfp-gGCRFHFTEPSGNEFAVWS 115 Vibrio cholerae O1 biovar eltor str. N16961
NP_386042  67 VIIYADQ-IEDAQRRVEAAGGKIVKPIFTfp-gGRRFHFADPDGYELAVWS 115 Sinorhizobium meliloti 1021
NP_746166  67 VILYADD-LEATQQRIEAAGAKISRATFAfp-gGRRFHFIDPDGYELAVWT 115 Pseudomonas putida KT2440
NP_865438  69 VVFYSNE-LEATMAKVQSSGGTVIQEIFSfp-gGRRFQFTDPSGNEFGVWS 117 Rhodopirellula baltica SH 1
ACB13608   71 IHTAVPEtVEDAAKRCVAAGGQVMGPVIDil-qGRFQYATDLDGNSIALIE 120 uncultured alpha proteobacterium 01-003886
EDX86605   67 IVLYSET-LEETQSQIEEAGGKVTKPIFSfp-gGRRFHFSDPSGNEYGVWS 115 Synechococcus sp. PCC 7335
EDY86981   66 VVLYSED-LEASQQAVEQAGGTIIKPIFSfp-gGRRFQFTDPCGNELAVWS 114 gamma proteobacterium HTCC5015
EDZ47319   74 LHLTAEGaLEDVMERVTDAGGKVVSETIAip-pGRFFYATDPDGNSLGFFK 123 Rhodobacterales bacterium Y4I
EEE44268   74 IHIACPDtLEETMERFAKAGGEVISDPIPip-aGRFAYGIDPDGNSIGMFA 123 Labrenzia alexandrii DFL-11
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