4XK2


Conserved Protein Domain Family
AKR_PsAKR

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cd19091: AKR_PsAKR 
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Polaromonas Sp. aldo-keto reductase and similar proteins
The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Statistics
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PSSM-Id: 381317
Aligned: 27 rows
Threshold Bit Score: 414.703
Created: 13-Mar-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
putative activecatalytic
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       ###                                   #    #                  
4XK2_A      2 MEHRYLGnSGFKVPALGFGTGTFGgqgplfsawgntdvAGARRIIDICLDAGVNLFDTADVYsnGASESILGAALKg--- 78  Polaromonas sp. JS666
AFZ30468    1 MQYTTLGhTGLVVSRLAFGAMTFGqgelvpgvtnnidqTVADQMVNRVLDAGINLFDTADAYtgGQSEIMLGKALAn--- 77  Gloeocapsa sp. PCC...
EEF25807  128 MEYRSLGhSGLRVSQLALGAMTFGagqgiwesvagvdrEEAARQVAMALDSGINLIDTADVYsqGQSEDIVGQVLAdlgv 207 castor bean
AEE14490    1 MEYRIFGkTGLKVSSLCLGTMTFGsnfyni---gavdqNLADQMVAKALEAGINFIDTADVYsyGESEIILGKSLKnlsv 77  Thermodesulfobium ...
PNY79488    1 MQYRTLGrSGLIVSAFALGTMQFGqamnm----gsldqAATTDMVKFALDQGINFIDTADVYsrGESESQLGVALRg--- 73  Deinococcus sp. SJ...
NP_355786   1 MKYKTLGnTGLLVSQLCLGTMTFSdgtgiyehigdvgqTGADELVKASIDAGINFFDTADVYsaGASERTLGQSFKnlgi 80  Agrobacterium tume...
NP_925642   1 MQYTRLGnTGLIVSRLAFGAMTFGsgegafasvykvdqAGADRLVAQALDAGINFFNTADAYagGQSEIMLGKALGn--- 77  Gloeobacter violaceus
SNZ02686    1 MEYRNLGnSGLKVSVICLGAMTFTekgwrt--agtmdfSEIKRVVDYALDNGINFFDTADIYafGESEELLGKALGn--- 75  Persephonella hydr...
KUO92870    1 MKYIRIGrTGVLGSVLALGAMTFGeknvwk--lggvdqELANKMVKRSIDAGINFFDTADVYdeGRSEVLLGRALTg--- 75  Thermocladium sp. ...
CAC12572    5 MKYVRYGkTASFVSVLAFGAMTLGeknrwk--lggvtqELSDKMVKAAFDAGINLYDTADVYdeGDSEIMLGKSLKp--- 79  Thermoplasma acido...
Feature 1              #                                               ##                     
4XK2_A     79 rRDKAIVSTKLSLri-------geGPNDVGSSRHHLIAATNAALQRLdTDYIDILQLHAFDamTPVEQVLGTLDDLVRAG 151 Polaromonas sp. JS666
AFZ30468   78 rRQDAIIATKVGFrt-------gnALTDTGLSYRHIIASAEASLKRLeTDYIDLYQLHIPDplTPIEETIHALDDLVRQG 150 Gloeocapsa sp. PCC...
EEF25807  208 dDTRMLVATKVRLrt-------gpGCNQVGLGRSHIIRSVEASLKRLrRDHVDLLQLHDRDalTPLDETLRALDDLVTQG 280 castor bean
AEE14490   78 nREKVIIATKVKGamskealhgtgDLNNVGLSKKHIIEACNNSLKRLgTDYIDLYQIHGVDliTSLLETLEALDILVKQG 157 Thermodesulfobium ...
PNY79488   74 lREEVVLASKFRLpms------dtNVNRSGATRVNILRGVESSLRRLqTDYLDLYQVHGWDshTPLEETLSTLNDLVRRG 147 Deinococcus sp. SJ...
NP_355786  81 aRNEIVLATKVYSrm-------gsGRNDVGASRGHIMDAVEASLKRLqTDHIDLYQIHATDtlTPVEETLRALDDLVRQG 153 Agrobacterium tume...
NP_925642  78 rRQDVAIATKVGMrt-------geALVHSGLSRRHIIASAEGSLRRLgTDYIDVYLVHRIDpyTPLEETLEALDSLVRQG 150 Gloeobacter violaceus
SNZ02686   76 kKNDVIIATKVRGvmd------ekDPNNRGLSRYHIFRSVDNSLKRLgRDYIDLYQLHWWDnhTPIEETLEALNDLIRMG 149 Persephonella hydr...
KUO92870   76 yREQVLIATKVRGrt-------gqGVNETGLSKHHINIAIRKSLERLnTTWIDFYQFHGWDalAPLEEAAQAMQRLVEEG 148 Thermocladium sp. ...
CAC12572   80 yRDQVMIATKVRGrt-------gnGINESGLSRHHMSIAIRKSLERLdTKWIDIYQYHGWDlhGEFDEFLSTMEHFVDSG 152 Thermoplasma acido...
Feature 1            ##                        #                           #######            
4XK2_A    152 KVRYIGLSNFsGWQLMKSLAAADrlglQRYVANQTYYSLIGRDYEwELMPLGIDQGVGAIVWSPLGWGRLTGKIRRGqpl 231 Polaromonas sp. JS666
AFZ30468  151 KVRYVGFSNFpAWKAALMLGIQKsknyTQFVAAQMYYSLLGRDLEhEIVPFVEDTGIGILVWSPLASGFLSGKYTREapv 230 Gloeocapsa sp. PCC...
EEF25807  281 KVRHVGACNFsASELERAHAISTaahwVRVCSNQVHYSLASRDIEhELMPVARLHGTALMVWSPLAGGYLSGKYTPDgsg 360 castor bean
AEE14490  158 KVIYIGCSNLaSRHIMKALAISQlknlSSFVSLQAYYSLLGRDLEhELLPLCIEESLALMTWSPLSGGFLSGKYTRDnpk 237 Thermodesulfobium ...
PNY79488  148 LVRHIGLSNYlAWQAATALGIQErrgwEPFVTAQLYYSLVGRELEhEWMDLAAYSGLGVLVWSPLAGGYLSAKYDRPeqa 227 Deinococcus sp. SJ...
NP_355786 154 KVRYVGVSNWqAWRIATALGVSArlglERFNTLQAYYSIAGRDLErELKPLLDAEKMGLLVWSPLAGGLLSGRFSRAnqs 233 Agrobacterium tume...
NP_925642 151 KVRYVGYSNWpAWLAAKAVGLQRehgwERFRANEMYYSLVGRDLEhEVVPFALDAGVGITVWSPLAGGFLSGKYTREdpe 230 Gloeobacter violaceus
SNZ02686  150 KIRYIGISDFaGWQIARSVSIQEmknyTKFVSAQMYYSLLGRDIEfEVVPACEALGLGILAWSPLAGGFLTGKYSKDsph 229 Persephonella hydr...
KUO92870  149 LVNYPGVSNFaAWQMAVLQTMVEergyARYETAQMNYSLLNRDIEhEVLPFLDYSGMTLLVWSPLHGGILTGKYTNYekp 228 Thermocladium sp. ...
CAC12572  153 YVIYPAVSNFtAWQMATLQAMAVergyARYESAQMNYSLLNRDIEhEVLPLMKYWSMTLLSWSPLHGGVLTGKYRRGekp 232 Thermoplasma acido...
Feature 1                                            #                ######  #  ##           
4XK2_A    232 pagsrlhdtagfaPPVDDERLYRVVDAMDEVALETGkTLPQIALNWLLQrpTVASVLIGARDEEQLMQNLGAlgWQLTTE 311 Polaromonas sp. JS666
AFZ30468  231 aeds--rrknfqfPPVDVEKGYAVVEVLQEVAHNHNaSPAQVAIAWILTksFISSVIIGANKIHHLEDNLGAakLKLSAS 308 Gloeocapsa sp. PCC...
EEF25807  361 sapargrrtsldfPPVDPARIDPIVHALRDIARALDaTPAQVALAWLLSrpGVATVIVGARSTEQLAANLRAadLRLPPA 440 castor bean
AEE14490  238 pqga--rrstfnfPPINEEKAYDTIDVLLGIAKERSvSPAQVALAWLLHqrGVTSVIIGANKMNQLEDNIKSadLKLTKN 315 Thermodesulfobium ...
PNY79488  228 pagtr-fgeagqfVPFSWEKGRPVLEALRAVAARHSvTPAQVALAWTVSqpGVSSVIIAARSTERLGENIRSldIVLSDE 306 Deinococcus sp. SJ...
NP_355786 234 pegs--rrssfdfPIVDKERAWNVIDVLKPIAKAHGcSPARIALAWLLAkpVVTSVIVGAKRLSQLEDNIAAvgTVLSDD 311 Agrobacterium tume...
NP_925642 231 gggg--rltgfdfLPFDRERGYAVVDKLREIAAVHGaTPAQVALAWLLSrpYVASILVGASRASQLADNLGAadLALTTE 308 Gloeobacter violaceus
SNZ02686  230 pedsrysrmerpfLRFDFEKGYFIIDELKKIAEKYNaTVSQVALNWVKSksFISSVIIGVRSLEQLKDNLGCvrWDLSQE 309 Persephonella hydr...
KUO92870  229 qpgtrmgnrgfffPPFDPALAQQVVEKLKDIAKQQGaTPAQVALAWLLT--KKLIVIIGARTMEQLEENLGAldVNLKPS 306 Thermocladium sp. ...
CAC12572  233 asgtrmgdrgfffPYFDEVHGWDIVDEVRNIAQEQGcTMSQAALAWIVS--KGHVAIIGARNMEQLQENLESinVNLKKE 310 Thermoplasma acido...
Feature 1              
4XK2_A    312 QVARLDAAS 320 Polaromonas sp. JS666
AFZ30468  309 EVEQLDTLT 317 Gloeocapsa sp. PCC 7428
EEF25807  441 DRERLDEMS 449 castor bean
AEE14490  316 EIDMLSEVS 324 Thermodesulfobium narugense
PNY79488  307 DRRELDRAS 315 Deinococcus sp. SJW1-2
NP_355786 312 EVARLDAVS 320 Agrobacterium tumefaciens complex
NP_925642 309 EIYGLDAST 317 Gloeobacter violaceus
SNZ02686  310 DVEYLDQIT 318 Persephonella hydrogeniphila
KUO92870  307 QVDELNELT 315 Thermocladium sp. ECH_B
CAC12572  311 QIERLDKIS 319 Thermoplasma acidophilum

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